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Early mortality and safety after transcatheter aortic valve replacement using the SAPIEN 3 in nonagenarians

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Journal of Geriatric Cardiology 2018年第6期15卷 387-393页

作者： Eiji Ichimoto Adam Arnofsky Michael Wilderman Richard Goldweit Joseph de gregorio department of Invasive Cardiology Englewood Hospital and Medical Center Englewood N J United States department of Cardiothoracic Surgery Englewood Hospital and Medical Center Englewood N J United States department of Vascular Surgery Englewood Hospital and Medical Center Englewood N J United States department of Interventional Cardiology Englewood Hospital and Medical Center Englewood NJ United States

Background Transcatheter aortic valve replacement （TAVR） has been performed for many elderly patients with severe aortic stenosis （AS）. The SAPIEN 3 is one of the latest balloon-expandable prosthesis. This study aimed to investigate the early clinical outcomes after TAVR using the SAPIEN 3 in nonagenarians. Methods A total of 97 consecutive patients underwent TAVR for severe AS between de- cember 2015 and december 2016. Of these, 85 consecutive patients who underwent TAVR using the SAPIEN 3 were included. According to the age, patients were classified into age 〉 90 years group （17 patients） or age 〈 90 years group （68 patients）. The clinical outcomes in- cluding all-cause mortality and composite endpoint of early safety at 30 days were evaluated. Results The Society of Thoracic Surgeons score in age 〉 90 years group was higher than age 〈 90 years group （12.3 ±6.1% vs. 8.5 ± 5.1%, P 〈 0.01）. There was no significant difference in 30-day mortality between the two groups. However, the life-threatening bleeding and major vascular complications in age 〉 90 years group were greater than age 〈 90 years group （11.8% vs. 1.5%, P = 0.04 and 11.8% vs. 1.5%, P = 0.04, respectively）. The composite endpoint of early safety at 30 days was similar between the two groups. Multivariate logistic regression analysis showed that prior myocardial infarction was an independent predictor of the composite endpoint of early safety （odds ratio： 4.76, 95% confidence interval： 1.02-22.21, P = 0.047）. Conclusions The early mortality and safety after TAVR using the SAPIEN 3 in nonagenarians were similar and acceptable despite of higher operative risk.

关键词： Nonagenarians SAPIEN 3 Transcatheter aortic valve replacement

Resveratrol attenuates metabolic,sperm,and testicular changes in adult Wistar rats fed a diet rich in lipids and simple carbohydrates

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Asian Journal of Andrology 2019年第2期21卷 201-207页

作者： Fabiana A de Oliveira Waldemar S Costa Francisco J B Sampaio Bianca M gregorio Urogenital Research Unit Biomedical CenterState University of Rio de JaneiroRio de Janeiro 20551-030Brazil

High-fat diets affect male reproduction and sexual ***,we evaluated the effects of prolonged resveratrol administration on the metabolic,sperm,and testicular parameters of rats fed a cafeteria *** Wistar rats were divided at weaning into control(Cv n=20)and cafeteria(CAF,n=16)*** 3 months,half of them were given daily supplementations of resveratrol(C-R,n=10;CAF-R,n=8)at a dosage of 30 mg kg-1 body mass for 2 *** were killed at 5 months of age,and blood,spermatozoa,and testes were collected for further *** were analyzed by one-way ANOVA,and Pdered statistically *** CAF diet promoted hyperglycemia(Pdeling,and abnormal sperm,which were attenuated by treatment with resveratrol,thus suggesting a protective effect of this antioxidant on spermatogenesis.

关键词： cafeteria diet morphology resveratrol spermatozoa testicle

Some facets of the Mg/Na_(3)VCr_(0.5)Fe_(0.5)(PO_(4))_(3) battery

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Chinese Chemical Letters 2024年第10期35卷 469-473页

作者： gregorio F.Ortiz Xiamen Key Laboratory of Optoelectronic Materials and Advanced Manufacturing Institute of Luminescent Materials and Information DisplaysCollege of Materials Science and EngineeringHuaqiao UniversityXiamen 361021China

Magnesium rechargeable batteries(MRBs)present opportunities for grid-scale energy storage applications as a complement to Li-ion batteries(LIBS).The major challenges are the low reversible capacity,inferior cycling stability and unsatisfactory energy ***_(3)VCr_(0.5)Fe_(0.5)(PO_(4))_(3) with a well-defined NASIONtype structure is used as cathode in Mg ***-electrons reaction(~116 m Ah/g),1.5 V average voltage and 65%of capacity retention over 100 cycles are *** is inserted by a biphasic reaction with the participation of V3+/V4+/V5+redox couples in the electrochemical reaction while the non-active redox couples such as Cr^(3+)/Cr^(4+)and Fe^(2+)/Fe^(3+)served as stabilizer to buffer the volume variation.A thermal stability up to~412℃ is also ***,incorporating a mixture of three transition metal(V/Cr/Fe)in this type of structures will broaden new perspectives for realizing high performance cathodes for MRBs.

