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Mind the gap among patches in arid plant communities:rapid root proliferation in response to N addition

Journal of Plant Ecology 2019年第1期12卷 89-95页

作者： maria fernanda Reyes Martín RAguiar Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura(IFEVA)and Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Universidad de Buenos AiresAv.San Martín 4453Buenos Aires C1417DSEArgentina

Aims In arid communities,it has been proposed that individual plants can extend their roots beyond their canopy exploring neighbour-ing bare ground *** becomes relevant in systems where the vegetation is distributed in patches surrounded by bare ***,whether roots of different species may be overlapping under bare ground areas is still *** factors control-ling root responses when no plants appear to be directly influ-encing the gap among patches are still *** aim of our study was to detect perennial grasses responses to an N enrich-ment *** In a semi-arid steppe(Patagonia,Argentina),we buried root traps filled with sieved soil with and without N addition,under bare soil *** were harvested after 4 and 6 *** neighbour-hoods(30 cm in diameter)included at least three of the dominant tussock *** harvests,we identified species in the traps by root traits and quantified diversity,biomass and specific relative growth *** Findings Bare ground areas show simultaneous root growth of different *** of perennial grass roots was higher with N addition than without it in the first harvest(4 months),but this difference disappeared in the second harvest(6 months).Root biomass was maximal after 6 months in N addition *** preferred by herbivores(Bromus pictus and Poa ligularis)showed rapid growth and responses to N *** between harvests may be an indicative that N pulses interact with rising temperatures and soil water content as growing season progress.

关键词： belowground community ecology grass species roots Patagonian steppe patchiness root growth rates zone of influence

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Regional validity of the parameters of a distributed runoff-erosion model in the semi-arid region of Brazil

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Science China(Technological Sciences) 2009年第11期52卷 3348-3356页

作者： SRINIVASAN Vajapeyam Srirangachar PAIVA fernanda maria de Lima Federal University of Campina Grande Post-graduate programme in Civil and Environmental Engineering Campus I 58429-900 Campina Grande PB Brazil

The present paper examines the validity of the application of a distributed rainfall-runoff-erosion model on a regional basis in a semi-arid region of Brazil. The model tested is known as WESP (Water Erosion Simulation Program) developed by Lopes (1987). The model simulates the hydrograph and the sediment graph for individual events and thus, the model when properly calibrated can serve as a predictive tool for runoff and soil erosion on an individual or a continuous basis. The possibility of the existence of regionally applicable values for the parameters of the model WESP would be very interesting from the point of view of predictability of runoff and soil erosion from ungauged basins in the region. For this purpose, data collected in several experimental units in the experimental basin of Sumé as well as in the experimental basin of So Joo de Cariri have been used. The model was calibrated and validated in each of the experimental units (consisting of erosion plots and micro-basins) and the average value from all of the units for each of the parameters was considered to be the regional value. With these average values, all the events in all the experimental units were simulated. The results show that the runoff and erosion values simulated with this single parameter set were very good in all the units, being well within the acceptable deviations.

关键词： regional parameters model WESP experimental basins semi-arid region soil erosion

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Molecular approaches for spinal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

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Homotypic Vacuole Fusion Requires VTI11 and Is Regulated by Phosphoinositides

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Molecular Plant 2014年第6期7卷 1026-1040页

作者： Sang Won Han maria fernanda Rodriguez-Welsh Marcela Rojas-Pierce Department of Plant and Microbial Biology North Carolina State University Raleigh NC 27695 USA

Most plant cells contain a large central vacuole that is essential to maintain cellular turgor. We report a new mutant allele of VTI11 that implicates the SNARE protein VTI11 in homotypic fusion of protein storage and lytic vacuoles. Fusion of the multiple vacuoles present in vtill mutants could be induced by treatment with Wortmannin and LY294002, which are inhibitors of Phosphatidylinositol 3-Kinase （PI3K）. We provide evidence that Phosphatidylinositol 3-Phosphate （Ptdlns（3）P） regulates vacuole fusion in vtill mutants, and that fusion of these vacuoles requires intact microtubules and actin filaments. Finally, we show that Wortmannin also induced the fusion of guard cell vacuoles in fava beans, where vacuoles are naturally fragmented after ABA-induced stomata closure. These results suggest a ubiquitous role of phosphoinositides in vacuole fusion, both during the development of the large central vacuole and during the dynamic vacuole remodeling that occurs as part of stomata movements.

