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Neural Regeneration Research 2011年第29期6卷 2295-2297页

作者： Rosa Morabito Annalisa Baglieri Rosella Ciurleo Francesco Corallo Rosaria De Luca Simona De Salvo Silvia Guerrera francesca Timpano maria Adele Marino Placido Bramanti Silvia Marino Neurobioimaging Laboratory IRCCS Centro Neurolesi "Bonino Pulejo"MessinaItaly

The diagnosis of sporadic Creutzfeldt-Jakob disease （sCJD） is extremely difficult. Diffusion-weighted imaging has been shown to be the most sensitive technique for the detection of signal alterations in sCJD patients. The present study analyzed the diagnostic value of diffusion-weighted imaging and fluid-attenuated inversion recovery sequence in the early stage of sCJD in one female patient and correlated the clinical symptoms during disease course and magnetic resonance manifestations. Thalamic and basal ganglia hyperintensities were observed on magnetic resonance images in a very early stage, i.e., when the clinical typical manifestations of the disease were not present. With the progression of the disease, cortical and basal ganglia hyperintensities were observed on magnetic resonance images, showing an obvious cerebral atrophy. These findings suggest that diffusion-weighted imaging and fluid-attenuated inversion recovery sequence are helpful in diagnosing sCJD.

关键词： Creutzfeldt-Jacob disease fluid-attenuated inversion recovery diffusion-weighted imaging magnetic resonance imaging

Endoscopic approach to malignant strictures at the hepatic hilum

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World Journal of Gastroenterology 2007年第30期13卷 4042-4045页

作者： Giovanni D De Palma Stefania Masone maria Rega Immacolata Simeoli francesca Salvatori Saverio Siciliano Francesco Maione Valerio Girardi Marta Celiento Giovanni Persico Department of General Surgery Oncologic Surgery and Advanced Technologies Center for Technological Innovation in Surgery (ITC) University of Naples Federico Ⅱ School of Medicine Naples Italy

Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to palliate malignant biliary obstruction. Prosthetic palliation of patients with malignant hilar stenoses poses particular difficulties, especially in advanced lesions （type Ⅱ lesions or higher）. The risk of cholangitis after contrast injection into the biliary tree in cases where incomplete drainage is achieved is well known. The success rate of plastic stent insertion is around 80% in patients with proximal tumors. Relief of symptoms can be achieved in nearly all patients successfully stented.

关键词： Malignant biliary stenoses Endoscopic retrograde cholangiopancreatography Endoscopic prostheses

Impact of body mass index in elderly patients treated with laparoscopic liver resection for hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 72-81页

作者： maria Conticchio Riccardo Inchingolo Antonella Delvecchio francesca Ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent Giulio Cesare Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de’Angelis Javier Briceño Antonio Rampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalBari 70021Italy Interventional Radiology Unit “F.Miulli”Regional General HospitalBari 70021Italy Unit of Hepatobiliary Surgery San Raffaele HospitalMilano 20132Italy Departement de Chirurgie Viscérale Gustave Roussy Cancer Campus Grand ParisParis 94800France Unit of Oncologic and Pancreatic Surgery Hospital University Reina SofíaCordoba 14004Spain Assistance Publique-Hôpitaux de Paris Department of Digestive and Hepatobiliary SurgeryCentre Hospitalier Universitaire Henri MondorCréteilParis 94000France Service of Abdominal Surgery Poliambulanza FoundationBrescia 25124Italy Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit University of Modena and Reggio EmiliaModena 41121Italy Institut de Recherche Contre les Cancers de l’Appareil Digestif(IRCAD) Strasbourg 67000France Service de Chirurgie Viscérale et Digestive Nouvel Hôpital CivilStrasbourg 67000France Department of Surgery Hôpital Robert DebréReims 51092France Interventional Radiology Unit Niguarda HospitalMilan 20162Italy Department of Surgery Centre HepatobiliaireHopital Paul BrousseParis 94000France

