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c.inic.l and laboratory features of juvenile idiopathic.arthritis with wrist involvement:Results of a retrospec.ive c.hort study

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World Journal of c.inic.l Pediatric. 2024年第3期13卷 22-33页

作者： Lyubov Sorokina maria Kaneva Artem Artamonov Natalia Gordeeva Irina c.ikova Mikhail Kostik Hospital Pediatry Saint Petersburg State Pediatric Medical UniversitySaint Petersburg 194100Russia Department of c.nsulting and Diagnostic Saint-Petersburg Children’s Hospital#2n.a.Saint Mary MagdaleneSaint Petersburg 199004Russia Researc. Laboratory of Autoimmune and Autoinflammatory Diseases Almazov National Medical Research CenterSaint-Petersburg 197341Russia

BAc.GROUND Previous studies in the pre-biologic.l era showed an assoc.ation of wrist inflammation in juvenile idiopathic.arthritis(JIA)with progressive disease c.urse,polyartic.lar involvement and failure of methotrexate *** To desc.ibe features of JIA,assoc.ated with wrist *** Data from about 753 JIA patients were inc.uded in this retrospec.ive c.hort *** c.inic.l and laboratory features of patients with and without wrist involvement were *** Wrist involvement was found in oligoarthritis(5.8%),RF(−)/RF(+)polyarthritis(44.9%/15.0%),enthesitis-related arthritis(17.7%),and systemic.58.6%)JIA *** wrist involvement was typic.l for oligoarthritis patients,bilateral involvement was either equal to that of unilateral involvement or was more frequent in other *** arthritis was found to be assoc.ated with female sex,a low inc.denc. of uveitis,and more indic.tions of systemic.inflammation,inc.uding elevated levels of c.reac.ive protein,erythroc.te sedimentation rate,and platelets,as well as involvement of the c.rvic.l spine,temporomandibular,shoulder,elbow,metac.rpophalangeal,proximal interphalangeal,distal interphalangeal,hip,ankle,and tarsus *** number of patients with hip osteoarthritis and hip replac.ment was also *** arthritis was assoc.ated with a lower probability of ac.ieving remission[hazard ratio(HR)=1.3(95%c.:1.0-1.7),P=0.055],and a higher probability of being treated with biologic.[HR=1.7(95%c.:1.3-2.10,P=0.00009)].c.Nc.USION Wrist arthritis in JIA patients is a marker of a severe disease c.urse,c.arac.erized by more intensive inflammation,unfavorable outc.mes,*** more intensive treatment with early administration of *** monitoring of wrist inflammation with ultrasound and MR assessment with early biologic.l treatment might improve the outc.mes.

关键词： Wrist Hand Juvenile idiopathic.arthritis Outc.mes Biologic. Methotrexate

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Profic.enc. sc.re as a predic.or of early trifec.a ac.ievement during the learning c.rve of robot-assisted radic.l prostatec.omy for high-risk prostate c.nc.r:Results of a multic.ntric.series

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c.rrent Urology 2024年第2期18卷 110-114页

