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Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第28期14卷 4454-4461页

作者： Luciana Rigoli Claudio Romano Rosario Alberto Caruso maria a lo presti Chiara Di Bella Vincenzo Procopio Giuseppina lo Giudice maria Amorini Giuseppe Costantino maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries Dipartimento di Scienze Pediatriche Mediche e Chirurgiche Università di MessinaMessina 98125Italy Dipartimento di Patologia Umana Università di MessinaMessina 98125Italy Dipartimento di Medicina Interna e Terapia Medica Università di MessinaMessina 98125Italy

AIM： To evaluate the role of genetic factors in the pathogenesis of Crohn＇s disease （CD） and ulcerative colitis （UC）, we investigated the single nucleotide polymorphisms （SNPs） of NOD2/CARD15 （R702W, Gg08R and L1007finsC）, and Toll-like receptor 4 （TLR4） genes （D299G and T399I） in a selected inflammatory bowel disease （IBD） population coming from Southern Italy. METHODS： Allele and genotype frequencies of NOD2/ CARD15 （R702W, Gg08R and L1007finsC） and TLR4 （D299G and T399I） SNPs were examined in 133 CD patients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS： NOD2/CARD15 R702W mutation was significantly more frequent in CD （9.8%） than in controls （2.4%, P = 0.001） and in UC （2.3%, P = 0.03）. No significant difference was found between UC patients and control group （P 〉 0.05）. In CD and UC patients, no significant association with G908R variant was found. L1007finsC SNP showed an association with CD （9.8%） compared with controls （2.9%, P = 0.002） and UC patients （2.3%, P = 0.01）. Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort （allele frequencies： D299G-controls 3.9%, CD 3.7%, UC 3.4%, P 〉 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P 〉 0.05）. CONCLUSION： These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with increased risk of CD.

关键词： Crohn's disease Ulcerative colitis NOD2/ CARD15 gene Toll-like receptor 4 gene Single nucleotide polymorphisms

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Twin-Wire Networks for Zero Interconnect,High-Density 4-Wire Electrical Characterizations of Materials

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Research 2022年第2期2022卷 225-234页

作者： Nerio Andres Montoya Valeria Criscuolo Andrea lo presti Raffaele Vecchione Christian Falconi Department of Electronic Engincering University of Rome Tor VergataVia del Politecnico 1Roma 00133Italy School of Physics Universidad Nacional de ColombiaA.A.3840 MedellinColombia Center for Advanced Biomaterial for Health Care Istituto Italiano di TecnologiaLargo Barsantie Matteucci 53Naples 80125Italy

Four-wire measurements have been introduced by lord Kelvin in 1861 and have since become the standard technique for characterizing small resistances and ***,high-density 4-wire measurements are generally complex,time-consuming,and inefficient because of constraints on interconnects,pads,external wires,and mechanical contacts,thus reducing reproducibility,statistical significance,and throu ***,we introduce,systematically design,analyze,and experimentally validate zero interconnect networks interfaced to external instrumentation by couples of twin wire.3D-printed holders with magnets,interconnects,nonadhesive layers,and spacers can effortlessly establish excellent electrical connections with tunable or minimum contact forces and enable accurate measurements even for delicate devices,such as thin metals on soft *** an example,we measured all the resistances of a twin-wire 29-resistor network made of silver-nanoparticle ink printed on polyimide,paper,or photo paper,including during sintering or temperature calibration,resulting in anunprecedentedly easy and accurate characterization of both resistivity and its temperature *** theoretical framework and experimental strategies reported here represent a breakthrough toward zero interconnect,simple,and efficient high-density 4-wire characterizations,can be generalized to other 4-wire measurements(impedances,sensors)and can open the way to more statistically meaningful and reproducible analyses of materials,high-throughput measurements,and minimally invasive characterizations of biomaterials.

关键词： impedance characterization breakthrough

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Molecular epidemiology and phylogeny of Nipah virus infection:A mini review

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 610-615页

作者： Silvia Angeletti Alessandra lo presti Eleonora Cella Massimo Ciccozzi Unit of Clinical Pathology and Microbiology University Campus Bio-Medico of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

Nipah virus(Ni V) is a member of the genus Henipavirus of the family Paramyxoviridae,characterized by high pathogenicity and endemic in South *** is classified as a Biosafety Level-4(BSL-4) *** case-fatality varies from 40%-70% depending on the severity of the disease and on the availability of adequate healthcare *** present no antiviral drugs are available for Ni V disease and the treatment is just *** and evolutionary analyses can be used to help in understanding the epidemiology and the temporal origin of this *** review provides an overview of evolutionary studies performed on Nipah viruses circulating in different *** phylogenetic studies have been published from 2000 to 2015 years,searching on pub-med using the key words ‘Nipah virus AND phylogeny' and twenty-eight molecular epidemiological studies from 2006 to 2015 have been performed,typing the key words ‘Nipah virus AND molecular epidemiology'.Overall data from the published study demonstrated as phylogenetic and evolutionary analysis represent promising tools to evidence NiV epidemics,to study their origin and evolution and finally to act with effective preventive measure.

