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Acute Pancreatitis during SARS CoV 2 Infection

Open Journal of Gastroenterology 2023年第1期13卷 28-32页

作者： marie Louise Bassène marième poléle fall Alioune Badara fall Salamata Diallo Coumba Kouba Cissé Téné Sidibé Aï ssé Thioubou Mamadou Ngoné Gueye Hô pital Aristide le Dantec Avenue Pasteur Dakar Sénégal Hô pital de la Paix Ziguinchor Sénégal Hô pital Général Idrissa Pouye Dakar Sénégal

Introduction: Covid-19 is a systemic disease that can spread to all systems. Among the gastrointestinal manifestations, pancreatic involvement can have a major prognostic impact. We report 3 acute pancreatitis cases occurring during Covid-19, in Dakar. Case 1: 65-year-old woman who presented with intense atypical epigastric pain. Physical examination revealed obesity, high blood pressure and abdominal tenderness. Biological tests found increase CRP (134 mg/l) and lipasemia (312 UI/l). Abdominal CT scan showed findings of Balthazar grade C acute pancreatitis. RT-PCR for SARS CoV 2 RT-PCR was positive. The outcome was favorable. Case 2: 56-year-old woman patient with history of nephroangiosclerosis who presented with dyspnea, cough, fever and moderate epigastric pain. Physical examination revealed epigastric tenderness, high blood pressure, anuria. Biological testing, noted increase CRP (96 mg/l), lipasemia (793 UI/l), creatinine (227 mg/l) and urea (3.84 g/l). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Case 3: 27-year-old man who presented with physical asthenia, headache, and epigastric pain. Physical examination found epigastric tenderness. Elevated CRP level was of 102 mg/l and lipasemia level was of 427 UI/l (7N). Abdominal CT scan showed acute edematous pancreatitis findings. SARS CoV 2 RT PCR was positive. The outcome was favorable. Conclusion: Acute pancreatitis can occur during Covid-19 infection. However, the imputability to the Covid-19 disease necessitates to rule out the most common causes.

关键词： Acute Pancreatitis SARS CoV 2 Covid-19

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Indications and Results of Lower Gastrointestinal Endoscopy in a Regional Hospital Center in Senegal

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Open Journal of Gastroenterology 2023年第1期13卷 43-48页

作者： marième polèle fall marie Louise Basséne Salamata Diallo Mamadou Ngoné Gueye Cheikh Ahamadou Bamba Cissé Madoky Magatte Diop Daouda Dia Mouhamadou Mbengue Department of Gastroenterology and Hepatology Aristide Le Dantec Hospital Dakar Senegal Department of Gastroenterology and Hepatology General Hospital Idrrisa Pouye Dakar Senegal Department of Internal medecine Regional Hospital Center of Thiès Thiès Senegal

Introduction: Gastrointestinal endoscopy plays a crucial role in the management of gastrointestinal diseases. The aim of this study was to report the indications and results of lower digestive endoscopy in a hospital center in Senegal. Patients and methods: We conducted a descriptive retrospective study from September 1st, 2017, to September 30, 2018 at the gastrointestinal endoscopy unit of the regional hospital center of Thiès. All patients received for lower gastrointestinal endoscopy and whose reports were usable, were included. In the reports, we collected and analyzed sociodemographic data, indication and results of the endoscopic examination. Results: We included 250 patients. There were 140 men (sex ratio 1.27). The average age was 42 years [range 1 - 92 years]. There were 37 colonoscopies (14.8%), 51 rectosigmoidoscopies (20.4%) and 162 anorectoscopies (64.8%). The patients were from the region of Thiès in 82% of cases. In most cases, they were most often referred by general practitioners (22.8%) and surgeons (20.8%). The main indications were rectal bleeding (36.8%), hemorrhoidal disease (23.2%) and proctalgia (11.6%). Hemorrhoidal disease (63.6%), anal fistula (14%) and tumors (8.8%) were the most common pathologies. Conclusion: Admitted patients at the gastrointestinal endoscopy unit of the regional hospital center of Thiès have many indications as well as pathologies. Anal pathology is dominated by hemorrhoidal disease.

