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Antimicrobial and Antioxidant Activity of Anacardium occidentale L. flowers in Comparison to Bark and Leaves Extracts

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Journal of Biosciences and Medicines 2016年第4期4卷 87-99页

作者： Rubenice Amaral da Silva Silvana Amado Liberio fl.via M. M. do Amaral fl.via Raquel Fernandes do Nascimento Luce maria Brandão Torres Valério monteiro Neto Rosane Nassar Meireles Guerra Laboratory of Immunophysiology Universidade Federal do Maranhao Campus do Bacanga Sao Luis Brazil Instituto Botanico de Sao Paulo Sao Paulo Brazil Departament of Pathology Universidade Federal do Maranhao Sao Luis Brazil Universidade Ceuma Sao Luís Brazil

Anacardium occidentale L., Anacardiaceae, is frequently used to treat infections. We evaluated the antimicrobial and antioxidant activity of extracts obtained from aerial parts of the plant in comparison with the extract prepared with the flowers. Ethanol extracts of the leaves (EEL), stem bark (EEB), and flowers (EEF) were prepared separately. The antimicrobial activity was evaluated by agar diffusion and broth dilution methods. The minimum bactericidal and fungicidal concentrations were determined against: Streptococcus mutans, Lactobacillus acidophilus, Staphylococcus aureus, MRSA, Enterococcus faecalis, Streptococcus pyogenes, Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Helicobacter pylori, Salmonella choleraesuis, Candida albicans, and Candida tropicalis. The antioxidant activity of the extracts was evaluated based on their scavenger capacity of 2,2-diphenyl-1-picrylhydrazyle. The phytochemical profile was analyzed by colorimetric methods and by HPLC with UV detection. All extracts exhibited antioxidant and antimicrobial activity. Although, the EEF was the most effective since it inhibited the growth of all 14 microorganisms tested. Anacardic and galic acids were identified in all extracts as well phenolic compounds, triterpenes, flavones and xanthones. In conclusion, the extracts obtained from the aerial parts of A. occidentale, mainly the extract of flowers that was the most effective, are rich in bioactive metabolites that exert a potent antioxidant and antimicrobial effect. Taken together, the results indicate an important biotechnological potential of A. occidentale as a source of compounds with broad-spectrum antimicrobial and of antioxidant activity to be used in the food and cosmetics industry.

关键词： Anacardium occidentale Antimicrobial Agents flowers Cashew Caju Antioxidant

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Antimicrobial Activity of a Formulation of <i>Libidibia ferrea</i>L. against Microorganisms of the Dental Biofilm

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Advances in Microbiology 2020年第9期10卷 434-442页

作者： Raquel de Oliveira Marreiro maria Fulgência Costa Lima Bandeira Carina Toda Fábio Correia Sampaio Tatiane Pereira de Souza Gisely Naura Venâncio Wanderleia monteiro de Souza Nikeila Chacon de Oliveira Conde School of Dentistry Federal University of Amazonas Manaus AM Brazil Federal University of Paraíba Health Sciences Center Department of Clinical and Social Dentistry Jo&atilde o Pessoa PB Brazil Faculty of Pharmaceutical Sciences Federal University of Amazonas Manaus AM Brazil Manaus Municipal Health Department SEMSA Manaus AM Brazil

This study aimed to evaluate the antimicrobial activity of the extract of Libidibia ferrea L. (228.022-INPA) and a mouthwash formulation against microorganisms of the dental biofilm. The extract of Libidibia ferrea L. was prepared and formulated with an alcohol-free mouthwash. The Minimum Inhibitory Concentration—MIC was determined by microdilution and cell viability was evaluated through fluorescence. The MICs for the extract were 4.375 μg/mL (Streptococcus mutans), 3.750 μg/mL (Streptococcus oralis), 4.375 μg/mL (Lactobacillus casei). In contrast, for the mouthwash, the MICs were 6.000 μg/mL (bacteriostatic against Streptococcus mutans and bactericidal against Streptococcus oralis). In 1.250 μg/mL of the extract, the number of viable cells measured by fluorescence tests was 16.47% and 14.12% for Streptococcus mutans and Lactobacillus casei, respectively. For the mouthwash (1.000 μg/mL), 20.60% of viable cells for Streptococcus mutans, and 9.60% for Lactobacillus casei were observed. It can be concluded that the extract and its mouthwash containig Libidibia ferrea L. showed antibacterial activity against microorganisms from the dental biofilm.

