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CNB-001 reduces paraplegia in rabbits following spinal cord ischemia

Neural Regeneration Research 2019年第12期14卷 2192-2198页

作者： Paul A. Lapchak Paul D. Boitano Rene Bombien Daisy Chou margot knight Anja Muehle Mihaela Te Winkel Ali Khoynezhad Neurocore LLC Pomona CA USA Department of Surgery Memorial Care Health System Long Beach CA USA

Spinal cord ischemia associated with trauma and surgical procedures including thoraco-abdominal aortic aneurysm repair and thoracic endovascular aortic repair results in devastating clinical deficits in patients. Because spinal cord ischemia is inadequately treated, we studied the effects of [4-((1 E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-phenyl-1 H-pyrazoyl-3-yl) vinyl)-2-methoxy-phenol)](CNB-001), a novel curcumin-based compound, in a rabbit SCI model. CNB-001 is known to inhibit human 5-lipoxygenase and 15-lipoxygenase and reduce the ischemia-induced inflammatory response. Moreover, CNB-001 can reduce the level of oxidative stress markers and potentiate brain-derived neurotrophic factor and brain-derived neurotrophic factor receptor signaling. The Tarlov scale and quantal analysis technique results revealed that CNB-001 administered as an intravenous dose(bolus) 30 minutes prior to spinal cord ischemia improved the behaviors of female New Zealand White rabbits. The improvements were similar to those produced by the uncompetitive N-methyl-D-aspartate receptor antagonist memantine. At 48 hours after aortic occlusion, there was a 42.7% increase(P < 0.05) in tolerated ischemia duration(n = 14) for rabbits treated with CNB-001(n = 16), and a 72.3% increase for rabbits treated with the positive control memantine(P < 0.05)(n = 23) compared to vehicle-treated ischemic rabbits(n = 22). CNB-001 is a potential important novel treatment for spinal cord ischemia induced by aortic occlusion. All experiments were approved by the CSMC Institutional Animal Care and Use Committee(IACUC #4311) on November 1,2012.

关键词： curcumin analog spinal cord injury spinal cord ischemia thoraco-abdominal aortic aneurysm thoracic endovascular aortic repair motor function neuroprotection neurorepair

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Genomic Mutations Within the Host Microbiome: Adaptive Evolution or Purifying Selection

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Engineering 2023年第1期20卷 96-102页

作者： Jiachao Zhang Rob knight School of Food Science and Engineering Hainan UniversityHaikou 570228China Department of Pediatrics University of California San DiegoLa JollaCA 92093USA Center for Microbiome Innovation Jacobs School of EngineeringUniversity of California San DiegoLa JollaCA 92093USA Department of Bioengineering University of California San DiegoLa JollaCA 92093USA Department of Computer Science and Engineering University of California San DiegoLa JollaCA 92093USA

Next-generation sequencing technology has transformed our ability to assess the taxonomic composition functions of host-associated microbiota and microbiomes. More human microbiome research projects—particularly those that explore genomic mutations within the microbiome—will be launched in the next decade. This review focuses on the coevolution of microbes within a microbiome, which shapes strain-level diversity both within and between host species. We also explore the correlation between microbial genomic mutations and common metabolic diseases, and the adaptive evolution of pathogens and probiotics during invasion and colonization. Finally, we discuss advances in methods and algorithms for annotating and analyzing microbial genomic mutations.

关键词： Gut microbiota Genomic mutations Adaptive evolution Purifying selection Single-nucleoti de variants

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Sediment Transport in Rivers with Overbank Flow

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四川大学学报（工程科学版） 2005年第S1期37卷 16-29页

作者： Donald W knight Water Eng. The Univ.of BirminghamUK

Some concepts related to sediment transport in rivers with overbank flow are *** a description of the physical processes that are involved when a river inundates its floodplains,some simple com- putational methods are presented which permit the depth-averaged velocity and boundary shear stress to be pre- dicted within a cross section of variable,but prismatic *** methoda account for the strong transverse shear in velocity that occurs when the stage is just above bankfull,as well as ...

关键词： sediment transport overbank flow

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Lateral distributions of streamwise velocity in compound channels with partially vegetated floodplains

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Science China(Technological Sciences) 2009年第11期52卷 3357-3362页

作者： knight Donald W School of Civil Engineering The University of Birmingham Birmingham B15 2TT UK

Natural rivers are commonly characterized by a main channel for primary flow conveyance and a floodplain, often partially covered with vegetation such as shrubs or trees, to carry extra flow during floods. The hydraulic resistance due to vegetation on the floodplain typically causes a further reduction of flow velocity and increases the velocity difference between the main channel and the floodplain. As a consequence a strong lateral shear layer leads to the exchange of mass and momentum between the main channel and floodplain, which in turn affects the overall channel conveyance and certain fluvial processes. The prediction of the lateral velocity distribution is important for many flood alleviation schemes, as well as for studies on sediment transport and dispersion in such channels. The present paper proposes a method for predicting the depth-averaged velocity in compound channels with partially vegetated floodplains, based on an analytical solution to the depth-integrated Reynolds-Averaged Navier-Stokes equation with a term included to account for the effects of vegetation. The vegetation is modelled via an additional term in the momentum equation to account for the additional drag force. The method includes the effects of bed friction, drag force, lateral turbulence and secondary flows, via four coefficients f, CD, λ & Γ respectively. The predicted lateral distributions of depth-averaged velocity agree well with the experimental data. The analytical solutions can also be used to predict the distribution of boundary shear stresses, which adds additional weight to the method proposed.

