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Environmental Science and Ecotechnology 2022年第3期11卷 32-39页

作者： Carolina Cruz Viggi Matteo Tucci Marco Resitano Simona Crognale maria letizia di franca Simona Rossetti Federico Aulenta Water Research Institute(IRSA) National Research Council(CNR)Via Salaria Km 2930000015MonterotondoRMItaly

Bioremediation of groundwater contaminated by a mixture of aromatic hydrocarbons and chlorinated solvents is typically challenged because these contaminants are degraded via distinctive oxidative and reductive pathways,thus requiring different amendments and redox ***,we provided the proof-of-concept of a single-stage treatment of synthetic groundwater containing toluene and trichloroethene(TCE)in a tubular bioelectrochemical reactor,known as a“bioelectric well”.Toluene was degraded by a microbial bioanode(up to 150 mmol L^(-1) d^(-1))with a polarized graphite anode(t0.2 V ***)serving as the terminal electron *** electric current deriving from microbially-driven toluene oxidation resulted in(abiotic)hydrogen production(at a stainless-steel cathode),which sustained the reductive dechlorination of TCE to less-chlorinated intermediates(i.e.,cis-DCE,VC,and ETH),at a maximum rate of 500 meq L^(-1) d^(-1),in the bulk of the reactor.A phylogenetic and functional genebased analysis of the“bioelectric well”confirmed the establishment of a microbiome harboring the metabolic potential for anaerobic toluene oxidation and TCE reductive ***,Toluene degradation and current generation were found to be rate-limited by external mass transport phenomena,thus indicating the existing potential for further process optimization.

关键词： Bioelectric well Dehalococcoides mccartyi Electrobioremediation Groundwater remediation Toluene Trichloroethene

Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib(Iressa^(TM))and to the antiangiogenic agent ZD6474:Cytotoxic and biomolecular effects

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World Journal of Gastroenterology 2006年第32期12卷 5140-5147页

作者： Amalia Azzariti letizia Porcelli Jian-Ming Xu Grazia maria Simone Angelo Paradiso Clinical Experimental Oncology Laboratory National Cancer Institute Bari Italy Beijing 307 Hospital Cancer Center Beijing 100039 China

AIM： To analyze the biological effects of prolonged in vitro exposure of HT-29 and LoVo colon cancer cell lines to gefitinib （Iressa^TM）, an inhibitor of epidermal growth factor receptor （EGFR） activity, and ZD6474, an inhibitor of both KDR and EGFR activities. METHODS： Cells were treated with each drug for up to 2 wk using either a continuous or an intermittent （4 d of drug exposure followed by 3 d of washout each week） schedule. RESULTS： In both cell types, prolonged exposure （up to 14 d） to gefitinib or ZD6474 produced a similar inhibition of cell growth that was persistent and independent of the treatment schedule. The effects on cell growth were associated with a pronounced inhibition of p-EGFR and/ or p-KDR expression. Treatment with gefitinib or ZD6474 also inhibited the expression of EGFR downstream signal molecules, p-Erkl/2 and p-Akt, although the magnitude of these effects varied between treatments and cell lines. Furthermore, expression of the drug resistance-related protein ABCG2 was shown to significantly increase after 14 d of continuous exposure to the two drugs. CONCLUSION： We conclude that long-term exposure of colon cancer cells to gefitinib and ZD6474 does not modify their cytotoxic effects but it might have an effect on sensitivity to classical cytotoxic drugs.

关键词： Gefitinib ZD6474 Colon cancer Tyrosine ki-nase Chemo-resistance

Design and criteria of electrospun fibrous scaffolds for the treatment of spinal cord injury

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Neural Regeneration Research 2017年第11期12卷 1786-1790页

作者： Barbara Vigani Silvia Rossi Giuseppina Sandri maria Cristina Bonferoni franca Ferrari Department of Drug Sciences University of PaviaViale TaramelliPaviaItaly

The complex pathophysiology of spinal cord injury may explain the current lack of an effective therapeutic approach for the regeneration of damaged neuronal cells and the recovery of motor functions. Many efforts have been performed to design and develop suitable scaffolds for spinal cord regeneration, keeping in mind that the reconstruction of a pro-regenerative environment is the key challenge for an effective neurogenesis. The aim of this review is to outline the main features of an ideal scaffold, based on biomaterials, produced by the electrospinning technique and intended for the spinal cord regeneration. An overview of the poly- mers more investigated in the production of neural fibrous scaffolds is also provided.