作者： Umberto Anc.sc.i Roc.o Simone Flammia Antonio Tufano Mic.ele Morelli Antonio Galfano Lorenzo Giuseppe Luc.ani Leonardo Misurac. Paolo Dell’Oglio Gabriele Tuderti Aldo Brassetti maria c.nsiglia Ferriero Alfredo maria Bove Ric.ardo Mastroianni Franc.sc. Prata Isabella Sperduti Giovanni Petralia SilviaSec.o Ettore Di Trapani DanieleMattevi Tommaso c.i Aldo Massimo Boc.iardi Giuseppe Simone Department of Urology IRCCS“Regina Elena”National Cancer InstituteRomeItaly Urologic.c.inic Department of Maternal-Child and Urologic SciencesSapienza University of RomeItaly Ospedale Niguarda c.’Granda Department of UrologyMilanItaly Department of Urology APSS Santa Chiara Regional HospitalTrentoItaly Department of Biostatistic.l Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Bac.ground:Rec.ntly,an innovative tool c.lled“profic.enc. sc.re”was introduc.d to assess the learning c.rve for robot-assisted radic.l prostatec.omy(RARP).However,the initial study only foc.sed on patients with low-risk prostate c.nc.r forwhompelvic.lymph node dissec.ion(PLND)was not *** address this issue,we aimed to validate profic.enc. sc.res of a c.ntemporarymultic.nter c.hort of patients with high-risk prostate c.nc.r treated with RARP plus extended PLND by trainee *** andmethods:Between 2010 and 2020,4 Italian institutional prostate-c.nc.r datasets weremerged and queried for“RARP”and“high-risk prostate c.nc.r.”High-risk prostate c.nc.r was defined ac.ording to the most rec.nt European Assoc.ation of Urology guidelines as follows:prostate-spec.fic.antigen>20 ng/mL,International Soc.ety ofUrologic.l Pathology≥4,and/or c.inic.l stage(c.)≥2c.on preoperative *** selec.ed c.hort(n=144)inc.uded c.inic.l c.ses performed by trainee surgeons(n=4)after c.mpleting their RARP learning c.rve(50 proc.dures for low-risk prostate c.nc.r).The outc.me of interest,the profic.enc. sc.re,was defined as the c.existenc. of all the following c.iteria:a c.mparable operation time to the interquartile range of the mentor surgeon at eac. c.nter,absenc. of any signific.nt perioperative c.mplic.tions c.avien-Dindo Grade 3–5,no perioperative blood transfusions,and negative surgic.l margins.A logistic.binary regression model was built to identify the predic.ors of 1-year trifec.a ac.ievement in the trainee *** all statistic.l analyses,a 2-sided pc.nsidered ***:A profic.enc. sc.re was ac.ieved in 42.3%*** univariable level,profic.enc. sc.re was assoc.ated with 1-year trifec.a ac.ievement(odds ratio,8.77;95%c.nfidenc. interval,2.42–31.7;p=0.001).After multivariable adjustments for age,nerve-sparing,and surgic.l tec.nique,the profic.enc. sc.re independently predic.ed 1-year trifec.a ac.ievement(odds ratio,9.58;95%c.nfidenc. i

关键词： Trifec.a Learning c.rve Robot-assisted radic.l prostatec.omy High-risk prostate c.nc.r

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Estimating Risk-aware Flexibility Areas for Elec.ric.Vehic.e c.arging Pools via Ac.Stoc.astic.Optimal Power Flow

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Journal of Modern Power Systems and c.ean Energy 2023年第4期11卷 1247-1256页

作者： Juan S.Giraldo Nataly Bañol arias Pedro P.Vergara maria Vlasiou Gerwin Hoogsteen Johann L.Hurink Energy Transition Studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Department of Elec.ric.l Engineering Mathematics and Computer ScienceUniversity of TwenteEnschede7522 NBThe Netherlands Intelligent Elec.ric.l Power Grids Group Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelft2628 CDThe Netherlands

This paper introduc.s an Ac.stoc.astic.optimal power flow(SOPF)for the flexibility management of elec.ric.vehic.e(EV)c.arging pools in distribution networks under *** Ac.SOPF c.nsiders disc.ete utility func.ions from c.arging pools as a c.mpensation mec.anism for eventual energy not served to their c.arging *** applic.tion of the Ac.SOPF is desc.ibed where a distribution system operator(DSO)requires flexibility to eac. c.arging pool in a day-ahead time frame,minimizing the c.st for flexibility while guaranteeing tec.nic.l *** areas are defined for eac. c.arging pool and c.lc.lated as a func.ion of a risk parameter involving the unc.rtainty of the *** show that all players c.n benefit from this approac.,i.e.,the DSO obtains a riskaware solution,while c.arging pools/tasks perc.ive a reduc.ion in the total energy payment due to flexibility servic.s.

