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The role of defects association in structural and transport properties of the Ce_(1-x)(Nd_(0.74)Tm_(0.26))_xO_(2-x/2) system

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Journal of Energy Chemistry 2021年第9期30卷 494-502页

作者： Cristina Artini Sabrina Presto Massimo Viviani Sara Massardo maria maddalena carnasciali Lara Gigli Marcella Pani DCCI Department of Chemistry and Industrial ChemistryUniversity of GenovaVia Dodecaneso 3116146 GenovaItaly Institute of Condensed Matter Chemistry and Technologies for Energy National Research CouncilCNR-ICMATEVia De Marini 616149 GenovaItaly Institute of Condensed Matter Chemistry and Technologies for Energy National Research CouncilCNR-ICMATEc/o DICCA-UNIGEVia all’Opera Pia 1516145 GenovaItaly INSTM Genova Research UnitVia Dodecaneso 3116146 GenovaItaly Elettra-Sincrotrone Trieste S.C.p.A. ss 14km 163.534149 BasovizzaTriesteItaly CNR-SPIN Genova Corso Perrone 2416152 GenovaItaly

An experimental investigation of the crystallographic,Raman and transport properties of the Ce_(1-x)(Nd_(0.74)Tm_(0.26))_xO_(2-x/2)(0.1≤x≤0.6) doped ceria system was performed with the aim of setting out correlations between structural features and ionic conductivity of the *** chosen composition ensures that the average size of the Nd^(3+) and Tm^(3+) doping ions coincides with the one of Sm^(3+);even so,the studied system presents larger cell parameters and a wider compositional extent of the CeO_(2)-based solid solution than Sm-doped ***,the occurrence of two different activation energies to ionic conduction below and above ~750 K determines the existence of two distinct conduction *** described experimental results agree with the formation below the threshold temperature of1 V_O2 Tm'_(Ce) trimers,which promote the incorporation of Nd'_(Ce) isolated defects into the CeO_(2)-based solid *** the high temperature range the dissociation of trimers induces the appearance of a lower activation energy;the extrapolation of its value at infinite dilution provides a result in good accordance with the expected binding energy of 1 V_ORE'_(Ce) dimers,pointing at their stability even in the high temperature conduction regime.

关键词： Solid oxide fuel cells RE-doped ceria High resolution X-ray powder diffraction Rietveld refinement μ-Raman spectroscopy Impedance spectroscopy

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Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis

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World Journal of Gastroenterology 2008年第43期14卷 6601-6615页

作者： Francesco Feo maddalena Frau Rosa maria Pascale Department of Biomedical Sciences Division of Experimental Pathology and OntologyUniversity of SassariSassari 07100Italy

Studies on rodents and humans demonstrate an inherited predisposition to hepatocellular carcinoma （HCC）. Analysis of the molecular alterations involved in the acquisition of a phenotype resistant or susceptible to hepatocarcinogenesis showed a deregulation of G1 and S phases in HCC of genetically susceptible F344 rats and a G1-S block in lesions of resistant Brown norway （BN） rats. Unrestrained extracellular signal-regulated kinase （ERK） activity linked to proteasomal degradation of dual-specificity phosphatase 1 （DUSP1）, a specific ERK inhibitor, by the CKS1-SKP2 ubiquitin ligase complex occurs in more aggressive HCC of F344 rats and humans. This mechanism is less active in HCC of BN rats and human HCC with better prognosis. Upregulation of iNos cross-talk with IKK/NF-KB and RAS/ERK pathways occurs in rodent liver lesions at higher levels in the most aggressive models represented by HCC of F344 rats and c-Myc-TGF-α transgenic mice. iNOS, IKK/NF-κB, and RAS/ERK upregulation is highest in human HCC with a poorer prognosis and positively correlates with tumor proliferation, genomic instability and microvascularization, and negatively with apoptosis. Thus, cell cycle regulation and the activity of signal transduction pathways seem to be modulated by HCC modifier genes, and differences in their efficiency influence the susceptibility to hepatocarcinogenesis and probably the prognosis of human HCC.

