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Use of hybrid chitosan membranes and human mesenchymal stem cells from the Wharton jelly of umbilical cord for promoting nerve regeneration in an axonotmesis rat model

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Neural Regeneration Research 2012年第29期7卷 2247-2258页

作者： Andrea Gärtner Tiago Pereira maria joāo s.mōes.paul. as.armada-da-s.l.a miguel l França Rosa sousa s.mone Bompasso stefania Raimondo Yuki shirosaki Yuri Nakamura satoshi Hayakawa Akiyoshi osakah Beatriz Porto Ana lúcia luís Artur sP Varejāo Ana Colette maurício Animal science and study Centre/Food and Agrarian sciences and Technologies Institute Porto University4099-003 PortoPortugal Institute of Biomedical sciences Abel salazar Veterinary Clinics DepartmentPorto UniversityPorto 4099-003Portugal Faculty of Human Kinetics Technical University of LisbonCruz Quebrada-Dafundo1499-002Portugal Institute of Biomedical sciences Abel salazar Cytogenetic DepartmentPorto UniversityPorto 4099-003Portugal Neuroscience Institute of the Cavalieri ottolenghi Foundation Orbassano 10043TurinItaly Department of Clinical and Biological sciences University of TurinOrbassano 10010TurinItaly Graduate school of Natural science and Technology Okayama UniversityOkayama 700-8530Japan Faculty of Engineering Okayama UniversityOkayama 700-8530Japan Department of Veterinary sciences Research Centre in SportsHealth and Human DevelopmentUniversity of Trás-os-Montes and Alto DouroVila Real 5001-801Portugal

many studies have been dedicated to the development of scaffolds for improving post-traumatic nerve regeneration. The goal of this study was to assess the effect on nerve regeneration, associating a hybrid chitosan membrane with non-differentiated human mesenchymal stem cells isolated from Wharton＇s jelly of umbilical cord, in peripheral nerve reconstruction after crush injury. Chromos.me analysis on human mesenchymal stem cell line from Wharton＇s jelly was carried out and no structural alterations were found in metaphase. Chitosan membranes were previously tested in vitro, to assess their ability in supporting human mesenchymal stem cell survival, expansion, and differentiation. For the in vivo testing, sasco sprague adult rats were divided in 4 groups of 6 or 7 animals each： Group 1, sciatic axonotmesis injury without any other intervention （Group 1-Crush）; Group 2, the axonotmesis lesion of 3 mm was infiltrated with a suspension of 1 250 -1 500 human mesenchymal stem cells （total volume of 50 pl）（Group 2-CrushCell）; Group 3, axonotmesis lesion of 3 mm was enwrapped with a chitosan type Ill membrane covered with a monolayer of non-differentiated human mesenchymal stem cells （Group 3-CrushChitlllCell） and Group 4, axonotmesis lesion of 3 mm was enwrapped with a chitosan type III membrane （Group 4-CrushChiUll）. motor and sensory functional recovery was evaluated throughout a healing period of 12 weeks using sciatic functional index, static sciatic index, extensor postural thrust, and withdrawal reflex latency. stereological analysis was carded out on regenerated nerve fibers. Results showed that infiltration of human mesenchymal stem cells, or the combination of chitosan membrane enwrapment and human mesenchymal stem cell enrichment after nerve crush injury provide a slight advantage to post-traumatic nerve regeneration. Results obtained with chitosan type III membrane alone confirmed that they significantly improve post-traumatic axonal regrowth and may represent

关键词： stem cells mesenchymal stem cells Wharton jelly umbilical cord biomaterials chitosan axonotmesis functional analysis rat karyotype analysis stereological analysis

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molybdenite as a Rhenium Carrier:First Results of a spectroscopic Approach Using synchrotron Radiation

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journal of minerals and materials Characterization and Engineering 2013年第5期1卷 207-211页

作者： Teresa Pereira da s.l.a maria-ondina Figueiredo daniel de oliveira joão Pedro Veiga maria joão Batista Unit of mineral Resources and Geophysics National Laboratory for Energy and GeologyAmadoraPortugal Faculty of sciences and Technology Campus da CaparicaNew University of LisbonLisbonPortugal

