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“回归”罗马——米开朗基罗与圣玛利亚·德利安杰利教堂

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华中建筑 2024年第3期42卷 29-32页

作者：李倩南京大学建筑与城市规划学院

圣玛利亚·德利安杰利教堂由古罗马的戴克里先大浴场遗迹改造而成,米开朗基罗串联起大浴场中最核心的三大浴厅,在打造教堂空间的同时对古罗马进行“回归”。该文从多个维度对米开朗基罗的设计做出界定和分析,解读设计中的超越性及启发性。

关键词：米开朗基罗古罗马改造圣玛利亚·德利安杰利教堂戴克里先大浴场

Neuro Touch: a virtual reality neurosurgical simulator for training and evaluating neurosurgeons

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Neuro Touch: a virtual reality neurosurgical simulator for t...

3D-printed scaffolds with 2D hetero-nanostructures and immunomodulatory cytokines provide pro-healing microenvironment for enhanced bone regeneration

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： maria li National Research Council Canada

＜正＞Medical simulation is a rapidly growing field, having a positive impact on how healthcare providers are being trained and evaluated. Over the last ten years, there has been a 15-fold increase in the number of me...

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Bioactive Materials 2023年第9期27卷 216-230页

作者： Xifeng liu Bipin Gaihre Sungjo Park linli li Babak Dashtdar maria D.Astudillo Potes Andre Terzic Benjamin D.Elder lichun Lu Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMN55905USA Department of Orthopedic Surgery Mayo ClinicRochesterMN55905USA Department of Cardiovascular Medicine and Center for Regenerative Medicine Mayo ClinicRochesterMN55905USA Department of Neurologic Surgery Mayo ClinicRochesterMN55905USA

Three-dimensional (3D) printing technology is driving forward the progresses of various engineering fields, including tissue engineering. However, the pristine 3D-printed scaffolds usually lack robust functions in stimulating desired activity for varied regeneration applications. In this study, we combined the two-dimensional (2D) hetero-nanostructures and immuno-regulative interleukin-4 (IL-4) cytokines for the functionalization of 3D-printed scaffolds to achieve a pro-healing immuno-microenvironment for optimized bone injury repair. The 2D hetero-nanostructure consists of graphene oxide (GO) layers, for improved cell adhesion, and black phosphorous (BP) nanosheets, for the continuous release of phosphate ions to stimulate cell growth and osteogenesis. In addition, the 2D hetero-nanolayers facilitated the adsorption of large content of immuno-regulative IL-4 cytokines, which modulated the polarization of macrophages into M2 phenotype. After in vivo implantation in rat, the immuno-functioned 3D-scaffolds achieved in vivo osteo-immunomodulation by building a pro-healing immunological microenvironment for better angiogenesis and osteogenesis in the defect area and thus facilitated bone regeneration. These results demonstrated that the immuno-functionalization of 3D-scaffolds with 2D hetero-nanostructures with secondary loading of immuno-regulative cytokines is an encouraging strategy for improving bone regeneration.

关键词： 3D-printing 2D materials Bone repair Osteo-immunomodulation Cytokines

Effect of Encapsulation Combined with Microwave Heating on Self-Healing Performance of Asphalt Mixture

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Journal of Renewable Materials 2021年第10期9卷 1781-1794页

作者： Benan Shu lixian Guo Bing Qiu Tengyu Yang Tao Sun Wenjun Qiu Min Zhou Putao Song Yuanyuan li Diego maria Barbieri Shaopeng Wu Foshan Transportation Science and Technology Co. Ltd.Foshan528000China China Academy of Building Research Beijing100000China School of Civil Engineering and Architecture Wuhan Institute of TechnologyWuhan430070China Department of Civil and Environmental Engineering Norwegian University of Science and TechnologyTrondheim7491Norway State Key Laboratory of Silicate Materials for Architectures Wuhan University of TechnologyWuhan430070China