关键词： vacuole SNARE phosphoinositides membrane fusion Wortmannin.

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Absence of galectin-3 attenuates neuroinflammation improving functional recovery after spinal cord injury

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Neural Regeneration Research 2016年第1期11卷 92-93页

作者： Caio Andrade Prins fernanda Martins Almeida Ana maria Blanco Martinez Laboratorio de Neurodegeneracao e Reparo-Departamento de Patologia-Faculdade de Medicina-HUCFF-UFRJ-Rio de Janeiro-RJ Brazil Instituto de Ciencia Biomedicas UFRJRio de JaneiroRJBrazil

After spinal cord injury （SCI）, a cascade of events begins. At first, there is physical damage with disruption of the blood-brain barrier （BBB） and the integrity of the nervous tissue. The disruption of central ner- vous system （CNS） BBB alters the endothelial permeability, the protein and chemokines expression and the propensity to release in situ inflam- matory cytokines, overcoming anti-inflammatory signals, facilitating the attraction and entry of immune system cells into the injured spinal cord parenchyma （Gaudet et al., 2011）. As a result, there is a neuroin- flammatory response with changes in blood flow, edema, cell infiltra- tion, apoptosis and release of axonal growth inhibitory factors. Nerve function loss occurs when the nerve impulse propagation is interrupted and do not reach its target. This disorder encompasses neuron and glia apoptosis, accompanied by Wallerian degeneration of disconnected axons, and CNS cells exposure to a hostile microenvironment that hampers axon regeneration （Mautes et al., 2000; Harkey et al., 2003）.

关键词： galectin disruption permeability facilitating attraction cascade macrophages cytokines morphologic exposure

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Genoprotection and metabolic benefits of marine macroalgae-Insights into the concept of functional foods through direct and indirect consumption

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Food Bioscience 2022年第3期47卷 524-533页

作者： Ana Marques João Ferreira Ana Cerqueda-Pacheco Vitória Pereira Helena Abreu Rui Pereira maria João Pires fernanda Seixas Paula Oliveira Isabel Gaivão Mário Pacheco Laboratory of Physiotoxicology CESAM-Centre for Environmental and Marine StudiesDepartment of BiologyUniversity of AveiroCampus Universitário de Santiago3810-193AveiroPortugal CECAV-Animal and Veterinary Research Center AL4AnimalsUniversity of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal Department of Genetics and Biotechnology University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal Department of Biology and Environment University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences Inov4AgroUniversity of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal Department of Veterinary Sciences University of Trás-os-Montes and Alto DouroQuinta de Prados5000-801Vila RealPortugal ALGAplus Lda.Travessa Alexandre da Conceição s/n3830-196ÍlhavoPortugal

The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain ***,we evaluated the genoprotective potential of a mixture of Ulva rigida,Fucus vesiculosus and Gracilaria gracilis,through direct consumption or via indirect intake using fish(Sparus aurata)as a vector of algal ***(Mus musculus)were subjected to a 1-month dietary supplementation with 5%of macroalgae mix or 10%of fillet of fish previously fed with an algae-supplemented aquafeed(for comparison purposes,10%supplementation with fillet of fish standardly fed was also considered).Thereafter,mice were challenged by the genotoxicant methyl methanesulfonate(MMS),and the genetic damage was evaluated through the micronuclei ***,a wider evaluation was carried out encompassing the assessment of energy metabolism,haematological and histological parameters,as well as growth *** unequivocally protected against MMS-induced *** activity profile of hepatic lactate and isocitrate dehydrogenases promoted by the supplemented diets reflected an improved energy *** properties were not transferred via fish fed with the algae-supplemented aquafeed,though the transference of phytocomponents with beneficial properties(*** balance improvement)should not be ***,these findings highlighted the genoprotection afforded by marine macroalgae,likely promoted by desmutagenic factors,reinforcing their definition as functional *** possibility of using fish as an indirect source of algae-borne phytocomponents proved to be plausible and worthy of further investigations.