The chemical and physical properties of rhenium render it a highly demanded metal for advanced applications in important industrial fields. This very scarce element occurs.mainly in ores of porphyry copper-molybdenum deposits associated with the mineral molybdenite, mos2, but it has also been found in granite pegmatites and quartz veins as well as in volcanic gases. molybdenite is a typical polytype mineral which crystal structure is based on the stacking of [s.mo-s] with molybdenum in prismatic coordination by sulphide anions;however, it is not yet clearly established if rhenium ions replace mo4+ cations in a disordered way or else, if such replacement gives rise to dispersed nanodomains of a rhenium-rich phase. As a contribution to clarify this question, an X-ray absorption spectroscopy (XANes) study using synchrotron radiation was performed at the Re l3-edge of rhenium-containing molybdenite s.mples. obtained results are described and discussed supporting the generally accepted structural perspective that rhenium is.mainly carried by molybdenite through the is.morphous replacement of mo, rather than by the formation of dispersed Re-specific nanophase(s).

关键词： molybdenite Polytypes Rhenium Re l_(3)Absorption Edge XANes

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Fibrosis asses.ment using Fibro meter combined to first generation tests in hepatitis C

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World journal of Hepatology 2017年第6期9卷 310-317页

作者： maria Chiara Chindamo Jerome Boursier Ronir Raggio luiz Isabelle Fouchard-Hubert Vera lúcia Nunes Pannain joao marcello de Araújo Neto Henrique sérgio moraes Coelho Renata de mello Perez paul Calès Cristiane Alves Villela-Nogueira Departament of Internal medicine Federal University of Rio de Janeiro Department of Hepatology University Hospital HIFIH laboratory UPRES 3859SFR 4208Bretagne Loire University Institute of Public Health studies Federal University of Rio de Janeiro Departament of Pathology Federal University of Rio de Janeiro Gastroenterology Department University of the State of Rio de Janeiro D’or Institute for Research and Education

AIm To evaluate the performance of Fibrometer^(Virus3G) combined to the first generation tests aspartate aminotransferase-to-platelet ratio index(APRI) or Forns index to assess significant fibrosis in chronic hepatitis C(CHC).mETHoDs First generation tests APRI or Forns were initially applied in a derivation population from Rio de Janeiro in Brazil considering cut-offs previously reported in the literature to evaluate significant ***^(Virus3G) was sequentially applied to unclassified cases from APRI or *** of non-invasive combination of tests,APRI plus Fibrometer^(Virus3G) and Forns plus Fibrometer^(Virus3G) was evaluated in the Brazilian derivation *** plus Fibrometer^(Virus3G) combination was validated in a population of CHC patients from Angers in *** patients were submitted to liver biopsy staged according to mETAVIR score by experienced *** fibrosis was considered as.mETAVIR F≥*** fibrosis stage classification was used as the reference for accuracy evaluation of non-invasive combination of *** s.mples for the calculation of serum tests were collected on the s.me day of biopsy procedure or within a maximum 3 mo interval and stored at-70 ℃.ResUlTs seven hundred and sixty CHC patients were included(222 in the derivation population and 538 in the validation group).In the derivation population,the Fibrometer^(Virus3G) AURoC was s.milar to APRI AURoC(0.855 vs 0.815,P=0.06) but higher than Forns AURoC(0.769,Pest Fibrometer^(Virus3G) cut-off to discriminate significant fibrosis was 0.61(80% diagnostic accuracy;75% in the validation population,P=0.134).The sequential combination of APRI or Forns with Fibrometer^(Virus3G) in derivation population presented s.milar performance compared to Fibrometer^(Virus3G) used alone(79% vs 78% vs 80%,respectively,P=0.791).Unclassified cases of significant fibrosis after applying APRI and Forns corresponded to 49% and 54%,respectively,of the

关键词：长期的丙肝纤维变性肝活体检视非侵略的方法 Fibrometer Virus3G 联合算法

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sub-percent precision measurement of neutrino oscillation parameters with JUNo

