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Weathering and accumulation of trace elements in the soils of the Porali Plain, Balochistan: repercussions in agriculture

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Acta Geochimica 2024年第2期43卷 214-234页

作者： maria Kaleem Erum Bashir Shahid Naseem Tahir Rafique Bushra Shahab Department of Geology University of KarachiKarachi 75270Pakistan Applied Chemistry research Centre PCSIR Laboratories ComplexKarachi 75280Pakistan

This study is theﬁrst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by multi-variate analysis based on geochemical *** outcomes of this study are expected to help farmers in soil manage-ment and selecting suitable crops for the ***-ﬁve soil samples were collected,mainly from the arable land of the Porali *** drying and coning-quarter-ing,soil samples were analyzed for major and trace ele-ments using the XRF technique;sieving and hydrometric methods were employed for granulometric ***-mated data were analyzed using Excel,SPSS,and Surfer software to calculate various indices,correlation matrix,and spatial *** granulometric analysis showed that 76%of the samples belonged to loam types of soil,12%to sand type,and 8%to silt *** indices:CIA,CIW,PIA,PWI,WIP,CIX,and ICV were calculated to infer the level of *** indices reﬂect mod-erate to intense weathering;supported by K_(2)O/AI_(2)O_(3),Rb/K_(2)O,Rb/Ti,and Rb/Sr *** of the geo-ac-cumulation and Nemerow Pollution indices pinpoint rela-tively high concentrations of Pb,Ni,and Cr concentration in the *** correlation matrix and Principal Compo-nent Analysis show that the soil in this study area is mainly derived from the weathering of igneous rocks of Bela Ophiolite(Cretaceous age)and Jurassic sedimentary rocks of Mor Range having SEDEX/MVT type *** may result in the undesirable accumulation of certain trace elements which adversely affects crops.

关键词： Weathering indices Pollution indices Accumulation repercussions Trace elements Multivariate analyses Porali Plain Balochistan

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira Silva mariana Santos Calmon Cláudio Lima Souza Ana carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

Helium Plasma Effects on Polymer Surfaces:from Plasma Parameters and Surface Properties towards Bioengineering Applications

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Chinese Journal of Polymer Science 2024年第8期42卷 1156-1166页

作者： Andrei Vasile Nastuta maria Butnaru Byron Cheatham Ramona Huzum Vasile Tiron Ionut Topala Physics and Biophysics Education research Laboratory(P&B-EduresLab) Biomedical Science DepartmentFaculty of Medical Bioengineering‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Faculty of Medical Bioengineering ‘Grigore T.Popa’University of Medicine and Pharmacy IasiM.Kogalniceanu 9-13Iasi 700454Romania Cytoviva Inc.570 Devall Drive Suite 301Auburn 36832ALUSA Integrated Center of Environmental Science Studies in the North-Eastern Development region(CERNESIM) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania research Center on Advanced Materials and Technologies(RAMTECH) Department of Exact and Natural SciencesInstitute of Interdisciplinary Research‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania Iasi Plasma Advanced research Center(IPARC) Faculty of Physics‘Alexandru Ioan Cuza’University of IasiBlvd.Carol I no.11Iasi 700506Romania

Plasma treatment is necessary to optimize the performance of biomaterial *** enhances and regulates the performance of biomaterial su rfaces,creating an effective interface with the human *** treatments have the ability to modify the chemical com position and physical structu re of a surface while leaving its properties *** possess the ability to modify material su rfaces,eliminate contaminants,conduct investigations on cancer therapy,and facilitate wound *** subject of study in question involves the integration of plasma science and technology with biology and *** a helium plasma jet source,applying up to 18 kV,with an average power of 10 W,polymer foils were treated for 60 *** treatment has the ability to alter the chemical composition and physical structure of a su rface while maintaining its *** investigation involved the application of helium plasma at atmospheric pressure to polyamide 6 and polyethylene terephthalate *** inquiry involves monitoring and assessing the plasma source and polymer materials,as well as analyzing the impacts of plasma *** the mean power of the discharge aids in assessing the economic efficacy of the plasma *** discharge in helium at atmospheric pressure has beneficial effects in technology,where it increases the surface free energy of polymer *** biomedicine,it is used to investigate cytotoxicity and cell survival,particularly in direct blood exposure situations that can expedite *** the specific parameters that influence the plasma source in the desired manner for the intended application is of utmost im portance.

