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以污染海域鱼类为食的斑海豹(Phoca vitulina)免疫功能的损害

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人类环境杂志 1994年第2期23卷 155-159页

作者： Rik de Swart peter Ross peter Reijnders Helga Timmerman Siem Heisterkamp Henk van Loveren joseph Vos Albert Osterhaus 蒋逸航荷兰Bilthoven的国家公共健康与环境保护研究所海豹恢复与研究中心 DLO-森林与自然研究所病理学实验室数学方法中心统计学和运算研究部病理学实验室免疫生物学部伊拉兹马斯大学

近来,海豹和海豚中高死亡率疾病的爆发,已引起公众和科学界的很大兴趣。虽然在大多数情况下,病毒的传播是疾病爆发的主要原因,但据推测污染所引起的免疫抑制起到了推波助澜的作用。这里我们介绍半野外条件下一项前瞻性研究结果,在这项... 详细信息

近来,海豹和海豚中高死亡率疾病的爆发,已引起公众和科学界的很大兴趣。虽然在大多数情况下,病毒的传播是疾病爆发的主要原因,但据推测污染所引起的免疫抑制起到了推波助澜的作用。这里我们介绍半野外条件下一项前瞻性研究结果,在这项研究中,两组斑海豹(Phoca vitulina)喂食了来自不同程度污染海区的鲱鱼,即高度污染的波罗的海和相对无污染的大西洋。在为期93周内,对与免疫功能有关的参数进行了监测,并对这两组参数进行了比较。我们发现:食用波罗的海鲱鱼的海豹的自然杀伤细胞NK活性和有丝分裂素所引起的T细胞增殖反应显著较低。另外,我们还注意到这些动物中循环的多形核粒细胞较多,这可能表明细菌传染发病率的增加。本文首次向人们展示了与长期受通过海洋食物链而积累的环境污染物的影响有关的哺乳动物免疫功能受损。

关键词：海水污染鱼类海豹免疫功能

Postharvest Quality and Safety of Potted Greenhouse Tomato Grown on Forest Soil-Biosolids substrate,Blended with NPK Fertilizer

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NASS Journal of Agricultural Sciences 2020年第2期2卷 24-36页

作者： peter Caleb Otieno Samuel Nyalala joseph Wolukau Department of Crops Horticulture and SoilsEgerton UniversityKenya

Studies on the effects of biosolids(BS)amended substrate on food quality and safety in tomato production have not been adequately *** objective of this study was to investigate the influence of composted BS and NPK fertilizer on post-harvest quality and safety of potted greenhouse tomato Solanum lycopersicum *** tomatoes"Maxim F1"were grown in a randomized complete block design with four *** fertilizer NPK(17:17:17) fertilizer was applied at 0,100 kg ha^(-1)(5g per pot)and 200 kg ha^(-1);(10g per pot),BS was applied at 0%,10%,20%,30%,and 40%v/v,in all possible *** were harvested and analyzed for ascorbic acid,chlorophylls,carotenoids and total phenolic compounds;weight loss,fruit firmness,titratable acidity and total soluble solids,as well as heavy metals and microbial *** revealed that tomato fruit at 10%BS in combination with NPK fertilizer at 100 kg ha^(-1) had the highestβ-carotene(6.1 mg 100 g^(-1)),lycopene(26.1 mg 100 g^(-1)),ascorbic acids(128.0 mg 100 g^(-1)),total phenolic acids(13.2 mg 100 g^(-1)),total soluble solids(17%).However,the same rates produced tomato fruit with lower titratable acidity(2.2%)and had heavy metal residues within the permissible level,according to International EPA standards on biosolids utilization for food crops ***,no trace of pathogenic bacteria;Salmonella,Escherichia coli,Staphylococcus was observed on the harvested *** study reveals at BS 10% with NPK fertilizer at 100 kg ha^(-1) substrate as a better option of plant nutrient source for quality and safe greenhouse tomato production.

关键词： Biosolids Contaminants Food safety Tomato quality

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印度Ispat CSP工厂生产优质热轧卷

钢铁 2004年第Z1期39卷 393-400页

作者： Fritz-peter Pleschiutschnigg Vilas Vishnu Jamnis Sukhdev Raj Talwar Atul Kumar Misra Ratna Prasad V. Atluri R. B. Singh Prem Shankar Rajendra K. Verma Rajesh K. Goyal Vidiya P. Mishra Bidyapati Deepu B. peter Meierling joseph Pleschiutschnig United Steel Center Operations SIP&HSM Operations Steel Melt Shop Operations Caster Operations Process Quality Rolling Mill Operations 　　　　 Ispat Industries Ltd Ispat Industries Ltd

　　1998年,印度Ispat公司开始投产CSP生产线(图1).这个生产线原计划年产300万t热轧卷,年产210万t高炉提供铁水.Midren装置年产160万吨海绵铁.……

关键词：印度工厂生产热轧卷生产线海绵铁装置投产铁水高炉

Characterization of the Stem Cell Fraction in Pancreatobiliary Carcinomas: The Notch Signaling Pathway as a Potential Therapeutic Target

