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Overview of the microbiota in the gut-liver axis in viral B and C hepatitis

World Journal of Gastroenterology 2021年第43期27卷 7446-7461页

作者： maria adriana neag Andrei Otto Mitre Adrian Catinean Anca Dana Buzoianu Department of Pharmacology Toxicology and Clinical PharmacologyIuliu Hatieganu University of Medicine and Pharmacy of Cluj-NapocaCluj-Napoca 400337Romania Faculty of Medicine Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-NapocaCluj-Napoca 400012Romania Department of Internal Medicine Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-NapocaCluj-Napoca 400006Romania

Viral B and C hepatitis are a major current health issue,both diseases having a chronic damaging effect on the liver and its *** liver disease can lead to even more severe and life-threatening conditions,such as liver cirrhosis and hepatocellular *** years have uncovered an important interplay between the liver and the gut microbiome:the gut-liver *** B and C infections often cause alterations in the gut microbiota by lowering the levels of‘protective’gut microorganisms and,by doing so,hinder the microbiota ability to boost the immune *** aimed at restoring the gut microbiota balance may provide a valuable addition to current practice therapies and may help limit the chronic changes observed in the liver of hepatitis B and C *** review aims to summarize the current knowledge on the anatofunctional axis between the gut and liver and to highlight the influence that hepatitis B and C viruses have on the microbiota balance,as well as the influence of treatments aimed at restoring the gut microbiota on infected livers and disease progression.

关键词： Viral B hepatitis Viral C hepatitis Gut-liver axis Immunomodulation Lipopolysaccharides Short-chain fatty acids

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Gastrointestinal microbiota:A predictor of COVID-19 severity?

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World Journal of Gastroenterology 2022年第45期28卷 6328-6344页

作者： maria adriana neag Damiana-maria Vulturar Diana Gherman Codrin-Constantin Burlacu Doina Adina Todea Anca Dana Buzoianu Department of Pharmacology Toxicology and Clinical PharmacologyIuliu Hațieganu University of Medicine and PharmacyCluj-Napoca 400337Romania Department of Pneumology Iuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 400332Romania Department of Radiology Iuliu Hațieganu University of Medicine and PharmacyCluj-Napoca 400347Romania Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca 400347Romania

Coronavirus disease 2019(COVID-19),caused by a severe acute respiratory syndrome coronavirus 2 infection,has raised serious concerns worldwide over the past 3 *** severity and clinical course of COVID-19 depends on many factors(e.g.,associated comorbidities,age,etc)and may have various clinical and imaging findings,which raises management *** microbiota composition is known to influence respiratory disease,and respiratory viral infection can also influence gut *** and lung microbiota and their relationship(gut-lung axis)can act as modulators of *** the intestinal microbiota,by improving its composition and diversity through nutraceutical agents,can have a positive impact in the prophylaxis/treatment of COVID-19.

关键词： Gut microbiota COVID-19 Prognostic biomarkers Gut-lung axis Probiotics Nutraceuticals

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