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Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann Christian klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Fatty acids derived from oviposition systems guide female black soldier flies(Hermetia illucens)toward egg deposition sites

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Insect Science 2024年第4期31卷 1231-1248页

作者： Patrick klüber Emna Arous Jeanny Jerschow Marco Fraatz Daniel Bakonyi Martin Rühl Holger Zorn Department Bioresources Fraunhofer Institute for Molecular Biology and Applied EcologyGiessenGermany Institute of Food Chemistry and Food Biotechnology Justus Liebig University GiessenGiessenGermany

The black soldier fly,Hermetia illucens,comes with big promises for industrial purposes since its larvae feed polyphagously on a broad spectrum of organic ***,research focusing on adult flies is scarce,which is inconsistent with their reproductive relevance within the rearing *** particular,directed oviposition is a challenge in artificial ***,decomposing organic matter is commonly used as oviposition substrate,which has extensive potential for improvement in view of the lack of standardization and the risk of microbial ***,we identified three fatty acids and one fatty acid methyl ester derived from the surface of old oviposition sites and targeted to elucidate their effect on preference behavior and oviposition site selection using Y-olfactometry and prepared oviposition sites,*** to tetradecanoic acid attracted gravid females and stimulated oviposition most strongly,while decanoic acid demonstrated a repulsive *** kept in mixed-sex populations were attracted by tetradecanoic acid,resulting in a higher egg mass found in the compound box(3.0–11.4 fold),a≥2.3 fold reduction of nonspecifically deposited eggs,and the highest total egg ***,decanoic and dodecanoic acid caused females to lay a greater proportion of eggs nonspecifically outside both *** data suggest that fatty acids,especially tetradecanoic acid,are important cues for oviposition site selection in black soldier *** order to achieve a directed oviposition behavior,the role of further short-and long-chain fatty acids as attractants should be examined.

关键词： black soldier fly Hermetia illucens fatty acids insects as food and feed oviposition oviposition site selection tetradecanoic acid

Clustering of voltage-gated ion channels as an evolutionary trigger of myelin formation

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Neural Regeneration Research 2024年第8期19卷 1631-1632页

作者： Henrike Ohm Simone Rey Christian klambt Institut fur Neuro-und Verhaltensbiologie MunsterGermany

Neurons carry apical dendrites that perceive information and a basal axon that transmits the computed information towards its to *** axon originates at the axon hillock which is followed by the axon initial ***,action potentials are initiated that are based on millisecond long openings of specific voltagegated sodium and potassium channels that are conserved in all parahoxozoa(Placozoa,Cnidaria,Bilateria)(Li et al.,2015).

关键词： initiated carry potassium

维普期刊数据库

Customized molecular tools to strengthen metabolic engineering of cyanobacteria

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Green Carbon 2024年第2期2卷 149-163页

作者： Stephan klähn Franz Opel Wolfgang R.Hess Department of Solar Materials Biotechnology Helmholtz Centre for Environmental Research–UFZLeipzig 04318Germany Genetics and Experimental Bioinformatics Albert-Ludwig University FreiburgFreiburg im Breisgau 79104Germany

Cyanobacteria are promising oxygenic phototrophs for the production of various *** their(photo)biotechnological exploitation,molecular tools are required,such as,for the introduction and expression of heterologous genes,or the modulation of enzyme activities or entire *** and strategies for the development of photosynthetic biomanufacturing technologies based on cyanobacteria have been extensively reviewed,as well as certain specialized aspects of their genetic ***,options for metabolic engineering of specific cyanobacterial cells are still less developed than those for other bacteria of biotechnological *** addition to the standard genetic toolbox for“classical”metabolic engineering,we emphasize certain aspects,including recently developed vector systems for the extrachromosomal maintenance of genes and approaches based on clustered regularly interspaced short palindromic repeats(CRISPR)*** highlight the development of custom molecular tools for specific strains or products,discuss the emerging use of small regulatory proteins that appear promising for advanced metabolic engineering approaches to promote specific product formation,and provide an overview of suitable online ***,we discuss the current trends in this field and indicate their potential,such as using suitable product sensors that enable systematic screening,and optimization approaches.