关键词： spinal cord injury biomaterials electrospun fibers conductive scaffolds morphological properties biodegradability

Benefits of Biochars and NPK Fertilizers for Soil Quality and Growth of Cowpea (Vigna unguiculata L. Walp.) in an Acid Arenosol

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Pedosphere 2019年第3期29卷 311-333页

作者： Rogerio Borguete Alves RAFAEL maria Luisa FERNANDEZ-MARCOS Stefania COCCO maria letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry Engineering Universidade Eduardo Mondlane Maputo 257 (Mozambique) Department of Agriculture Food and Environmental Sciences Univ er sit a Politecnica delle Marche Ancona 60131 (Italy) Department of Soil Science and Agricultural Chemistry Universidad de Santiago de Compostela Lugo 27002 (Spain) Department of Materials Environmental Sciences and Urban Planning Universita Politecnica delle Marche Ancona 60131 (Italy) Centro di Ricerca Viticoltura ed Enologia Gorizia 34170 (Italy) Instituto de Biodiv ersidade Agraria e Desenvolvimento Rural Universidad de Santiago de Compostela Lugo 27002 (Spain)

Fertilization is required for optimum plant growth, particularly in unfertile soils, while optimizing nutrient use effciency is an alternative to reduce inorganic fertilizer needs and reduce environmental problems caused by nutrient leaching. This study investigated soil properties and cowpea yield responses to biochars(BCs) made from different feedstocks, baby corn peel biochar(BC1), branches of mango tree biochar(BC2), and rice husk biochar(BC3), applied in combination with nitrogen-phosphorus-potassium(NPK) *** experiment was conducted in a greenhouse, using an acid sandy soil(Arenosol) that was submitted for 70 d to the following eight treatments: i) control;ii) full dose of NPK(a commercial compound fertilizer(12-24-12 of N-P2O5-K2O)+ urea(46% N));iii) BC1+ half dose of NPK;iv) BC1 + full dose of NPK;v) BC2 + half dose of NPK;vi) BC2 + full dose of NPK;vii) BC3 + half dose of NPK;and viii) BC3 + full dose of NPK. All biochars were applied at a rate of 0.9%(weight/weight), and each type of biochar was combined with half and full doses of NPK fertilizers. Soil pH increased significantly(P died.

关键词： acid soil nutrient use effciency organic amendment plant growth potential enzyme activity soil fertility soil pH

Precision medicine in gastric cancer

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World Journal of Gastrointestinal Oncology 2019年第10期11卷 804-829页

作者： Patrizia Bonelli Antonella Borrelli franca maria Tuccillo Lucrezia Silvestro Raffaele Palaia Franco maria Buonaguro Molecular Biology and Viral Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Abdominal Medical Oncology Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy Gastro-pancreatic Surgery division Istituto Nazionale Tumori-IRCCS-Fondazione G PascaleNapoli 80131Italy

Gastric cancer(GC)is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits,and especially to genetic *** represents the second leading cause of cancer-related deaths *** onset is subtle,and the majority of patients are diagnosed once the cancer is already *** recent years,there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular *** to new technologies such as next-generation sequencing and microarray,the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC,making it possible to integrate diagnostic and therapeutic *** the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results;many lines of research have been initiated to this *** phase III clinical trials,trastuzumab,anti-Erb-B2 receptor tyrosine kinase 2(commonly known as ERBB2)and ramucirumab,anti-vascular endothelial growth factor receptor 2(commonly known as VEGFR2)monoclonal antibodies,were approved and introduced into first-and second-line therapies for patients with advanced/metastatic ***,the heterogeneity of this neoplasia makes the practical application of such approaches ***,scientific progress has not been matched by progress in clinical practice in terms of significant improvements in *** continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal,lung,breast,and prostate *** several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols,the overall approach to treating advanced stage GC has not substantially ***,surgical resection with adjuvant or neoadjuvant radiotherapy and ch

关键词： Gastric cancer Molecular characterization Biomarkers Precision medicine Targeted therapy

Characterization and catalytic activity of soft-templated Ni0-CeO_(2) mixed oxides for CO and CO_(2) co-methanation