关键词： Antigenotoxicity Desmutagens Fish consumption Functional food Marine macroalgae consumption Metabolic benefits

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Secreted protein acidic and rich in cysteine(SPARC)induces epithelial-mesenchymal transition,enhancing migration and invasion,and is associated with high Gleason score in prostate cancer

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Asian Journal of Andrology 2019年第6期21卷 557-564页

作者： fernanda Lopez-Moncada maria Jose Torres Enrique A Castellon Hector R Contreras Department of Basic and Clinic Oncology Faculty of Medic泊eUniversity of ChileSantiago 8389100Chile

Secreted protein acidic and rich in cysteine(SPARC)is a matricellular protein highly expressed in bone tissue that acts as achemoattractant factor promoting the arrival of prostate cancer(PCa)cells to the bone ***,the contribution of SPARCduring the early stages of tumor progression remains *** this study,we show that SPARC is highly expressed in PCa tissueswith a higher Gleason *** stable knockdown and overexpression of SPARC in PC3 and LNCaP cells,respectively,here wedem on strate that en doge nous SPARC induces the epithelial-mesenchymal tran sition(EMT),decreasing E-cadheri n and cytokeratin18 and increasing N-cadheri n and vime ***,SPARC in duces the expression of EMT regulatory tran scription factors Snailfamily transcriptional repressor 1(Snail),Snail family transcriptional repressor 2(Slug),and zinc finger E-box binding homeobox 1(Zeb1).In addition,SPARC knockdown in PC3 cells decreases migration and invasion in vitro,without modifying cell *** results indicate that SPARC might facilitate tumor progression by modifying the cellular phenotype in cancer cells.

关键词： epithelial-mesenchymal transition invasion migration prostate cancer secreted protein acidic and rich in cysteine(SPARC)

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Chronic urticaria associated with lung adenocarcinoma—a paraneoplastic manifestation:A case report and literature review

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World Journal of Clinical Cases 2022年第21期10卷 7553-7564页

作者： Luisa fernanda Jiménez Evis Adriana Castellón Juan David Marenco Josémaria Mejía Camilo Andrés Rojas Franklin Torres Jiménez Linda Coronell Estefanie Osorio-Llanes Evelyn Mendoza-Torres Faculty of Health Sciences Universidad Libre de ColombiaSeccional BarranquillaBarranquilla 08000Colombia Faculty of Exact and Natural Sciences Universidad Libre de ColombiaSeccional BarranquillaBarranquilla 08000Colombia lty of Health Sciences Universidad Libre De ColombiaSeccional BarranquillaBarranquilla 08000AtlánticoColombia

BACKGROUND Urticaria is one of the most common causes of emergency room *** is defined as an acute inflammatory dermatosis,characterized by localized degranulation of mast cells,with consequent dermal microvascular and formation of edematous and pruritic plaques called *** affects the skin and tissues of the superficial *** it is accompanied by angioedema,which is characterized by deeper edema of the dermis and subcutaneous cellular tissue known as the urticarial-angioedema *** 15%-25%of the general population has suffered at least one type of urticaria at some point during their lifetime and hyperpermeability estimated at 7.6%-16%and has experienced acute urticaria that is usually self-limited and spontaneously resolves without requiring medical *** SUMMARY We present the case of a young male patient who was referred to our department with a clinical picture of 4 mo of pruritus associated with hives of variable sizes,irregular borders,with interlesional confluence,that were non-painful,without involvement of the palms and soles of the feet but with a tendency to progression in a generalized *** had multiple emergency room visits and poor response to antihistamines and systemic *** studies demonstrated nodules in the lower lingula segment,at the level of the greater fissure and in the anterior contour of the left anterior basal segment associated with parahiliar adenopathies in the absence of findings suggestive of infectious or autoimmune *** lobectomy was performed by thoracoscopy with resection of a lung nodule in the lingula and biopsy of the para-aortic mediastinal *** histopathological report showed the presence of poorly differentiated invasive adenocarcinoma with a solid morphological and acinar pattern with immunohistochemical description of lung tissue that expresses strong positive and diffuse reaction for thyroid transcription factor 1(TTF-1)with negati