关键词： vegetation compound channel floodplain velocity

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From fundamental quantum optics to quantum information technology:the personal journey of Sir Peter knight

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Advanced Photonics 2021年第6期3卷 3-7页

作者： Xiaosong Ma Peter knight Nanjing University School of PhysicsNanjingChina the Physics Department at Imperial College the UK National Quantum Technology Programme Strategic Advisory Board the National Physical Laboratory Quantum Metrology Institute

Xiaosong Ma:What inspired you to choose quantum optics as your major when you were a student,and can you share your experience or research journey in this field?Peter knight:Quantum optics,as a discipline,was more or less formed during the time I’ve been active in the area.I started thinking about things that we would now call quantum optics in the middle of the 1960s when I was a student.

关键词： optics quantum Quantum

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Residual Romanticism in a Contemporary Shanghai Novel

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第1期11卷 106-132页

作者： Sabina knight Department of Comparative Literature Smith College Northampton Massachusetts 01063 USA

Through a close reading of Wei Hui＇s bestseller Shanghai Baby 0999）, this article highlights five elements to delimit a post-romantic neoliberal literary sensibility and its ruptures：（1） a ＂melotraumatic＂ quest for exuberance, （2） denial of dependency, （3） a celebration of individual choice and market rationalities, （4） disillusionment and disappointment, and （5） a quest for intelligibility through narrative. Along the way I probe the narrator＇s residual romanticism as a little-addressed foundation of the novel＇s testimony to a generational sensibility. By examining the relationship between Coco the narrator and Coco the protagonist, I contend that the narrator＇s sustained self-remembering evokes her growing unease with neoliberal values. The tension between post-romantic cynicism and residual romanticism suggests the extent to which a supposedly dissident novel may entice precisely for the ways its deep structure reinforces dominant discourses. Whereas Coco the protagonist follows a logic of consumerism, Coco the narrator gestures to non-commercial values--loyalty, care, empathy, trust, and solidarity. Appreciating the novel＇s residual romanticism alongside its post-romantic cynicism sheds new light on the story, its context, ambiguous feminism, and reception.

关键词： market rationality residual romanticism feminism Shanghai Baby Wei Hui chick lit body writing

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REVIEW OF REGIME THEORY OF ALLUVIAL CHANNELS

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Journal of Hydrodynamics 2002年第3期14卷 1-7页

作者： Cao, Shu-You knight, Donald W. Hydraulics Lab. of High Speed Flows Sichuan Univ. Chengdu 610065 China Sch. of Civil Eng. Univ. of Birmingham Birmingham B15 2TT United Kingdom

One of the most important problems in river engineering is to determine a stable cross section geometry and slope for an alluvial channel. This has been the subject of considerable research for about a century and continues to be of great practical interest. Ignoring plan geometry, an alluvial channel can adjust its slope, depth and width, to develop a dynamic stable condition in which it can transport a certain amount of water and sediment. The brief history of regime theory and its new development are reviewed in this paper.

关键词： Channel flow Dynamics Slope protection Stability

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Stable reinforcement learning with recurrent neural networks

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控制理论与应用（英文版） 2011年第3期9卷 410-420页

作者： James Nate knight Charles ANDERSON Department of Computer Science Colorado State UniversityFort CollinsCO 80523U.S.A

In this paper,we present a technique for ensuring the stability of a large class of adaptively controlled *** combine IQC models of both the controlled system and the controller with a method of filtering control parameter updates to ensure stable behavior of the controlled system under adaptation of the *** present a specific application to a system that uses recurrent neural networks adapted via reinforcement learning *** work presented extends earlier works on stable reinforcement learning with neural ***,we apply an improved IQC analysis for RNNs with time-varying weights and evaluate the approach on more complex control system.

关键词： Stability analysis Integral quadratic constraint Recurrent neural network Reinforcement learning Linear matrix inequality

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Economic Causes and Cures of Social Instability in China

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China & World Economy 2014年第2期22卷 5-21页

作者： John knight Department of Economics University of Oxford

China＇s leaders have often expressed concerns about social instability, viewed as a threat both to the political order and to continued rapid growth. Slower growth might, in turn, further undermine social stability. Using survey data, the present paper examines the economic determinants of social instability. Four main determinants are identified.＇past and expected growth of income, income inequality, economic insecurity and misgovernance. The paper then considers possible policies to reduce social instability, examining each of the determinants in turn.

关键词： China economic growth economic policy governance inequality insecurity social instability

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Fair and unfair inequality in China

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Economic and Political Studies 2017年第3期5卷 256-265页

作者： John knight St Edmund Hall Oxford UniversityOxfordOX14ARUK

The paper questions the normative value in the Chinese case of standard measures of aggregate income inequality such as the Gini *** is adduced that people have narrow frames of reference and that they distinguish between income inequalities that they perceive to be fair and those that they perceive to be *** is suggested that value judgements about what is fair or unfair can be guided by people’s own ***’s perceptions of unfairness can also be important to a government concerned to avoid social *** estimation of happiness functions can help to make the relevant *** are given of how fair and unfair inequalities might be identified,using either a criterion of people’s perceptions or one of informed *** might be more strongly felt in inequalities of economic power than in inequalities of income,although the former can in turn result in inequalities of *** argument is made for China researchers to extend inequality research and research instruments towards an economics of fairness and unfairness.

关键词： Fairness frames of reference Gini coefficient inequality of income inequality of economic power unfairness

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