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吉兰-巴雷综合征诊治的10个步骤(Diagnosis and management of Guillain-Barrésyndrome in ten steps全译)

中华诊断学电子杂志 2023年第3期11卷 198-211页

作者： Sonja E Leonhard Melissa R Mandarakas Francisco AA Gondim Kathleen Bateman maria lb ferreira David R Cornblath Pieter A van Doorn Mario E Dourado Richard AC Hughes Badrul Islam Susumu Kusunoki Carlos A Pardo Ricardo Reisin James J Sejvar Nortina Shahrizaila Cristiane Soares Thirugnanam Umapathi 王玉忠 Eppie M Yiu Hugh J Willison Bart C Jacobs 伊拉斯姆斯大学医疗中心神经内科鹿特丹市3015 CE 福塔莱萨联邦大学沃尔特·坎迪奥大学医院塞阿拉州60430-370 开普敦大学格鲁特·舒尔医院开普敦市7925 累西腓市康复医院神经内科伯南布哥州52171-011 约翰·霍普金斯大学医学院神经病学系马里兰州21218 北里奥格兰德州联邦大学奥诺弗雷卢佩斯医院综合医学部纳塔尔市59012-300 伦敦大学学院皇后广场神经病学研究所伦敦市WC1N 3BG 国际腹泻病研究中心达卡市1212 金代大学医学院大阪市589-8511 不列颠医院布宜诺斯艾利斯市C1280AEB 亚特兰大市疾病预防控制中心乔治亚州30329 马来亚大学神经病学系吉隆坡市50603 埃斯塔多联邦医院里约热内卢市20221-903 国家神经科学研究所新加坡308433 济宁医学院附属医院神经内科济宁272029 墨尔本皇家儿童医院神经内科维多利亚州3052 默多克儿童研究所神经科学研究组维多利亚州3052 墨尔本大学儿科学系维多利亚州3052 格拉斯哥大学医学、兽医学与生命科学学院格拉斯哥市G611QH 伊拉斯姆斯大学医疗中心免疫科鹿特丹市3015 GD

吉兰-巴雷综合征(GBS)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBS通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBS的临床... 详细信息

吉兰-巴雷综合征(GBS)是一种少见但可危及生命的、自身免疫介导的周围神经病。GBS通常由感染引发,发病率可在感染性疾病暴发期间增加,如2013年法属波利尼西亚和2015年拉丁美洲的寨卡病毒流行期间,该病的发病率明显上升。由于GBS的临床表现和病程多种多样,其诊疗存在一定的复杂性,而目前尚无可用的国际性临床诊疗指南。本文作者撰写了一份适用于全球的GBS诊疗指南,特别是在疾病暴发期间,以期为临床医生提供指导。本指南根据当前文献和专家共识撰写而成,采用10步式结构,以便在临床实践中更好地应用。本文首先介绍了GBS的诊断标准、临床变异和鉴别诊断;其次,通过10个步骤介绍了GBS的早期识别和诊断、收治重症监护室的指征、治疗指征和选择、疾病进展的监测和处理、临床病程和结局的预测,以及并发症和后遗症的处理。

关键词：吉兰-巴雷综合征诊断治疗

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Anionic liposomes for small interfering ribonucleic acid （siRNA） delivery to primary neuronal cells： Evaluation of alpha-synuclein knockdown efficacy

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Nano Research 2017年第10期10卷 3496-3508页

作者： Michele Schlich Francesca Longhena Gaia Faustini Caitriona M. O'Driscoll Chiara Sinico Anna maria Fadda Arianna Bellucci Francesco Lai Department of Life and Environmental Sciences University of Cagliari Cagliari 09124 Italy Division of Pharmacology Department of Molecular and Translational Medicine University of Brescia Brescia 25123 Italy Pharmacodelivery Group School of Pharmacy University College Cork Cork Ireland

Alpha-synuclein （a-syn） deposition in Lewy bodies （lb） is one of the main neuropathological hallmarks of Parkinson＇s disease （PD）. lb accumulation is considered a causative factor of PD, which suggests that strategies aimed at reducing a-syn levels could be relevant for its treatment. In the present study, we developed novel nanocarriers suitable for systemic delivery of small interfering ribonucleic acid （siRNA） that were specifically designed to reduce neuronal α-syn by RNA interference. Anionic liposomes loaded with an siRNA-protamine complex for α-syn gene silencing and decorated with a rabies virus glycoprotein （RVG）-derived peptide as a targeting agent were prepared. The nanoparticles were characterized for their ability to load, protect, and deliver the functional siRNA to mouse primary hippocampal and cortical neurons as well as their efficiency to induce gene silencing in these cells. Moreover, the nanocarriers were evaluated for their stability in serum. The RVG-decorated liposomes displayed suitable characteristics for future in vivo applications and successfully induced α-syn gene silencing in primary neurons without altering cell viability. Collectively, our results indicate that RVG-decorated liposomes may be an ideal tool for further studies aimed at achieving efficient in vivo α-syn gene silencing in mouse models of PD.