As an innovative maintenance technology of asphalt pavement,encapsulated rejuvenator used to improve its self-healing performance has been widely investigated by researchers in recent *** this work,the selfhealing properties of asphalt mixture with and without encapsulations were comparatively studied considering these parameters:Healing time,healing cycles and microwave ***-point bending strength recovery test and fatigue loading cycles recovery test were conducted for two kinds of encapsulations containing the healing agents present inside the asphalt mixture,namely compartmented Ca-alginate/SiO_(2) fiber and compartmented Ca-alginate/graphene oxide *** results showed that the optimum healing time was three *** the 30 s of microwave heating,the recovery of fatigue loading cycles of asphalt mixture with compartmented Ca-alginate/graphene oxide fiber was four times larger than that of control asphalt *** with the single effect related to the encapsulated healing agent or temperature,the synergistic effect of temperature and encapsulation could further significantly improve the self-healing properties of asphalt *** compartmented Ca-alginate/graphene oxide fiber not only could soften asphalt through the encapsulated healing agent to improve self-healing properties of asphalt,but also could repeatedly and quickly heal cracks thanks to microwave *** synthesis of the fiber breaks the current boundary between the two technologies(capsules healing method and induction healing method)and opens up a new horizon for the asphalt self-healing technology.

关键词： Asphalt mixture self-healing compartmented fiber encapsulation microwave heating

Breakthrough cancer medicine and its impact on novel drug development in China: report of the US Chinese Anti-Cancer Association (USCACA) and Chinese Society of Clinical Oncology (CSCO) Joint Session at the 17th CSCO Annual Meeting

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Chinese Journal of Cancer 2014年第12期33卷 620-624页

作者： Feng Roger Luo Jian Ding Helen X. Chen Hao liu Man-Cheong Fung maria Koehler Jean Pierre Armand Lei Jiang Xiao Xu Ge Zhang li Xu Pascal Qian li Yan The US Chinese Anti-Cancer Association MartinezCA 94553 USA Department of Oncology Janssen Research & Development LLC RaritanNJ 08869 USA Shanghai Institute of Materia Medica Chinese Academy of Sciences Cancer Therapy Evaluation Program National Cancer Institute Novartis Pharmaceuticals (China) Oncology Pfizer Oncology New YorkNY 10017 USA Institut Gustave Roussy Cancer Campus Grand Paris ACEA Biosciences Inc. Jiangsu Hengrui Medicine Co. Ltd. Beijing Cancer Hospital and Institute Peking University School of Oncology

The US Chinese Anti-Cancer Association(USCACA)teamed up with Chinese Society of Clinical Oncology(CSCO)to host a joint session at the17th CSCO Annual Meeting on September 20th,2014in Xiamen,*** a focus on breakthrough cancer medicines,the session featured innovative approaches to evaluate breakthrough agents and established a platform to interactively share successful experiences from case studies of 6 novel agents from both the United States and *** goal of the session is to inspire scientific and practical considerations for clinical trial design and strategy to expedite cancer drug development in China.A panel discussion further provided in-depth advice on advancing both early and full development of novel cancer medicines in China.

关键词：抗癌药物中国临床美国学会肿瘤协会新药

Sulphur-doped ordered mesoporous carbon with enhanced electrocatalytic activity for the oxygen reduction reaction

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Journal of Energy Chemistry 2016年第4期25卷 566-570页

作者： liping Wang Weishang Jia Xiaofeng liu Jingze li maria Magdalena Titirici State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China School of Materials Science and Engineering Zhejiang University School of Materials Science and Engineering Queen Mary University of London Materials Research Institute Queen Mary University of London

Metal-free, heteroatom functionalized carbon-based catalysts have made remarkable progress in recent years in a wide range of applications related to energy storage and energy generation. In this study, high surface area mesoporous ordered sulphur doped carbon materials are obtained via one-pot hydrothermal synthesis of carbon/SBA-15 composite after removal of in-situ synthesized hard template SiO2. 2-thiophenecarboxy acid as sulphur source gives rise to sulphur doping level of 5.5 wt%. Comparing with pristine carbon, the sulphur doped mesoporous ordered carbon demonstrates improved electro-catalytic activity in the oxygen reduction reaction in alkaline solution. (C) 2016 Science Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.

关键词： Mesoporous ordered carbon Oxygen reduction reaction Electrocatalyst Heteroatom doping In-situ synthesis

NiWO4 powders prepared via polymeric precursor method for application as ceramic luminescent pigments

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Journal of Advanced Ceramics 2020年第1期9卷 55-63页

作者： Naiara A.liMA Lorena D.S.ALENCAR Máximo SIU-li Carlos A.C.FEITOSA Alexandre MESQUITA Jean-Claude M’PEKO maria I.B.BERNARDI Instituto de Física de Sao Carlos Universidade de Sao Paulo13560-970 Sao CarlosSPBrazil Instituto Federal de Mato Grosso do Sul IFMS79200-000 AquidauanaMSBrazil Departamento de Física Centro de Ciências Exatas e TecnologiaUniversidade Federal do MaranhaoUFMA65080-805Sao LuisMABrazil Instituto de Geociências e Ciências Exatas Departamento de FísicaUniversidade Estadual Paulista13506-900Rio ClaroSPBrazil

