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Nonasthmatic eosinophilic bronchitis in an ulcerative colitis patient-a putative adverse reaction to mesalazine:A case report and review of literature

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World Journal of Clinical Cases 2020年第18期8卷 4162-4168页

作者： Andrei tudor Cernomaz Gabriela Bordeianu Cristina Terinte Cristina maria Gavrilescu Department of Internal Medicine Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Biochemistry Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Pathology Regional Oncology InstituteIasi 700483Romania

BACKGROUND Lung and airway involvement in inflammatory bowel disease are increasingly frequently reported either as an extraintestinal manifestation or as an adverse effect of *** SUMMARY We report a case of a patient with ulcerative colitis controlled under mesalazine treatment who presented with chronic cough and *** computed tomography and bronchoscopy findings supported tracheal involvement in ulcerative colitis;pathology examination demonstrated an unusual eosinophilrich inflammatory pattern,and together with clinical data,a nonasthmatic eosinophilic bronchitis diagnosis was *** recovery was observed within days of mesalazine *** Mesalazine-induced eosinophilic respiratory disorders have been previously reported,generally involving the lung *** the best of our knowledge,this is the first report of mesalamine-induced eosinophilic involvement in the upper airway.

关键词： Mesalamine Ulcerative colitis Hemoptysis Bronchitis Drug-related side effects Case report

A rare case of renal hydatidosis in a child with congenital solitary kidney

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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 671-672页

作者： Livius Tirnea Radu Minciu tudor Rares Olariu Victor Dumitrascu Adriana maria Neghina Raul Neghina Victor Babes University of Medicine and Pharmacy 2 Eftimie Murgu Sq 300041 TimisoaraRomania Private Practice 5 Vasile Lucaciu Str. 300051 TimisoaraRomania

Hydatid cyst of a solitary congenital kidney is a rare entity because of the small percentage of cases with renal hvdatidosis and the reduced number of cases with this renal *** report a case presenting this extremely rare combination and having a favorable *** diagnosis was confirmed based on an association of iniagistic techniques and positive *** case was managed using a minimal invasive surgical technique(PAIR) that reduced the operative ***,an antihelminthic agent[albendazole) was *** our knowledge,this is the first case with such comorbidity and treated through percutaneous approach.

关键词： Hydatid disease Cystic echinococcosis Renal cyst Congenital solitary kidney Child

Did the severe acute respiratory syndrome-coronavirus 2 pandemic cause an endemic Clostridium difficile infection?

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World Journal of Clinical Cases 2021年第33期9卷 10180-10188页

作者： Camelia Cojocariu Irina Girleanu Anca Trifan Andrei Olteanu Cristina maria Muzica Laura Huiban Stefan Chiriac Ana maria Singeap tudor Cuciureanu Catalin Sfarti Carol Stanciu Department of Gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”University HospitalInstitute of Gastroenterology and HepatologyIasi 700115Romania

BACKGROUND Clostridium difficile infection(CDI)has increased in prevalence during the last *** coronavirus disease 2019(COVID-19)pandemic has negatively influenced patient *** majority of the severe acute respiratory syndrome-coronavirus 2(SARS-CoV-2)-infected patients received antibiotics during *** To analyze the factors that influenced CDI development after SARS-CoV-2 *** Between March 2020 to December 2020,we performed a prospective observational study including 447 patients diagnosed with CDI who were admitted to our tertiary referral university *** diagnosis of CDI was based on the presence of diarrhea(≥3 watery stools within 24 h)associated with Clostridium difficile toxins A or *** excluded patients with other etiology of acute *** Among the total 447(12.5%)patients with CDI,most were male(54.3%)and mean age was 59.7±10.8 ***-six(17.0%)had history of COVID-19,most being elderly(COVID-19:62.6±14.6 years vs non-COVID-19:56.8±17.6 years,P=0.007),with history of alcohol consumption(43.4%vs 29.4%,P=0.017),previous hospitalizations(81.6%vs 54.9%,P<0.001)and antibiotic treatments(60.5%vs 35.5%,P<0.001),requiring higher doses of vancomycin and prone to recurrent disease(25.0%vs 13.1%,P=0.011).Age over 60 years[odds ratio(OR):2.591,95%confidence interval(CI):1.452-4.624,P=0.001],urban residence(OR:2.330,95%CI:1.286-4.221,P=0.005),previous antibiotic treatments(OR:1.909,95%CI:1.083-3.365,P=0.025),previous hospitalizations(OR:2.509,95%CI:1.263-4.986,P=0.009)and alcohol consumption(OR:2.550,95%CI:1.459-4.459,P=0.001)were risk factors of CDI in *** CDI risk is unrelated to history of SARS-CoV-2 ***,previous COVID-19 may necessitate higher doses of vancomycin for CDI.