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Frontiers of Chemical Science and Engineering 2021年第2期15卷 251-268页

作者： Luciano Atzori maria Giorgia Cutrufello Daniela Meloni Barbara Onida Delia Gazzoli Andrea Ardu Roberto Monaci maria franca Sini Elisabetta Rombi Department of Chemical and Geological Sciences University of Cagliari09042 Monserrato(CA)Italy Department of Materials Science and Chemical Engineering CR-INSTM for Materials with Controlled PorosityPolytechnic of Turin10129 TurinItaly Department of Chemistry University of Rome“La Sapienza”00185 RomeItaly

Nanosized NiO,CeO_(2) and NiO-CeO_(2) mixed oxides with different Ni/Ce molar ratios were prepared by the soft template *** the samples were characterized by different techniques as to their chemical composition,structure,morphology and *** the catalysts submitted to the same reduction pretreatment adopted for the activity tests the surface basic properties and specific metal surface area were also *** and CeO_(2) nanocrystals of about 4 nm in size were obtained,regardless of the Ni/Ce molar *** Raman and X-ray photoelectron spectroscopy results proved the formation of defective sites at the NiO-CeO_(2) interface,where Ni species are in strong interaction with the *** microcalorimetric and Fourier transform infrared analyses of the reduced samples highlighted that,unlike metallic nickel,CeO_(2) is able to effectively adsorb CO_(2),forming carbonates and hydrogen *** reduction in H2 at 400°C for 1 h,the catalytic performance was studied in the CO and CO_(2) co-methanation *** tests were performed at atmospheric pressure and 300°C,using CO/CO_(2)/H_(2) molar compositions of 1/1/7 or 1/1/5,and space velocities equal to 72000 or 450000 cm^(3)∙h^(-1)∙gcat^(-1).Whereas CO was almost completely hydrogenated in any investigated experimental conditions,CO_(2) conversion was strongly affected by both the CO/CO_(2)/H_(2) ratio and the space *** faster and definitely preferred CO hydrogenation was explained in the light of the different mechanisms of CO and CO_(2) *** a selected sample,the influence of the reaction temperature and of a higher number of space velocity values,as well as the stability,were also *** that the Ni content is optimized,the NiCe system investigated was very promising,being highly active for the CO_(x) co-methanation reaction in a wide range of operating conditions and stable(up to 50 h)also when submitted to thermal stress.

关键词： soft template method Ni0-CeO_(2)catalystss CO and CO_(2)co-mtharation synthetic natural gas production

Increased phosphorus availability to corn resulting from the simultaneous applications of phosphate rock, calcareous rock, and biochar to an acid sandy soil

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Pedosphere 2020年第6期30卷 719-733页

作者： Rogério Borguete Alves RAFAEL maria Luisa FERNÁNDEZ-MARCOS Stefania COCCO maria letizia RUELLO Flavio FORNASIER Giuseppe CORTI Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257Mozambique Department of Agriculture Food and Environmental SciencesUniversitàPolitecnica delle MarcheAncona 60131Italy Department of Soil Science and Agricultural Chemistry Universidad de Santiago de CompostelaLugo 27002Spain Department of Materials Environmental Sciences and Urban PlanningUniversitàPolitecnica delle MarcheAncona 60131Italy Consiglio per la Ricerca e la Sperimentazione in Agricoltura Centro di Ricerca per lo Studio delle Relazioni tra Pianta e Suolo(C.R.E.A.-R.P.S.)Gorizia 34170Italy Instituto de Biodiversidade Agraria e Desenvolvemento Rural Universidad de Santiago de CompostelaLugo 27002Spain