Ni WO4 was prepared using the polymeric precursor method and studied in terms of physical and chemical properties to verify its stability for industrial applications as *** characterization was accomplished using thermal analyses,X-ray diffraction(XRD),scanning electron microscopy(SEM),photoluminescence(PL)and UV–Vis spectroscopies,colorimetric coordinates,and Raman *** the temperature,successive exothermic reactions were observed and they are related with thermal decomposition of the organic *** stability was reached at^700℃.The material is verified to become completely free of second phase at^800℃.The end Ni WO4 powders showed an intense charge transfer(CT)-related tail centered in the ultraviolet region,resulting in a yellow *** addition,the powders exhibited broad excitation band and broad deep blue–green emission band,which were enhanced with increasing powders’crystallinity.

关键词： nickel tungstate yellow pigment colorimetric coordinate optical property structural characterization

Comprehensive Metabolic Profiling of Modified Gegen Qinlian Decoction by Ultra-high-Performance liquid Chromatography-Diode Array Detection-Q-Exactive-Orbitrap-Electrospray Ionization-Mass Spectrometry/Mass Spectrometry and Application of High-Performance

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 11-32页

作者： Xuehong Nöst Eva-maria Pferschy-Wenzig Xiao-Tong Yu Min li Xiao-lin Tong Rudolf Bauer Department of Pharmacognosy Institute of Pharmaceutical SciencesUniversity of GrazGrazAustria Department of Endocrinology Guang’Anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Endocrinology Laboratory of Molecular BiologyGuang’Anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina

Objective:Gegen Qinlian decoction(GQD)is a classical traditional Chinese medicine formulation which has been used for almost 2000 *** Guang'anmen Hospital,Beijing,a modified GQD version(m GQD)with seven instead of four herbal ingredients has been applied to treat Type 2 *** control is a crucial prerequisite for the therapeutic application of herbal *** the identification of products derived from classical GQD,the Chinese Pharmacopeia requires the analysis of only three marker *** m GQD is a more complex mixture containing seven herbs and hundreds of constituents,the pharmacopoeia method for GQD is *** and Methods:A more comprehensive characterization of the formula's constituents has been developed using ultra-high-performance liquid chromatography-diode array detection(UHPLC-DAD)-Q-Exactive-mass spectrometry(MS)in electrospray ionization positive and negative ***,a new method for the fingerprint analysis of m GQD via high-performance thin-layer chromatography(HPTLC)has been ***:Altogether,91 compounds have been assigned to their originating plants and 84 substances were identified either by comparison with authentic references or with data from the *** HPTLC method is based on the application of two different mobile phases and is able to detect both lipophilic and hydrophilic constituents of m ***:The modified GQD was extensively characterized by UHPLC combined with DAD and Q-Exactive Orbitrap high-resolution MS detection,leading to the assignment and identification of compounds present in the *** addition,a new method for the fingerprint analysis of the m GQD using HPTLC was established,which allows fast and simple identification of the herbal ingredients in the mixture.

关键词： Fructus jujubae HPTLC Modified gegen qinlian decoction Radix et rhizoma glycyrrhizae praeparata cum melle Radix puerariae lobatae Radix scutellariae Rhizoma coptidis Rhizoma anemarrhenae Rhizoma zingiberis UHPLC-DAD-Q-Exactive-MS

The many faces of cGAS:how cGAS activation is controlled in the cytosol,the nucleus,and during mitosis

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2261-2263页

作者： Anna-maria Herzner Martin Schlee Eva Bartok Department of Cancer Immunology and Immune Modulation Boehringer Ingelheim Pharma GmbH&Co.KGBiberach an der RiBGermany lnstitute of Clinical Chemistry and Clinical Pharmacology University HospitalUniversity of BonnBonnGermany Unit of Experimental Immunology Department of Biomedical SciencesInstitute of Tropical MedicineAntwerpBelgium

In their recently published study in Science,li et al.1 unravel how hyperphosphorylation and chromatin-tethering of the double-stranded(dsDNA)sensor cGAMP synthase(cGAS)prevent self DNA recognition during mitosis(Fig.1);providing important insight into how this innate immune sensor balances its essential function for pathogen defense against potential autoinflammation.

关键词： activation sensor insight