关键词： Atmopheric pressure plasmas Plasma-polymer interaction Plasma Medicine Plasma diagnosis Polymer characterization

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Long chikungunya?An overview to immunopathology of persistent arthralgia

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World Journal of Virology 2024年第2期13卷 48-57页

作者： Jayme Euclydes Picasky Silveira-Freitas maria Luiza Campagnolo mariana dos Santos Cortez Fabrício Freire de Melo Ana carla Zarpelon-Schutz Kádima Nayara Teixeira Campus Toledo Universidade Federal do ParanáToledoParaná85919-899Brazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaCampus Anísio TeixeiraVitória da ConquistaBahia 45029-094Brazil Programa de Pós-graduação em Biotecnologia PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil Programa Multicêntrico de Pós-graduação em Bioquímica e Biologia Molecular PalotinaUniversidade Federal do Paraná-Setor PalotinaParaná85950-000Brazil

Chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent *** clinical signs triggered by the Chikungunya virus are similar to those of other ***,fever starts abruptly and reaches high levels,followed by severe polyarthralgia and myalgia,as well as an erythematous or petechial maculopapular rash,varying in severity and *** 40%to 60%of affected individuals report persistent arthralgia,which can last from months to *** symptoms of CF mainly represent the tissue tropism of the virus rather than the immunopathogenesis triggered by the host's immune *** main mechanisms associated with arthralgia have been linked to an increase in T helper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-Βligand and bone *** review suggests that persistent arthralgia results from the presence of viral antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member 7 in synovial macrophages,leading to local infiltration of CD4+T cells,which sustains the inflammatory process in the joints through the secretion of pro-inflammatory *** term"long chikungunya"was used in this review to refer to persistent arthralgia since,due to its manifestation over long periods after the end of the viral infection,this clinical condition seems to be characterized more as a sequel than as a symptom,given that there is no active infection involved.

关键词： Chikungunya Immunopathology Inflammation process Persistent arthralgia Signaling lymphocytic activation molecule family member 7

Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias—the PrePoP guidelines

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Journal of Integrative Medicine 2024年第5期22卷 533-544页

作者： Alexander L.Tournier Leoni V.Bonamin Susann Buchheim-Schmidt Steven Cartwright Christoph Dombrowsky Paul Doesburg carla Holandino maria Olga Kokornaczyk Everine B.van de Kraats Jesús Antonio López-Carvallo Papiya Nandy JoséManuel Mazón-Suástegui Fateme Mirzajani Bernard Poitevin Claudia Scherr Karin Thieves Sandra Würtenberger Stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern Institute of Integrative Medicine Witten/Herdecke University Homeopathy research Institute Graduate Program on Environmental and Experimental Pathology Paulista University Department of Medical Science Deutsche Hom?opathie-Union DHU-Arzneimittel GmbH&Co.KG Cherwell Laboratory for Fundamental research in Homeopathy Society for Cancer research Hiscia Research Institute Laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de Janeiro World Water Community Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte Centre for Interdisciplinary research and Education Laboratorio de Homeopatía Acuícola y Semillas Marinas Centro de Investigaciones Biológicas del Noroeste Protein research Center Shahid Beheshti University Department of Medical Laboratory Science College of ScienceKnowledge University Socie′te′Savante d’Hom′eopathie Sola Salus Institute for Homeopathic Research Scientific Society for Homeopathy

Objective: Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative medicine. The physicochemical properties and biological activity of these preparations are often investigated in preclinical research, yet no guidelines for experimental research currently exist in this area. The present PrePoP guidelines aim to provide recommendations to promote high-quality, statistically sound, and reproducible preclinical research on potentised ***: Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls, sample preparation and handling, and statistics. After three rounds of feedback, a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised ***: We present a series of recommendations on a range of topics including experimental controls,system stability, blinding and randomisation, environmental influences, and procedures for the preparation of potentised samples and controls, and we address some specific challenges of this research ***: This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

关键词： research guidelines Fundamental research Basic research Complementary and integrative medicine Potentisation Potentised preparations

“OMINO”: A Modern Approach to Postural Standing reeducation through Breathing Techniques

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Health 2024年第5期16卷 383-394页

作者： maria Chiara Patriarca Medicine and rehabilitation Department Faculty of Medicine and Surgery Catholic University of Holy Heart Rome Italy

Postural problems are very common, which is why plenty of Techniques have been created to solve them: Mezieres Technique (including muscle chains), RPG (Global Postural re-Education, including pelvic diaphragm), Pilates Method (including core muscles), Bobath Concept (including COG, center of gravity) and Yoga. In this work, I show a new way of treating and solving postural problems. I am basing this physiotherapy approach on a new Image I created. Every patient can use it for every correction and change in posture. I called the new Image: “OMINO (little man)”. “Postural Card” could be a good work to make “OMINO” possible. “OMINO” is immediately understandable and, using “OMINO POCKET INSTRUCTIONS”, it can be easily done. Contribution of paper: • Trunk is a vital element for any kind of rehabilitation;• “Core stability” is the key to activating the trunk. • Doing “OMINO” means working on “core stability”;• “OMINO” makes rehabilitation simple for the patient.

