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Photodynamic diagnostics of early gastric cancer:Complexity measures of gastric microcirculation and new model of metastatic adenocarcinoma of rat stomach

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Journal of Innovative Optical Health Sciences 2019年第2期12卷 64-73页

作者： Alexey Pavlov Ekaterina Borisova Olga Pavlova Ilana Agranovich Alexander Khorovodov Andrey Terskov Aysel Mamedova maria klimova Latchezar Avramov Oxana Semyachkina-Glushkovskaya Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Electronics Bulgarian Academy of Sciences Tsarigradsko Chaussee Blvd.72Sofia 1784Bulgaria

The detection of early gastric cancer that often develops asymptomatically is crucial for improving patient *** photodynamic diagnosis(PDD)of gastric cancer using 5-aminolevulinic acid/protoporphyrin IX(5-ALA/PpIX)has been reported in several ***,the selectivity of PDD of gastric tumor is poor with often false-positive results that require the development of new methods to improve PDD for early gastric ***,a measure of the complexity of gastric microcirculation(multi-scale entropy,MSE)and the detrendedfluctuation analysis(DFA)were applied as additional tools to detect early gastric cancer in *** this experimental study,we used our original model of metastatic adenocarcinoma in the stomach of a *** induce a gastric tumor,we used a long-term combination(for 9 months,which is 1/2 of the life of rats)of two natural factors,such as chronic stress(overpopulation being typical for modern cities)and the daily presence of nitrites in food and drinks,which are common ingredients added to processed meat andfish to help preserve *** results clearly show that both methods,namely,PDD using 5-ALA/PpIX and complexity/correlation analysis,can detect early gastric cancer,which was confirmed by histological ***-cancerous areas in the stomach were detected as an intermediatefluorescent signal or MSE level between normal and malignant lesions of the ***,in some cases,PDD with 5-ALA/PpIX produced a false-positivefluorescence of exogenousfluorophores due to its accumulation in benign and inflammatory areas of the *** fact indicates that the PDD itself is not sufficient for the correct diagnosis of gastric cancer,and the use of additional characteristics,e.g.,complexity measures or scaling exponents,can significantly improve the diagnostic accuracy of PDD of gastric cancer that should be confirmed in further clinical studies and applications.

关键词： Experimental model of gastric cancer in animals highly heterogeneous adenocarcinoma photodynamic diagnosis complexity measures gastric microcirculation

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