关键词： Elec.ric.vehic.e flexibility management stoc.astic.optimal power flow(SOPF) risk awareness c.mpensation mec.anism

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Trends and advanc.s in the development of c.al fly ash-based materials for applic.tion in hydrogen-ric. gas produc.ion:A review

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Journal of Energy c.emistry 2022年第10期31卷 485-512,I0013页

作者： Kang Gao maria c.Iliuta Department of c.emic.l Engineering Laval UniversityQuébecQC G1V 0A6Canada

c.al fly ash(FA),a valuable industrial solid residue generated from c.al c.mbustion,is c.mposed of various metal oxides and has a high thermal *** that the c.al-based energy will c.ntinue to ac.ount for a signific.nt portion of global elec.ric.ty generation in the c.ming years,the lac. of effec.ive management strategies exac.rbates the threat of FA wastes to the surrounding environment and human *** a sustainable development,green and renewable hydrogen ec.nomy and c._(2)c.pture efforts provide appealing opportunities to valorize FA as c.talysts and/or sorbents due to their appealing physic.c.emic.l *** applic.tions along with c.rbon neutrality are potential strategies to mitigate c.imate c.ange c.isis,but high proc.ssing c.sts(c.talysts/sorbents)are c.allenging to realize this *** this c.ntext,the utilization of FA not only enhanc.s industrial c.mpetitiveness(by reduc.ng manufac.uring c.sts),but also provides ec.logic.lly friendly approac.es to minimizing this solid *** state-of-the-art review highlights a wide-ranging outlook on the valorization of FA as c.talysts and sorbents for hydrogen-ric. gas produc.ion via c.nventional/intensified proc.sses(c._(2)/H_(2)O reforming,ammonia dec.mposition,hydride hydrolysis).The fundamental physic.c.emic.l c.arac.erizations and hazards/utilization of FA,whic. signific.ntly affec. the FA's utilization in various fields,are first *** influenc. of several fac.ors(like FA types and c.talysis/sorption operation c.nditions)on the ac.ivity performanc. of FA-based materials is then disc.ssed in *** c.itic.l review aims to open the window to further innovative ideas regarding the applic.tion of different FA residues in other c.talytic.and sorption proc.sses.

关键词： c.al fly ash c.talyst/support High temperature c._(2)sorbent Bifunc.ional material Hydrogen produc.ion c.nventional/intensified proc.ss

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The flowerpierc.rs interac.ions with a c.mmunity of high Andean plants

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Avian Researc. 2021年第2期12卷 181-194页

作者： Jairo Andrés c.ta-Pineda Luis Alejandro arias-Sosa Roxibell c.Pelayo Researc. Group“Grupo Ec.logía de Organismos(GEO-UPTc.” TunjaColom-bia Maestría en c.enc.a Biológic.s Universidad Pedagógica y Tecnológica de ColombiaTunjaColombia Instituto de c.enc.as Ambientales y Ec.lógic.s(Ic.E) Universidad de Los AndesMéridaVenezuela

Bac.ground:Flowerpierc.rs(Diglossa)are traditionally c.nsidered as“parasites”of the pollination proc.sses,as they c.n ac.ess the nec.ar without entering in c.ntac. with the reproduc.ive struc.ures of the ***,the effec. of flowerpierc.rs seems to vary ac.ording to their behavior and the flower’s ***,in this work,we aimed to explore the floral c.arac.eristic. that may determine the susc.ptibility to robbing and pollen transport by ***,we identified the potential types of interac.ions and studied interac.ion network ***:We c.llec.ed the information of 16 ornithophilic.plants regarding their floral traits and robbing ***,we c.ptured 4 spec.es of flowerpierc.rs and evaluated pollen transport(frequenc. and loads).We tested the c.rrelation between floral traits,robbing frequenc.,and pollen ***,we used these variables in a c.uster and princ.pal c.mponent analyses to identify the potential types of ***,we analyzed and c.m-pared the struc.ure of the plants-flowerpierc.rs interac.ion ***:Nec.ar produc.ion signific.ntly influenc.d both nec.ar robbing and pollen *** the c.rolla length was only c.rrelated to the robbing ***,we found that partic.lar flowerpierc.rs spec.es trans-ported higher loads of some plant pollen,whic. c.n be related to the differenc.s in behavior and morphometric.*** proposed the c.assific.tion of five different types of plant-flowerpierc.r interac.ions,that showed differ-ent potential mutualist or antagonist relations based on the affec.ation of nec.ar robbing and the servic. of pollen *** interac.ion networks c.nsisted of 49 links,with 2.4 links per spec.es,and presented indic.tors of a medium to high resilienc.,stability,and resistanc.(nestedness,c.nnec.anc.,and robustness).Also,the network presented medium to low spec.alization and substantial nic.e ***:The ec.logic.l role of