关键词： Metabolic engineering Cyanobacteria Synthetic plasmids Regulatory proteins Sensors

未控制高血压患者进行家庭血压监测与药剂师管理后的心血管事件及费用

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中华高血压杂志 2020年第11期28卷 1018-1018页

作者：赵狄(摘译) 刘莉(审校) margolis kl Dehmer SP Sperl-Hillen J O’Connor PJ Asche SE Bergdall AR Green BB Nyboer RA Pawloski PA Trower NK Maciosek MV 不详

未控制高血压是心血管病的主要病因。在16家初级保健诊所进行的整群随机试验结果表明:12个月的远程家庭血压监测与药剂师管理可较常规治疗24个月降压幅度更大。该文报道心血管事件(非致死性心肌梗死、非致死性脑卒中、心力衰竭住院、冠... 详细信息

未控制高血压是心血管病的主要病因。在16家初级保健诊所进行的整群随机试验结果表明:12个月的远程家庭血压监测与药剂师管理可较常规治疗24个月降压幅度更大。该文报道心血管事件(非致死性心肌梗死、非致死性脑卒中、心力衰竭住院、冠状动脉再血管化及心血管病死亡)与随访5年的花费。在远程干预组(TI组,n=228),10例患者发生15次心血管事件(5次心肌梗死、4次脑卒中、5次心力衰竭、1次心血管病死亡)。

关键词：心血管事件降压幅度家庭血压监测心血管病心力衰竭心肌梗死高血压患者保健诊所

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Pathogenesis and clinical features of severe hepatitis E virus infection

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World Journal of Virology 2024年第2期13卷 19-33页

作者： László Orosz Károly Péter Sárvári Áron Dernovics András Rosztóczy klára Megyeri Department of Medical Microbiology University of SzegedSzeged 6720Csongrád-CsanádHungary Department of Internal Medicine Division of GastroenterologyUniversity of SzegedSzeged 6725Csongrád-CsanádHungary

The hepatitis E virus(HEV),a member of the Hepeviridae family,is a small,non-enveloped icosahedral virus divided into eight distinct genotypes(HEV-1 to HEV-8).Only genotypes 1 to 4 are known to cause diseases in *** 1 and 2 commonly spread via fecal-oral transmission,often through the consum-ption of contaminated *** 3 and 4 are known to infect pigs,deer,and wild boars,often transferring to humans through inadequately cooked *** hepatitis caused by HEV in healthy individuals is mostly asymptomatic or associated with minor symptoms,such as ***,in immunosup-pressed individuals,the disease can progress to chronic hepatitis and even escalate to *** pregnant women,an HEV infection can cause fulminant liver failure,with a potential mortality rate of 25%.Mortality rates also rise amongst cirrhotic patients when they contract an acute HEV infection,which can even trigger acute-on-chronic liver failure if layered onto pre-existing chronic liver *** the prevalence of HEV infection continues to rise worldwide,highlighting the particular risks associated with severe HEV infection is of major medical *** text offers a brief summary of the characteristics of hepatitis developed by patient groups at an elevated risk of severe HEV infection.

关键词： Hepatitis E virus Cirrhosis Acute-on-chronic liver failure Pregnancy Immune dysfunction Open reading frames 1-4

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合并多种疾病的高血压患者的自测血压

中华高血压杂志(中英文) 2021年第2期29卷 198-198页

作者： Sheppard JP Tucker kl Davison WJ Stevens R Aekplakorn W Bosworth HB Bove A Earle K Godwin M Green BB Hebert P Heneghan C Hill N Hobbs FDR Kantola I Kerry SM Leiva A Magid DJ Mant J margolis kl McKinstry B McLaughlin MA McNamara K Omboni S Ogedegbe O Parati G Varis J Verberk WJ Wakefield BJ McMa-nus RJ 周卫叶鹏

研究表明自测血压结合干预是有效的,但其有效性受一些合并症的影响。本研究探讨自我监测血压是否能降低高血压合并症患者的诊室血压。方法:研究者对Medline、Embase和Cochrane图书馆发表的文章(截至2018年1月)进行了系统性回顾。对血压...

