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A Metamodel for Agile requirements Engineering

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Journal of Computer and Communications 2019年第2期7卷 1-22页

作者： Eva-maria Schon Jorge Sedeno Manuel Mejías Jorg Thomaschewski María José Escalona Department of Computer Languages and Systems University of SevilleSevilleSpain Faculty of Technology University of Applied Sciences Emden/LeerEmdenGermany

Value delivery is becoming an important asset for an organization due to increasing competition in industry. Therefore, companies apply Agile Software Development (ASD) to be more competitive and reduce time to market. Using ASD for the development of systems implies that established approaches of requirements Engineering (re) undergo some changes in order to be more flexible to changing requirements. To this end, the field of agile re is emergent and different process models for agile re have arisen. The aim of this paper is to build an abstract layer about the variety of existing process models by means of a metamodel for agile re. It has been created in several iterations and relies on the evaluation of related process models. Furthermore, we have derived process models for agile re in industry by presenting instances of the metamodel in two different cases: one is based on Scrum whereas the other is based on Kanban. This paper contributes to the software development body of knowledge by delivering a metamodel for agile re that supports researchers and practitioners modeling and improving their own process models. We can conclude that the agile re metamodel is highly relevant for the industry as well as for the research community, since we have derived it following empirical research in the field of ASD.

关键词： Agile Software Development requirements Engineering Human-Centered Design Metamodel

Effect of LDL-apheresis on plasma lipids, chitotriosidase and anti-oxLDL antibodies in heterozygous familial hypercholes-terolemia

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Journal of Biomedical Science and Engineering 2009年第7期2卷 499-505页

作者： maria Musumeci Francesco Pappalardo GianCarlo Tonolo Fernando Torrisi Francesca Gullo Salvatore Musumeci 不详

Forty four consecutive subjects aged 29-58 years (21 males and 23 females) with a clinical diagnosis of heterozygous familial hypercholesterolemia periodically treated every 30 days with LDL-apheresis for statin resistance, were enrolled in this study. A lipid profile was obtained immediately before starting LDL-apheresis, a second profile was obtained within four hours after LDL-apheresis. Chit activity and anti-oxLDL levels were determined with appropriate methods in all patients before and after LDL- apheresis. Total cholesterol, LDL-cholesterol, HDL- cholesterol and triglycerides decreased significantly after LDL-apheresis, while the variations of Chit activity and anti-oxLDL were not significant after LDL-apheresis. The correlation between Chit and total cholesterol was negative (r= –0.44 and –0.50 res- pectively) before and after LDL-apheresis as between Chit and LDL-cholesterol (r= –0.45 and –0.55 respectively). Anti-oxLDL concentration before and after LDL-apheresis positively correlated with Chit activity (r= 0.52 and r = 0.63 respectively), negatively with total cholesterol (r= –0.33 and r = –0.35 res- pectively) and with LDL (r = –0.32 and r = –0.21 respectively). We think that removing LDL with LDL-apheresis the anti-oxLDL/oxLDL ratio could increase and the excess of anti-oxLDL could induce macrophage activation through the surface Fc receptors. Alternatively with high levels of LDL- cholesterol, the deposition of foam cells represent the characteristic evolution of atherosclerosis process. Macrophage activation in the heterozygous familial hypercholesterolemia could represent an attempt for re-modeling the vessel wall, reducing the growth of lipid plaques.

关键词： LDL-Apheresis Heterozygous Familial Hyper- Cholesterolemia Lipids Chitotriosidase Anti-oxLDL Anti- bodies Sardinia

Prevalence of hypercoagulable states in stented thrombotic iliac vein compression syndrome with comparison of re-intervention and anticoagulation regimens

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World Journal of Radiology 2021年第12期13卷 371-379页

作者： Peyton Cramer Cheryl Mensah maria DeSancho Anuj Malhotra Ronald Winokur Andrew Kesselman Department of Radiology Division of Interventional RadiologyNew York Presbyterian Hospital/Weill Cornell MedicineNew YorkNY 10065United States Department of Medicine Division of Hematology-OncologyNew York Presbyterian Hospital/Weill Cornell MedicineNew YorkNY 10065United States Department of Radiology Division of Interventional RadiologyThomas Jefferson University HospitalPhiladelphiaPennsylvania 19107United States

