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Relationship of MTHFR gene polymorphisms with renal and cardiac disease

World Journal of Nephrology 2015年第1期4卷 127-137页

作者： Francesca M Trovato Daniela Catalano Angela Ragusa G Fabio Martines Clara Pirri maria antonietta buccheri Concetta Di Nora Guglielmo M Trovato Department of Internal Medicine University of Catania95100 CataniaItaly AOU Prenatal Diagnosis and Medical Genetics University of Catania95100 CataniaItaly Internal and Emergency Medicine Department University of Catania95100 CataniaItaly

AIM: To investigate the effects of different methylenetetrahydrofolate reductase(MTHFR) 677C>T gene polymorphism and hyperhomocysteinemia for the development of renal failure and cardiovascular events, which are ***: We challenged the relationship, if any, of MTHFR 677C>T and MTHFR 1298A>C polymorphisms with renal and heart function. The present article is a reappraisal of these concepts, investigating within a larger population, and including a subgroup of dialysis patients, if the two most common MTHFR polymorphisms, C677 T and A1298 C, as homozygous, heterozygous or with a compound heterozygous state, show different association with chronic renal failure requiring hemodialysis. MTHFR polymorphism could be a favorable evolutionary factor, i.e., a protective factor for many ominous conditions, like cancer and renal failure. A similar finding was reported in fatty liver disease in which it is suggested that MTHFR polymorphisms could have maintained and maintain their persistence by an heterozygosis advantage mechanism. We studied a total of 630 Italian Caucasian subject aged 54.60 ± 16.35 years, addressing to the increased hazard of hemodialysis, if any, according to the studied MTHFR genetic polymorphisms. RESULTS: A favorable association with normal renal function of MTHFR polymorphisms, and notably of MTHFR C677 T is present independently of the negative effects of left ventricular hypertrophy, increased IntraRenal arterial Resistance and hyperparathyroidism. CONCLUSION: MTHFR gene polymorphisms could have a protective role on renal function as suggested by their lower frequency among our dialysis patients in end-stage renal failure; differently, the association with left ventricular hypertrophy and reduced left ventricular relaxation suggest some type of indirect, or concurrent mechanism.

关键词： Homocysteine Glomerular filtration rate Renal function Mediterranean diet Genetic Methyle-netetrahydrofolate reductase polymorphism Insulinresistance Obesity Left ventricular hypertrophy Echo-cardiography

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Generation and detection of pulsed terahertz waves in gas： from elongated plasmas to microplasmas

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Frontiers of Optoelectronics 2018年第3期11卷 209-244页

作者： Fabrizio buccheri Pingjie HUANG Xi-Cheng ZHANG The Institute of Optics University of Rochester Rochester NY 14627 USA State Key Laboratory of IndustrialControl Technology College of Control Science and Engineering Zhejiang University Hangzhou 310027 China The Beijing Advanced Innovation Center for Imaging Technology Capital Normal University Beijing 100037 China

The past two decades have seen an exponential growth of interest in one of the least explored region of the electromagnetic spectrum, the terahertz （THz） frequency band, ranging from to 0.1 to 10 THz. Once only the realm of astrophysicists studying the background radiation of the universe, THz waves have become little by little relevant in the most diverse fields, such as medical imaging, industrial inspection, remote sensing, fundamental science, and so on. Remarkably, THz wave radiation can be generated and detected by using ambient air as the source and the sensor. This is accomplished by creating plasma under the illumination of intense femtosecond laser fields. The integration of such a plasma source and sensor in THz time-domain techniques allows spectral measurements covering the whole THz gap （0.1 to 10 THz）, further increasing the impact of this scientific tool in the study of the four states of matter. In this review, the authors introduce a new paradigm for implementing THz plasma techniques. Specifically, we replaced the use of elongated plasmas, ranging from few mm to several cm, with sub-mm plasmas, which will be referred to as microplasmas, obtained by focusing ultrafast laser pulses with high numerical aperture optics （NA from 0.1 to 0.9）. The experimental study of the THz emission and detection from laser-induced plasmas of submillimeter size are presented. Regarding the microplasma source, one of the interesting phenomena is that the main direction of THz wave emission is almost orthogonal to the laser propagation direction, unlike that of elongated plasmas. Perhaps the most important achievement is the demonstra- tion that laser pulse energies lower than 1 μJ are sufficientto generate measurable THz pulses from ambient air, thus reducing the required laser energy requirement of two orders of magnitude compared to the state of art. This significant decrease in the required laser energy will make plasma-based THz techniques more accessible to the

关键词： terahertz waves Terahertz Air Photonics generation and detection elongated plasmas microplasmas

