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α,β-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats

World Journal of Gastroenterology 2010年第34期16卷 4272-4280页

作者： Caroline Mouro Melo Karine maria martins Bezerra Carvalho Julliana Catharina de Sousa Neves Talita Cavalcante Morais Vietla Satyanarayana Rao Flávia Almeida Santos Gerly Anne de Castro Brito mariana Helena Chaves Department of Physiology and Pharmacology Biomedical Institute of Brazilian Semiarid Faculty of Medicine Federal University of Ceará Department of Morphology Faculty of Medicine Federal University of Ceará Department of Organic and Inorganic Chemistry Federal University of Piauí

AIM: To study the benef icial effects of triterpene α,β-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS: Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 × 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of α,β-amyrin (10, 30 and 100 mg/kg),methylprednisolone (30 mg/kg) and vehicle (3% Tween 80). A saline (0.9% NaCl) treated group served as a normal control. Efficacy was assessed at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-6], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation [thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Tissue histology and the immunoreactivity for TNF-α and inducible nitric oxide synthetase (iNOS) were performed. RESULTS: α,β-amyrin and methylprednisolone treatments significantly (P < 0.05) attenuated the L-arginine-induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6, as compared to the vehicle control. Also, pancreatic levels of MPO activity, TBARS, and nitrate/nitrite were signifi cantly lower. Histological f indings and TNF-α and iNOS immunostaining further confirmed the amelioration of pancreatic injury by α,β-amyrin. CONCLUSION: α,β-amyrin has the potential to combat acute pancreatitis by acting as an anti-in? ammatory and antioxidant agent.

关键词： Acute pancreatitis L-arginine Cytokines Lipid peroxidation α,β-amyrin

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New variola(mpox)in Brazil:Epidemiological update and perspectives

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Asian Pacific Journal of Tropical Medicine 2022年第12期15卷 525-528页

作者： Ana Caroline Edwiges Evangelista maria Eduarda Queiroz Santos Bandeira Larissa martins de Sena Williana de Paula Marli do Carmo Cupertino Andréia Patrícia Gomes Rodrigo Siqueira-Batista School of Medicine Faculdade Dinâmica do Vale do PirangaPonte NovaMinas GeraisBrazil Departament of Medicine and Nursing Universidade Federal de ViçosaViçosaMinas GeraisBrazil

New variola(NV)-mpox(monkeypox)-is a zoonosis caused by the mpox virus,which belongs to the genus Orthopoxvirus in the family *** disease,in the present year(2022),has caused several cases and deaths around the world,including Brazil[1].The group of poxviruses,in which the species that causes NV is included,consists of agents widely distributed in *** to their considerably large size,they were among the first viruses to be microscopically *** Poxviridae family is capable of infecting epithelial and connective tissue ***,such a viral family is classified as a genome lineage composed of doublestranded DNA,completely independent of the host nucleus[1].

关键词： Brazil belongs considerably

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Characterization and Biological Activities of Protein-Bound Polysaccharides Produced by Cultures of Pleurotus ostreatus

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Journal of Agricultural Science and Technology(A) 2012年第11期2卷 1296-1306页

作者： Catia Salvador maria do Rosario martins maria de Fatima Candelas Amin Karmali Jose maria Arteiro Ana Teresa Caldeira Chemistry Department and Chemistry Centre of Evora University of Evora Evora 7000-671 Portugal Chemistry Department and ICAAM-Institute of Mediterranean Agricultural and Environmental Sciences University of EvoraEvora7002-554 Portugal Chemical Engineering Department and Chemical Engineering and Biotechnology Research Center Lisbon Superior EngineeringInstitute Lisboa 1950-062 Portugal

Several species of mushrooms, as Pleurotus ostreatus, have been valued as edible and medicinal resources. These mushrooms may be an important source of polysaccharides with medicinal properties as antioxidant, antitumoral, antimicrobial and immunological properties. The aim of this work was to produce and to evaluate the biological properties of protein-bound polysaccharide complexes, extra intracellular （E-PPS and I-PPS）, extracted from P. ostreatus cultures, using agricultural sunflower wastes as carbon source. Three main compounds in the E-PPS and four main compounds in the I-PPS were identified by SEC-UV-RI-HPLC. These complexes of P. ostreatus present no toxicity in Artemia salina cultures, after 24 h of incubation. Antioxidant properties of the complexes were evaluated by radical scavenging activity using DPPH method and lipid peroxidation inhibition capacity, determined by erytbsocytes hemolysis. Additionally, E-PPS and I-PPS extracts revealed capacity to mimetize superoxide dismutase and catalase enzymatic activities. The hepatoprotector effect of E-PPS extracts in Wistar rats was evaluated by AST, ALT, ALP and y-GT activities, showing capacity to reduce the liver damage induced by ethanol-administration. This hepatoprotective effect is equivalent to that observed by silymarin, a standard drug. Our results suggests that the extracts of E-PPS and I-PPS produced by P. ostreatus cultures, using agricultural sunflower wastes as main carbon source, can be used as an important source of bioactive compounds with potential medicinal value.