关键词： rabies virus glycoprotein (RVG) peptide liposomes small interfering ribonudeic acid (siRNA) alpha-synuclein primary neuronal cells Parkinson's disease

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Boosting the Performance of Solar Cells with Intermediate Band Absorbers--The Case of ZnTe：O

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Journal of Energy and Power Engineering 2017年第6期11卷 417-426页

作者： Othmane Skhouni Ahmed E1 Manouni Hamza Bayad Bemabe maria Laboratory of Atmospheric Physics Materials and Modeling (LPAMM) Department of Physics University Hassan II Faculty of Sciences and Technics Mohammedia 20650 Morocco Department of Applied Physics-ETSED Polytechnic University Valencia Carol de Vera s/n 46022 Spain

Abstract： This work reports on modeling IB （intermediate band） solar cells based on ZnTe：O semiconductor and determination of their photovoltaic parameters using SCAPS （solar cell capacitance simulator） software. A comparative study between photovoltaic performance of ZnTe and ZnTe：O based solar cells has been carried out. It has been found that the energy conversion efficiency r/, short-circuit current density Jsc, EQE （external quantum efficiency） and FF （fill factor） increased with increasing oxygen doping concentration Nt up to the shallow acceptor density NA and decreased when Nt was higher than NA. The open circuit-voltage Voc remained constant for N lower than the acceptor doping concentration NA and decreased for Nt higher than NA. The increase of , Jsc and FF is due to the fact that IB is fully empted, so sub-bandgap photons can be absorbed by hole photoemission process from the VB （valence band） to the IB. The decrease of r/, J, EQE and FF is attributed to overcompensation for the base doping NA making electron photoemission process from IB to the CB （conduction band） maximized. This indicates that there is a competition between oxygen doping and intrinsic acceptor defects. The optimal concentrations of oxygen and shallow acceptor carriers were found to be Nr 1015 cm-3 and NA 1014 cm3, The corresponding photovoltaic parameters were r/= 41.5%, J = 31.2 mA/cm2, Voc = 1.80 V and FF = 75.1%. Finally, the EQE spectra showed a blue shift of absorption edge indicating that the absorption process is extended to the sub-bandgap photons through lb.

关键词： ZnTe:O IB solar cell energy conversion efficiency current-voltage characteristic SCAPS.

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Liver biopsy:analysis of results of two specialist teams

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World Journal of Gastrointestinal Pathophysiology 2014年第2期5卷 114-119页

作者： Giulia Anania Elia Gigante Matteo Piciucchi Emanuela Pilozzi Eugenio Pucci Adriano maria Pellicelli Carlo Capotondi Michele Rossi Flavia Baccini Giulio Antonelli Paola Begini Gianfranco Delle Fave Massimo Marignani Department of Digestive and Liver Disease School of Medicine and Psychology University "Sapienza" Department of Pathology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera Liver Unit Azienda Ospedaliera San Camillo Department of Radiology School of Medicine and Psychology University "Sapienza" Azienda Ospedaliera

AIM:To analyze the safety and the adequacy of a sample of liver biopsies(lb)obtained by gastroenterologist(G)and interventional radiologist(IR)***:Medical records of consecutive patients evaluated at our GI unit from 01/01/2004 to31/12/2010 for whom lb was considered necessary to diagnose and/or stage liver disease,both in the setting of day hospital and regular admission(RA) care,were retrieved and the data entered in a *** were divided into two groups:one undergoing an ultrasonography(US)-assisted procedure by the G team and one undergoing US-guided biopsy by the IR *** the first group,an intercostal approach(US-assisted) and a Menghini modified type needle 16 G(length 90 mm) were *** IR team used a subcostal approach(US-guided) and a semiautomatic modified Menghini type needle 18 G(length 150 mm).All the biopsies were evaluated for appropriateness according to the current *** number of portal tracts present in each biopsy was assessed by a revision performed by a single pathologist unaware of the previous pathology ***,laboratory and demographic patient characteristics,the adverse events rate and the diagnostic adequacy of lb were ***:During the study period,226 patients,126 males(56%) and 100 females(44%),underwent lb:167(74%) were carried out by the G team,whereas 59(26%) by the IR *** was mostly performed in a day hospital setting by the G team,while IR completed more procedures on inpatients(P < 0.0001).The groups did not differ in median age,body mass index(BMI),presence of comorbidities and coagulation *** occurred in 26 patients(16 G team vs 10 IR team,P = 0.15).Most gross samples obtained were considered suitable for basal histological evaluation,with no difference among the two teams(96.4% G team vs 91.5% IR,P = 0.16).However,the samples obtained by the G team had a higher mean number of portal tracts(G team 9.5 ± 4.8; range 1-29 vs IR team 7.8 ± 4.1; range 1-2

关键词： Liver biopsy Ultrasound-guided biopsy Ultrasound-assisted biopsy Menghini needle Sample adequacy Portal tracts

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