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Hydrogen sulfide:A novel component in Arabidopsis peroxisomes which triggers catalase inhibition

Journal of Integrative Plant Biology 2019年第7期61卷 871-883页

作者： Francisco J.Corpas Juan B.Barroso Salvador Gonzalez-Gordo maria a.munoz-vargas Jose M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstacion Experimental del ZaidfnCSICC/Profesor Albareda 1E-18008 GranadaSpain Group of Biochemistry and Cell Signaling in Nitric oxide Department of Biochemistry and Molecular BiologyCampus"Las Lagunillas"E-23071University of JaenJaenSpain

Plant peroxisomes have the capacity to gen erate different reactive oxygen and nitrogen species(ROS and RNS),such as H2O2,superoxide radical(O2^·-),nitric oxide and peroxynitrite(ONOO^-).These organelles have an active nitrooxidative metabolism which can be exacerbated by adverse stress *** sulfide(H2S)is a new signaling gasotransmitter which can mediate the posttranslational modification(PTM)*** used Arabidopsis thaliana transgenic seedlings expressing cyan fluorescent protein(CFP)fused to a canonical peroxisome targeting signal 1(PTS1)to visualize peroxisomes in living cells,as well as a specific fluorescent probe which showed that peroxisomes contain H2S.H2S was also detected in chloroplasts under glyphosate-induced oxidative stress *** enzyme activities,including catalase,photorespiratory H2O2-generating glycolate oxidase(GOX)and hydroxypyruvate reductase(HPR),were assayed in vitro with a H2S *** line with the persulfidation of this enzyme,catalase activity declined significantly in the presence of the H2S *** corroborate the inhibitory effect of H2S on catalase activity,we also assayed pure catalase from bovine liver and pepper fruit-enriched samples,in which catalase activity was *** together,these data provide evidenee of the presence of H2S in plant peroxisomes which appears to regulate catalase activity and,consequently,the peroxisomal H2O2 metabolism.

关键词： Hydrogen sulfide triggers catalase inhibition

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Precipitation analysis of as-cast HK40 steel after isothermal aging

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1125-1133页

作者： M.L. Saucedo-munoz A. Ortiz-Mariscal V.M. Lopez-Hirata J.D. Villegas-Cardenas Orlando Soriano-vargas Erika O. Avila-Davila Instituto Politecnico Nacional (ESIQIE) Apdo. Postal 118-395 Mexico D.F. 07300 Universidad Politecnica Metepec y Tultitlan Edo. Mex. Mexico Tecnológico de Estudios Superiores de Jocotitlan Jocotitlan Edo. Mex. Mexico

As-cast HK40 steel was aged at 700, 800, or 900℃ for times as long as 2000 h. Microstructural characterization showed that the primary M_7C_3 carbide network contained a substantial content of manganese, in agreement with the microsegregation of manganese calculated by Thermo-Calc using the Scheil–Gulliver module. The dissolution of primary carbides caused the solute supersaturation of austenite and subsequent precipitation of fine M_(23)C_6 carbides in the austenite matrix for aged specimens. During prolonged aging, the carbide size increased with increasing time because of the coarsening process. A time–temperature–precipitation diagram for M_(23)C_6 carbides was calculated using the Thermo-CalcPRISMA software; this diagram showed good agreement with the experimental growth kinetics of precipitation. The fine carbide precipitation caused an increase in hardness; however, the coarsening process of carbides promoted a decrease in hardness. Nanoindentation tests of the austenite matrix indicated an increase in ductility with increasing aging time.

关键词： as-cast HK40 steel carbide precipitation aging precipitation simulation

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Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient

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World Journal of Gastroenterology 2015年第36期21卷 10475-10479页

作者： maria Salvado Victor vargas Marta Vidal Macarena Simon-Talero Jessica Camacho Josep Gamez ALS Unit Neurology DepartmentHospital Universitari Vall d'HebronVall d'Hebron Research InstituteAutonomous University of Barcelona Liver Unit Department of MedicineHospital Universitari Vall d'HebronVall d'Hebron Research InstituteAutonomous University of BarcelonaBarcelona. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)Instituto de Salud Carlos IIIMadridSpain Pathology Department Hospital Universitari Vall d’HebronVall d’HebronAutonomous University of Barcelona

We report a case of acute severe hepatitis resulting from masitinib in a young amyotrophic lateral sclerosis patient. Hepatotoxicity induced by masitinib,a tyrosine kinase inhibitor,is usually transient with mild elevation of transaminases,although acute hepatitis has been not reported to date. The hepatitis was resolved after masitinib was discontinued and a combination of prednisone and azathioprine was started. The transaminases returned to baseline normal values five months later. This is the first case in the hepatitis literature associated with masitinib. The autoimmune role of this drug-induced liver injury is discussed. Physicians should be aware of this potential complication.