关键词： Mouthwash Juca Natural Products

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Composition of forests and vegetation in the Kailash Sacred Landscape,Nepal

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Journal of Forestry Research 2020年第5期31卷 1625-1635页

作者： Ripu Mardhan Kunwar maria Fadiman Tobin Hindle Madan Krishna Suwal Yagya Prasad Adhikari Kedar Baral Rainer Bussmann Department of Geosciences Florida Atlantic University777 Glades RoadBoca RatonFL 33431USA Department of Geography University of BergenFosswinckelsgate 6P.O.Box 78025020 BergenNorway Department of Biogeography University of BayreuthUniversitatsstr.3095447 BayreuthGermany Department of Forests Kathmandu 44600Nepal Ilia State University Kakutsa Cholokashvili Ave 3/50162 TbilisiRepublic of Georgia

A total of 141 quadrats were sampled using stratified random sampling to study forest,environment and human interactions along an elevation gradient 1800 to 3665 m at the remote Kailash Sacred Landscape,*** forest types were identified,including Laurel-Oak to Rhododendron to Blue pine,comprising 191 species including 60 useful from 166 genera and 87 *** environmental variables elevation,slope,and temperature were significant(p<0.001)in determining the composition and distribution of forest *** of large numbers of useful plants along with diverse forest and vegetation types suggest a strong association between the culture of local villages and nature *** to changes in climate,socio-culture and land-use,forest degradation is expected to accelerate,thus forcing government and indigenous community forest management measures to acknowledge human,cultural and environmental variables for sustainable forest management.

关键词： Phyto-sociological assessment Environmental factors Forest types Culture Kailash Sacred Landscape Nepal

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Prevalence of Frailty Syndrome in the Elderly and Associated Factors in Brazil

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Health 2015年第11期7卷 1591-1599页

作者： Anna Ferla monteiro Silva Passos Iris do Céu Clara Costa Fábia Barbosa de Andrade maria do Carmo Eulálio Anita Liberalesso Neri Romulo Lustosa Pimenteira de Melo Adrianna Ribeiro Lacerda Postgraduation Program in Health Sciences Federal University of Rio Grande do Norte Natal Brazil Department of Dentistry Federal University of Rio Grande do Norte Natal Brazil Nursing Faculty of Health Sciencies of Trairi/Federal University of Rio Grande do Norte Santa Cruz Brazil Department of Psychology State University of Paraíba Campina Grande Brazil Department of Educational Psychology State University of Campinas Campinas Brazil

This paper aims to identify the prevalence of frailty syndrome and its association with demographic, economic, health, psychological and functional variables in Brazilian population. The study was cross-sectional and composed of 385 elderly aged from 65 years, an average age of 73.92 years. A multivariate Poisson regression was used to check for conditions associated with frailty and to determine the prevalence (α = 0.05). The prevalence of frailty was 8.7% and pre-frailty of 50.4%. The frail and pre-frail older adults showed larger and increasing prevalence ratios for marital status, difficulty performing instrumental activities of daily living, old age, involuntary loss of feces, depression and negative affections. These results can guide the establishment of preventive measures and the development of intervention strategies aimed at minimizing the adverse effects of frailty in elderly people.

关键词： Aging Frail Elderly Frailty Frailty Syndrome

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Therapeutic drug monitoring in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2014年第13期20卷 3475-3484页

作者： Andres J Yarur maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman Division of Gastroenterology University of Miami Leonard Miller School of MedicineMiamiFL 33136United States

Thiopurine analogs and anti-tumor necrosis factor (TNF) agents have dramatically changed the therapeutics of inflammatory bowel diseases (IBD), improving short and long-term outcomes. Unfortunately some patients do not respond to therapy and others lose response over time. The pharmacokinetic properties of these drugs are complex, with high inter-patient variability. Thiopurine analogs are metabolized through a series of pathways, which vary according to the patients’ pharmacogenetic profile. This profile largely determines the ratios of metabolites, which are in turn associated with likelihoods of clinical efficacy and/or toxicity. Understanding these mechanisms allows for manipulation of drug dose, aiming to reduce the development of toxicity while improving the efficacy of treatment. The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables. Several factors may alter drug clearance, including the concomitant use of immunomodulators (thiopurine analogs and methotrexate), systemic inflammation, the presence of anti-drug antibodies, and body mass. The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications, with good evidence for improvement in patient outcomes observed when measuring metabolic pathway indices. The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care.

