检索结果-南通市图书馆

Evaluation of participants' feedback after a simulation-based training in neonatal resuscitation using a realistic delivery room

引用

Open Journal of Pediatrics 2012年第4期2卷 281-287页

作者： Alejandro Avila-Alvarez Iria Gonzalez-Rivera Jose L.Fernandez-Trisac maria I.Taboada-Perianes Bruno Rodriguez-Gonzalez Alberto Centeno-Cortes maria diaz-gomez Teresa Rei-Serra Rita Jacome-Feijoo Unidade de Neonatoloxia Servizo de PediatriaComplexo Hospitalario Universitario A CorunaA CorunaSpain Unidade de Cuidados Intensivos Pediatricos Servizo de PediatriaComplexo Hospitalario Universitario A CorunaA CorunaSpain Servizo de Urxencias Hospital Arquitecto MarcideFerrolSpain Centro Tecnoloxico de Formacion Complexo Hospitalario Universitario de A CorunaA CorunaSpain Servizo de Xinecoloxia e Obstetricia Complexo Hospitalario Universitario de A CorunaA CorunaSpain

BACKGROUND: Low-frequency and high-risk situations, such as neonatal resuscitation, are the ideal targets for simulation-based learning. The aim of this paper is to present the structure of our internal neonatal resuscitation training program, using a realistic, simulated delivery room, and to present the participants' opinions about teamwork, emotional stress, and their subjective ability to face a resuscitation. METHODS: We administered a training course to 24 doctors and midwives. One of the simulation classrooms was modified to appear similar to a real delivery room. Four scenarios were conducted using a previously designed checklist of primary and secondary goals. Upon completion, all students participated in a debriefing session with the help of a video review. RESULTS: Students rated the achievement of their previously defined goals on a scale of 1 to 5. Grouping together the percentages of the highest ratings (Categories 4 and 5), 83.4% (20/24) of the students considered the course useful for acquiring clinical skills. For 87.5% (21/24) of the students, the scenarios simulated real clinical situations, the room properly simulated a real delivery room, and the course improved the students' ability to work in a team. For 66.6% (16/24) of the students, the course improved their stress in confronting neonatal resuscitation. Initially, only 33.3% (8/24) of the students considered themselves very capable or fully able to cope with a resuscitation. After the course, that percentage rose to 62.5% (15/24). CONCLUSIONS: The incorporation of simulation-based learning into neonatal resuscitation teaching programs, using realistic scenarios, is useful and offers the possibility of acquiring technical skills, but it also allows for the improvement of teamwork and the adoption of different roles and positive attitudes towards emotional stress.

关键词： Neonatal Resuscitation Simulation Training

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Activation of stress-response genes by retrograde signaling-mediated destabilization of nuclear importin IMPα-9 and its interactor TPR2

引用

Molecular Plant 2024年第6期17卷 884-899页

作者： Liping Zeng maria Fernanda gomez Mendez Jingzhe Guo Jishan Jiang Bailong Zhang Hao Chen Brandon Le Haiyan Ke Katayoon Dehesh Department of Botany and Plant Sciences Institute of Integrative Genome BiologyUniversity of CaliforniaRiversideRiversideCA 92521USA School of Medicine University of CaliforniaRiversideRiversideCA 92521USA

Stress-induced retrograde signal transmission from the plastids to the nucleus has long puzzled plant *** address this,we performed a suppressor screen of the ceh1 mutant,which contains elevated 2-C-methyl-d-erythritol-2,4-cyclopyrophosphate(MEcPP)levels,and identified the gain-of-function mutant impα-9,which shows reversed dwarfism and suppressed expression of stress-response genes in the ceh1 background despite heightened *** genetic and biochemical analyses established that the accumulation of MEcPP initiates an upsurge in Arabidopsis SKP1-like 1(ASK1)abundance,a pivotal component in the proteasome degradation *** increase in ASK1 prompts the degradation of IMPα-***,we uncovered a protein-protein interaction between IMPα-9 and TPR2,a transcriptional co-suppressor and found that a reduction in IMPα-9 levels coincides with a decrease in TPR2 ***,the interaction between IMPα-9 and TPR2 was disrupted in impα-9 mutants,highlighting the critical role of a single amino acid alteration in maintaining their *** of their interaction results in the reversal of MEcPP-associated *** immunoprecipitation coupled with sequencing analyses revealed that TPR2 binds globally to stress-response genes and suggested that IMPα-9 associates with the *** function together to suppress the expression of stress-response genes under normal conditions,but this suppression is alleviated in response to stress through the degradation of the suppressing *** biological relevance of our discoveries was validated under high light stress,marked by MEcPP accumulation,elevated ASK1 levels,IMPα-9 degredation,reduced TPR2 abundance,and subsequent activation of a network of stress-response *** summary,our study collectively unveils fresh insights into plant adaptive mechanisms,highlighting intricate interactions among retrograde signaling,the proteasome,and nuclear transport machinery.