关键词： Drug-induced liver injury Masitinib Amyotrophic la

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Optimal Positioning Strategy for Multi-Camera Zooming Drones

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1802-1818页

作者： Manuel vargas Carlos Vivas Teodoro Alamo Department of System Engineering and Automation University of SevilleSeville 41092Spain

In the context of multiple-target tracking and surveillance applications,this paper investigates the challenge of determining the optimal positioning of a single autonomous aerial vehicle or agent equipped with multiple independently-steerable zooming cameras to effectively monitor a set of targets of *** camera is dedicated to tracking a specific target or cluster of *** key innovation of this study,in comparison to existing approaches,lies in incorporating the zooming factor for the onboard cameras into the optimization *** enhancement offers greater flexibility during mission execution by allowing the autonomous agent to adjust the focal lengths of the onboard cameras,in exchange for varying real-world distances to the corresponding targets,thereby providing additional degrees of freedom to the optimization *** proposed optimization framework aims to strike a balance among various factors,including distance to the targets,verticality of viewpoints,and the required focal length for each *** primary focus of this paper is to establish the theoretical groundwork for addressing the non-convex nature of the optimization problem arising from these *** this end,we develop an original convex approximation *** paper also includes simulations of diverse scenarios,featuring varying numbers of onboard tracking cameras and target motion profiles,to validate the effectiveness of the proposed approach.

关键词： Convex optimization projective transformation unmanned aerial vehicle visual object tracking visual surveillance.

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Effect of Multipoint Heterogeneity on Nonlinear Transformations for Geological Modeling: Porosity-Permeability Relations Revisited

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Journal of China University of Geosciences 2008年第1期19卷 85-92页

作者： J A vargas-Guzmán Saudi Aramco Dhahran 31311 KSA

An analysis of statistical expected values for transformations is performed in this study to quantify the effect of heterogeneity on spatial geological modeling and evaluations. Algebraic transformations are frequently applied to data from logging to allow for the modeling of geological properties. Transformations may be powers, products, and exponential operations which are commonly used in well-known relations （e.g., porosity-permeability transforms）. The results of this study show that correct computations must account for residual transformation terms which arise due to lack of independence among heterogeneous geological properties. In the case of an exponential porosity-permeability transform, the values may be positive. This proves that a simple exponential model back-transformed from linear regression underestimates permeability. In the case of transformations involving two or more properties, residual terms may represent the contribution of heterogeneous components which occur when properties vary together, regardless of a pair-wise linear independence. A consequence of power- and product-transform models is that regression equations within those transformations need corrections via residual cumulants. A generalization of this result is that transformations of multivariate spatial attributes require multiple-point random variable relations. This analysis provides practical solutions leading to a methodology for nonlinear modeling using correct back transformations in geology.

关键词： reservoir static model intrinsic permeability non-Gaussian nonlinear residual moment cumulant unbiased simulation parameter.

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Global stability for multi-species Lotka-Volterra cooperative systems： One hyper-connected mutualistic-species

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International Journal of Biomathematics 2015年第3期8卷 215-223页

作者： Cruz vargas-De-Leon Unidad de Medicina Experimental Hospital General de Mexico"Dr. Eduardo Liceaga" DF 06726 Mexico

We propose two models of one hyper-connected mutualistic-species described by delay differential equations of Lotka-Volterra type. An hyper-connected model comprises a central species interacting with a number of peripheral species around it, that is to say, one animal species （pollinators or dispersers） that interacts with several plant species （flowering plants or fruit trees）, or several animal species that interact with one plant species. We derive a necessary and sufficient condition for the global asymptotic stability of the unique coexisting steady state of hyper-connected systems by means of novel Lyapunov functionals.

关键词： Lotka Volterra cooperative system discrete delays distributed delays Lyapunov functional global stability.