关键词： Nipah virus Phylogenetic analysis Molecular epidemiology NiV reservoir

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Activity of Tagetes minuta Linnaeus(Asteraceae)essential oil against L3 Anisakis larvae type 1

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 440-444页

作者： Filippo Giarratana Daniele Muscolino Graziella Ziino Alessandro Giuffrida Stefania maria Marotta Vittorio lo presti Vincenzo Chiofalo Antonio Panebianco Department of Veterinary Sciences University of MessinaPolo Universitario dell’Annunziata98168 MessinaItaly

Objective:To evaluate in vitro effects of Tagetes minuta L. essential oil(TEO) on L3 Anisakis larvae type 1. Methods:In order to evaluate the potential use of Tagetes minuta essential oil against L3 Anisakis larvae three different media were tested:1) a saline solution(SS); 2) an industrial marinating solution; 3) sunflower seeds oil(SO). For each media and concentrations of TEO(0.1%,0.5%,1.0% and 5.0% v/v),20 parasites were introduced into plastic Petri dishes(diameter 90 mm) and maintained at room temperature. As controls,larvae were maintained without TEO under identical experimental conditions in SS,MS and SO. A total of 900 larvae were tested. The normalized mean viability,LT100,LT50 and the percentage of inactivation at 24 hours were calculated. Results:In vitro tests revealed a complete inactivation of parasites in saline solution after 2 hours with 5% and 1% of TEO. In marinating solution,a complete inactivation of parasites was observed after 4 hours at all concentrations used. A slower activity for all TEO concentration was reported in SO. Conclusions:The results obtained,showing a strong activity against Anisakis larvae,confirm TEO as a larvicidal agent in the treatment of human anisakidosis and in the industrial marinating process.

关键词： Anisakis Essential oil Tagetes minuta Biocidal activity Parasites

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Chikungunya virus,epidemiology,clinics and phylogenesis:A review

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Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 925-932页

作者： Alessandra lo presti Alessia Lai Eleonora Cella Gianguglielmo Zehender Massimo Ciccozzi Department of Infectious Parasitic and Immunomediated Diseases Epidemiology UnitReference Centre on Phytogeny Molecular Epidemiology and Microbial Evolution(FEMEM).Istituto Superiore di Sanita RomeItaly Department of Biomedical and Clinical Sciences L Sacco HospitalUniversity of MilanMilanItaly University Campus-Biomedico RomeItaly

Chikungunva virus is a mosquito-transmitted alphavirus that causes chikungunva fever,a febrile illness associated with severe arthralgia and *** virus is transmitted by culicine mosquitoes:Chikungunya virus replicates in the skin,disseminates to liver,muscle,*** tissue and brain,presumably through the *** studies showed that the Indian Ocean and the Indian subcontinent epidemics were caused by two different introductions of distinct strains of East/Central/South African genotype of *** paraphyletic grouping of African CHIK viruses supports the historical evidence that the virus was introduced into Asia from *** analysis divided Chikungunva virus isolates into three distinct genotypes based on geographical origins:the first,the West Africa genotype,consisted of isolates from Senegal and Nigeria;the second contained strains from East/Central/South African genotype,while the third contained solely *** most recent common ancestor for the recent epidemic,which ravaged Indian Ocean islands and Indian subcontinent in 2004- *** found to date in *** lineage dated about 1952 and exhibits similar spread patterns of the recent Indian Ocean outbreak lineage,with successive epidemics detected along an eastward *** group splitted into two clades:an Indian lineage and a south east *** of Chikungunya virus fever in Asia have not been associated necessarily with outbreaks in *** tools can reconstruct geographic spread of Chikungunva virus during the epidemics *** good management of patients with acute Chikungunva virus infection is essential for public health in susceptible areas with current Aedes spp activity.

