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Perspective on automated in vivo drug screening using the chodl mutant zebrafish line

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Neural Regeneration Research 2022年第11期17卷 2437-2438页

作者： Ana-maria Oprisoreanu Center for Regenerative Therapies Dresden(CRTD) TU Dresden

Since the early 2000s, the popularity of zebrafish in in vivo drug screening has shown a substantial *** zebrafish has become an important screening tool covering a wide range of tissue-specific pathologies and diseas... 详细信息

关键词： fish vivo screening

N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury

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Neural Regeneration Research 2015年第6期10卷 976-981页

作者： Christian Witzel Werner Reutter G.bj?rn Stark Georgios Koulaxouzidis Plastic and Reconstructive Surgery Interdisciplinary Breast CenterCharité–Universit?tsmedizin Berlin Institute of Laboratory Medicine Clinical Chemistry and PathobiochemistryCharité–Universit?tsmedizin Berlin Department of Plastic and Hand Surgery University of Freiburg Medical Centre

Increasing evidence indicates that sialic acid plays an important role during nerve regeneration. Sialic acids can be modified in vitro as well as in vivo using metabolic oligosaccharide engineering of the N-awl side chain. N-Propionylmannosamine （ManNProp） increases neurite outgrowth and accelerates the reestablishment of functional synapses in vitro. We investigated the influence of systemic ManNProp application using a specific in vivo mouse model. Using mice expressing axonal fluorescent proteins, we quantified the extension of regenerating axons, the number of regenerating axons, the number of arborising axons and the number of branches per axon 5 days after injury. Sciatic nerves from non-expressing mice were grafted into those expressing yellow fluorescent protein. We began a twice-daily intraperitoneal application of either peracetylated ManNProp （200 mg/kg） or saline solution 5 days before injury, and continued it until nerve harvest （5 days after transection）. ManNProp significantly increased the mean distance of axonal regeneration （2.49 mm vs. 1.53 mm; P 〈 0.005） and the number of arborizing axons （21% vs. 16%; P = 0.008） 5 days after sciatic nerve grafting. ManNProp did not affect the number of regenerating axons or the number of branches per arborizing axon. The biochemical glycoengineering of the N-acyl side chain of sialic acid might be a promising approach for improving peripheral nerve regeneration.

关键词： N-propionylmannosamine sialic acid glycoengineering sciatic nerve peripheral nerve branching arborisation Thyl-YFP mouse nerve regeneration

A Reinforcement Learning approach for the continuous electricity market ofGermany: Trading from the perspective of a wind park operator

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Energy and AI 2022年第2期8卷 67-78页

作者： Malte Lehna björn Hoppmann Christoph Scholz RenéHeinrich Fraunhofer Institute for Energy Economics and Energy System Technology(IEE) Königstor 5934119 KasselGermany

With the rising extension of renewable energies, the intraday electricity markets have recorded a growingpopularity amongst traders as well as electric utilities to cope with the induced volatility of the energysupply. Through their short trading horizon and continuous nature, the intraday markets offer the abilityto adjust trading decisions from the day-ahead market or reduce trading risk in a short-term notice. Producersof renewable energies utilize the intraday market to lower their forecast risk, by modifying their providedcapacities based on current forecasts. However, the market dynamics are complex due to the fact that thepower grids have to remain stable and electricity is only partly storable. Consequently, robust and intelligenttrading strategies are required that are capable to operate in the intraday market. In this work, we proposea novel autonomous trading approach based on Deep Reinforcement Learning (DRL) algorithms as a possiblesolution. For this purpose, we model the intraday trade as a Markov Decision Process (MDP) and employ theProximal Policy Optimization (PPO) algorithm as our DRL approach. A simulation framework is introducedthat enables the trading of the continuous intraday price in a resolution of one minute steps. We test ourframework in a case study from the perspective of a wind park operator. We include next to general tradeinformation both price and wind forecasts. On a test scenario of German intraday trading results from 2018,we are able to outperform multiple baselines with at least 45.24% improvement, showing the advantage of theDRL algorithm. However, we also discuss limitations and enhancements of the DRL agent, in order to increasethe performance in future works.

关键词： Deep Reinforcement Learning German intraday electricity trading Deep neural networks Markov Decision Process Proximal Policy Optimization Electricity price forecast

Thermodynamics of Ordering-Disordering Transformation in Cu-Zn Alloy System

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Journal of Materials Science & Technology 1999年第5期15卷 478-479页

作者： Wang, LD Chen, CG Shi, YM Kang, MK Ji, bj Northwestern Polytech Univ Xian 710072 Peoples R China Xian Inst Precis Mech Xian 710075 Peoples R China

The alpha and beta phases in Cu-Zn alloy system were regarded as regular solutions at elevated temperature, the results calculated from the experimental data have showed that the value of the interaction parameter of components Cu and Zn in the alpha phase E-CuZn(alpha) varied obviously with decreasing component Zn. Substituting the function relation between E-CaZn(alpha) and X-Zn obtained through curve-fitting into expression of free-energy variation of the system, the calculated martensitic transformation temperature M-s was in good agreement with experimental curve, so as to have more comprehensive information for fully making use of binary Cu-base functional materials.