关键词： plastidial retrograde signal MEcPP ASK1 impα-9 TPR2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

从美声唱法视角下对女高音咏叹调《严刑酷罚千般万种》的诠释性建议

从美声唱法视角下对女高音咏叹调《严刑酷罚千般万种》的诠释性建...

引用

作者： maria GUADALUPE SALAZAR gomez 成都大学

学位级别：硕士

选自沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart)的歌剧《后宫诱逃》(Die Entführung aus dem Serail)的咏叹调“Marten Aller Arten”,被认为是最具挑战性的女高音咏叹调之一。演唱这首咏叹调需要歌唱者具备较高的歌唱技... 详细信息

选自沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart)的歌剧《后宫诱逃》(Die Entführung aus dem Serail)的咏叹调“Marten Aller Arten”,被认为是最具挑战性的女高音咏叹调之一。演唱这首咏叹调需要歌唱者具备较高的歌唱技术,包含歌唱中气息的灵活性、音与音之间的过渡和衔接、可长时间保持发声与音准的气息强度。此外,还需要歌唱者拥有宽广的音域和能够随时转换音高的能力。现今大众仍普遍认同的观点是,戏剧性的声音是沉重的、强烈的、甚至阴暗的,这与敏捷、灵活与明亮的声音几乎是对立的。通常情况下,敏捷、清晰的声音会更多地与闹剧或喜剧作品联系在一起,而沉重、强烈的声音则更多地与戏剧联系在一起。本文中,笔者尝试证明这两种音色可以同时存在于一个曲目中,由抒情花腔女高音扮演的康斯坦斯这一角色正好可以证明笔者的观点。本文提出了一些可供参考的观点,以帮助读者从不同的技术角度了解女高音如何处理声区转换,以支持其在主要音域中以饱满的嗓音演唱歌曲,使声音放开,并实现咏叹调“Marten Aller Arten”所要求的戏剧性。同时,本文以意大利美声学派的原则为基础,介绍了该咏叹调的技术方法——其重点集中于四个声区:胸声区、弱混声区、强混声区和头声区。本文比较了意大利美声学派的一些歌唱方法和关于声区的不同技术的概念。尽管这些概念仍会引起混淆,但这一新的视角有助于帮助人们理解女高音声区的结构,并将其更清晰地带入实践当中。了解了这四个音区的工作原理,女高音歌唱家就能更自如地去演绎这首咏叹调,并将嗓音发挥到极致,帮助歌唱家们更深入地了解自己的“乐器”,加强声音本身的柔韧性、肌肉和嗓音的调节能力,这些都是演唱咏叹调“Marten Aller Arten”所需要的。

关键词： Marten Aller Arten 美声学派音区女高音

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease

引用

Asian Journal of Urology 2024年第2期11卷 208-220页

作者： Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid Rapoport Nirmish Singla Eric Barret Elena Poddubskaya maria Borodina Georg Salomon Juan gomez Rivas Dmitry Enikeev Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Young Academic Urologists EAUthe Netherlands Department of Urology James Buchanan Brady Urological InstituteThe Johns Hopkins University School of MedicineBaltimoreUSA Department of Urology Institut Mutualiste MontsourisParisFrance Sechenov University MoscowRussia Hertsen Moscow Oncology Research InstituteMoscowRussia Hertsen Moscow Oncology Research Institute MoscowRussia Martini Clinic University Medical Center Hamburg-EppendorfHamburgGermany Department of Urology Clinico San Carlos University HospitalMadridSpain Department of Urology Medical University of ViennaViennaAustria