关键词： Trunk Core Stability “OMINO” Patient rehabilitation

Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments

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World Journal of Stem Cells 2024年第5期16卷 604-614页

作者： Edoardo Agosti Marco Zeppieri Mattia Ghidoni Tamara Ius Alessandro Tel Marco maria Fontanella Pier Paolo Panciani Division of Neurosurgery Department of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy Clinic of Maxillofacial Surgery Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and *** stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,and *** studies reveal GSCs’role in therapeutic resistance,driven by DNA repair mechanisms and dynamic transitions between cellular *** mechanisms can involve different cellular pathways,most of which have been recently reported in the *** progress,targeted therapeutic approaches lack consensus due to GSCs’high *** To analyze targeted therapies against GSC-mediated resistance to radio-and chemotherapy in gliomas,focusing on underlying *** A systematic search was conducted across major medical databases(PubMed,Embase,and Cochrane Library)up to September 30,*** search strategy utilized relevant Medical Subject Heading terms and keywords related to including“glioma stem cells”,“radiotherapy”,“chemotherapy”,“resistance”,and“targeted therapies”.Studies included in this review were publications focusing on targeted therapies against the molecular mechanism of GSC-mediated re-sistance to radiotherapy resistance(RTR).reSULTS In a comprehensive review of 66 studies on stem cell therapies for SCI,452 papers were initially identified,with 203 chosen for full-text *** them,201 were deemed eligible after excluding 168 for various *** temporal breakdown of studies illustrates this trend:2005-2010(33.3%),2011-2015(36.4%),and 2016-2022(30.3%).Key GSC models,particularly U87(33.3%),U251(15.2%),and T98G(15.2%),emerge as significant in research,reflecting their representativeness of glioma *** analysis indicates a focus on phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(mTOR)(27.3%)and Notch(12.1%)pathways,suggesting their crucial roles in resistance *** molecules with mTOR(18.2%),CHK1/2(15.2%),and ATP binding cassette

关键词： Glioma stem cells Chemoresistance Radioresistance Molecular pathways Targeted therapies Systematic review

When Design Defines a City

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China Today 2024年第7期73卷 38-40页

作者： maria JOSÉMASNOU Cátedra China

Both Spain and China’s practices in urban design show how urban governance,local social development,and people’s needs shape a city’s *** the 20th century,China and Spain faced the common challenge of urban *** China,it began with the urbanization and revitalization process with the inception of the reform and opening-up in 1978,and in Spain.

关键词： transition. urban fines

Earthquake distribution and lithospheric rheology beneath the Northwestern Andes, Colombia

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Geodesy and Geodynamics 2021年第1期12卷 1-10页

作者： carla Lagardère Carlos A.Vargas Department of Geosciences Universidad Nacional de ColombiaBogotaColombia Ecole nationale superieure en environnement georessources et ingenierie du developpement durable(ENSEGID)BordeauxFrance

The rheological behavior of the lithosphere beneath the Northwestern(NW)Andes(Colombian)remains uncertain under a complex geological ***,we analyze the earthquake distribution and the stress drop on the western and the eastern of the transition area between the Upper Magdalena Valley(UMV)and the Middle Magdalena Valley(MMV),a zone related to a plate tectonic transition from steeper to flatter subduction style slabs(Nazca and Caribbean plates).Our results consistently explain the tectonic and geodynamic context of the study area supported in two rheological profiles,which reveal the brittle/ductile transition of the lithospheric crust and mantle and allow to constrain the lithospheric rheological *** subduction phenomenon of the Nazca Plate under the South American Plate is observed in the western *** the eastern region,we find a remarkable aseismic zone under the Eastern Cordillera below 20-km-deep,which made more difficultan accurate estimation of the crust/mantle *** seismic particularity leads us to support the hypothesis of a delamination process due to the tectonic overload generated by the Eastern Cordillera,and that promotes thermal *** results also suggest that the earthquake dataset correlated with rheological estimations may offer a consistent interpretation of the mechanical behavior of the lithosphere.

关键词： Lithosphere rheology Seismicity Northwestern Andes Delamination process

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