关键词： Inflammatory bowel disease Anti-tumor necrosis factor Infliximab Adalimumab Drug level Azathioprine Thiopurines Antibodies Drug monitoring Thioguanine

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Nanowire encapsulation with polymer for electrical isolation and enhanced optical properties

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Nano Research 2017年第8期10卷 2657-2666页

作者： Tuomas Haggren Ali Shah Anton Autere Joona-Pekko Kakko Veer Dhaka maria Kim Teppo Huhtio Zhipei Sun Harri Lipsanen Department of Micro- and Nanosciences Micronova Aalto University P.O. Box 13500 Fl-00076 Aalto Finland

Light management and electrical isolation are essential for the majority of optoelectronic nanowire （NW） devices. Here, we present a cost-effective technique, based on vapor-phase deposition of parylene-C and subsequent annealing, that provides conformal encapsulation, anti-reflective coating, improved optical properties, and electrical insulation for GaAs nanowires. The process presented allows facile encapsulation and insulation that is suitable for any nanowire structure. In particular, the parylene-C encapsulation functions as an efficient antireflection coating for the nanowires, with reflectivity down to 〈1% in the visible spectrum. Furthermore, the parylene-C coating increases photoluminescence intensity, suggesting improved light guiding to the NWs. Finally, based on this process, a NW LED was fabricated, which showed good diode performance and a clear electroluminescence signal. We believe the process can expand the fabrication possibilities and improve the devices. performance of optoelectronic nanowire

关键词： antireflection GaAs parylene-C metallo-organic vapor phase epitaxy (MOVPE) annealing light emitting diode (LED)

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Vulvar Rejuvenation Using High-Intensity Focused Ultrasound (HIFU): Fundamentals and Technique

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Journal of Biosciences and Medicines 2022年第12期10卷 239-252页

作者： Fábio dos Santos Borges Mylana Almeida de Carvalho Carla Barreto Silva de Cerqueira Tais Andrade Cravo monteiro Isabelle maria Almeida e Benevides Adriele Machado Dantas Thiago Gusmão da Silva Carolina Barreto Ribeiro Martins dos Santos Estácio de Sá University Rio de Janeiro Brazil IDE Faculty—Institute for Educational Development Salvador Brazil Longevitat Clinic—Advanced Aesthetics Salvador Brazi FAINOR Independent College of the Northeast Vitória da Conquista Brazil UFBA Federal University of Bahia Salvador Brazil

Background: The unaesthetic appearance of the female intimate area (vulva, “mound of venus” and perianal region) is a triggering factor of negative psychological responses, embarrassment, anxiety and insecurity in many women. Using rejuvenating equipment for vaginal structure or for the intimate area as a whole is already widespread in the literature, and High-Intensity Focused Ultrasound (HIFU) has proven to be very effective in the clinical practice of many professionals. This study, therefore, aims to describe the fundamentals and applicability that guide the use of HIFU in vulvar rejuvenation. Materials and Methods: Exploratory research was carried out, presented in a narrative review, to highlight the action of HIFU in female intimate rejuvenation. The review explored scientific articles published and available in the following databases: MEDLINE (Medical Literature Analysis and Retrieval System Online), PubMed (National Library of Medicine), SCIELO (Scientific Electronic Library Online), and LILACS (Latin Literature American and the Caribbean in Health Sciences). In addition, some clinical findings obtained through a retrospective analysis of medical records were added to describe the authors’ clinical experience in the use of Focused Ultrasound (HIFU) for vulvar rejuvenation. Results: We verified that the tissues of female external genitalia respond very well to the stimuli of the focused sound waves of the HIFU, being able to produce immediate and lasting results through isolated applications or in association with intradermotherapy or other therapeutic resources. Conclusion: We conclude that using High Intensity Focused Ultrasound aimed at vulvar rejuvenation is safely indicated and assures excellent aesthetic results at the end of the treatment because similarly to other treatment techniques, the thermal stimuli of HIFU are also able to produce an excellent therapeutic response in the dermal tissue of the female intimate area, promoting intense neocollagen

关键词： Intimate Aesthetics Vulvar Rejuvenation Vaginal Rejuvenation HIFU Focused Ultrasound Micro Focused Ultrasound and Cosmetic Gynecology

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Caseous calcification of mitral annulus in the setting of multivessel disease

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Journal of Geriatric Cardiology 2022年第3期19卷 238-240页

作者： Swetha R Nuthulaganti Bijal R Patel Carly A Rabinowitz maria Gutierrez Khadeeja Esmail Reeba Omman Department of Medicine Division of CardiologyUF Health JacksonvileJacksonville FlUnited States

Caseous calcification of the mitral annulus(CCMA)is a chronic degenerative process affecting the mitral valve fibrous *** is a rare variant of mitral annular calcification(MAC)that is frequently misdiagnosed as endocarditis,cardiac tumor,or *** can present with palpitations and dyspnea;however,CCMA does not have a specific clinical presentation and diagnosis is typically made incidentally by presence of an intracardiac mass on cardiac imaging.