关键词： Hepatocarcinogenesis Genetic predisposition Polygenic disease, Redifferentiation Signal transduction pathways Cell cycle Cell proliferation Apoptosis Proteasomal degradation

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Assay of ghrelin concentration in infant formulas and breast milk

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World Journal of Gastroenterology 2011年第15期17卷 1971-1975页

作者： Francesco Savino Elisa Petrucci maria maddalena Lupica Giuliana Eva Nanni Roberto Oggero Department of Pediatrics "Regina Margherita" Children's Hospital Piazza Polonia 94-10126 Turin Italy

AIM: To test if total ghrelin is present in infant formulas. METHODS: Using a radioimmunoassay, we measured total ghrelin concentrations in 19 samples of commercial infant formulas and in 20 samples of human milk. We also determined ghrelin concentration in the serum of infants and lactating mothers. RESULTS: Ghrelin concentrations were significantly higher in artificial milk (2007.1 ± 1725.36 pg/mL) than in human milk (828.17 ± 323.32 pg/mL) (P = 0.005). The mean ghrelin concentration in infant serum (n = 56) was 1115.86 ± 42.89 pg/mL, and was significantly higher (P = 0.023) in formula-fed infants (1247.93 ± 328.07 pg/mL) than in breast-fed infants (1045.7 ± 263.38 pg/mL). The mean serum ghrelin concentration (mean ± SD) in lactating mothers (n = 20) was 1319.18 ± 140.18 pg/mL. CONCLUSION: This study provides evidence that total ghrelin is present in infant formulas. This findingraises diverse questions regarding the uptake, absorption and metabolic effects of this hormone.

关键词： Breast feeding Ghrelin Human milk Infants Infant formulas

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Hepatitis C virus micro-elimination:Where do we stand?

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World Journal of Gastroenterology 2021年第16期27卷 1728-1737页

作者： Alessandra Mangia Rosa Cotugno Giovanna Cocomazzi maria maddalena Squillante Valeria Piazzolla Liver Unit Department of Medical SciencesIRCCS Casa Sollievo della SofferenzaSan Giovanni Rotondo 71013FgItaly

Hepatitis C virus (HCV) elimination by 2030, using direct-acting antiviraltreatments, has been promoted by the World Health Organization. Thisachievement is not attainable, however, particularly after the 2020 pandemic ofthe coronavirus disease 2019. Consequently, the more realistic objective ofeliminating HCV from population segments for which targeted strategies ofprevention and treatment are easily attained has been promoted in Europe, as avalid alternative. The underlying idea is that micro-elimination will ultimatelylead to macro-elimination. The micro-elimination strategy may target differentspecific populations and at-risk groups. Different settings, including prisons andhospitals, have also been identified as micro-elimination scenarios. In addition,dedicated micro-elimination strategies have been designed that are tailored at thegeographical level according to HCV epidemiology and individual country’sincome. The main elements of a valid and successful micro-elimination project arereliable epidemiological data and active involvement of all the *** involvement represents another essential component for a successfulprogram.

关键词： Hepatitis C virus antibodies Hepatitis C virus elimination Hepatitis C virus epidemiology Hepatitis C virus RNA Hepatitis C virus diagnosis Hepatitis C virus infection

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ABCB1 and ABCB19 auxin transporters have synergistic effects on early and late Arabidopsis anther development

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Journal of Integrative Plant Biology 2015年第12期57卷 1089-1098页

作者： Valentina Cecchetti Patrizia Brunetti Nadia Napoli Laura Fattorini maria maddalena Altamura Paolo Costantino Maura Cardarelli IBPM-CNR Institute of Molecular Biology and Pathology National Research Council Sapienza University of Rome Department of Biology and Biotechnology Sapienza University of Rome Department of Environmental Biology Sapienza University of Rome