关键词： COVID-19 infection Clostridium difficile infection Risk factors Antibiotic use Pandemic Recurrence

Ulcerated intussuscepted jejunal lipoma-uncommon cause of obscure gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3765-3771页

作者： tudor Cuciureanu Laura Huiban Stefan Chiriac Ana-maria Singeap Mihai Danciu Florin Mihai Carol Stanciu Anca Trifan Nutu Vlad Department of Gastroenterology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of Pathology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of Radiology “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania Department of General Surgery “Grigore T.Popa”University of Medicine and Pharmacy“St.Spiridon”Emergency HospitalIasi 700115Romania

BACKGROUND Intestinal lipomas are rare benign gastrointestinal(GI)tumors,usually asymptomatic,but may become symptomatic as the result of some complications such as intussusception,intestinal obstruction,volvulus or *** can occur at any site along the entire GI tract,more frequent in colon and rarely in small *** patient reported here is a very rare case of jejunal lipoma,ulcerated and intussuscepted,diagnosed in an adult investigated for a chronic iron deficiency anemia(IDA),and successfully managed by segmental jejunal *** SUMMARY A 63-year-old male was referred to“***”Hospital,Institute of Gastroenterology and Hepatology,Iasi,to investigate an obscure GI bleeding with an *** upper GI endoscopy and colonoscopy were performed,excluding potentially bleeding lesions,videocapsule endoscopy was then carried out,revealing fresh blood and a protruding lesion in proximal jejunum,findings confirmed by a single-balloon *** biopsies were taken from the lesion,but histological results were ***,contrast-enhanced computed tomography was performed showing jejunal polypoid mass with homogenous fat density,suggestive for lipoma.A week later a laparotomy was performed revealing the intussuscepted jejunal segment which was resected enbloc,and sent for further histopathologic *** patient made an uneventful recovery and was discharged seven days later,and at six months follow-up he had no complains and his hemoglobin returned to normal *** Lipomas are very rarely located in the jejunum,usually asymptomatic,but they may lead to complications such as intussusception and *** resection remains the treatment of choice.

关键词： Lipoma Intussusception Computed tomography Video capsule endoscopy Gastrointestinal bleeding Case report

Role of ammonia in predicting the outcome of patients with acuteon- chronic liver failure

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World Journal of Clinical Cases 2021年第3期9卷 552-564页

作者： Stefan Chiriac Carol Stanciu Camelia Cojocariu Ana-maria Singeap Catalin Sfarti tudor Cuciureanu Irina Girleanu Razvan Alexandru Igna Anca Trifan Department of Gastroenterology “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Institute of Gastroenterology and Hepatology "St.Spiridon"Emergency HospitalIasi 700111Romania Intensive Care “Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania

BACKGROUND High venous ammonia(VA)values have been proven to be a part of the mechanism of hepatic encephalopathy in patients with liver cirrhosis(LC)as well as acute ***,VA has been associated with poor prognosis and high mortality in these clinical ***,the role of ammonia in acuteon-chronic liver failure(ACLF)has not yet been clearly *** To assess the role of VA in predicting the outcome of cirrhotic patients with ACLF in a tertiary care *** We performed a retrospective observational study including consecutive patients with LC hospitalized for acute non-elective indications such as ascites,hepatic encephalopathy(HE),upper gastrointestinal bleeding,or bacterial infections that fulfilled the Asian Pacific Association for the Study of the Liver(APASL)criteria for *** study was conducted in“***”University Hospital,Iasi,Romania,a tertiary care center,between January 2017 and January *** APASL ACLF Research Consortium(AARC)score was calculated and ACLF grade was established ***-haven classification was used for *** analysis was performed using IBM SPSS version *** Four hundred and forty-six patients were included,aged 59(50-65)years,57.4%***-Pugh,model for end-stage liver disease(MELD)and AARC scores were 11(10-12),19.13±6.79,and 7(6-8),respectively.66.4%had ACLF grade I,31.2%ACLF grade II,and 2.5%ACLF grade *** was diagnosed in 83.9%,34%grade I,37.2%grade II,23.5%grade III,and 5.3%grade *** mortality was 7.8%.VA was 103(78-148)μmol/*** operating characteristic analysis showed good accuracy for the prediction of in-hospital mortality for the AARC score[Area under the curve(AUC)=0.886],MELD score(AUC=0.816),VA(AUC=0.812)and a fair accuracy for the Child-Pugh score(AUC=0.799).Subsequently,a cut-off value for the prediction of mortality was identified for VA(152.5μmol/L,sensitivity=0.706,1-specificity=0.190).Univariate analysis found acute kidney in