关键词： Multi-electron reaction Mg batteries NASICON Na_(3)VCr_(0.5)Fe_(0.5)(PO_(4))_(3) Ironand chromium doping

Evidence for acoustic discrimination in lemurs: A playback study on wild indris Indri indri

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Current Zoology 2023年第1期69卷 41-49页

作者： Giovanni Spezie Valeria Torti Giovanna Bonadonna Chiara de gregorio Daria Valente Cristina Giacoma Marco Gamba Konrad Lorenz Institute of Ethology University of Veterinary MedicineViennaAustria department of Life Sciences and Systems Biology School of Nature SciencesUniversity of TurinTurinItaly

Indris Indri indri are group-living lemurs that occupy stable territories over several years and perform remarkable long-distance vocal *** exchanges between long-term territory neighbors may contribute to assessing reciprocal resource-holding potentials, thus adaptivelyreducing the costs of territorial defense by limiting aggressive escalation. Previous work showed that indris’ songs show distinctive acousticfeatures at individual and group level. However, the possibility that indris use such cues for individual or group-level recognition has never beeninvestigated experimentally. We conducted a playback experiment to test whether indris discriminate between familiar and nonfamiliar *** rationale lies in the hypothesis of the dear enemy phenomenon, which predicts that territorial animals will show reduced aggression levelstoward familiar neighbors compared with novel rivals. We played back stimulus recordings to wild indris from their territory boundaries andexamined their responses in terms of vocal and behavioral indicators of willingness to engage in a fight. In line with our predictions, focal animals responded more rapidly and approached more often the speaker in response to playback stimuli of nonfamiliar individuals than to stimuliof neighboring groups. These results indicate that indris can discriminate between different classes of intruders based on distinctive acousticfeatures of their song choruses. We suggest that increased aggression directed toward unfamiliar intruders may be explained by higher threatlevels associated with dispersal and group formation dynamics. We further discuss the relevance of these findings in a strepsirrhine primatemodel for comparative studies of vocal communication and sociality.

关键词： acoustic communication dear-enemy effect neighbor-stranger discrimination primate communication song territoriality

Assessing the Performance of a Three Dimensional Hybrid Central-WENO Finite Difference Scheme with Computation of a Sonic Injector in Supersonic Cross Flow

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Advances in Applied Mathematics and Mechanics 2012年第6期4卷 719-736页

作者： Wai-Sun Don Antonio de gregorio Jean-Piero Suarez Gustaaf B.Jacobs department of Mathematics Hong Kong Baptist UniversityKowloon TongHong KongChina department of Aerospace Engineering&Engineering Mechanics San Diego State University5500 Campanile Drive San DiegoCA 92182USA

A hybridization of a high order WENO-Z finite difference scheme and a high order central finite difference method for computation of the two-dimensional Euler equations first presented in[*** and ***,***.,204(2)(2007)]is extended to three-dimensions and for parallel *** Hybrid scheme switches dynamically from a WENO-Z scheme to a central scheme at any grid location and time instance if the flow is sufficiently smooth and vice versa if the flow is exhibiting sharp shock-type *** smoothness of the flow is determined by a high order multi-resolution *** method is tested on a benchmark sonic flow injection in supersonic cross *** of the order of the method reduces the numerical dissipation of the underlying schemes,which is shown to improve the resolution of small dynamic vortical *** are captured sharply in an essentially non-oscillatory manner via the high order shockcapturing WENO-Z *** of the injector flow with a WENO-Z scheme only and with the Hybrid scheme are in very close *** percent of grid points require a computationally expensive WENO-Z scheme for highresolution capturing of shocks,whereas the remainder of grid points may be solved with the computationally more affordable central *** computational cost of the Hybrid scheme can be up to a factor of one and a half lower as compared to computations with a WENO-Z scheme only for the sonic injector benchmark.

关键词： Weighted essentially non-oscillatory central difference multi-resolution hybrid shock injector

Female indris determine the rhythmic structure of the song and sustain a higher cost when the chorus size increases

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Current Zoology 2019年第1期65卷 89-97页

作者： Chiara de gregorio Anna Zanoli Daria Valente Valeria Torti Giovanna Bonadonna Rose Marie Randrianarison Cristina Giacoma Marco Gamba Dipartimento di Scienze della Vita e Biologia dei Sistemi Universita di Torino via Accademia Albertina Torino Italia Dipartimento di Scienze Chimiche della Vita e della Sostenibilita Ambientale Universita di Parma Parma Italia Group d'Ttude et de Recherche sur les Primates de Madagascar (GERP) Antananarivo Madagascar departement de Anthropobiologie et developpement Durable Universite d'Antananarivo Faculte des Sciences Antananarivo Madagascar

Among the behavioral traits shared by some nonhuman primate species and humans there is singing. Unfortunately, our understanding of animals' rhythmic abilities is still in its infancy. Indris are the only lemurs who sing and live in monogamous pairs, usually forming a group with their offspri ng. All adult members of a group usually participate in choruses that are emitted regularly and play a role in advertising territorial occupa ncy and in tergroup spaci ng. Males and females emit phrases that have similar frequency ranges but may differ in their temporal structure. We examined whether the individuals' contribution to the song may change according to chorus size, the total duration of the song or the duration of the individual con tribution using the in ter-on set intervals within a phrase and between phrases. We found that the rhythmic structure of indri's songs depends on factors that are different for males and females. We showed that females have sigrdficantly higher variation in the rhythm of their contribution to the song and that, changes according to chorus size. Our findings indicate that female indris sustain a higher cost of singing than males whe n the nu mber of singers in creases. These results suggest that cross-species investigatio ns will be crucial to un derstanding the evoluti on ary frame in which such sexually dimorphic traits occurred.