关键词： mitral cardiac diagnosis

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Enterobacteria and Vibrio from Macrobrachium amazonicum prawn farming in Fortaleza,Ceará,Brazil

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 24-28页

作者： Débora de Souza Collares Maia Castelo-Branco Jamille Alencar Sales Raimunda Samia Nogueira Brilhante Glaucia Morgana de Melo Guedes Yago Brito de Ponte Celia maria de Souza Sampaio Tereza de Jesus Pinheiro Gomes Bandeira José Luciano Bezerra Moreira Lucas Pereira de Alencar Manoel de Araújo Neto Paiva Rossana de Aguiar Cordeiro André Jalles monteiro Waldemiro de Aquino Pereira-Neto José Júlio Costa Sidrim Marcos Fábio Gadelha Rocha Department of Pathology and Legal Medicine Postgraduate Program in Medical MicrobiologySpecialized Medical Mycology CenterFederal University of Ceará School of Veterinary Medicine Postgraduate Program in Veterinary SciencesState University of Ceará Department of Statistics and Applied Mathematics Federal University of Ceará

Objective:To investigate the isolation of enterobacteria associated with Macrobrachium amazonicum(***) farming and evaluate the in vitro antimicrobial susceptibility of Vibrio ***:Strains were isolated from female *** prawns and environmental and hatchery *** assays were used to identify bacterial genera and those belonging to the genus Vibrio were submitted to further analyses for species identification,through Vitek 2 automated system and *** test was performed according to Clinical Laboratory Standards ***:The following genera of enlerobacteria were recovered:Enterobacter(n=11),Citrobacter(n=10),Proteus(n=2),Serratia(n=2),Kluyvera(n=2),Providencia(n=2),Cedecea(n=1),Escherichia(n=1).Edwardsiella(n=1) and BulliauxeUa(n=1).As for Vibrio,three species were identified:Vibrio cholerae non-O1/non-O139(n=4).Vibrio vulnificus(***)(n=1) and Vibrio mimicus(n=1).Vibrio *** minimum inhibitory concentrations values within the susceptibility range established by Clinical Laboratory Standards Institute for almost all antibiotics,except for ***,which presented intermediate profile to ***:Enterobacteria do not seem to be the most important pathogens associated with *** farming,whereas the recovery of Vibrio *** larviculture,with emphasis on Vibrio cholerae and ***,deserves special attention due to their role as potentially zoonotic aquaculture-associated ***,the intermediate susceptibility of *** to ampicillin reflects the importance of monitoring drug use in prawn farming.

关键词： Prawn Water Enterobacteria Vibrio Antibiotics

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Disaster Risk Management Through the Design Safe Cyberinfrastructure

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International Journal of Disaster Risk Science 2020年第6期11卷 719-734页

作者： Jean-Paul Pinelli maria Esteva Ellen M.Rathje David Roueche Scott J.Brandenberg Gilberto Mosqueda Jamie Padgett Frederick Haan Department of Mechanical and Civil Engineering Florida Institute of TechnologyMelbourneFL 32901USA Texas Advanced Computing Center University of Texas at AustinAustinTX 78712USA Department of Civil Engineering University of Texas at AustinAustinTX 78712USA Department of Civil Engineering Auburn UniversityAuburnAL 36849USA Department of Civil and Environmental Engineering University of California in Los AngelesLos AngelesCA 90095USA Department of Structural Engineering University of California in San DiegoLa JollaCA 92093USA Department of Civil and Environmental Engineering Rice UniversityHoustonTX 77005USA Engineering Department Calvin CollegeGrand RapidsMI 49546USA

Design Safe addresses the challenges of supporting integrative data-driven research in natural hazards *** is an end-to-end data management,communications,and analysis platform where users collect,generate,analyze,curate,and publish large data sets from a variety of sources,including experiments,simulations,field research,and post-disaster *** achieves key objectives through:(1)integration with high performance and cloud-computing resources to support the computational needs of the regional risk assessment community;(2)the possibility to curate and publish diverse data structures emphasizing relationships and understandability;and(3)facilitation of real time communications during natural hazards events and disasters for data and information *** resultant services and tools shorten data cycles for resiliency evaluation,risk modeling validation,and forensic *** article illustrates salient features of the *** summarizes its design principles,architecture,and *** focus is on case studies to show the impact of Design Safe on the disaster risk *** Next Generation Liquefaction project collects and standardizes case histories of earthquake-induced soil liquefaction into a relational database—Design Safe—to permit users to interact with the *** can correlate in Design Safe building dynamic characteristics based on data from building sensors,with observed damage based on ground motion *** groups upload,curate,and publish wind,seismic,and coastal damage data they gather during field reconnaissance missions,so these datasets are available shortly after a *** a part of the education and community outreach efforts of Design Safe,training materials and collaboration space are also offered to the disaster risk management community.

关键词： Cyberinfrastructure Design Safe Disaster risk management Natural hazard data management

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