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam shakeel Ahmad Rizwan Ahmed sebastiano Aiello muhammad Akram Abid Aleem 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop joão Pedro Athayde marcondes de André Didier Auguste 白伟东 Nikita Balashov Wander Baldini Andrea Barresi davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld sylvie Blin david Blum s.mon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Ross.l.a Caruso Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学陈羽陈志源陈梓康程捷程雅苹 Yu Chin Cheng Alexey Chetverikov davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux s.l.a Conforti Di lorenzo daniele Corti Flavio dal Corso olivia dalager Christophe De la Taille 邓智邓子艳 Wilfried Depnering marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich marcos Dracos Frédéric Druillole 杜然杜书先 stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan 樊磊方建方文兴 marco Fargetta Dmitry Fedoseev 费政勇 li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男高峰 Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel marco Grassi Vasily Gromov 顾旻皓谷肖飞古宇关梦云管宇铎 Nunzio Guardone 郭聪郭竞渊郭万磊 Xinheng Guo 郭宇航 paul Hackspacher Caren Hagner 韩然 Yang Han 何苗 Wei He Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航 Jianrun Hu 胡俊胡守扬胡涛胡宇翔胡焯钧黄桂鸿黄翰雄黄凯旋黄文昊 Xin Huang 黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Ignacio Jeria 季筱璐贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山荆小平 Cécile jollet Jari joutsenvaara leonidas Kalousis Philipp Kampmann 康丽 Rebin Karaparambil Narine Kazarian Amina Khatun Yerevan Physics Institute YerevanArmenia Universiélibre de Bruxelles BrusselsBelgium Universidade estadual de londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico santa maria ValparaisoChile Beijing Institute of spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina school of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of sciences BeijingChina Jilin University ChangchunChina College of Electronic science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of south China HengyangChina Wuyi University JiangmenChina shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of science and Technology ShanghaiChina school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-dao lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina school of Physics and microelectronics Zhengzhou UniversityZhengzhou

JUNo is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAo satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the s.me period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNo

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNo

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam shakeel Ahmad sebastiano Aiello muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop joão Pedro Athayde marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan marco Bellato Antonio Bergnoli Enrico Bernieri david Biare Thilo Birkenfeld sylvie Blin david Blum s.mon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano max Buesken mario Buscemi jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Ross.l.a Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen shaomin Chen shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux s.l.a Conforti Di lorenzo daniele Corti s.l.atore Costa Flavio dal Corso Christophe De la Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong damien Dornic Evgeny Doroshkevich marcos Dracos Frédéric Druillole shuxian Du stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri lukas Fajt Donghua Fan lei Fan Can Fang Jian Fang marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani maxim Gonchar Guanghua Gong Hui Gong oleg Gorchakov Yuri Gornushkin marco Grassi Christian Grewing maxim Gromov Vasily Gromov minghao Gu Xiaofei Gu Yu Gu mengyun Guan Nunzio Guardone maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia Universitélibre de Bruxelles BrusselsBelgium Universidade estadual de londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico santa maria ValparaisoChile Beijing Institute of spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina school of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of sciences BeijingChina Jilin University ChangchunChina College of Electronic science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina sun Yat-sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of south China HengyangChina Wuyi University JiangmenChina shandong University JinanChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of science and Technology ShanghaiChina school of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-dao lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina school of Physics and microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino observatory(JUNo)features a 20 kt multi-purpose underground liquid scintillator sphere as its.main *** of JUNo's features.make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive asses.ment of JUNo's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 meV threshold for the recoil electron energy is found to be achievable,ass.ming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large s.mple will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNo can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNo can s.multaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the s.me detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamlAND experiment.

关键词： neutrino oscillation solar neutrino JUNo

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JUNo sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam shakeel Ahmad Rizwan Ahmed sebastiano Aiello muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop joão Pedro Athayde marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld sylvie Blin david Blum s.mon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano mario Buscemi jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Ross.l.a Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux s.l.a Conforti Di lorenzo daniele Corti Flavio dal Corso olivia dalager Christophe De la Taille 邓智邓子艳 Wilfried Depnering marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich marcos Dracos Frédéric Druillole 杜然杜书先 stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 marco Fargetta Dmitry Fedoseev li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Agnese Giaz Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 paul Hackspacher Caren Hagner 韩然 Yang Han muhammad sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile jollet Jari joutsenvaara sirichok Jungthawan leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of science and Technology ShanghaiChina University of science and Technology of China HefeiChina joint Institute for Nuclear Research DubnaRussia INFN sezione di milano and Dipartimento di Fisica dell Universitàdi milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJClab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN milano Bicocca and University of milano Bicocca MilanoItaly INFN sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina sUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN sezione di Padova PadovaItaly University of Roma Tre and INFN sezione Roma Tre RomaItaly Aix marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN milano Bicocca and Politecnico of milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina sun Yat-sen University GuangzhouChina Beijing Institute of spacecraft Environment Engineering BeijingChina Universidade estadual de londrina LondrinaBrazil INFN sez

The Jiangmen Underground Neutrino observatory(JUNo)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNo is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNo permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNo liquid scintillator detector

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