关键词： CHIKV Epidemiology Phylogeny

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The phylogenetic and evolutionary history of Kokobera virus

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 945-950页

作者： Aletheia Blasi Alessandra lo presti Eleonora Cella Silvia Angeletti Massimo Ciccozzi Unit of Clinical Pathology and Microbiology University Campus Bio-Medico of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

Objective: To estimate the genetic diversity of Kokobera virus, the date of origin and the spread among different viruses in the endemic regions of Australia. Methods: Two datasets were built. The first consisting of 29 sequences of the NS5/3' UTR region of Kokobera group downloaded from Gen Bank, the second including only 24 sequences of Kokobera viruses, focus is on this group. Results: Bayesian time analysis revealed two different entries in Australia of Kokobera virus in the 50 s years with the dated ancestor in 1861 year. Clade A and B showed a clear separation of the Kokobera sequences according to the geographic region. Conclusions: Data from the study showed as Kokobera virus, despite of its ancient origin and its circulation before the European colonization, remained limited to the Australian Country and nowadays limited mostly to the regions were Australian marsupials are mostly found.

关键词： Kokobera virus Phylogeny Date of origin Evolution

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Second Generation Nitrogen Doped Titania Nanoparticles:A Comprehensive Electronic and Microstructural Picture

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中国化学:英文版 2014年第12期32卷 1195-1213页

作者： Francesca Spadavecchia Michele Ceotto Leonardo lo presti Chiara Aieta Iolanda Biraghi Daniela Meroni Silvia Ardizzone Giuseppe Cappellettia Dipartimentodi Chimica Universitàdegli Studidi MilanoVia Golgi 1920133 MilanoItaly Consorzio Interuniversitario Nazionaleperla Scienzaela Tecnologiadei Materiali(INSTM) Via Giusti 950121 FirenzeItaly Istitutodi Scienzee Tecnologie Molecolari Italian CNRVia Golgi 1920133 MilanoItaly Center for Materials Crystallography Aarhus UniversityLangelandsgade 1408000 AarhusDenmark

A state-of-the-art overview of N-dopant characterizations in nano-TiO_(2)second-generation photocatalysts is *** related literature is very rich and sometimes offers contrasting *** we critically discuss up-to-date literature results and our own findings,as retrieved by several experimental(BET,HR-TEM,XPS,DRS,HR-XRPD,EXAFS,electrochemical tools)and theoretical(periodic DFT)*** intent is to pull together outcomes from very different and complementary sources to make an as much as possible coherent picture of the morphological,electrochemical and electronic properties of N-TiO_(2)*** is commonly accepted that critical issues to be considered in the design of high-performing N-TiO_(2)photocatalysts are synthetic strategy,defect concentration and chemical nature of the lattice point *** focus on the latter two issues,with emphasis on sol-gel prepared materials,according to the specific area of expertise of our *** problem of the chemical nature of guest N species into the lattice is crucial,as substitutional(N_(s))or interstitial(N_(i))nitrogen place their valence states just above the valence band or deeper into the band ***,we show how synergism among experimental and theoretical techniques is decisive to disentangle structural,electronic and morphological effects in complex N-doped TiO_(2)matrices.

关键词： point defects flatband potential photovoltage photocurrent DFT calculations

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From trees to fleas: masting indirectly affects flea abundance on a rodent host

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Integrative Zoology 2023年第3期18卷 440-452页

作者： Ivan BALÁŽ MichałBOGDZIEWICZ Sylwia DZIEMIAN-ZWOLAK Carlotta lo presti Aleksandra WRÓBEL Milena ZDUNIAK RafałZWOLAK Faculty of Natural Sciences and Informatics Constantine the Philosopher University in NitraNitraSlovakia Department of Systematic Zoology Adam Mickiewicz University in Pozna´nPozna´nPoland INRAE LESSEMUniversity Grenoble AlpesSaint-Martind’HèresFrance University of Catania CataniaItaly Department of Zoology Pozna´n University of Life SciencesPozna´nPoland

Mast seeding causes strongﬂuctuations in populations of forest ***,this phenomenon can be used as a natural experiment to examine how variation in host abundance affects parasite *** investigatedﬂeas infesting yellow-necked mice in beech forest after 2 mast and 2 non-mast *** tested 2 mutually exclusive scenarios:(1)as predicted by classical models of density-dependent transmission,an increase in host density will cause an increase in ectoparasite abundance(deﬁned as the number of parasites per host),versus(2)an increase in host density will cause a decline inﬂea abundance(“dilution,”which is thought to occur when parasite population growth is slower than that of the host).In addition,we assessed whether masting alters the relationship between host traits(sex and body mass)andﬂea *** found a hump-shaped relationship between host andﬂea ***,the most basic predictions are too simple to describe ectoparasite dynamics in this *** addition,masting modiﬁed seasonal dynamics ofﬂea abundance,but did not affect the relationship between host traits andﬂea abundance(individuals with the highest body mass hosted the mostﬂeas;after controlling for body mass,parasite abundance did not vary between sexes).Our results demonstrate that pulses of tree reproduction can indirectly,through changes in host densities,drive patterns of ectoparasite infestation.