研究表明自测血压结合干预是有效的,但其有效性受一些合并症的影响。本研究探讨自我监测血压是否能降低高血压合并症患者的诊室血压。方法:研究者对Medline、Embase和Cochrane图书馆发表的文章(截至2018年1月)进行了系统性回顾。对血压自我监测进行随机对照试验,并要求提供个体患者数据(individual patient data,IPD)。根据是否联合低强度/高强度干预进行前瞻性分类。在一阶段IPD荟萃分析中,根据高血压相关合并症的数量和类型,评估12个月时血压的变化和血压控制不达标的风险比。

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无心血管病老年人群的高血压治疗和控制相关影响因素:一项横断面研究

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中华高血压杂志(中英文) 2021年第4期29卷 398-398页

作者：周卫叶鹏 Chowdhury EK Nelson MR Ernst ME margolis kl Beilin LJ Johnston CI Woods RL Murray AM Wolfe R Storey E Shah RC Lockery JE Tonkin AM Newman AB Williamson JD Abhayaratna WP Stocks NP Fitzgerald SM Orchard SG Trevaks RE Donnan GA Grimm R McNeil JJ Reid CM

虽已有各种降压疗法,但在老龄化人口中,血压控制仍不够理想。另外,人们对老年人群高血压管理的认识也有差距。研究者探讨无明显心血管病的老年高血压患者的降压治疗和控制情况,试图确定"未治疗"和"治疗但未控制"高血压的相关因素。方法...

虽已有各种降压疗法,但在老龄化人口中,血压控制仍不够理想。另外,人们对老年人群高血压管理的认识也有差距。研究者探讨无明显心血管病的老年高血压患者的降压治疗和控制情况,试图确定"未治疗"和"治疗但未控制"高血压的相关因素。方法:研究者分析了参加老年人阿司匹林减少心血管事件研究的年龄≥65岁,来自澳大利亚和美国的参与者19 114例的基线数据。

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MicroRNA in TLR signaling and endotoxin tolerance

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Cellular & Molecular Immunology 2011年第5期8卷 388-403页

作者： Md A Nahid Minoru Satoh Edward kl Chan Department of Oral Biology University of FloridaGainesvilleFLUSA Division of Rheumatology and Clinical Immunology Department of Medicineand PathologyImmunologyand Laboratory MedicineUniversity of FloridaGainesvilleFLUSA

Toll-like receptors(TLRs)in innate immune cells are the prime cellular sensors for microbial *** activation leads to the production of proinflammatory mediators and thus TLR signaling must be properly regulated by various mechanisms to maintain ***4-ligand lipopolysaccharide(LPS)-induced tolerance or cross-tolerance is one such mechanism,and it plays an important role in innate *** is established and sustained by the activity of the microRNA miR-146a,which is known to target key elements of the myeloid differentiation factor 88(MyD88)signaling pathway,including IL-1 receptor-associated kinase(IRAK1),IRAK2 and tumor-necrosis factor(TNF)receptor-associated factor 6(TRAF6).In this review,we comprehensively examine the TLR signaling involved in innate immunity,with special focus on LPS-induced *** function of TLR ligand-induced microRNAs,including miR-146a,miR-155 and miR-132,in regulating inflammatory mediators,and their impact on the immune system and human diseases,are *** of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases.

关键词： innate immunity lipopolysaccharide LPS tolerance microRNA Toll-like receptor