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Dielectrophoretic assembly of carbon nanotubes and stability analysis

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Progress in Natural Science:Materials International 2013年第4期23卷 367-373页

作者： Libao An craig Friedrich College of Mechanical engineering Hebei Provincial Key Laboratory of Inorganic Nonmetallic MaterialsHebei United University Department of Mechanical engineering-engineering Mechanics Multi-Scale Technologies InstituteMichigan Technological University

Nanoscale dimensions and remarkable properties of carbon nanotubes make them promising building blocks for *** requirement is the need to manipulate single or multiple carbon nanotubes to bridge electronic *** this paper,multi-walled carbon nanotubes with a variety of sizes are assembled onto electrodes using alternative current electric felds by *** effect of the dielectrophoretic parameters and the nanotube size as well as the length uniformity on the assembly is experimentally ***–voltage characteristics of assembled carbon nanotubes are *** experimental results showed that both the dielectrophoretic parameters and length uniformity of carbon nanotubes have an infuence on the stability of assembly *** uniform carbon nanotubes with an appropriate length and suffcient stiffness,which are more controllable by dielectrophoresis,is necessary for an assembly of a small number of carbon nanotubes.

关键词： Carbon nanotube Assembly Dielectrophoresis Process parameter Stability

Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia

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Journal of Geriatric Cardiology 2017年第6期14卷 407-415页

作者： enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte Clare Bradley Stephanie L Harrison emmanuel Gnanamanickam craig Whitehead maria Crotty Department of Rehabilitation Aged and Extended Care Faculty of Medicine Nursing and Health Sciences School of Health Sciences Flinders University Daw Park Australia NHMRC Cognitive Partnership Centre The University of Sydney Sydney NSW Australia Kolling Institute of Medical Research St Leonards NSW Australia and Sydney Medical School University of Sydney Sydney NSW Australia Institute for Choice University of South Australia GPO Box 2471 Adelaide SA Australia Infection & Immunity - Aboriginal Health SAHMRI PO Box 11060 Adelaide SA Australia

Objective To examine associations between cardiovascular system medication use with cognition function and diagnosis of dementia in older adults living in nursing homes in Australia. Methods As part of a cross-sectional study of 17 Australian nursing homes examining quality of life and resource use, we examined the association between cognitive impairment and cardiovascular medication use （identified using the Anatomical Therapeutic Classification System） using general linear regression and logistic regression models. People who were receiving end of life care were excluded. Results Participants included 541 residents with a mean age of 85.5 years （± 8.5）, a mean Psychogeriatric Assessment Scale–Cognitive Impairment （PAS-Cog） score of 13.3 （± 7.7）, a prevalence of cardiovascular diseases of 44% and of hypertension of 47%. Sixty-four percent of participants had been diagnosed with dementia and 72% had received cardiovascular system medications within the previous 12 months. Regression models demonstrated the use of cardiovascular medications was associated with lower （better） PAS-Cog scores [Coefficient （β） = -3.7; 95% CI： -5.2 to -2.2; P 〈 0.0001] and a lower probability of a dementia diagnosis （OR = 0.44; 95% CI： 0.26 to 0.75, P = 0.0022）. Analysis by subgroups of medications showed cardiac therapy medications （C01）, beta blocking agents （C07）, and renin-angiotensin system agents （C09） were associated with lower PAS-Cog scores （better cognition） and lower dementia diagnosis probability. Conclusions This analysis has demonstrated an association between greater cardiovascular system medication use and better cognitive status among older adults living in nursing homes. In this population, there may be differential access to health care and treatment of cardiovascular risk factors. This association warrants further investigation in large cohort studies.

关键词： Cardiovascular agents Cognitive dysfunction Dementia Residential facilities

Forward： Proceedings of the 2008 ecological and evolutionary ethology of Fishes Conference, Boston, Massachusetts, USA

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Current Zoology 2010年第1期56卷 I0001-I0002页

作者： maria e. ABATe Guest editor Department of Biology Boston University Boston Massachusetts 02215 USA.