关键词： Apodemusﬂavicollis Fagus sylvatica indirect effects pulsed resources Siphonaptera

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Multimodality imaging in the diagnosis and management of prosthetic valve endocarditis:A contemporary narrative review

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World Journal of Cardiology 2021年第8期13卷 254-270页

作者： Saberio lo presti Tarec K Elajami Mohammad Zmaili Reza Reyaldeen Bo Xu Advanced Cardiac Imaging Fellows Sydell and Arnold Miller Family Heart Vascular and Thoracic Institute at Cleveland ClinicClevelandOH 44195United States Department of Cardiology Mount Sinai Medical CenterMiami BeachFL 33140United States Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44195United States Section of Cardiovascular Imaging in the Robert and Suzanne Tomsich Department of Cardiovascular MedicineSydell and Arnold Miller Family Heart Vascular and Thoracic Institute at Cleveland ClinicClevelandOH 44195United States

Infective endocarditis is one of the leading life-threatening infections around the *** the exponential growth in the field of transcatheter interventions and advances in specialized surgical techniques,the number of prosthetic valves and cardiac implantable devices has significantly *** has led to a steep rise in the number of cases of prosthetic valve endocarditis(PVE)comprising up to 30%of all *** guidelines rely on the use of the modified Duke criteria;however,the diagnostic sensitivity of the modified Duke criteria is reduced in the context of *** is in part attributed to prosthesis related artifact which greatly affects the ability of echocardiography to detect early infective changes related to PVE in certain *** has been increasing recognition of the roles of complementary imaging modalities and updates in international society *** diagnosis and treatment can prevent the devastating consequences of this *** modalities such as cardiac computed tomography and 18-fluorodeoxyglucose positron emission tomography/computed tomography are diagnostic tools that provide a complementary role to echocardiography in aiding diagnosis,pre-operative planning,and treatment decisionmaking process in these challenging *** the strengths and limitations of these adjuvant imaging modalities is crucial for the implementation of appropriate imaging modalities in clinical practice.

关键词： Prosthetic valve endocarditis Multimodality cardiac imaging echocardiography Cardiac computed tomography 18-fluorodeoxyglucose photon emission tomography/computed tomography

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Enigmatic origin of hepatitis B virus:An ancient travelling companion or a recent encounter?

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World Journal of Gastroenterology 2014年第24期20卷 7622-7634页

作者： Gianguglielmo Zehender Erika Ebranati Elena Gabanelli Chiara Sorrentino Alessra lo presti Elisabetta Tanzi Massimo Ciccozzi Massimo Galli L.Sacco Department of Biomedical and Clinical Sciences University of Milan20157 MilanItaly Department of Infectious Parasitic and Immunomediated DiseasesNational Institute of Health00161 RomeItaly Department of Biomedical Sciences for Health University of Milan20157 MilanItaly

Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people *** is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral *** ten genotypes(A-J)that have been described so far further segregate into a number of subgenotypes which have distinct ethno-geographic *** A and D are ubiquitous and the most prevalent genotypes in Europe(mainly represented by subgenotypes D1-3 and A2);genotypes B and C are restricted to eastern Asia and Oceania;genotype E to central and western Africa;and genotypes H and F(classified into 4 subgenotypes)to Latin America and *** review summarises the data obtained by studying the global phylodynamics and phylogeography of HBV genotypes,particularly those concerning the origin and dispersion histories of genotypes A,D,E and F and their *** lack of any consensus concerning the HBV substitution rate and the conflicting data obtained using different calibration approaches make the time of origin and divergence of the various genotypes and subgenotypes largely *** is hypothesised that HBV evolutionary rates are time dependent,and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations.

关键词： Hepatitis B virus genotypes and subgenotypes Phylogeography Population dynamics and epidemics Molecular epidemiology Hepatitis B virus phylodynamics

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