关键词： Urticaria Lung adenocarcinoma Undifferentiated carcinoma Paraneoplastic syndromes Thyroid nuclear factor 1 Case report

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Oxypropylation of Brazilian Pine-Fruit Shell Evaluated by Principal Component Analysis

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Journal of Renewable Materials 2018年第7期6卷 715-723页

作者： Stephany Cde Rezende João APinto Isabel PFernandes fernanda VLeimann maria-Filomena Barreiro Laboratory of Separation and Reaction Engineering-Laboratory of Catalysis and Materials(LSRE-LCM) Polytechnic Institute of BragançaBragançaPortugal Programa de Pós-Graduação em Tecnologia de Alimentos(PPGTA) Universidade Tecnológica Federal do Paraná-UTFPR Campus Campo MourãoVia Rosalina Maria Dos Santos1233.CEP 87301-899.Caixa Postal:271Campo Mourão-PR-Brasil Mountain Research Centre(CIMO) Polytechnic Institute of BragançaBragançaPortugal

Pine-fruit shell (PFS) is a lignocellulosic residue derived from the fruit of Araucaria angustifolia, a coniferoustree native of South America, part of a whole vegetation of the Atlantic Forest, found in the South and Southwestof Brazil. In this work PFS will be characterized and used in the production of PFS-based polyols throughoxypropylation. Three series were chosen (PFS/propylene oxide (PO) (w/v, g/mL) of 30/70, 20/80 and 10/90)with four catalyst levels (5%, 10%, 15% and 20%, (w/w, PFS based)). Oxypropylation occurred at moderateconditions of temperature, pressure and time giving rise to liquid polyols with a homopolymer content (PPO)ranging from 4-65%, a hydroxyl number (IOH) between 257-605 mg KOH/g and viscosities (V) varying from0.76 Pa.s to 373.90 Pa.s (20°C) for the series 20/80 and 10/90, while for the series 30/70, the viscosity reachedvalues higher than 500 Pa.s, 20°C. The unreacted PFS (UR) varied between 3.6% and 77.4% (PFS-basis). Afterthe PFS-based polyols production and characterization, a principal component analysis (PCA) was performed inorder to evaluate the established interactions between the used formulation variables and the obtained polyolproperties. The PCA analysis allowed to clarify the interactions between PFS and PO contents and the finalbiopolyol properties (PPO, IOH, V and UR). This approach showed to be a simple method to rationally analyzethe influence of the input formulation variables on the final polyol properties.

关键词： Principal components analysis Brazilian pine-fruit shell (PFS) oxypropylation polyols

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A survey of semantic web technology for agriculture

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Information Processing in Agriculture 2019年第4期6卷 487-501页

作者： Brett Drury Robson Fernandes maria-fernanda Moura Alneu de Andrade Lopes ICMC University of Sa˜o Paulo-Av.Trabalhador Sa˜o-carlense400CentroSa˜o CarlosSP 13566-590Brazil Embrapa Agriculture Informatics-Av.Dr.Andre´Tosello 209 CidadeUniversita´ria CampinasSPBrazil Scicrop Rua Henrique Monteiro90-14 Andar-PinheirosSa˜o PauloSPBrazil

Semantic web technologies have become a popular technique to apply meaning to unstructured *** have been infrequently applied to problems within the agricultural domain when compared to complementary *** this lack of application,agriculture has a large number of semantic resources that have been developed by large NGOs such as the Food and Agriculture Organization(FAO).This survey is intended to motivate further research in the application of semantic web technologies for agricultural problems,by making available a self contained reference that provides:a comprehensive review of preexisting semantic resources and their construction methods,data interchange standards,as well as a survey of the current applications of semantic web technologies.

关键词： Knowledge Representation Semantic web technology Ontologies Linked data Survey

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