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微型等离子体的太赫兹科技探究

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物理 2015年第8期44卷 497-502页

作者：刘抗 F.buccheri 张希成美国罗彻斯特大学光学研究所美国纽约州罗彻斯特14627

激光诱导产生的空气等离子体作为太赫兹时域技术中的发射源和探测器,使涵盖整个太赫兹波段(0.1—10THz)光谱测量成为可能,进一步加强了太赫兹时域技术在研究光和物质的相互作用时的重要作用。文章作者通过实验研究了从激光诱导的亚毫米... 详细信息

激光诱导产生的空气等离子体作为太赫兹时域技术中的发射源和探测器,使涵盖整个太赫兹波段(0.1—10THz)光谱测量成为可能,进一步加强了太赫兹时域技术在研究光和物质的相互作用时的重要作用。文章作者通过实验研究了从激光诱导的亚毫米量级等离子体(微型等离子体)中发射的太赫兹波,并发现这种技术可能大大降低基于等离子体的太赫兹技术所需的激光能量。另外,文中还介绍了其他和微型等离子体相关的未来研究方向,包括利用微型等离子体进行太赫兹探测的可能性。

关键词：太赫兹太赫兹源太赫兹探测光电离等离子体

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线条的秩序美

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现代装饰 2019年第7期 90-95页

作者： Accardi buccheri Cara\Davide Debonademeo Vivlana Degrandi Fran Silvestre Claesson Koivisto Rune Gabriel Teixidó 李薇(编译) 不详

亚里士多德认为,美的主要形式是'秩序、匀称与明确',美就是'整一性'。'整一性'既不是单一,也不是杂多,而是像音乐一样,五律调和,八音和谐,在复杂丰富的多样性中又保持统一。秩序美是音乐、美术、设计等艺术创作的美的形式规律之一,在重... 详细信息

亚里士多德认为,美的主要形式是'秩序、匀称与明确',美就是'整一性'。'整一性'既不是单一,也不是杂多,而是像音乐一样,五律调和,八音和谐,在复杂丰富的多样性中又保持统一。秩序美是音乐、美术、设计等艺术创作的美的形式规律之一,在重复、渐变、规律的变化中,使设计或艺术展现出一种节奏或韵律。线条不论在设计中还是在艺术中都是最为简单的一种表现元素,运用线条的曲直、长短、疏密的变换可以赋予作品不同的张力与美感。

关键词：家具产品秩序美

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2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography initial staging impacts on survival in Hodgkin lymphoma

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World Journal of Radiology 2013年第12期5卷 484-490页

作者： Juliano J Cerci Camila C G Linardi Luís F Pracchia José Soares Junior Evelinda Trindade Dominique Delbeke Rodrigo J Cerci Robert Carr José C Meneghetti Valeria buccheri Department of Nuclear Medicine Heart Institute (InCor) University of Sāo Paulo Medical School Division of PET/CT Quanta-Diagnóstico Nuclear Division of Hematology Clinical Hospital of the University of Sāo Paulo Medical School Health Technology Assessment/Executive Direction Heart Institute (InCor) University of Sāo Paulo Medical School Department of Radiology and Radiological Sciences Vanderbilt University Medical Center Department of Haematology St Thomas’ Hospital

AIM:To assess the prognostic value and risk classification improvement of metabolic staging(MS)with Initial2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography(FDG-PET)in initial staging of Hodgkin’s Lymphoma(HL)patients to predict 5 years overall survival(5y-OS)and event free survival(EFS).METHODS:A total of 275 patients were included in this retrospective study,155 patients were staged with conventional anatomical staging(AS),and 120 also submitted to MS(FDG-PET).Prognostic analysis compared 5y-OS and 5y-EFS of patients staged with AS and ***-adjusted models incorporated clinical risk factors,computed tomography and FDG-PET ***:During the follow up of 267 evaluated patients,220(122 AS and 98 MS)achieved complete remission after first-line therapy(median follow-up:70±29 mo),treatment failure occurred in 79 patients and 34 *** 5y-EFS for early vs advanced disease in AS patients was 79.3%and 66.7%,and 85.6%and53.6%in MS patients,respectively(P<0.01).The5y-OS for early and advanced disease with AS was91.3%and 81.5%,and 97.5%and 80.7%for patients staged with MS,*** proportional hazards analysis demonstrated that FDG-PET added signifcant prognostic information and improved risk prediction(P=0.02).CONCLUSION:Initial staging FDG-PET could be used as an accurate and independent predictor of OS and EFS in HL,with impact in 5y-EFS and OS.

关键词： Hodgkin disease Positron-emission tomography 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography Neoplasm staging Prognosis

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