关键词： chorus coordination duets lemurs singing synchrony

A Script-Based Prototyping Framework to Boost Agile-UX developments

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Journal of Computer Science & Technology 2016年第6期31卷 1246-1261页

作者： Pedro Luis Mateo Navarro gregorio Martinez Perez Diego Sevilla Ruiz Catedra Sociedad Anonima de Electrdnica Submarina ( SAES) Laboratories University of Murcia Murcia 30100 Spain

Prototypes are described as a successful mechanism to incorporate user-experience design （UX） into Agile de- velopments, but their integration into such developments is not exempt from difficulties. Prototypes and final applications are often developed using different tools, which hinders the collaboration between designers and developers and also compli- cates reuse. Moreover, integrating stakeholders such as clients and users into the Agile process of designing, evaluating, and refining a prototype is not straightforward mainly because of its iterative nature. In an attempt to tackle these problems, this work presents the design and implementation of a new framework in which scripting languages are used to code prototyped behaviors. Prototyping is then treated as a separate aspect that coexists and runs together with final functionality. Using this framework communication is enhanced because designers and developers work in parallel on the same software artifact. Prototypes are fully reused and iteratively added with final functionality while prototyped behaviors are removed. They can be also modified on the fly to implement participatory design techniques.

关键词： prototype Agile development aspect-oriented development scripting language participatory design

Localized amyloidosis of the stomach:A case report

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World Journal of Gastroenterology 2007年第12期13卷 1877-1878页

作者： Gianluca Rotondano Raffaele Salerno Fabio Cipolletta maria Antonia Bianco Antonino de gregorio Raffaele Miele Antonio Prisco maria Lucia Garofano Livio Cipolletta Division of Gastroenterology Hospital Maresca Torre del Greco Italy University of Naples School of Medicine Department of Gastroenterology Naples Italy Division of Pathology Hospital Maresca Torre del Greco Italy

We report an unusual case of primary amyloidosis of the stomach in a patient complaining of dyspeptic symptoms. The diagnosis was confirmed histologically and other gastrointestinal site or systemic involvement was ru... 详细信息

关键词： Amyloidosis Gastrointestinal tract Dyspepsia

Acute heart failure in elderly patients:a review of invasive and non-invasive management

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Journal of Geriatric Cardiology 2021年第7期18卷 560-576页

作者： gregorio Tersalvi Alessio Gasperetti Marco Schiavone Jeroen Dauw Cecilia Gobbi marialessia denora Joel Daniel Krul Giacomo maria Cioffi Gianfranco Mitacchione Giovanni B.Forleo department of Internal Medicine Hirslanden Klinik St.AnnaLucerneSwitzerland Cardiology Unit ASST-Fatebenefratelli SaccoLuigi Sacco University HospitalMilanItaly department of Cardiology Ziekenhuis Oost-LimburgGenkBelgium Doctoral School for Medicine and Life Sciences Hasselt UniversityDiepenbeekBelgium Institut Cardiovasculaire de Caen Hôpital PrivéSaint MartinCaenFrance Division of Cardiology Fondazione Cardiocentro TicinoLuganoSwitzerland Division of Cardiology Heart CenterLuzerner KantonsspitalLucerneSwitzerland

Acute heart failure(AHF)is a major cause of unplanned hospitalisations in the elderly and is associated with high *** prevalence has grown in the last years due to population aging and longer life expectancy of chronic heart failure *** international societies have provided guidelines for the management of AHF in the general population,scientific evidence for geriatric patients is often lacking,as these are underrepresented in clinical *** have a different risk profile with more comorbidities,disability,and frailty,leading to increased morbidity,longer recovery time,higher readmission rates,and higher ***,therapeutic options are often limited,due to unfeasibility of invasive strategies,mechanical circulatory support and cardiac ***,the in-hospital management of AHF should be tailored to each patient's clinical situation,cardiopulmonary condition and geriatric *** care should be considered in some cases,in order to avoid unnecessary diagnostics and/or *** discharge,a strict follow-up through outpatient clinic or telemedicine is can improve quality of life and reduce rehospitalisation *** aim of this review is to offer an insight on current literature and provide a clinically oriented,patient-tailored approach regarding assessment,treatment and follow-up of elderly patients admitted for AHF.

关键词： patients mortality invasive