Objective: To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this ***: We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary endpoints were oncologic outcomes. The secondary endpoints were complication rates and functional ***: In all studies, overall survival was better or at least comparable variable in the groups with CRP compared to no local treatment. The greatest benefit from CRP in 5-year overall survival in one study was 67.4% for CRP versus 22.5% for no local treatment. Cancer-specific survival (CSS) showed the same trend. Several authors found significant benefits from CSS in the CRP group: from 79% vs. 46% to 100% vs. 61%. CRP was a predictor of better CSS (hazard ratio 0.264, p=0.004). Positive surgical margin rates differed widely from 28.6% to 100.0%. Urinary continence in CRP versus RP for localized PCa was significantly lower (57.4% vs. 90.8%, p<0.0001). Severe incontinence occurred seldom (2.5%-18.6%). Total complication rates after CRP differed widely, from 7.0% to 43.6%. Rates of grades 1 and 2 events prevailed. Patients on ADT alone also showed a considerable number of complications varying from 5.9% to 57.7%.Conclusion: CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease.

关键词： Systematicreview Prostatecancer Oligometastatic Bone metastases Cytoreductive prostatectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

引用

Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto gomez-Carballa maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-Lopez Jose gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrogen storage in a rare-earth perovskite-type oxide La_(0.6)Sr_(0.4)Co_(0.2)Fe_(0.8)O_3 for battery applications

引用

Rare Metals 2018年第12期37卷 1003-1013页

作者： John Henao Oscar Sotelo Maura Casales-diaz Lorenzo Martinez-gomez CONACYT-CIATEQ A.C. Av. Manantiales 23-AParque Industrial Bernardo Quintana Instituto de Ciencias Fisicas (ICF) Universidad Nacional Autonoma de Mexico (UNAM)-Campus Morelos

Recently, rare-earth perovskite-type oxides with the general formula ABO(A rare earth element, B transition metal, O oxygen) are regarded as promising materials for Ni/oxide batteries due to their hydrogen storage ability. In the present study, the hydrogen storage properties of the rare-earth perovskite-type oxide LaSrCoFeOwere evaluated in alkaline solution and at various temperatures. The hydrogen storage properties were investigated electrochemically by applying galvanostatic charge/discharge currents. Electrochemical pressurecomposition-temperature isotherms were constructed using the Nernst equation. The exchange current density and proton hydrogen diffusion coefficient were calculated using linear polarization measurements and the potential-step method, respectively. Interestingly, the maximum hydrogen absorption capacity, re-calculated from the electrochemical capacity, is 1.72 wt% at 333 K and 6 mol·LKOH. In addition, the hysteresis value, calculated from pressure-composition-temperature isotherms, was429 J·molat 333 K,while the self-discharge rate was about 25% after 24-h storage at open circuit and at 333 K.

关键词： Hydrogen storage Rare earths Perovskites Ni/oxide batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

引用

World Journal of Gastroenterology 2014年第42期20卷 15632-15649页

作者： Julio Plaza-diaz Carolina gomez-Llorente Luis Fontana Angel Gil Department of Biochemistry and Molecular Biology Ⅱ School of Pharmacy and Institute of Nutrition and Food Technology "Jose Mataix" Biomedical Research Center University of Granada

The potential for the positive manipulation of the gut microbiome through the introduction of beneficial microbes, as also known as probiotics, is currently an active area of investigation. The FAO/WHO define probiotics as live microorganisms that confer a health benefit to the host when administered in adequate amounts. However, dead bacteria and bacterial molecular components may also exhibit probiotic properties. The results of clinical studies have demonstrated the clinical potential of probiotics in many pathologies, such as allergic diseases, diarrhea, inflammatory bowel disease and viral infection. Several mechanisms have been proposed to explain the beneficial effects of probiotics, most of which involve gene expression regulation in specific tissues, particularly the intestine and liver. Therefore, the modulation of gene expression mediated by probiotics is an important issue that warrants further investigation. In the present paper, we performed a systematic review of the probiotic-mediated modulation of gene expression that is associated with the immune system and inflammation. Between January 1990 to February 2014, PubMed was searched for articles that were published in English using the MeSH terms “probiotics' and 'gene expression' combined with “intestines', 'liver', 'enterocytes', 'antigen-presenting cells', 'dendritic cells', 'immune system', and 'inflammation'. Two hundred and five original articles matching these criteria were initially selected, although only those articles that included specific gene expression results (77) were later considered for this review and separated into three major topics: the regulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver. Particular strains of Bifidobacteria, Lactobacilli, Escherichia coli, Propionibacterium, Bacillus and Saccharomyces influence the gene expression of mucins, Toll-like receptors, caspases, nuclear factor-κ