Arabidopsis abcbl abcb19 double mutants defective in the auxin transporters ABCB1/PGP1 and ABCB19/PGP19 are altered in stamen elongation, anther dehiscence and pollen maturation. To assess the contribution of these transporters to stamen development we performed phenotypic, histological analyses, and in situ hybridizations on abcbl and abcbl9 single mutant flowers. We found that pollen maturation and anther dehiscence are precocious in the abcbl but not in the abcb19 mutant. Accordingly, endothecium ligniflcation is altered only in abcbl anthers. Both abcbl and abcb1 abcb19 stamens also show altered early development, with asynchronous anther Iocules and a multilayer tapetum. DAPI staining showed that the timing of meiosis is asynchronous in abcbl abcb19 anther Iocules, while only a small percentage of pollen grains are non- viable according to Alexander＇s staining. In agreement, TAM （TARDY ASYNCHRONOUS MEIOSIS）, as well as BAM2 （BARELY ANY MERISTEM）involved in tapetal cell development--areoverexpressed in abcbl abcb19 young flower buds. Corre- spondingly, ABCB1 and ABCB19 mRNA localization supports the observed phenotypes of abcbl and abcbl abcb19 mutant anthers. In conclusion, we provide evidence that auxin transport plays a significant role both in early and late stamen development： ABCB1 plays a major role during anther development, while ABCB19 has a synergistic role.

关键词： Anther development Arabidopsis auxin transport endothecium lignification tapetum differentiation

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Helicobacter pylori infection in bleeding peptic ulcer patients after non-steroidal antiinflammatory drug consumption

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World Journal of Gastroenterology 2011年第40期17卷 4509-4516页

作者： Francesco Manguso Elisabetta Riccio Germana de Nucci maria Luisa Aiezza Gerardino Amato Linda Degl'Innocenti maria maddalena Piccirillo Gianfranco De Dominicis Tara Santoro Elena Trimarco Antonio Balzano Complex Operating Unit of Gastroenterology AORN A Cardarelli 80131 Napoli Italy Complex Operating Unit of Pharmacy AORN A Cardarelli 80131 Napoli Italy Complex Operating Unit of Microbiology AORN A Cardarelli 80131 Napoli Italy Complex Operating Unit of Pathology AORN A Cardarelli 80131 Napoli Italy

AIM： TO establish the prevalence of He/icobacterpy/on （H. pylori） infection in patients with a bleeding peptic ulcer after consumption of non-steroidal antiinflammatory drugs （NSAIDs）.METHODS： A very early upper endoscopy was performed to find the source of upper gastrointestinal bleeding and to take biopsy specimens for analysis of H. pylori infection by the rapid urease （CLO） test, his- tological examination, and bacterial culture. TgG anti- CagA were also sought. The gold standard for identifying H. pylori infection was positive culture of biopsy specimens or contemporary positivity of the CLO test and the presence of H. pylori on tissue ***： Eighty patients, 61 males （76.3%）, mean age 61.2 ~ 15.9 years, were consecutively enrolled. Forty-seven （58.8%） patients occasionally consumed NSAIDs, while 33 （41.3%） were on chronic treatment with low-dose aspirin （LD ASA）. Forty-four （55.0%） patients were considered infected by H. pylori. The infection rate was not different between patients who occasionally or chronically consumed NSAIDs. The culture of biopsy specimens had a sensitivity of 86.4% and a specificity of 100%; corresponding figures for histological analysis were 65.9% and 77.8%, for the CLO test were 68.2% and 75%, for the combined use of histology and the CLO test were 56.8% and 100%, and for IgG anti-CagA were 90% and 98%. The high- est accuracy （92.5%） was obtained with the culture of biopsy ***： Patients with a bleeding peptic ulcer after NSAID/LD ASA consumption frequently have H. pylori infection. Biopsy specimen culture after an early upper gastrointestinal tract endoscopy seems the most efficient test to detect this infection.