Phosphorus(P)deficiency is one of the main constraints on crop production in Arenosols(acid sandy soil).The high cost of P fertilizers may represent an insurmountable obstacle in many poor countries,leaving the exploitation of their own calcareous and phosphate rocks as the only low-cost and long-term *** is suggested to have positive effects on soil properties;however,there is no published research on the synergistic effects of biochar and rocky materials in modifying soil *** aim of this study was to investigate the chemical and biochemical responses of an acid Arenosol treated with phosphate rock(PR),calcareous rock(CR),and biochar(BC),and the implications for corn yield.A soil from Marracuene district,Mozambique was used,where corn was grown for 90 d with the soil treated with:no addition(control),water-soluble zinc phosphite fertilizer(WSP),PR,WSP+CR,WSP+BC,WSP+CR+BC,PR+BC,and PR+CR+*** was produced by pyrolysis of babycorn peels for 4 h at 450?C and applied at 11 g *** soil pHH2 Oincreased from about 4.54 in the control to 7.38 in the PR+CR+BC *** oxidizable organic carbon,cation exchange capacity,and available P were higher in the treatments containing BC than in the *** treatments containing CR and/or BC led to the highest activities of alkaline phosphomonoesterase,phosphodiesterase,andα-glucosidase,which increased P availability and gave the greatest biomass and *** suggest that biochar provides additional soluble P and supplies adsorption sites for phosphate,preventing its evolution to unavailable ***,PR applied together with BC contributed to an 840%yield increase compared to the *** treatments containing WSP and BC facilitated phosphite oxidation to phosphate and increased crop yield.

关键词： Arenosols available P enzyme activity phosphite oxidation soil fertility

Ticagrelor therapy and atrioventricular block:Do we need to worry?

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World Journal of Clinical Cases 2017年第5期5卷 178-182页

作者： Elia De maria Ambra Borghi letizia Modonesi Stefano Cappelli Cardiology Unit Ramazzini Hospital

Ticagrelor is a potent,direct P2Y12 antagonist with rapid onset of action and intense platelet inhibition,indicated in patients with acute coronary syndromes(ACS).This drug is usually well tolerated,but some patients experience serious adverse effects:Major bleeding;gastrointestinal disturbances;dyspnoea;ventricular pauses > 3 *** the unexpected high incidence of bradyarrhythmias,a PLATO substudy monitored this side effect,showing that ticagrelor was associated with an increase in the rate of sinus bradycardia and sinus arrest compared to *** side effect was usually transient,asymptomatic and not associated with higher incidence of severe atrioventricular(AV) block or pacemaker needs.A panel of experts from Food and Drug Administration did not consider bradyarrhythmias a serious problem in clinical practice and,accordingly,current labeling of the drug does not give any precaution or contraindication regarding this ***,recently some articles have described ACS patients with high-degree,life-threatening,AV block requiring drug discontinuation and,in some cases,pacemaker *** this paper,we describe and discuss five published case reports of severe AV block following ticagrelor therapy and two other cases managed in our *** analysis of literature suggests that,although rarely,ticagrelor can be associated with lifethreatening AV *** and careful monitoring are required especially in patients with already compromised conduction system and/or treated with AV blocking *** studies,with long-term rhythm monitoring,would help to define the outcome of patients at higher risk of developing this complication.

关键词： Ticagrelor Atrioventricular block

Recent advances concerning polyurethane in leather applications:an overview of conventional and greener solutions

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Collagen and Leather 2023年第1期5卷 1-15页

作者： Jize Liu Federica Recupido Giuseppe Cesare Lama maria Oliviero letizia Verdolotti Marino Lavorgna Institute for Polymers Composites and Biomaterials(IPCB-CNR)Piazzale Enrico Fermi 180055 Portici(Naples)Italy

Leather is one of the most popular products across globe and holds a significant place in the economy,while the pollution,associated to traditional leather industry,is far away on the"green chemistry"*** this sense,polyurethanes,which exhibit tunable chemical structures by selecting suitable precursors,can fit specific requirements,and the developments of green strategies make them important candidates for leather *** mini review briefly outlines the recent development of conventional(petrol-based)and sustainable polyurethanes in the leather industry,including their design and properties,in applications such as synthetic leather and surface-finishing(coatings/binders).Finally,outlooks of the future tendency,including more environmental-friendly strategies,bio-sourced/recycled materials and development of high-value multifunctional leather materials,are also here proposed.

关键词： Conventional leather Artificial leather polyurethane-synthetic leather polyurethane-based binders polyurethane-based-materials Polyurethane-based-coatings

How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center

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Cancer Biology & Medicine 2015年第4期12卷 302-307页

作者： Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni maria letizia Bacchi Reggiani Daniele Parlanti Isacco Montroni Department of Medical and Surgical Sciences University of Bologna S.Orsola Malpighi Hospital

Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for ***: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk ***: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality ***: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients.

关键词： Elderly geriatric assessment surgical oncology risk assessment screening tools colorectal cancer(CRC)