This special issue of Current Zoology concerning the behavior, ecology, and evolution of fishes is comprised of the peer-reviewed Proceedings of the 2008 ecological and evolutionary ecology of Fishes Biennial Conference that was held June 29 - July 3 at Boston University, Boston, Massachusetts, USA. The conference and its four symposia were organized by a local organization committee and scientific program committee which included maria Abate, host at Boston University; Sigal Balshine, McMaster University; Michael Clancy, Boston University; Ronald Coleman, California State University, Sacramento; John Godwin, North Carolina State University; Les Kaufinan, Boston University;

关键词：波士顿大学马萨诸塞州美国加州行为学生态鱼类进化学术委员会

Degradation of indomethacin in river water under stress and non-stress laboratory conditions:degradation products,long-term evolution and adsorption to sediment

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Journal of environmental Sciences 2017年第1期29卷 13-20页

作者： Juan J.Jimenez maria I.Sanchez Rafael Pardo Beatriz e.Munoz Department of Analytical Chemistry Faculty of SciencesCampus Miguel DelibesUniversity of ValladolidPaseo de Belen 747012 ValladolidSpain I.U.CINQUIMA Campus Miguel DelibesUniversity of ValladolidPaseo de Belen 547011 ValladolidSpain Department of Analytical Chemistry School of Industrial EngineersUniversity of ValladoliclFrancisco Mendizdbal 147014 ValladolidSpain

The pharmaceutical compound indomethacin is not totally removed in wastewater treatment plants,whose effluents flow into aquatic environments;concentrations in the 0.1-100 ng/L range are commonly found in surface waters,and its fate is ***,biological,photochemical and thermal degradation assays were conducted under stress and non-stress conditions to estimate its degradation rate in river water and establish its degradation products over *** results revealed that direct sunlight irradiation promoted the complete degradation of indomethacin（2 μg/L） in less than 6 hr,but indomethacin was detected over a period of 4 months when water was kept under the natural day-night cycle and the exposure to sunlight was partially limited,as occurs inside a body of *** biological degradation in water was negligible,while the hydrolysis at pH 7.8 was *** were monitored by ultra-pressure liquid chromatography/quadrupole time-of-flight/mass spectrometry after solid-phase extraction,and six degradation products were found;their structures were proposed based on the molecular formulae and fragmentation observed in high-resolution tandem mass spectra.4-Chlorobenzoic and 2-acetamido-5-methoxybenzoic acids were the long-term transformation products,persisting for at least 30 weeks in water kept under non-stress ***,the degradation in the presence of sediment was also monitored over time,with some differences being *** adsorption coefficients of indomethacin and degradation products on river sediment were calculated;long-term degradation products did not have significant adsorption to sediment.

关键词： Indomethacin Degradation products River water Adsorption coefficients High-resolution mass spectrometry

Which Inspection Approach Is Better to Prevent Drug Fraud: Announced or Unannounced?

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Journal of Systems Science & Complexity 2018年第6期31卷 1571-1590页

作者： ZHANG Manman ZHANG Juliang CHeNG T.C.e. SALLAN Jose maria HUA Guowei Department of Logistics Management School of Economics and ManagementBeijing Jiaotong UniversityBeijing 100044China. Department of Logistics and Maritime Studies The Hong Kong Polytechnic UniversityHung HornKowloonHong KongChina Department d'Organizacio d'empreses Universitat Politecnica de CatalunyaTerrassa 08222Spain.

In recent years,there are many crimes related drug fraud occuring in China and many experts think that the main cause is that China Food and Drug Administration (CFDA)adopts announced inspection (AI).In order to circumvent this difficulty,CFDA has exploited unannounced inspection (UI)since *** this paper,the authors study the problem of which one performs better, AI or ***,the authors consider a supervisor,which decides the inspection approach,inspection strength and punishment to force the firm to put self-inspection effort to meet the requirements of Good Manufacturing Practice,and a firm,which produces a drug and decides its self-inspection effort. The authors use game theory to model this problem,characterize the equilibrium policies under AI, and compare the effects of the two approaches on preventing drug fraud under complete and incomplete *** results show that under the complete information,UI performs better if the firm's technical level and the inspection cost are low and AI performs better *** the supervisor doesn't know the firm's technical level,if the low technical level is high,AI performs ***, UI performs better if the inspection cost is low and AI performs better if the inspection cost is high.