关键词： Helicobacter pylori Helicobacter pylori in-fection Low-dose aspirin Non-steroidal antiinflamma-tory drugs Peptic ulcer hemorrhage Endoscopy

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Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum

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World Journal of Gastroenterology 2006年第24期12卷 3933-3935页

作者： maddalena Zippi maria Chiara Colaiacomo Adriana Marcheggiano Roberta Pica Paolo Paoluzi Giancarlo Iaiani Renzo Caprilli Francesca Maccioni Department of Clinical Sciences GI Unit Umberto Ⅰ Viale del Policlinico 15500161RomeItaly Department of Radiological Sciences Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly Department of Infectious Diseases Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly

Although the association between inflammatory bowel disease and gastrointestinal infections has been suggested, the mechanisms involved in the pathogenesis of Crohn＇s disease （CD） are still undetermined. We report the case of a man, who presented with mesenteric adenitis initially due to a Yersinia pseudotubercolosis infection, who was later diagnosed with Crohn＇s disease. This case is in keeping with recent evidence in the literature which suggests that CD is a disease linked to abnormal immune responses to enteric bacteria in genetically susceptible individuals.

关键词： Yersinia pseudotubercolosis Crohn's disease Ileitis

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Genetic analysis of Italian patients with congenital tufting enteropathy

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World Journal of Pediatrics 2016年第2期12卷 219-224页

作者： maria d'Apolito Daniela Pisanelli Flavio Faletra Ida Giardino maddalena Gigante Massimo Pettoello-Mantovani Olivier Goulet Paolo Gasparini Angelo Campanozzi Unit of Pediatrics Department of Medical and Surgical SciencesUniversity of FoggiaItaly Institute for Maternal and Child Health-IRCCS"BurloGarofolo" TriesteItaly Laboratory Medicine Department of Clinical and Experimental MedicineUniversity of FoggiaFoggiaItaly Department of Medical and Surgical Sciences University of FoggiaFoggiaItaly Department of Pediatric Gastroenterology-Hepatology and Nutrition and Reference Center for Rare Digestive Disease Hopital Necker-EnfantsMaladesParisFrance

Background:Congenital tufting enteropathy(CTE),an inherited autosomal recessive rare disease,is a severe diarrhea of infancy which is clinically characterized by absence of infl ammation and presence of intestinal villous *** in the EpCAM gene were identified to cause *** cases of syndromic tufting enteropathy harboring the SPINT2(19q13.2)mutation were ***:Four CTE Italian patients were clinically and immunohistochemically *** DNA sequencing of EpCAM and SPINT2 genes was ***:All patients were of Italian *** different mutations were detected(***219Metfs*15,Tyr186Phefs*6 and ***146Asn)in the EpCAM gene;one of them is novel(***146Asn).Two patients(P1 and P2)showed compound heterozygosity revealing two mutations in separate alleles.A third patient(P3)was heterozygous for only one novel EpCAM missense mutation(***146Asn).In a syndromic patient(P4),no deleterious EpCAM mutation was *** SPINT2 mutational analysis was performed.P4 showed a homozygous SPINT2 mutation(p.Y163C).No SPINT2 mutation was found in ***7 was also evaluated as a candidate gene by mutational screening in P3 but no mutation was identifi ***:This study presented a molecular characterization of CTE Italian patients,and identified three mutations in the EpCAM gene and one in the SPINT2 *** of EpCAM mutations was novel,therefore increasing the mutational spectrum of allelic variants of the EpCAM *** analysis of the SPINT2 gene also allowed us to identify a SPINT2 substitution mutation(c.488A>G)recently found to be associated with syndromic CTE subjects.

关键词： diarrhea gastroenterology gene mutation

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Is positivity for hepatitis C virus antibody predictive of lower risk of death in COVID-19 patients with cirrhosis?