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Journal of Cancer Therapy 2018年第6期9卷 480-502页

作者： Elisabeth Seidel Cynthia de Carvalho Fischer Christopher Neumann Anja Reutzel-Selke Andreas Andreou joseph Gassner Julia Gogolok peter Tang Anja Schirmeier Fritz Klein Igor M. Sauer Johann Pratschke Marcus Bahra Rosa B. Schmuck Charité—Universitatsmedizin Berlin Corporate Member of Freie Universitat Berlin Humboldt-Universitatzu Berlin and Berlin Institute of Health Institute of Surgery Augustenburger Platz 1 Berlin Germany

Pancreatic adenocarcinoma (PDAC) and extrahepatic cholangiocarcinoma (ECC) are highly lethal malignancies with limited treatment options. Both a small subpopulation of cancer stem cells (CSC) and the deregulation of the notch pathway have been considered potential sources of tumor formation. In this study, flow cytometry (FCM) was conducted to identify the CSC population and Notch-associated proteins in ECC and PDAC cell lines. Additionally, the treatment effect of Gemcitabine and the specific notch-inhibitor DAPT on ECC and PDAC cell lines was evaluated. Our results show that the amount of SP cells in ECC cell lines is significantly higher than in PDAC cell lines, and that SP-ECC cells show a higher sensitivity to therapy. In conclusion, inhibition of Notch signaling with DAPT may be of therapeutic value in ECC, but seems to show no effect on more aggressive PDAC. As it could be essential for the improvement in outcomes of the ECC patients, other trials are needed to determine the role of further Notch components.

关键词： Notch Pathway Cancer Stem Cells Pancreatic Adenocarcinoma Extrahepatic Cholangiocarcinoma Targeted Therapy

用显微镜观察皮革的松面及其对皮革机械性能的影响

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北京皮革（中外鞋讯）（下） 2010年第11期 91-94页

作者： CHENG-Kun Liu P. Latona joseph Lee peter H.Cooke 李魏（编译）戴红（校） US.Department of Agriculture Agriculture Eesearch Service EAstern Eegional Research Center 600 East Mermaid LAne Wyndmoor PA 19038-8598 四川大学生物质和皮革工程系四川成都610065

对皮革结构和皮革产品来说，松面是一个非常棘手的问题。制革工人尤其关注松面，他们会想尽一切办法，通过添加不同的化学物质来解决松面的问题。然而，人们对松面的纤维结构和松面对皮革机械性能的影响还不是很清楚。这篇论文采用显微... 详细信息

对皮革结构和皮革产品来说，松面是一个非常棘手的问题。制革工人尤其关注松面，他们会想尽一切办法，通过添加不同的化学物质来解决松面的问题。然而，人们对松面的纤维结构和松面对皮革机械性能的影响还不是很清楚。这篇论文采用显微镜观察松面革的纤维结构，并且研究松面对抗张强度、抗冲击性等机械性能的影响，从而更好的了解松面。显微镜观察显示，在空松革的间隙层与真皮层之间有可见的缝隙。此外，粒面层显示为片层结构，而在正常皮革中，粒面层是紧紧粘在一起的，而且其纤维束看起来要比空松革的纤维束小得多。机械性能研究显示，松面会导致皮革的韧性降低，然而测量也显示其抗张强度和伸长率也有微小变化。并且，粘弹性研究表明在应力松弛曲线上，空松革与紧实革非常相似，两种革都显示出在最初的几秒钟内应力迅速减小，然后是缓慢的衰减。然而，空松革的初始应力比紧实革大，也表明其坚实性比紧实革大。这篇研究对松面进行了更加深入的了解，进而促使人们研究一些方法来解决松面问题，例如对皮革进行填充。

关键词：显微镜观察皮革产品机械性能松面纤维结构抗张强度化学物质抗冲击性

Influence of Land Use Activities on Riparian Vegetation, Soil and Water Quality:An Indicator of Biodiversity Loss, South West Mau Forest, Kenya

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IFN-γ^(+) cytotoxic CD4^(+) T lymphocytes are involved in thepathogenesis of colitis induced by IL-23 and the foodcolorant Red 40

Open Journal of Forestry（林学期刊） 2016年第5期

作者： Naomi Njue Eric Koech joseph Hitimana peter Sirmah

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Cellular & Molecular Immunology 2022年第7期19卷 777-790页

作者： Lili Chen Zhengxiang He Bernardo S.Reis Jesse D.Gelles Jerry Edward Chipuk Adrian T.Ting Julie A.Spicer joseph A.Trapani Glaucia C.Furtado Sergio A.Lira Precision Immunology Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Laboratory of Mucosal Immunology The Rockefeller UniversityNew YorkNY 10065USA Department of Oncological Sciences Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA The Tisch Cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA The Diabetes Obesityand Metabolism InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Immunology Mayo ClinicRochesterMN 55905USA Auckland Cancer Society Research Centre Faculty of Medical and Health SciencesThe University of AucklandPrivate Bag 92019Auckland 1142New Zealand Cancer Immunology Program Peter MacCallum Cancer Centre305 Grattan StreetMelbourneVIC 3000Australia