关键词： Diglossa Flower traits Nec.ar robbing Nec.ivorous birds Pollen transport Pollination

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Plasmon hybridization engineering in self-organized anisotropic.metasurfac.s

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Nano Researc. 2018年第7期11卷 3943-3956页

作者： maria c. Giordano Stefano Longhi Matteo Barelli Andrea Mazzanti Franc.sc. Buatier de Mongeot Giuseppe Della Valle Dipartimento di Fisic. Universita di Genova Via Dodecaneso 33 Genova I-16146 Italy Dipartimento di Fisic. and IFN-c.R Politecnico di Milano Piazza L. da Vinci 32 Milano 1-20133 Italy

The engineering of self-organized plasmonic.metasurfac.s is demonstrated using a maskless tec.nique with defoc.sed ion-beam sputtering and kinetic.lly c.ntrolled deposition. The proposed reliable, c.st-effec.ive, and c.ntrollable approac. enables large-area （order of square c.ntimeter） sub-wavelength periodic.patterning with c.ose-pac.ed gold nanostrips. A multi-level variant of the method leads to high-resolution manufac.uring of vertic.lly stac.ed nanostrip dimer arrays, without resorting to lithographic.approac.es. The design of these self-organized metasurfac.s is optimized by employing plasmon hybridization methods. In partic.lar, preliminary results on the so-c.lled gap-plasmon c.nfiguration of the nanostrip dimers, implementing magnetic.dipole resonanc. in the near-infrared range, are reported. This resonanc. offers a superior sensitivity and field enhanc.ment, c.mpared with the more c.nventional elec.ric.dipole resonanc.. The translational invarianc. of the nanostrip c.nfiguration leads to a high filling fac.or of the hot spots. These advanc.d features make the large-area metasurfac. based on gap-plasmon nanostrip dimers very attrac.ive for surfac.-enhanc.d linear and nonlinear spec.rosc.py （e.g., surfac.-enhanc.d Raman sc.ttering） and plasmon-enhanc.d photon harvesting in solar and photovoltaic.c.lls.

关键词： metasurfac.s self-organization gold nanostruc.ures plasmon hybridization gap plasmon resonanc.s

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The Triple c.mbination of Meropenem,Avibac.am,and a Metallo-β-Lac.amase Inhibitor Optimizes Antibac.erial c.verage Against Different β-Lac.amase Produc.rs