BACKGROUND The impact of obesity on surgical outcomes in elderly patients candidate for liver surgery is still *** To evaluate the impact of high body mass index(BMI)on perioperative and oncological outcome in elderly patients(>70 years old)treated with laparoscopic liver resection for hepatocellular carcinoma(HCC).METHODS Retrospective multicenter study including 224 elderly patients(>70 years old)operated by laparoscopy for HCC(196 with a BMI<30 and 28 with BMI≥30),observed from January 2009 to January *** After propensity score matching,patients in two groups presented comparable results,in terms of operative time(median range:200 min vs 205 min,P=0.7 respectively in non-obese and obese patients),complications rate(22%vs 26%,P=1.0),length of hospital stay(median range:4.5 d vs 6.0 d,P=0.1).There are no significant differences in terms of short-and long-term postoperative *** The present study showed that BMI did not impact perioperative and oncologic outcomes in elderly patients treated by laparoscopic resection for HCC.

关键词： Hepatocellular carcinoma Body mass index Laparoscopy Surgical resection Elderly patients Propensity score matching

Clinical and histopathological correlations of fecal calprotectin release in colorectal carcinoma

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World Journal of Gastroenterology 2014年第17期20卷 4994-4999页

作者： Frank Serge Lehmann francesca Trapani Ida Fueglistaler Luigi maria Terracciano Markus von Flüe Gieri Cathomas Andreas Zettl Pascal Benkert Daniel Oertli Christoph Beglinger Division of Gastroenterology and Hepatology University Hospital4031 BaselSwitzerland Institute of Pathology University Hospital4003 BaselSwitzerland St.Clara Hospital 4016 BaselSwitzerland Institute of Pathology University Hospital4410 LiestalSwitzerland Institute of Pathology Viollier AG4002 BaselSwitzerland Clinical Trial Unit University Hospital4031 BaselSwitzerland Department of Surgery University Hospital4031 BaselSwitzerland

AIM: To determine calprotectin release before and after colorectal cancer operation and compare it to tumor and histopathological parameters.

关键词： Calprotectin Colorectal cancer Inflammation Tumor size Granulocytes

^(18)F-fluorodeoxyglucose positron emission tomography for intrahepatic cholangiocarcinoma N-and M-staging:should guidelines recommend it at last?

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 789-792页

作者： Maurizio Zizzo Magda Zanelli francesca Sanguedolce Annibale Versari Pierpaolo Pattacini Andrea Morini Federica Mereu Antonia Lavinia Zuliani Alessandro Giunta Surgical Oncology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Pathology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Pathology Unit Azienda Ospedaliero-UniversitariaOspedali Riuniti di FoggiaFoggiaItaly Nuclear Medicine Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Radiology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly

We really appreciated Lin et al.’s“The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma”in HepatoBiliary Surgery and Nutrition(1).A 291-patient population affected by intrahepatic cholangiocarcinoma(ICC)was retrospectively analyzed with the aim of assessing the accuracy of preoperative staging and treatment reallocation by ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)(1).

关键词： positron deoxy

Portal vein thrombosis:Insight into physiopathology,diagnosis,and treatment

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World Journal of Gastroenterology 2010年第2期16卷 143-155页

作者： francesca R Ponziani maria A Zocco Chiara Campanale Emanuele Rinninella Annalisa Tortora Luca Di Maurizio Giuseppe Bombardieri Raimondo De Cristofaro Anna M De Gaetano Raffaele Landolfi Antonio Gasbarrini Department of Internal Medicine Catholic University of Rome Department of Bioimaging and Radio-logical Sciences Catholic University of Rome

Portal vein thrombosis (PVT) is a relatively common complication in patients with liver cirrhosis, but might also occur in absence of an overt liver disease. Several causes, either local or systemic, might play an important role in PVT pathogenesis. Frequently, more than one risk factor could be identified; however, occasionally no single factor is discernable. Clinical examination, laboratory investigations, and imaging are helpful to provide a quick diagnosis, as prompt treatment might greatly affect a patient's outcome. In this review, we analyze the physiopathological mechanisms of PVT development, together with the hemodynamic and functional alterations related to this condition. Moreover, we describe the principal factors most frequently involved in PVT development and the recent knowledge concerning diagnostic and therapeutic procedures. Finally, we analyze the implications of PVT in the setting of liver transplantation and its possible influence on patients' future prognoses.