关键词： Drug inspection game theory healthcare incomplete information public policy.

Cumulative effects of volcanic ash on the food preferences of two Orthopteran species

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Insect Science 2017年第4期24卷 640-646页

作者： Valeria Fern&ndez-Arhex maria e. Amadio Octavio A. Bruzzone Instituto Nacional de Tecnologia Agropecuaria Estacion Experimental Agropecuaria-Bariloche CC277 A v Modesta Victoria 4450 (8400) San Carlos de Bariloche Argentina Lab ECO TONO-INIBIOMA Pie. Gutierrez 850 San Carlos de Bariloche Rio Negro Argentina Centro Cientifico Tecnologico - Consejo Nacional de Investigaciones Cientificas y Tocnicas (CCT-CONICeT) Patagonia Norte. Av. de los Pioneros 2350 San Carlos de Bariloche Rio Negro Argentina

Inert dusts are an early form of insecticide which is still in use. One of the most common inert dusts is volcanic ash. In order to study the reaction ofrangeland grasshoppers, Dichroplus vittigerum （Acrididae） and a katydid, t]wgilis mendosensis （Phaneropteridae）, to the presence of volcanic ash in their food sources and how this reaction changed as a function of time, we conducted paired preference tests between clean leaves of their pre- ferred host plant and leaves exposed to volcanic ash of different grain size. The behavioral response was measured as the rating on the Thurstonian preference scale of leaves with ash in relation to clean leaves. The results showed that the avoidance of volcanic ash increased as a function of time in both species. Both species studied are occasionally exposed to vol- canic activity, and come from an area in which a volcanic eruption had recently occurred. As their populations did not decrease after the ash fall, we propose that some behavioral responses such as avoidance of places with ash, works as tolerance mechanism to inert dusts exposure.

关键词： Burgilis mendosensis Dichroplus vittigerum inert dust preference test thurstone scale

Translating current biomedical therapies for long duration,deep space missions

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Precision Clinical Medicine 2019年第4期2卷 259-269页

作者： Sonia Iosim Matthew MacKay craig Westover Christopher e.Mason Department of Physiology and Biophysics Weill Cornell MedicineNew YorkNY 10021USA The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNew YorkNY 10021USA The WorldQuant Initiative for Quantitative Prediction Weill Cornell MedicineNew YorkNY 10021USA

It is been shown that spaceflight-induced molecular,cellular,and physiologic changes cause alterations across many modalities of the human body,including cardiovascular,musculoskeletal,hematological,immunological,ocular,and neurological *** Twin Study,a multi-year,multi-omic study of human response to spaceflight,provided detailed and comprehensive molecular and cellular maps of the human response to radiation,microgravity,isolation,and *** rich data identified epigenetic,gene expression,inflammatory,and metabolic responses to spaceflight,facilitating a better biomedical roadmap of features that should be monitored and safe-guarded in upcoming ***,by exploring new developments in pre-clinical models and clinical trials,we can begin to design potential cellular interventions for exploration-class missions to Mars and potentially *** paper will discuss the overall risks astronauts face during spaceflight,what is currently known about human response to these risks,what pharmaceutical interventions exist for use in space,and which tools of precision medicine and cellular engineering could be applied to aerospace and astronaut medicine.