关键词： Venous ammonia Hepatic encephalopathy Acute-on-chronic liver failure Asian Pacific Association for the Study of the Liver Acute-on-chronic Liver Failure Research Consortium score Cirrhosis Mortality

Extracellular vesicles small RNA clusters:hit the nail on the head of liver cancer detection

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 100-102页

作者： Artur Słomka Bingduo Wang tudor Mocan maria González-Carmona Christian P.Strassburg Veronika Lukacs-Kornek Miroslaw T.Kornek Department of Pathophysiology Nicolaus Copernicus University in ToruńLudwik Rydygier Collegium MedicumBydgoszczPoland Department of Internal Medicine I University Hospital of the Rheinische Friedrich-Wilhelms-UniversityBonnGermany Octavian Fodor Institute for Gastroenterology and Hepatology Iuliu HaţieganuUniversity of Medicine and PharmacyCluj-NapocaRomania Institute of Experimental Immunology University Hospital of the Rheinische Friedrich-Wilhelms-UniversityBonnGermany

There is a very urgent need and clinical demand of robust biomarkers in cancer screening,especially in early hepatocellular carcinoma(HCC)surveillance as outlined by various professional international associations as the European Association for the study of the Liver(EASL),or the Asian Pacific Association for the Study of the Liver(APASL)and national professional organisations as the American Association for the Study of Liver Diseases(AASLD),besides *** data on primarily HCC is still depicting this cancer entity as the sixth most frequently diagnosed cancer,with over 900,000 new cases and over 830,000 deaths worldwide(1).This type of cancer,therefore,remains at the forefront of malignant ***,every element of patient management,including early diagnosis and prognosis of treatment response and survival,is a challenge.

关键词： Liver diagnosis clinical

Novel approaches in search for biomarkers of cholangiocarcinoma

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World Journal of Gastroenterology 2022年第15期28卷 1508-1525页

作者： Lavinia-Patricia Mocan maria Ilieș Carmen Stanca Melincovici Mihaela Spârchez RareșCrăciun Iuliana Nenu Adelina Horhat Cristian Tefas Zeno Spârchez Cristina Adela Iuga tudor Mocan Carmen Mihaela Mihu Department of Histology Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Proteomics and Metabolomics MedFUTURE Research Center for Advanced Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400349Romania ^(nd)Pediatrics Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania ^(rd)Medical Department Faculty of Medicine"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania Department of Gastroenterology "Prof.dr.Octavian Fodor"Institute for Gastroenterology and HepatologyCluj-Napoca 400162Romania Department of Pharmaceutical Analysis Faculty of Pharmacy"Iuliu Hațieganu"University of Medicine and PharmacyCluj-Napoca 400012Romania

Cholangiocarcinoma(CCA)arises from the ductular epithelium of the biliary tree,either within the liver(intrahepatic CCA)or more commonly from the extrahepatic bile ducts(extrahepatic CCA).This disease has a poor prognosis and a growing worldwide *** poor outcomes of CCA are partially explained by the fact that a final diagnosis is challenging,especially the differential diagnosis between hepatocellular carcinoma and intrahepatic CCA,or distal CCA and pancreatic head *** patients present with an advanced disease,unresectable disease,and there is a lack in non-surgical therapeutic *** least,there is an acute lack of prognostic biomarkers which further complicates disease ***,there is a dire need to find alternative diagnostic and follow-up pathways that can lead to an accurate result,either singlehandedly or combined with other *** the"-omics"era,this goal can be attained by various means,as it has been successfully demonstrated in other primary *** variants can reach a biomarker status ranging from circulating nucleic acids to proteins,metabolites,extracellular vesicles,and ultimately circulating tumor ***,given the relatively heterogeneous data,extracting clinical meaning from the inconsequential noise might become a tall *** current review aims to navigate the nascent waters of the non-invasive approach to CCA and provide an evidence-based input to aid clinical decisions and provide grounds for future research.