关键词： Zn Thermodynamics of Ordering-Disordering Transformation in Cu-Zn Alloy System Cu

Xenoestrogens challenge 17β-estradiol protective effects in colon cancer

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World Journal of Gastrointestinal Oncology 2014年第3期6卷 67-73页

作者： maria Marino Department of Science University Roma TreI-00146 RomaItaly

Several epidemiological,cellular,and molecular studies demonstrate the role of environmental chemicals with endocrine disrupting activities,typical of Westernized societies,in the pathogenesis of numerous diseases including *** this information,the design and execution of studies on endocrine disruptors are not yet cognizant that the specific actions of individual hormones often change with development and ageing,they may be different in males and females and may be mediated by different receptors isoforms expressed in different tissues or at different life *** statements are particularly true when assessing the hazard of endocrine disruptors against 17β-estradiol(E2)actions in that this hormone is crucial determinant of sexrelated differences in anatomical,physiological,and behavioral traits which characterize male and female ***,E2 is also involved in *** oncogenic effects of E2 have been investigated extensively in breast and ovarian cancers where hormone-receptor modulators are now an integral part of targeted *** is known about the E2preventive signalling in colorectal cancer,although this disease is more common in men than women,the difference being more striking amongst pre-menopausal women and age-matched *** review aims to dissect the role and action mechanisms of E2 in colorectal cancer evaluating the ability of estrogen disruptors(i.e.,xenoestrogens)in impair these E2 *** discussed here lead to define the possible role of xenoestrogens in the impairment and/or activation of E2signals important for colorectal cancer prevention.

关键词： 17β-Estradiol Estrogen receptors Xenoestrogens Bisphenol A Flavonoids Colorectal cancer

Synthesis of Dibenzo-sulfur-heterocycles through Reaction of Diphenyl-type Compounds with Elemental Sulfur over USY Zeolite

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Chinese Chemical Letters 1997年第10期8卷 849-852页

作者： Zuo, bj Ma, YD Tian, Y Wang, QL SHANDONG UNIV DEPT CHEMJINAN 250100PEOPLES R CHINA

A series of dibenzo-sulfur-heterocycle compounds, such as phenothiazine, phenoxthine, thianthrene, thioxanthene and derivatives of dibenzothiophene were synthesized with satisfactory yields through reaction of the cor... 详细信息

关键词： over USY type Synthesis of Dibenzo-sulfur-heterocycles through Reaction of Diphenyl-type Compounds with Elemental Sulfur over USY Zeolite

Comment on “Artificial intelligence in gastroenterology: A state-ofthe- art review”

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World Journal of Gastroenterology 2022年第16期28卷 1722-1724页

作者： Thomas bjørsum-Meyer Anastasios Koulaouzidis Gunnar Baatrup Department of Surgery Odense University HospitalSvendborg 5700Denmark Department of Clinical Research University of Southern DenmarkFaculty of Health ScienceOdense 5230Denmark

Colon capsule endoscopy(CCE)was introduced nearly two decades ***,it was limited by poor image quality and short battery time,but due to technical improvements,it has become an equal diagnostic alternative to optical colonoscopy(OC).Hastened by the coronavirus disease 2019 pandemic,CCE has been introduced in clinical practice to relieve overburdened endoscopy units and move investigations to out-patient clinics.A wider adoption of CCE would be bolstered by positive patient experience,as it offers a diagnostic investigation that is not inferior to other *** shortcomings of CCE include its inability to differentiate adenomatous polyps from hyperplastic *** this issue would improve the stratification of patients for polyp *** intelligence(AI)has shown promising results in polyp detection and characterization to minimize incomplete CCEs and avoid needless *** AI appears to be a needed application to enable near-real-time decision-making in order to diminish patient waiting times and avoid superfluous subsequent *** this letter,we discuss the potential and role of AI in CCE as a diagnostic tool for the large bowel.

关键词： Video capsule endoscopy Wireless capsule endoscopy Artificial intelligence Colonic polyps Endoscopic surgical procedures Colon neoplasm

FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma

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World Journal of Gastroenterology 2000年第2期6卷 223-227页

作者： Sun BH Zhao XP Wang bj Yang DL Hao LJ Tongji Med Univ Tongji Hosp Dept Clin Immunol Wuhan 430030 Hubei Province Peoples R China

AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with *** FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD *** positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver *** Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to *** cell apoptosis in HCC isassociated with FADD expres

关键词： FADD TRADD apoptosis carcinoma hepatocellular liver neoplasms

Zeolite-Catalyzed Thionation of Diphenyl-type Compounds

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Chinese Chemical Letters 1997年第5期8卷 381-384页

作者： Jiang, W Wang, QL Ma, YD Zuo, bj Wang, L SHANDONG UNIV DEPT CHEMJINAN 250100PEOPLES R CHINA SHANDONG MED UNIV DEPT PHARMJINAN 250012PEOPLES R CHINA

The synthesis of phenothiazine and phenoxthine was performed very efficiently through the thionation of diphenylamine and diphenyl ether, respectively, with elemental sulfur by using hydrothermally treated HY zeolites... 详细信息

关键词： type Wang Zeolite-Catalyzed Thionation of Diphenyl-type Compounds