BACKGROUND Endovascular therapy is playing an increasing role in the treatment of iliofemoral venous *** stent patency is multifactorial,and current management is based on best clinical practices,varying by *** To evaluate how thrombophilia influences management and outcomes of patients who undergo venous stenting for thrombotic iliac vein compression *** A retrospective observational analysis was performed on 65 patients with thrombotic iliac vein compression syndrome that underwent common iliac vein(CIV)stenting between December 2013 and December 2019 at a large academic *** criteria included CIV stenting and iliac vein *** lesions and iliocaval thrombosis and/or occlusions were excluded.A total of 65 patients were selected for final *** information,procedural data points,and post-procedural management and outcomes were *** analyses included Fisher's exact and Chi-square tests to compare discrete variables and the Wilcoxon rank-sum test to compare continuous variables between thrombophilia positive and negative *** 65 patients underwent successful balloon angioplasty and CIV *** these patients,33(50.8%)underwent thrombophilia testing,with 16(48.5%)testing *** patency on ultrasound did not significantly differ between thrombophilia positive and negative patients at 1 mo(92.3%vs 81.3%,P=0.6),6 mo(83.3%vs 80%,P>0.9),or 12 mo(77.8%vs 76.9%,P=0.8).Immediately after stent placement,thrombophilia patients were more likely to be placed on dual therapy(aspirin and anticoagulation)or triple therapy(aspirin,clopidogrel,and anticoagulation)(50%vs 41.2%,P>0.9),and remain on dual therapy at 6 mo(25%vs 12.5%,P=0.5)and 12 mo(25%vs 6.7%,P=0.6).There was no significant difference in re-intervention rates(25%vs 35.3%,P=0.7)or number of reinterventions(average 2.3 vs 1.3 per patient,P=0.4)between thrombophilia positive and negative ***

关键词： Thrombophilia Iliac vein compression syndrome Iliac vein stent May Thurner Anticoagulation Endovascular

Canine Prostate Carcinoma: Four Clinical Cases in Sexually Intact and Neutered Dogs

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The heterogeneity-diversity-system performance nexus

Open Journal of Urology（泌尿学期刊） 2012年第4期

作者： Enrico Bigliardi carla Bresciani Anna maria Cantoni Francesco Di Ianni Giorgio Morini Simone Voccia Attilio Corradi Enrico Parmigiani

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National Science review 2023年第7期10卷 251-260页

作者： Nico Eisenhauer Gerrit Angst Ana E.B.Asato Rémy Beugnon Elisabeth B?nisch Simone Cesarz Peter Dietrich Stephanie D.Jurburg Anna-maria Madaj Rine C.reuben Christian Ristok Marie Sünnemann Huimin Yi Carlos A.Guerra Jes Hines German Centre for Integrative Biodiversity research (iDiv) Halle-Jena-Leipzig Institute of Biology Leipzig University Institute of Soil Biology and Biogeochemistry Biology Centre of the Czech Academy of Sciences Leipzig Institute for Meteorology Universit?t Leipzig CEFE Univ Montpellier CNRS EPHE IRD Department of Environmental Microbiology Helmholtz Centre for Environmental Research – UFZ

Ever-growing human population and nutritional demands,supply chain disruptions,and advancing climate change have led to the re alization that changes in diversity and system performance are intimately ***,diversity and system performance depend on *** changes in system performance and promoting sustainable living conditions requires transformative ***,we introduce the heterogeneity-diversity-system performance(HDP) nexus as the conceptual basis upon which to formulate transformative *** suggest that managing the heterogeneity of systems will best allow diversity to provide multiple benefits to *** on ecological theory,we pose that the HDP nexus is broadly applicable across systems,disciplines,and sectors,and should thus be considered in future decision making as a way to have a more sustainable global future.

关键词： heterogeneity diversity biodiversity-ecosystem functioning global change homogenization