关键词： NASA spaceflight International Space Station NASA Twin Study multi-scale omics

Methods used in microbial forensics and epidemiological investigations for stronger health systems

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Forensic Sciences Research 2022年第4期7卷 650-661页

作者： Arizaldo e.Castro maria Corazon A.De Ungria Microbial ecology of Terrestrial and Aquatic Systems Laboratory Institute of BiologyUniversity of the Philippines DilimanQuezon CityPhilippines DNAAnalysis Laboratory Natural Sciences Research InstituteUniversity of the Philippines DilimanQuezon CityPhilippines Program on Biodiversity Ethnicityand ForensicsPhilippine Genome CenterUniversity of the Philippines DilimanQuezon CityPhilippines

This review discusses microbial forensics as an emerging science that finds application in protecting human *** is important to distinguish naturally acquired infections from those caused by the intentional release of microorganisms to the *** information is crucial in formulating procedures against the spread of infectious diseases and prosecuting persons who may be involved in acts of biocrime,bioterrorism,or biowarfare.A comparison between epidemiological investigations and microbial forensic investigations is *** addition,a discussion on how microbial forensics strengthens health systems is included in this *** forensic investigations and epidemiologic examinations employ similar concepts and involve identifying and characterising the microbe of *** fields require formulating an appropriate case definition,determining a pathogen’s mode of transmission,and identifying the source(s)of ***,the two subdisciplines differ in their *** epidemiological investigation aims to identify the pathogen’s source to prevent the spread of the *** forensics focuses on source-tracking to facilitate the prosecution of persons responsible for the spread of a *** fields use molecular techniques in analysing and comparing DNA,gene products,and biomolecules to identify and characterise the microorganisms of *** included case studies to show methods used in microbial forensic investigations,a brief discussion of the public significance of microbial forensic systems,and a roadmap for establishing a system at a national *** system is expected to strengthen a country’s capacity to respond to public health *** factors must be considered in establishing national microbial forensic *** is the inherent ubiquity,diversity,and adaptability of microorganisms that warrants the use of robust and accurate molecular typing ***,the availability of facilit

关键词： Forensic sciences microbial forensics epidemiology infectious diseases molecular methods health system resilience microbial forensic systems

Poor maternal nutrition inhibits muscle development in ovine offspring

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Journal of Animal Science and Biotechnology 2015年第1期6卷 79-89页

作者： Sarah A Reed Joseline S Raja maria L Hoffman Steven A Zinn Kristen e Govoni Department of Animal Science University of ConnecticutStorrsCT 06269USA

Background： Maternal over and restricted nutrition has negative consequences on the muscle of offspring by reducing muscle fiber number and altering regulators of muscle growth. To determine if over and restricted maternal nutrition affected muscle growth and gene fed 60%, 100% or 140% of National Research Council and protein expression in offspring, 36 pregnant ewes were requirements from d 31 ＋ 1,3 of gestation until parturition. Lambs from control-fed （CON）, restricted-fed （ReS） or over-fed （OVeR） ewes were necropsied within 1 d of birth （n = 18） or maintained on a control diet for 3 mo （n = ] 5）. Semitendinosus muscle was collected for immunohistochemistry, and protein and gene expression analysis. Results： Compared with CON, muscle fiber cross-sectional area （CSA） increased in ReS （58%） and OVeR （47%） lambs at 1 d of age （P〈 0.01）; however at 3 mo, CSA decreased 15% and 17% compared with CON, respectively （P 〈 0.01）. Compared with CON, muscle lipid content was increased in OVeR （212.4%） and ReS （92.5%） at d 1 （P 〈 0.0001）. Muscle lipid content was increased 36.1% in OVeR and decreased 23.6% in ReS compared with CON at 3 mo （P 〈 0.0001）. At d 1, myostatin mRNA abundance in whole muscle tended to be greater in OVeR （P = 0.07） than CON. Follistatin mRNA abundance increased in OVeR （P = 0.04） and tended to increase in ReS （P = 0.06） compared with CON at d 1. However, there was no difference in myostatin or follistatin protein expression （P 〉 0.3）. Phosphorylated Akt （ser473） was increased in ReS at 3 mo compared with CON （P = 0.006）. Conclusions： In conclusion, maternal over and restricted nutrient intake alters muscle lipid content and growth of offspring, possibly through altered gene and protein expression.

关键词： Growth Maternal nutrition Muscle development Sheep