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Linear Biseparating Maps between Vector-valued Little Lipschitz Function Spaces

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Acta Mathematica Sinica,English Series 2010年第6期26卷 1005-1018页

作者： A. JIMENEZ-vargas Ya-Shu WANG Departamento de Algebra y Andlisis Matemdtico Universidad de Almerla 04120 Almerla Spain Department of Applied Mathematics National Sun Yet-Sen University 804 Kaohsinug Taiwan

In this paper we provide a complete description of linear biseparating maps between spaces lip0（X^a, E） of Banach-valued little Lipschitz functions vanishing at infinity on locally com-pact HSlder metric spaces X^a=（X,dx^a） with 0〈a〈***, it is proved that any linear bijection T ： lip0（X^a,E）→lip0（Y^a,F）satisfying that ｜｜Tf（y）｜｜F｜｜Tg（y）｜｜F= 0 for all y ∈ Y if and only if ｜｜f（x）｜｜E｜｜g（x）｜｜E=0 for all x E X, is a weighted composition operator of the form Tf（y） = h（y）（f（φ（y）））, where φ is a homeomorphism from Y onto X and h is a map from Y into the set of all linear bijections from E onto F. Moreover, T is continuous if and only if h（y） is continuous for all y ∈ Y. In this case, φ becomes a locally Lipschitz homeomorphism and h a locally Lipschitz map from Y^a into the space of all continuous linear bijections from E onto F with the metric induced by the operator canonical norm. This enables us to study the automatic continuity of T and the existence of discontinuous linear biseparating maps.

关键词： linear biseparating map little Lipschitz function Banach-Stone theorem automatic continuity

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Study of Spider Silk Fibers by Raman Microscopy

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American Journal of Analytical Chemistry 2018年第10期9卷 529-545页

作者： maria Fernanda vargas-Charry Carlos vargas-Hernández Laboratorio de Propiedades Opticas de Materiales (POM) Universidad Nacional de Colombia sede Manizales Manizales-Caldas Colombia

Spider silk fibers of species of the genera Araneus, Gasteracantha, and Linothele sericata were studied. The fibers are composed of axial threads and lateral villi, allowing adhesion to surfaces. Raman spectroscopy was used to determine the surface and internal composition of the threads forming the structure. In the three species, the characteristic amino acid peaks of the spider web were found between 2871 and 2975 cm-1, which belong to L-glycine, L-alanine, L-glutamine, and L-proline. The threads are composed of a protective layer mainly composed of amides, alanine, and glycine. The fibrils surrounding the axial fibers consist mainly of amide II (1533 cm-1), which allows adhesion between the thread and the surfaces onto which the spider weaves the web. For the genus Linothele sericata, there is a peak on the surface of this spider web located at 2145 cm-1, which is associated with isonitriles with R-N-C bonds.

关键词： Spider Silk Fibers Raman Spectroscopy

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Don´t give up on mitochondria as a target for the treatment of diabetes and its complications

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World Journal of Diabetes 2024年第10期15卷 2015-2021页

作者： Christian Cortés-Rojo Manuel Alejandro vargas-vargas Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico

In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin *** numerous in vitro and pre-clinical studies supporting the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of diabetes and its complications,efforts to target mitochondria for glycemic control in diabetes using mitochondria-targeted antioxidants have produced inconsistent *** intricate functionality of mitochondria is summarized to underscore the challenges it poses as a therapeutic *** mitochondria-targeted antioxidants have demonstrated improvement in mitochondrial function and oxidative stress in pre-clinical diabetes models,the results regarding glycemic control have been mixed,and no studies have evaluated their hypoglycemic effects in diabetic ***,pre-clinical trials have shown promising outcomes in ameliorating diabetes-related ***,we review some reasons why mitochondria-targeted antioxidants may not function effectively in the context of mitochondrial *** also highlight several alternative approaches under development that may enhance the targeting of mitochondria for diabetes treatment.

关键词： Diabetes mellitus Insulin resistance Mitochondrion Mitochondrial dysfunction MitoQ MitoTEMPO SkQ Elamipretide Mitochondria transplantation Glycemic control

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Construction of Dulac functions for mathematical models in population biology

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International Journal of Biomathematics 2015年第3期8卷 135-154页

作者： Osvaldo Osuna Cruz vargas-De-Leon Instituto de Fisica y Matematicas Universidad MichoacanaEdif. C-3 Cd. Universitaria CP 58040 Morelia Michoacan Mexico Unidad de Medicina Experimental Hospital General de Mexico "Dr. Eduardo Liceaga" DF 06726 Mdxieo

In this paper, we present a method for constructing a Dulac function for mathematical models in population biology, in the form of systems of ordinary differential equations in the plane.

关键词： Population models epidemic models chemostat models Dulac function nonexistence of periodic orbits.

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