关键词： Lower Gastrointestinal Endoscopy Rectal Bleeding Hemorrhoidal Disease

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo le Tong Jianhong Dong Ziwei Fan mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAEI H.GHANDVAR E.JUMAEV S.KHATIR T.CUONG-le School of mechanical Engineering Babol Noshirvani University of Technology Department of mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Strength evolution and deformation behaviour of cemented paste backfill at early ages： Effect of curing stress, filling strategy and drainage

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International Journal of Mining Science and Technology 2016年第5期26卷 809-817页

作者： Ghirian Alireza fall Mamadou Department of Civil Engineering University of Ottawa 161 Louis Pasteur Ottawa K1N 6N5 ON Canada

In this study, a pressure cell apparatus is developed to investigate the early age evolution of the strength and deformation behaviour of cemented paste backfill(CPB) when subjected to various loading conditions under different curing scenarios. The different curing scenarios that are simulated include:(1)drained and undrained conditions,(2) different filling rates,(3) different filling sequences, and(4) different curing stresses. The findings show that drainage, curing stress, curing time and filling rate influence the mechanical and deformation behaviours of CPB materials. The coupled effects of consolidation, drainage and suction contribute to the strength development of drained CPB subjected to curing stress. On the other hand, particle rearrangement caused by the applied pressure and suction development due to self-desiccation plays a significant role in the strength gain of undrained CPB cured under ***, curing stress induces slightly faster rate of cement hydration, which can contribute to strength acquisition.

关键词： Cemented paste backfill Tailings Pore pressure Curing under stress Plug fill Cement

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Chemically induced changes in the geotechnical response of cementing paste backfill in shaking table test

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Journal of Rock mechanics and Geotechnical Engineering 2021年第3期13卷 513-528页

作者： Imad Alainachi Mamadou fall Department of Civil Engineering University of OttawaOttawaOntarioK1N 6N5Canada

Cemented paste backfill(CPB)is extensively used for underground mine support and/or tailings ***,CPB behavior under cyclic loadings might be affected by the chemistry of its porewater,which often contains sulphate *** today,no studies have addressed the effect of sulphate on the response of CPB to cyclic loadings by using shaking table *** study presents new findings of assessing the effect of the sulphate in the pore water of CPB on its geotechnical response to cyclic loading by using shaking *** mixtures were prepared(with and without sulphate),poured into a flexible laminar shear box,cured to 4 h,and then exposed to cyclic loading using one-dimensional(1D)shaking *** parameters(*** water pressure,settlement,lateral deformation,acceleration,electrical conductivity,effective stress,and liquefaction susceptibility)were monitored or determined before,during,and after *** results indicate that the sulphate-bearing CPB cured to 4 h can be prone to liquefaction under the studied ***,sulphate-free CPB samples are resistant to *** results are expected to contribute to a better understanding of the effect of water chemistry on the cyclic behavior of CPB,consequently enhancing the cost-effective design of CPB structures.

关键词： Cemented paste backfill(CPB) Liquefaction Shaking table Tailings Mine Sulphate

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A column study of the hydro-mechanical behavior of mature fine tailings under atmospheric drying

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International Journal of Mining Science and Technology 2017年第2期27卷 203-209页

作者： Anis Roshani Mamadou fall Kevin Kennedy Department of Civil Engineering University of OttawaOttawa KIN 6N5Canada

In this paper, the hydro-mechanical behavior and physical properties of mature fine tailings(MFT) under atmospheric drying are investigated through a column study. In the study, evaporation takes place in the development of suction in the upper parts of the column and increasing suction leads to higher strength in the tailings. After 5 days, the suction in the first lift is around 17 k Pa in the upper part of the *** a second lift is added, the first lift initially loses strength but over a 30 days' period, the strength is recovered to its prior value and suction in the second lift reaches 500 k Pa. The vane shear strength values show a substantial increase in the strength of the MFT after 30 days under atmospheric drying and drainage. The 90% strength found in the column exceeds the threshold(5 k Pa). The hydraulic-mechanical properties of the deposited tailings are closely coupled due to several mechanisms, such as evaporation,drainage, self-consolidation, suction and crack development. The findings of this study will provide a better understanding of the placement behavior of multiple lifts of MFT and thus contribute to reclamation design standards and reduce the use of dedicated disposal areas.