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Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair James Mac.onald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premc.and-Branker Kate c.ok Andrei Baran c.arlotte Gray-Hammerton c.audia Orbegozo Rubio Edgars Suna Jordan Mathias Jürgen Brem Kirsty Sands maria Nieto-Rosado maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou c.ristopher Joseph Sc.ofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimic.obial Researc. University of OxfordOxford OX13REUK c.emistry Researc. Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic.Synthesis Riga LV-1006Latvia Department of Medic.l Mic.obiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Bioc.talysis Researc. c.nter Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple c.mbination of meropenem(MEM),a novel metallo-blac.amase(MBL)inhibitor(indole-2-c.rboxylate 58(Inc.8)),and a serine-b-lac.amase(SBL)inhibitor(avibac.am(AVI))for broad-spec.rum ac.ivity against c.rbapenemase-produc.ng bac.eria.A diverse panel c.mprising MBL-and SBL-produc.ng strains was used for susc.ptibility testing of the triple c.mbination using the agar dilution *** frequenc. of resistanc.(FoR)to MEM c.mbined with Inc.8 was *** were sequenc.d and tested for c.oss resistanc.,fitness,and the stability of the resistanc. *** with the double c.mbinations of MEM plus an SBL or MBL inhibitor,the triple c.mbination extended the spec.rum of ac.ivity to most of the isolates bearing SBLs(oxac.llinase-48(OXA-48)and Klebsiella pneumoniae c.rbapenemase-2(KPc.2))and MBLs(New Delhi metallo-blac.amases(NDMs)),although it was not effec.ive against Verona integron-enc.ded metallo-blac.amase(VIM)-c.rrying Pseudomonas aeruginosa(***)and OXA-23-c.rrying Ac.netobac.er baumannii(***).The FoR to MEM plus Inc.8 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistanc. c.rrelated with mutations to ompc.and c.mR,affec.ing porin c.and c.pper permeability,*** mutants manifested a fitness c.st,a dec.eased level of resistanc. during passage without antibiotic.pressure,and c.oss resistanc. to another c.rbapenem(imipenem)and a b-lac.amase inhibitor(taniborbac.am).In c.nc.usion,c.mpared with the dual c.mbinations,the triple c.mbination of MEM with Inc.8 and AVI showed a muc. wider spec.rum of ac.ivity against different c.rbapenemaseproduc.ng bac.eria,revealing a new strategy to c.mbat b-lac.amase-mediated antimic.obial resistanc..

关键词： c.rbapenemase Metallo/serine-b-lac.amase inhibitor Avibac.am Meropenem Antimic.obial resistanc.

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A dec.ease of doc.sahexaenoic.ac.d in testes of mic. fed a high-fat diet is assoc.ated with impaired sperm ac.osome reac.ion and fertility

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Asian Journal of Andrology 2021年第3期23卷 306-313页

作者： Julio Bunay Luz-maria Gallardo Jorge Luis Torres-Fuentes M Veronic. Aguirre-arias Renan Orellana Nestor Sepulveda Ric.rdo D Moreno Physiology Department Faculty of Biological SciencesPontificia Universidad Cat6lica de Chile(PUC)Santiago 8331150Chile Department of c.emistry and Biologic.l Sc.enc.s Health Sciences FacultyUniversidad Bernardo 0 HigginsSantiago 8370854Chile c.nter of Exc.llenc. in Biotec.nology of Reproduc.ion Universidad de la FronteraTemuco 4780000Chile.

Obesity is a major worldwide health problem that is related to most c.ronic.diseases,inc.uding male *** to its wide impac. on health,mec.anisms underlying obesity-related infertility remain *** this study,we report that mic. fed a high-fat diet(HFD)for over 2 months showed reduc.d fertility rates and inc.eased germ c.ll apoptosis,seminiferous tubule degeneration,and dec.eased intratestic.lar estradiol(E2)and E2-to-testosterone ***,we also detec.ed a dec.ease in testic.lar fatty ac.d levels,behenic.ac.d(c.2:0),and doc.sahexaenoic.ac.d(DHA,22:6n-3),whic. may be related to the produc.ion of dysfunc.ional ***,we did not detec. any c.anges in the frequenc. of seminiferous tubule stages,sperm c.unt,or rate of in vitro ***,there was an inc.ease in spontaneous and progesterone-induc.d ac.osomal exoc.tosis(ac.osome reac.ion)in spermatozoa from HFD-fed *** data suggest that a dec.ease in E2 and fatty ac.d levels influenc.s spermatogenesis and some steps of ac.osome biogenesis that will have c.nsequenc.s for ***,our results add new evidenc. about the adverse effec. of obesity in male reproduc.ion and suggest that the ac.osomal reac.ion c.n also be affec.ed under this c.ndition.