关键词： Protein-polysaccharides Pleurotus ostreatus edible mushrooms submerged fermentation agro-industrial residues bioactive compounds antioxidant properties hepatoprotective effect.

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Structural Optimization of Metal and Polymer Ore Conveyor Belt Rollers

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 601-618页

作者： Joao Pedro Ceniz Rodrigo de Sá martins Marco Antonio Luersen Tiago Cousseau Department of Mechanical Engineering Federal University of Technology-Parana(UTFPR)Curitiba81280-340Brazil

Ore conveyor belt rollers operate in harsh environments,making them prone to premature *** service lives are highly dependent on the stress field and bearing misalignment angle,for which limit values are defined in a *** this work,an optimization methodology using metamodels based on radial basis functions is implemented to reduce themass of twomodels of *** a structural point of view,one of the rollers ismade completely of metal,while the other also has some components made of polymeric *** objective of this study is to develop and apply a parametric structural optimization methodology to minimize the mass of the two models of *** represent the mechanical behavior of the rollers,simulations were performed using the finite element *** the numerical optimization process,the variable parameters were the dimensions of the shaft and external *** geometric configuration that corresponded at the same time to the lowest mass and acceptable ranges for the stress and bearingmisalignment angle was *** the proposed methodology,a 32.3% reduction in mass was obtained for a metal roller design and an 18.9% reduction for a polymer *** both cases,the constraints were not *** the all-metal roller,the safety factors for the maximum stress and bearingmisalignment angle were 1.44 and 1.75,respectively,while for the polymer roller the corresponding figures were 1.50 and *** work describes a low-computational-cost optimization methodology for roller designs that have been little studied in the ***,the methodology could be adapted for use with other types of rollers and rollers made of different materials.

关键词： Conveyor belt rollers structural optimization surrogate models radial basis functions

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Do vegetative and reproductive phenophases of deciduous tropical species respond similarly to rainfall pulses?

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Journal of Forestry Research 2013年第4期24卷 643-651页

作者： A.P.Silveira F.S.Araújo F.R.martins Itapipoca Faculty of Education Av.Monsenhor Tabosa s/ no.Ceará State University -- UECE Graduate Course of Ecology and Natural Resources Department of BiologyBuilding 906Federal University of Ceará-UFC Department of Plant Biology Institute of BiologyP.O.Box 610University of Campinas – UNICAMP

Deciduous trees with high-density wood that occur in dry seasonal tropical regions respond to rainfall seasonality with synchrony in phenophases. However, they may exhibit interannual differences in synchrony and intensity of phenophases, as strategy for large variations in duration and intensity of rainfall pulses. Nevertheless, it remains unknown how phenophases of deciduous trees of the Brazilian semi-arid region respond to rainfall variations. The phenology of Cordia oncocalyx was monitored in deciduous thorny woodland （Caatinga）, from April 2009 to March 2011, and was correlated with rainfall, soil humidity, temperature, and photoperiod. The rainy years 2009 and 2011 exhibited higher duration of rainfall pulses and lower frequency of interpulses, but in 2010 pulse duration and total rainfall were lower. Circular statistics showed leaf flush followed by flowering and fruiting in the rainy season, and leaf fall and seed dispersal in the dry season.

关键词： asynchrony circular analysis deciduous phenology riskspreading seasonality.

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NK cell dysfunction in severe COVID-19:TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity

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Signal Transduction and Targeted Therapy 2022年第2期7卷 346-348页

作者： Joana Barros-martins Reinhold Förster Berislav Bošnjak Institute of Immunology Hannover Medical School30625 HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625 HannoverGermany German Centre for Infection Research(DZIF) Partner site HannoverHannoverGermany

In a recent study published in Nature,Witkowski et *** that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGF-β)secretion counteracts interferon-alpha(IFN-α)-induced activation of NK cells by decreasing expression of transcription factor ***,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells.

关键词： interferon cytotoxicity

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Machine perfusion of the liver:Putting the puzzle pieces together

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World Journal of Gastroenterology 2021年第34期27卷 5727-5736页

作者： Yuri L Boteon Paulo N martins Paolo Muiesan Andrea Schlegel Liver Unit Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e Pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States Hepatobiliary Unit Careggi University HospitalUniversity of FlorenceFlorence 50134Italy Department of Visceral Surgery and Transplantation University Hospital ZurichSwiss HPB and Transplant CenterZurich 8091Switzerland

The realm of extended criteria liver transplantation created the'adjacent possible'for dynamic organ *** perfusion of the liver greatly expanded donor organ preservation possibilities,reaching before unattainable goals,including the mitigation of ischemia-reperfusion injury,viability assessment,and organ reconditioning prior to ***,current scientific evidence lacks uniformity between studies,perfusion protocols,and acceptance *** of collaborative research networks for sharing knowledge should,therefore,enable the development of high-level evidence and guidelines for machine perfusion utilization,including donor acceptance ***,this approach shall guarantee conditions for further progress to occur.