关键词： Cholangiocarcinoma Biomarker Proteomics Metabolomics Extracellular vesicles Circulating nucleic acids

The COVID-19 Pandemic’s Consequences on Medical Students’ Sleep Patterns and Technology Addiction

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Journal of Biosciences and Medicines 2022年第11期10卷 214-225页

作者： tudor Cojocaru Giulia-Mihaela Pinzariu Andrei Ion Hurjui Ruxandra maria Hurjui Roxana Mihaela Barbu Faculty of Medicine “Grigore T. Popa” University of Medicine and Pharmacy Iasi Romania Department of Morpho-Functional Science II Faculty of Medicine “Grigore T. Popa” University of Medicine and Pharmacy Iasi Romania

Introduction: Sleep disorders are an important public health problem. In the case of young people, and especially students, due to both academic demands and social life, many situations can lead to sleep disturbances. Aim: To evaluate the quality of sleep in medical students and its relationships with technology addiction. Background: Current research indicates that the technology usage by the university students determined an impaired sleep quality and a shortened sleep duration. Method: One hundred eleven second-year students attending medical education were included in the study. Its dependent variable was low sleep quality and independent variables were behavioral factors, smartphone addiction, computer usage, watching TV and other questioned features. A sleep questionnaire to assess the sleep quality in medical students was provided to medical students. This study was conducted in the University of Medicine and Pharmacy of Iasi, Romania. Results: The majority of medical students had shorter, irregular sleep duration and consumed energizing and stimulating drinks. Conclusions: In COVID-19 pandemic, the students’ tech addiction associated with the behavioral factors was found as risk factors for poor sleep quality.

关键词： Student Sleep Technology Addiction COVID-19 Questionnaire Electronic Devices

Designing a High-Performance Deep Learning Theoretical Model for Biomedical Image Segmentation by Using Key Elements of the Latest U-Net-Based Architectures

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Journal of Computer and Communications 2021年第7期9卷 8-20页

作者： Andreea Roxana Luca tudor Florin Ursuleanu Liliana Gheorghe Roxana Grigorovici Stefan Iancu maria Hlusneac Cristina Preda Alexandru Grigorovici Faculty of General Medicine “Grigore T. Popa” University of Medicine and Pharmacy Iasi Romania Departament Obstetrics and Gynecology Integrated Ambulatory of Hospital “Sf. Spiridon” Iasi Romania Department of Surgery VI “Sf. Spiridon” Hospital Iasi Romania Iasi Departament of Surgery I Regional Institute of Oncology Iasi Romania Department of Radiology “Sf. Spiridon” Hospital Iasi Romania Department of Endocrinology “Sf. Spiridon” Hospital Iasi Romania

Deep learning (DL) has experienced an exponential development in recent years, with major impact in many medical fields, especially in the field of medical image and, respectively, as a specific task, in the segmentation of the medical image. We aim to create a computer assisted diagnostic method, optimized by the use of deep learning (DL) and validated by a randomized controlled clinical trial, is a highly automated tool for diagnosing and staging precancerous and cervical cancer and thyroid cancers. We aim to design a high-performance deep learning model, combined from convolutional neural network (U-Net)-based architectures, for segmentation of the medical image that is independent of the type of organs/tissues, dimensions or type of image (2D/3D) and to validate the DL model in a randomized, controlled clinical trial. We used as a methodology primarily the analysis of U-Net-based architectures to identify the key elements that we considered important in the design and optimization of the combined DL model, from the U-Net-based architectures, imagined by us. Secondly, we will validate the performance of the DL model through a randomized controlled clinical trial. The DL model designed by us will be a highly automated tool for diagnosing and staging precancers and cervical cancer and thyroid cancers. The combined model we designed takes into account the key features of each of the architectures Overcomplete Convolutional Network Kite-Net (Kite-Net), Attention gate mechanism is an improvement added on convolutional network architecture for fast and precise segmentation of images (Attention U-Net), Harmony Densely Connected Network-Medical image Segmentation (HarDNet-MSEG). In this regard, we will create a comprehensive computer assisted diagnostic methodology validated by a randomized controlled clinical trial. The model will be a highly automated tool for diagnosing and staging precancers and cervical cancer and thyroid cancers. This would help drastically minimiz

关键词： Combined Model of U-Net-Based Architectures Medical Image Segmentation 2D/3D/CT/RMN Images