关键词： Portal vein thrombosis Portal hypertension Thrombophilic factors Liver cirrhosis Liver transplantation Anticoagulants

One size does not fit all for pancreatic cancers: A review on rare histologies and therapeutic approaches

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 833-849页

作者： Monica Niger Michele Prisciandaro maria Antista Melissa Anna Teresa Monica Laura Cattaneo Natalie Prinzi Sara Manglaviti Federico Nichetti Marta Brambilla Martina Torchio francesca Corti Sara Pusceddu Jorgelina Coppa Vincenzo Mazzaferro Filippo de Braud maria Di Bartolomeo Medical Oncology Department Fondazione IRCCS Istituto Nazionale dei TumoriMilan 20133Italy First Pathology Division Department of Pathology and Laboratory MedicineFondazione IRCCS Istituto Nazionale dei TumoriMilan 20133Italy Hepato-biliary-pancreatic Surgery and Liver Transplantation Department Fondazione IRCCS Istituto Nazionale dei TumoriMilan 20133Italy Universitàdegli studi di Milano Milan 20133Italy

Exocrine pancreatic neoplasms represent up to 95%of pancreatic cancers(PCs)and are widely recognized among the most lethal solid cancers,with a very poor 5-year survival rate of 5%-10%.The remaining<5%of PCs are neuroendocrine tumors that are usually characterized by a better prognosis,with a median overall survival of 3.6 *** most common type of PC is pancreatic ductal adenocarcinoma(PDAC),which accounts for roughly 85%of all exocrine *** up to 10%of exocrine PCs have rare histotypes,which are still poorly *** subtypes can be distinguished from PDAC in terms of pathology,imaging,clinical presentation and ***,due to their rarity,any knowledge regarding these specific histotypes is mostly based on case reports and a small series of retrospective ***,treatment strategies are generally deduced from those used for PDAC,even if these patients are often excluded or not clearly represented in clinical trials for *** these reasons,it is essential to collect as much information as possible on the management of PC,as assimilating it with PDAC may lead to the potential mistreatment of these ***,we report the most significant literature regarding the epidemiology,typical presentation,possible treatment strategies,and prognosis of the most relevant histotypes among rare PCs.

关键词： Rare pancreatic cancers Pancreatic acinar cell cancer Pancreatic adenosquamous cancer Undifferentiated pancreatic cancer Pancreatoblastoma Pseudopapillary pancreatic cancer

Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

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World Journal of Gastroenterology 2018年第19期24卷 2095-2107页

作者： Carolina González David Tabernero maria francesca Cortese Josep Gregori Rosario Casillas Mar Riveiro-Barciela Cristina Godoy Sara Sopena Ariadna Rando Marcal Yll Rosa Lopez-Martinez Josep Quer Rafael Esteban maria Buti Francisco Rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d’Hebron Institut Recerca-Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadrid 28029Spain Roche Diagnostics SL Sant Cugat del Vallès 08174Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain

AIM To detect hyper-conserved regions in the hepatitis B virus(HBV) X gene(HBX) 5' region that could be candidates for gene *** The study included 27 chronic hepatitis B treatmentnaive patients in various clinical stages(from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeA g-negative and HBeA g-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia > 3.5 log IU/m L, the HBX 5' end region [nucleotide(nt) 1255-1611] was PCRamplified and submitted to next-generation sequencing(NGS). We assessed genotype variants by phylogenetic analysis, and evaluated conservation of this region by calculating the information content of each nucleotide position in a multiple alignment of all unique sequences(haplotypes) obtained by NGS. Conservation at the HBx protein amino acid(aa) level was also *** NGS yielded 1333069 sequences from the 27 samples, with a median of 4578 sequences/sample(2487-9279, IQR 2817). In 14/27 patients(51.8%), phylogenetic analysis of viral nucleotide haplotypes showed a complex mixture of genotypic variants. Analysis of the information content in the haplotype multiple alignments detected 2 hyper-conserved nucleotide regions, one in the HBX upstream non-coding region(nt 1255-1286) and the other in the 5' end coding region(nt 1519-1603). This last region coded for a conserved amino acid region(aa 63-76) that partially overlaps a Kunitz-like *** Two hyper-conserved regions detected in the HBX 5' end may be of value for targeted gene therapy, regardless of the patients' clinical stage or HBV genotype.

关键词： Hepatitis B virus Hepatitis B X gene Hepatitis B X protein Gene therapy Next-generation sequencing HBV conserved regions Small interference RNA

Cocoa Powder as Delivery Medium for Probiotic Lactobacillus Strains

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Advances in Microbiology 2011年第1期1卷 1-6页

作者： Giovanni Ricci francesca Borgo Chiara Ferrario maria Grazia Fortina 不详

Three Lactobacillus strains previously isolated from artisanal Italian cheeses and identified by species-specific PCR as L. helveticus, L. paracasei and L. rhamnosus, were evaluated for the presence of functional traits, such as acidifying activity, cell surface hydrophobicity, antibiotic resistance, survival in low pH and in presence of bile salts, in comparison with two commercially available probiotic strains (Lactobacillus acidophilus La-5 and L. rhamnosus GG). Subsequently, with the aim to develop a new non-dairy functional product, cocoa powder was used as a medium for incorporating freeze-dried cultures of each tested strain and survival at different time/temperature conditions was investigated. The results obtained demonstrated that artisanal dairy products are interesting sources of new probiotic strains;in particular, the dairy origin strain L. rhamnosus showed a good probiotic performance and the highest level of survival during storage. Finally, we showed that cocoa powder represents a good delivery medium for lactobacilli: it could be considered a novel functional food exhibiting high antioxidant power and presenting probiotic potential.

关键词： Lactobacilli Probiotics Cocoa Powder

The Calibration of Some Stochastic Volatility Models Used in Mathematical Finance

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Open Journal of Applied Sciences 2014年第2期4卷 23-33页

作者： Lorella Fatone francesca mariani maria Cristina Recchioni Francesco Zirilli Dipartimento di Management Università Politecnica delle Marche Ancona Italy Dipartimento di Matematica “G. Castelnuovo” Università di Roma “La Sapienza” Roma Italy Dipartimento di Matematica e Informatica Università di Camerino Camerino (MC) Italy Dipartimento di Scienze Economiche Università degli Studi di Verona Verona Italy

Stochastic volatility models are used in mathematical finance to describe the dynamics of asset prices. In these models, the asset price is modeled as a stochastic process depending on time implicitly defined by a stochastic differential Equation. The volatility of the asset price itself is modeled as a stochastic process depending on time whose dynamics is described by a stochastic differential Equation. The stochastic differential Equations for the asset price and for the volatility are coupled and together with the necessary initial conditions and correlation assumptions constitute the model. Note that the stochastic volatility is not observable in the financial markets. In order to use these models, for example, to evaluate prices of derivatives on the asset or to forecast asset prices, it is necessary to calibrate them. That is, it is necessary to estimate starting from a set of data the values of the initial volatility and of the unknown parameters that appear in the asset price/volatility dynamic Equations. These data usually are observations of the asset prices and/or of the prices of derivatives on the asset at some known times. We analyze some stochastic volatility models summarizing merits and weaknesses of each of them. We point out that these models are examples of stochastic state space models and present the main techniques used to calibrate them. A calibration problem for the Heston model is solved using the maximum likelihood method. Some numerical experiments about the calibration of the Heston model involving synthetic and real data are presented.

关键词： Stochastic Volatility Models Calibration