关键词： Machine perfusion of the liver Liver transplantation Organ donation Extended criteria donors Liver preservation Clinical trials

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Characterization of a Putative Filovirus Vaccine:Virus-Like Particles

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Virologica Sinica 2013年第2期28卷 65-70页

作者： Karen A O martins Travis K Warren Sina Bavari US Army Medical Research Institute of Infectious Diseases

Filoviruses are hemorrhagic fever viruses endemic to parts of Africa and the Philippines. Infection carries with it a mortality rate of up to 90% and currently there are no effective vaccines or therapeutics available to combat infection. However, the filovirus virus-like particles (VLP), which are currently under development, have been shown to be a promising vaccine candidate. They provide protection from infection in the mouse, guinea pig, and nonhuman primate models of infection, eliciting high anti-glycoprotein antibody titers and T cell responses to viral proteins. In this review, we will highlight the development of the filovirus VLP and describe the current understanding of VLP immunogenicity and correlates of protection.

关键词： Filovirus Ebola Marburg Vaccine Virus-like particle Correlates of Protection

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HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein

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Virologica Sinica 2019年第2期34卷 211-221页

作者： Ayslan Castro Brant Vladimir Majerciak Miguel Angelo martins Moreira Zhi-Ming Zheng Tumor Virus RNA Biology Section RNA Biology Laboratory Center for Cancer Research National Cancer Institute NIH Frederick MD 21702 USA Genetics Post-Graduation Program Rio de Janeiro Federal University Rio de Janeiro Brazil Genetics Program Nacional Cancer Institute INCA Rio de Janeiro 20231-050 Brazil

Human papillomavirus 18(HPV18) E6 and E7 oncogenes are transcribed as a single bicistronic E6 E7 pre-mRNA. The E6 ORF region in the bicistronic E6 E7 pre-mRNA contains an intron. Splicing of this intron disrupts the E6 ORF integrity and produces a spliced E6*I RNA for efficient E7 translation. Here we report that the E6 intron has two overlapped branch point sequences(BPS) upstream of its 30 splice site, with an identical heptamer AACUAAC, for E6*I splicing. One heptamer has a branch site adenosine(underlined) at nt 384 and the other at nt 388. E6*I splicing efficiency correlates to the expression level of E6 and E7 proteins and depends on the selection of which branch site. In general, E6*I splicing prefers the 30 ss-proximal branch site at nt 388 over the distal branch site at nt 384. Inactivation of the nt 388 branch site was found to activate a cryptic acceptor site at nt 636 for aberrant RNA splicing. Together, these data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment.

关键词： Human papillomavirus 18 (HPV18) HPV splicing Branch point E6,E7,E6 intron HPV oncogenes

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Preparation and evaluation of colon targeted drug delivery systems for albendazole using kneading,extrusion and compaction technology

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药学学报 2009年第10期44卷 1152-1158页

作者： martins EMEJE Phyllis NWABUNIKE Yetunde ISIMI Olobayo KUNLE Sabinus OFOEFULE Department of Pharmaceutical Technology and Raw Materials Development National Institute for Pharmaceutical Research and Development Department of Pharmaceutical Technology and Industrial Pharmacy University of Nigeria

Albendazole is an orally administered broad-spectrum benzimidazole anthelmintic used against helminthiasis,hydatid cyst disease and *** objectives of this investigation are to develop a sustained release drug delivery system for albendazole,and to target its delivery to *** matrix tablets containing varying proportions of single and binary blends of four polymers;polyacrylic acid(carbopol 971),ethylcellulose(Etcell),eudragit L100-55(EUD),and sodium carboxymethyl cellulose(CMC) were prepared by a modified wet granulation technique of kneading,extrusion and *** vitro release profiles of albendazole was sequentially determined in simulated gastric fluid(SGF),simulated intestinal fluid(SIF) without enzymes and in rat caecal content medium(RCCM) at 37 ℃.The in vitro drug release from matrix tablets containing CMC and Etcell as single polymers showed initial burst effect in the first 2 h(>20% and 50% respectively),followed by a slow release in ***,matrix tablets containing polymer blends showed that no appreciable drug release occurred up to 5 *** release from tablets containing polymer blends in the dissolution medium containing rat caecal material suddenly increased to ≥30% after 5 h(RCCM),and reaching up to 90% in 24 *** matrix tablets containing carbopol 971,Etcell,EUD,and CMC as single polymers and as blends were formulated for oral *** release from the tablet matrices containing carbopol alone,binary blends of carbopol/Etcell,and CMC/EUD were found to be very slow and dependent on polymer *** tablets containing blends of these polymers formulated using kneading,extrusion and compaction technique could provide sustained drug release and can be utilized in the colonic delivery of albendazole.

关键词：制剂学药学医学蠕虫病

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