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Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses

International Journal of Oral Science 2018年第4期10卷 263-272页

作者： Susan Yost Philip Stashenko Yoonhee Choi maria kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge Frias-Lopez Forsyth Institute 245 First StreetCambridgeMA 02142USA Boston University Henry M.Goldman School of Dental Medicine 100 East Newton StreetBostonMA 02118USA Department of Integrative Physiology and Pathobiology Tufts University School of Medicine136 Harrison AvenueBostonMA 02111USA Department of Oral Biology College of DentistryUniversity of Florida1395 Center DriveGainesvilleFL 32610-0424USA

Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients.

关键词： profiles analyses

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