关键词： Gene expression Immunity Immunotolerance Inflammation Microbiota Probiotics Gut Liver

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Correlating the global increase in type 1 diabetes incidence across age groups with national economic prosperity: A systematic review

引用

World Journal of Diabetes 2019年第12期10卷 560-580页

作者： Natalia gomez-Lopera Nicolas Pineda-Trujillo Paula Andrea diaz-Valencia Grupo Mapeo Genetico Departamento de PediatríaFacultad de MedicinaUniversidad de AntioquiaMedellín 050010470Colombia Epidemiology Group.School of Public Health.Universidad de Antioquia Medellín 050010470Colombia

BACKGROUND The global epidemiology of type 1 diabetes(T1D)is not yet well known,as no precise data are available from many countries.T1D is,however,characterized by an important variation in incidences among countries and a dramatic increase of these incidences during the last decades,predominantly in younger *** the United States and Europe,the increase has been associated with the gross domestic product(GDP)per *** our previous systematic review,geographical variation of incidence was correlated with socio-economic *** To investigate variation in the incidence of T1D in age categories and search to what extent these variations correlated with the GDP per *** A systematic review was performed to retrieve information about the global incidence of T1D among those younger than 14 years of *** study was carried out according to the PRISMA *** the analysis,the incidence was organized in the periods:1975-1999 and *** searched the incidence of T1D in the age-groups 0-4,5-9 and *** compared the incidences in countries for which information was available for the two *** obtained the GDP from the World *** analysed the relationship between the incidence of T1D with the GDP in countries reporting data at the national *** We retrieved information for 84 out of 194 countries around the *** found a wide geographic variation in the incidence of T1D and a worldwide increase during the two *** largest contribution to this increase was observed in the youngest group of children with T1D,with a relative increase of almost double when comparing the two periods(P value=2.5×e-5).Twenty-six countries had information on the incidence of T1D at the national level for the two *** was a positive correlation between GDP and the incidence of T1D in both periods(Spearman correlation=0.52 from 1975-1999 and Spearman correlation=0.53 from 2000-2017).CONCLUSION The incidence increase was

关键词： Type 1 diabetes Incidence Children Age categories Gross domestic product per capita

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-technical approach to the challenges of ecological architecture： Learning from Van der Laan

引用

Frontiers of Architectural Research 2016年第2期5卷 202-212页

作者： maria-Jesus Gonzalez-diaz Justo Garcia-Navarro Department of Agroforestry Engineering Construction Unit Universidad Politécnica de Madrid Madrid 28040 Spain

Up to now, ecology has a strong influence on the development of technical and instrumental aspects of architecture, such as renewable and efficient of resources and energy, COz emissions, air quality, water reuse, some social and economical aspects. These concepts define the physical keys and codes of the current ＇sustainable＇ architecture, normally instrumental but rarely and insufficiently theorised. But is not there another way of bringing us to nature？ We need a theoretical referent. This is where we place the Van der Laan＇s thoughts： he considers that art completes nature and he builds his theoretical discourse on it, trying to better understand many aspects of architecture. From a conceptual point of view, we find in his works sense of timelessness, universality, special attention on the ＇locus＇ and a strict sense of proportions and use of materials according to nature. Could these concepts complement our current sustainable architecture？ How did Laan apply the current codes of ecology in his architecture？ His work may help us to get a theoretical interpretation of nature and not only physical. This paper develops this idea through the comparison of thoughts and works of Laan with the current technical approach to ＇sustainable＇ architecture.

关键词： Nature Architecture Van-der-Laan Ecology Ethics Environment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease

引用

World Journal of Gastroenterology 2009年第22期15卷 2768-2777页

作者： Eduardo Vilar gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier diaz Elias Oscar Villa Jiménez maria del Rosario Abreu Vazquez Department of Hepatology National Institute of Gastroenterology Department of Pathology National Institute of Gastroenterology Department of Gastroenterology National Institute of Gastroenterology Deparment of Gastroenterology The"Calixto Garcia"Hospital Department of Biostatistics National Institute of Gastroenterology

AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic ***:We prospectively evaluated the survival of 172 cirrhotic *** model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards *** was applied to estimate 12-,52-and 104-wk *** model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation ***,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was *** proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,*** addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients.

关键词： Liver cirrhosis Prognosis Statistical models Prognostic factors Model for end-stage liver disease score Child-Pugh score Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：