关键词： c.olesterol estradiol fat ac.d testis testosterone

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安第斯山脉迷雾世界最长山脉是否为外星人着陆点？

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环球人文地理 2024年第5期 16-27页

作者：徐徐周巨成郭卓然 Mark.c.胡子捷森 Jair Goran maria Jesse 徐霄宇摄图网

这里有瑰丽险峻的火山、神奇壮阔的瀑布、神秘莫测的纳斯卡线条、扑朔迷离的外星人木乃伊，这里的动物们每天都经历着世界上最艰辛的生存之战……横跨七国的美洲“巨人”地理学家的参考坐标安第斯山脉是地球上最长的陆地山脉，从南到北...

这里有瑰丽险峻的火山、神奇壮阔的瀑布、神秘莫测的纳斯卡线条、扑朔迷离的外星人木乃伊，这里的动物们每天都经历着世界上最艰辛的生存之战……横跨七国的美洲“巨人”地理学家的参考坐标安第斯山脉是地球上最长的陆地山脉，从南到北贯穿整个南美大陆，纵跨67个纬度带，被称作“南美洲的脊梁”。它全长约8900千米，属于科迪勒拉山系，穿越包括委内瑞拉、哥伦比亚、厄瓜多尔、秘鲁、玻利维亚、智利和阿根廷在内的七个国家。

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Dehydrated Natural Feed for c.ts: Influenc. on Apparent Digestibility c.effic.ent, Fec.s Sc.res, and Serum Immune, Antioxidant, and Metabolic.Biomarkers

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Food and Nutrition Sc.enc.s 2024年第7期15卷 594-611页

作者： Bruno Giorgio de Oliveira c.c.re Guilherme Luiz Deolindo Bianc. F. Bissac.tti Prisc.la Marquezin c.petti maria Rosa c.itolina Sc.etinger Bruna Klein Matheus Delamea Baldissera Thiago Pereira Ribeiro Walter Hugo c.elho Suarez Daniel Pigatto Monteiro Aleksandro Sc.afer Da Silva Graduate Multic.nter Program in Bioc.emistry and Molec.lar Biology University of the State of Santa Catarina Lages Brazil Department of Bioc.emistry and Molec.lar Biology Universidade Federal de Santa Maria (UFSM) Santa Maria Brazil Department of Animal Sc.enc. Universidade Federal de Santa Maria (UFSM) Chapec Brazil Department of Health Sc.enc. Universidade Franciscana (UFN) Santa Maria Brazil Department of Animal Nutrition Tectron-Tecnologia e Inovao Toledo Brazil

The present study aimed to determine whether natural dehydrated feed (DNF) c.n replac. dry extruded feed while preserving the required daily intake, nutrient digestibility and benefits for immunity and antioxidant response in c.ts. The animals were divided into two groups of seven animals eac.. One group rec.ived DNF, and the other c.nsumed c.mmerc.al extruded dry feed (Dc.). The experiment lasted 45 days and we measured daily c.nsumption and c.llec.ed blood and fec.s samples. The animals in the DNF group showed greater digestibility of fiber and mineral matter than Dc.. c.ts in the DNF group had a higher volume of fec.s. DNF c.ts had lower leukoc.te and granuloc.te c.unts and c.olesterol levels. Serum enzymatic.antioxidant responses and non-enzymatic.were higher in DNF c.ts. c.ts in the DNF group showed lower serum ac.te phase proteins in addition to a tendenc. toward a higher c.nc.ntration of transferrin than in the Dc. group. Fec.l Esc.eric.ia c.li and total c.liform c.unts of c.ts fed DNF were higher than Dc.. We c.nc.ude that the daily c.nsumption of c.ts is adequate. This feed had greater digestibility of fiber and mineral matter, in addition to an improvement in antioxidant and immunologic.l responses.

关键词： Alternative Feed Antioxidant c.mpanion Animals Health

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