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World Journal of Clinical Cases 2020年第22期8卷 5831-5834页

作者： Alessandra Mangia Giovanni Cenderello Gabriella Verucchi Alessia Ciancio Andrea Fontana Valeria Piazzolla Nicola Minerva maria maddalena Squillante Massimiliano Copetti Liver Unit Department of Medical SciencesFondazione IRCCS“Casa Sollievo della Sofferenza”San Giovanni Rotondo 71013Italy Department of Infectious Disease ASL1 ImperieseSanremo 18038Italy Department of Infectious Disease University of BolognaBologna 40138Italy Department of Gastroenterology University of TurinTorino 10156Italy Department of Biostatistics Fondazione IRCCS“Casa Sollievo della Sofferenza”San Giovanni Rotondo 71013Italy Department of Internal Medicine Ospedale BonomoAndria 76123Italy

Liver injury has been reported in coronavirus disease 2019(COVID-19)cases but the impact of pre-existing liver damage and related etiology have not been completely *** research interests include the potential reciprocal influence of COVID-19 and pre-existing liver damage related to hepatitis C virus(HCV)infection,in *** this end,we have evaluated three cohorts of patients admitted at three Italian hospitals during the coronavirus pandemic;these included 332 patients with COVID-19 and 1527 patients with HCV who were from established real-world antiviral treatment study cohorts(sofosbuvir/velpatasvir),with either liver disease(various severities;n=1319)or cirrhosis(n=208).Among the COVID-19 patients,10 had cirrhosis(3%),including 7 of metabolic origin and 3 of viral *** among the COVID-19 patients was 27.1%,with 70%of those with cirrhosis of metabolic etiology having ***,older age,low white blood cell count and lymphocyte count being identified as risk predictors of death[odds ratio(OR)=13.7,95%confidence interval(CI):2.59-83.01,P=0.006;OR=1.05,95%CI:1.03-1.08,P=0.0001;OR=1.09,95%CI:1.36-1.16,P=0.001;OR=0.61,95%CI:0.39-0.93,P=0.023,respectively].In the two cohorts of HCV patients,COVID-19 diagnosis was made in 0.07%of those with liver disease and 1%of those with ***,the prevalence of HCV antibodies among COVID-19-infected patients was comparable to that currently reported for the general population in *** the COVID-19 patients,pre-existing metabolic cirrhosis appears to be associated with higher mortality,while HCV antibodies may be suggestive of“protection”against COVID-19.

关键词： Hepatitis C virus Hepatitis B virus Cirrhosis COVID-19 Sofosbuvir Velpatasvir

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Treatment of gastric cancer

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World Journal of Gastroenterology 2014年第7期20卷 1635-1649页

作者： Michele Orditura Gennaro Galizia Vincenzo Sforza Valentina Gambardella Alessio Fabozzi maria maddalena Laterza Francesca Andreozzi Jole Ventriglia Beatrice Savastano Andrea Mabilia Eva Lieto Fortunato Ciardiello Ferdinando De Vita Division of Medical Oncology Dipartimento di MedicinaClinica e Sperimentale ‘F. Magrassi-A. Lanzara’Seconda Università degli Studi di Napoli80131 NaplesItaly Divisione di Chirurgia Oncologia Dipartimento di Scienze AnestesiologicheChirurgiche e delle EmergenzeSeconda Università degli Studi di Napoli80131 NaplesItaly

The authors focused on the current surgical treatment of resectable gastric cancer, and significance of peri- and post-operative chemo or chemoradiation. Gastric cancer is the 4th most commonly diagnosed cancer and the second leading cause of cancer death worldwide. Surgery remains the only curative therapy, while perioperative and adjuvant chemotherapy, as well as chemoradiation, can improve outcome of resectable gastric cancer with extended lymph node dissection. More than half of radically resected gastric cancer patients relapse locally or with distant metastases, or receive the diagnosis of gastric cancer when tumor is disseminated; therefore, median survival rarely exceeds 12 mo, and 5-years survival is less than 10%. Cisplatin and fluoropyrimidine-based chemotherapy, with addition of trastuzumab in human epidermal growth factor receptor 2 positive patients, is the widely used treatment in stage IV patients fit for chemotherapy. Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance status

关键词： Gastric cancer Surgery Radiotherapy Adjuvant chemotherapy Palliative chemotherapy Chemoradiation

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