关键词： Tailings Oil sand Environment Drying Multi-lift deposition

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Swelling ability and behaviour of bentonite-based materials for deep repository engineered barrier systems:Influence of physical,chemical and thermal factors

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Journal of Rock mechanics and Geotechnical Engineering 2022年第3期14卷 689-702页

作者： Mohammed Alzamel Mamadou fall Sada Haruna Department of Civil Engineering University of OttawaOttawaOntarioK1N 6N5Canada

Compacted bentonite-sand(B/S)mixtures have been used as a barrier material in engineered barrier systems(EBSs)of deep geological repositories(DGR)to store nuclear *** study investigates the individual and combined effects of different chemical compositions of deep groundwaters(chemical factor)at potential repository sites in Canada(the Trenton and Guelph regions in Ontario),heat generated in DGRs(thermal factor),dry densities and mass ratios of bentonite and sand mixtures(physical factors)on the swelling behavior and ability of bentonite-based *** this study,swelling tests are conducted on B/S mixtures with different B/S mix ratios(20/80 to 70/30),compacted at different dry densities(ρd=1.6-2 g/cm^(3)),saturated with different types of water(distilled water and simulated deep groundwater of Trenton and Guelph)and exposed to different temperatures(20℃-80℃).Moreover,scanning electron microscopy(SEM)analyses,mercury intrusion porosimetry(MIP)tests and X-ray diffractometry(XRD)analyses are carried out to evaluate the morphological,microstructural and mineralogical characteristics of the B/S *** test results indicate that the swelling potential of the B/S mixtures is significantly affected by these physical and chemical factors as well as the combined effects of the chemical and thermal factors.A significant decrease in the swelling capacity is observed when the B/S materials are exposed to the aforementioned groundwaters.A large decrease in the swelling capacity is observed for higher bentonite content in the ***,higher temperatures intensify the chemically-induced reduction of the swelling capacity of the B/S barrier *** decrease in the swelling capacity is caused by the chemical and/or microstructural changes of the *** results from this research will help engineers to design and build EBSs for DGRs with similar groundwater and thermal conditions.

关键词： Deep geological repository Engineered barrier Bentonite-sand materials Nuclear waste Swelling capacity Swelling strain

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A multiphysics-viscoplastic cap model for simulating blast response of cemented tailings backfill

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Journal of Rock mechanics and Geotechnical Engineering 2017年第3期9卷 169-182页

作者： Gongda Lu Mamadou fall Liang Cui Civil Engineering Department University of Ottawa Ottawa ON Canada

Although a large number of previous researches have significantly contributed to the understanding of the quasi-static mechanical behavior of cemented tailings backfill,an evolutive porous medium used in underground mine cavities,very few efforts have been made to improve the knowledge on its response under sudden dynamic loading during the curing *** fact,there is a great need for such information given that cemented backfill structures are often subjected to blast loadings due to mine *** this study,a coupled thermo-hydro-mechanical-chemical(THMC)-viscoplastic cap model is developed to describe the behavior of cementing mine backfill material under blast loading.A THMC model for cemented backfill is adopted to evaluate its behavior and evolution of its properties in curing processes with coupled thermal,hydraulic,mechanical and chemical ***,the model is coupled to a Perzyna type of viscoplastic model with a modified smooth surface cap envelope and a variable bulk modulus,in order to reasonably capture the nonlinear and rate-dependent behaviors of the cemented tailings backfill under blast *** of the parameters required for the variable-modulus viscoplastic cap model were obtained by applying the THMC model to reproducing evolution of cemented paste backfill(CPB)properties in the curing ***,the behavior of hydrating cemented backfill under high-rate impacts can be evaluated under any curing time of *** validation results of the proposed model indicate a good agreement between the experimental and the simulated *** authors believe that the proposed model will contribute to a better understanding of the performance of hydrating cemented backfill under blasting,and also to practical risk management of backfill structures associated with such a dynamic condition.

关键词： Thermo-hydro-mechanical-chemical (THMC) coupling Multiphysics processes Tailings Paste backfill Cap model Blast

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