The food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin(IL)-*** immune response is mediated by CD4^(+)T cells,but mechanistic insights into how these CD4^(+)T cells trigger andperpetuate colitis have remained ***,using single-cell transcriptomic analysis,we found that several CD4^(+)T-cell subsetsare present in the intestines of colitic mice,including an interferon(IFN)-γ-producing *** vivo challenge of primed mice withRed 40 promoted rapid activation of CD4^(+)T cells and caused marked intestinal epithelial cell(IEC)apoptosis that was attenuated bydepletion of CD4^(+)cells and blockade of IFN-γ.Ex vivo experiments showed that intestinal CD4^(+)T cells from colitic mice directlypromoted apoptosis of IECs and intestinal ***4^(+)T cell-mediated cytotoxicity was contact-dependent and required FasL,which promoted caspase-dependent cell death in target *** ablation of IFN-γconstrained IL-23-and Red 40-inducedcolitis development,and blockade of IFN-γinhibited epithelial cell death in *** results advance the understanding of themechanisms regulating colitis development caused by IL-23 and food colorants and identify IFN-γ^(+)cytotoxic CD4^(+)T cells as a newpotential therapeutic target for colitis.

关键词： Allura Red IL23 Cytotoxic CD4^(+)T cells CD4^(+)CTL Inflammation Epithelium damage Colitis

Portal vein thrombosis in liver transplantation: radiologic evaluation, risk factors, and occult diagnosis

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Hepatoma Research 2016年第1期2卷 36-41页

作者： Adam Hauch Carl Winkler Eric Katz peter W.Lundberg Mary Killackey Anil S.Paramesh Luis A.Balart Nathan J.Shores Martin Moehlen Ward Miller Douglas P.Slakey joseph F.Buell Bob H.Saggi Tulane Transplant Institute Tulane University School of MedicineNew OrleansLA 70112USA Department of Gastroenterology Section of HepatologyTulane University School of MedicineNew OrleansLA 70112USA

Aim:Portal vein thrombosis(PVT)in the liver transplant recipient poses many ***,the risk factors and effects on outcomes of PVT are not ***:This study analyzed the experience with PVT in liver transplant program from 2007 to *** included the effectiveness of PVT diagnostics and its risk factors using logistical *** primary endpoints were Kaplan-Meir patient and graft *** secondary endpoints were the length of stay(LOS),transfusion rate,and overall *** predictors of survival were identified using a Cox’s proportional hazards ***:Two hundred and sixteen consecutive liver transplant recipients were examined,and 30(13.8%)had either a total or partial *** hundred and five patients had imaging within 1 year of liver transplantation with only 7(23.3%)of the 30 PVTs identified *** sensitivity(4.8-50%)and negative predictive values(10.5-22.2%)were ***,age significantly predicted PVT[P=0.037/hazard ratio(HR)=0.95].Ninety-day-patient and graft survival for PVT was similar at 6 months,although 1-year survival was significantly lower.“Occult”PVT was not associated with inferior *** for end-stage liver disease score>25(P=0.001,HR=0.49/P=0.004,HR=0.52)and age>60 years(P=0.017,HR=0.64/P=0.013,HR=0.67)were significant predictors of patient and graft *** the transfusion rate was significantly greater with PVT,LOS,and morbidity were ***:Older recipients had a greater likelihood of *** studies were not effective at excluding PVT,and occult diagnosis did not affect the *** was not an independent predictor of mortality or graft loss,but was associated with greater blood loss but not increased LOS or morbidity.

关键词： Advanced age graft survival patient survival post-transplant outcomes resource utilization

热年代学年龄温度法和年龄高程法的应用条件:对采样策略及年龄表达的启示

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地学前缘 2011年第6期18卷 347-357页

作者：曹凯王国灿 peter van der Beek 中国地质大学地质过程与矿产资源国家重点实验室湖北武汉430074 中国地质大学(武汉)地球科学学院湖北武汉430074 Institut des Sciences de la Terre Université Joseph Fourier

热年代学的年龄温度法和年龄高程法是研究造山带长期构造演化过程的常用方法。相对于年龄温度法而言,年龄高程法在计算岩石剥露速率上的优势在于回避了地温梯度的假设,但前提条件中最重要的方面则要求地温梯度达到稳定状态。然而,地温... 详细信息

热年代学的年龄温度法和年龄高程法是研究造山带长期构造演化过程的常用方法。相对于年龄温度法而言,年龄高程法在计算岩石剥露速率上的优势在于回避了地温梯度的假设,但前提条件中最重要的方面则要求地温梯度达到稳定状态。然而,地温场通常会受到地形变化、地表剥露速率、断层活动及岩浆侵入等作用的干扰,导致地温梯度处于非稳定状态。此时,针对造山带长期演化过程中的具体问题采取合理的热年代学采样策略以及对年龄信息的有效提取方法是十分必要的。

关键词：热年代学年龄温度法年龄高程法地温梯度采样策略