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Cancer Res:HDAC抑制剂可促进单抗药物对HER2阳性肿瘤的治疗效果

Health（健康） 2009年第2期

作者： Bryan joseph Renton Patricia Denise Morrell Richard peter Davidson Cooke peter David Owen Davies

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现代生物医学进展 2017年第18期17卷 I0001-I0002页

作者： Mikolaj Medon Eva Vidacs Stephin J Vervoort Jason Li Misty R. Jenkins Kelly M. Ramsbottom joseph A. Trapani Mark J. Smyth Phillip K. Darcy peter W. Atadja Michael A. Henderson Ricky W. Johnstone Nicole M. Haynes Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Bioinformatics Consulting Core Facility Cancer Research Division Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute Herston Queensland Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. China Novartis Institute for Biomedical Research Shanghai China. Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australi

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究... 详细信息

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究人员发现组蛋白去乙酰化酶抑制剂panobinostat可以通过宿主免疫增强trastuzumab这种单抗治疗药物的抗肿瘤效果。

关键词：组蛋白去乙酰化酶抑制剂抗肿瘤效应治疗药物治疗效果 HDAC 单抗 Res 阳性

两性霉素B两种剂型治疗真菌感染的药物经济学分析

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中国药物经济学 2008年第1期3卷 6-14页

作者： joseph L. Kuti Srividya Kotapati peter Williams Blair Capitano Charles H.Nightingale David P.Nicolau 陶立波美国康涅狄格州Hartford 医院抗感染研究中心美国匹兹堡大学药学院

研究背景:对于两性霉素B治疗真菌感染.如果将所有的治疗成本和治疗收益都纳入考虑,那么该药物不同脂质剂型之间安全性、有效性和经济性等方面的差异依然是模糊不清的。研究设计:对于两性霉素B的两种剂型,两性霉素B脂质复合物(amphoteric... 详细信息

研究背景:对于两性霉素B治疗真菌感染.如果将所有的治疗成本和治疗收益都纳入考虑,那么该药物不同脂质剂型之间安全性、有效性和经济性等方面的差异依然是模糊不清的。研究设计:对于两性霉素B的两种剂型,两性霉素B脂质复合物(amphotericin B lipid complex,ABLC)和两性霉素B脂质体(liposomal amphotericin B,L-AMB),采用回顾性最小成本法进行比较分析,研究角度采用医疗机构角度。治疗成本(以美元计数,2001年的水平)被分成3个层次,第一为只有药品费用,第二为包括相关医疗措施的成本,第三为包括全部住院治疗的相关成本。结果:两组研究对象的社会人口学情况和治疗时间均没有显著性差异。两组的临床有效率比较接近(ABLC为53%,L-AMB为60%,P=0.68),所以本经济学评估采用了最小成本法。ABLC组47%的研究对象血清肌酸酐(SCr)出现上升,而L-AMB组只有10%,P值为0.025。对于3个层次的总治疗成本,两组间均没有明显差异。但当校正了治疗时间因素后,L-AMB组的治疗成本显著地高于ABLC组(第一层次,ABLC为340美元,L-AMB为435美元,P=0.002;第二层次,ABLC为361美元,L-AMB为454美元,P=0.027)。预防或治疗不良事件(adverse events)的成本在两组间并无差异。敏感性分析表明,经济学评估结果对药品价格和用药剂量敏感。二维敏感性分析显示,只要L-AMB的价格高于ABLC的135%,ABLC的经济性优势就可以保持。结论:这两种药品的总院内治疗成本并无差别。但校正了治疗时间因素后,ABLC的治疗成本明显低于L-AMB。治疗成本的计算包括了药品费用、相关治疗费用、不良反应的预防和治疗费用。研究提示药品价格是治疗成本的重要影响因素。

关键词：治疗成本真菌感染两性霉素经济学分析不良事件治疗时间敏感性分析第二层次最小成本法药品价格

Effectiveness of Firewise Approach(FWA)in Controlling Forest Fire:A Case of Uluguru Nature Forest Reserve(UNFR),Morogoro,Tanzania

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Journal of Agricultural Science and Technology(B) 2020年第3期10卷 175-185页

作者： Pilly joseph Kagosi Siwa Ernest Nkya Chelestino peter Balama Innocent Hamisi Babili Tanzania Forestry Research Institute(TAFORI) P.O.BOX 1854MorogoroTanzania Institute of Continue Education(ICE) Sokoine University of Agriculture(SUA)P.O.BOX 3000MorogoroTanzania

Forest fire has received considerable attention in literature because it is considered one of the most common factors causing disturbances in ecosystems and at the same time considered vital in maintaining *** Approach(FWA)has been proposed and used for controlling forest fire and achieving sustainable forest *** approach requires involvement of communities in managing forest fire incidences in reserved *** considerable period since FWA has been practiced,there is insufficient scholarly knowledge on effectiveness of the approach in managing forest *** paper examines the effectiveness of FWA in managing forest fires in Uluguru Nature Forest Reserve(UNFR).The study employed cross-section research design that involved quantitative and qualitative data *** data were analysed using Statistical Package for Social Science(SPSS)software and content *** study found alternating periods:the period of overall decrease of wildfire incidences within initial five years of practising the *** study concludes that the FWA is useful in reducing forest fire incidences during early period of practising the approach and another period of huge fire occurrence beyond five ***,the FWA has challenges of sustaining successes in controlling forest fires including limited fire management training to common *** study recommends sustaining communities’trainings on forest fire management.

关键词： Effectiveness of firewise approach controlling forest fire Uluguru Nature Forest Reserve.

The Perspectives of Kwame Nkrumah University of Science and Technology Dental School Graduates

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Open Journal of Stomatology 2018年第5期8卷 158-167页

作者： Alex Oti Acheampong Felix Ampofo Anafi Nana Tuffuor Ampem Gyimah Ama Amuasi Solomon Obiri-Yeboah Daniel Kwesi Sabbah Alfred Nyarko Merley Newman Nartey Patrick Ampofo Stephen Ankoh joseph Abu-Sakyi Isaac Kwaku Asiamah Robert Nii Lamy Larmie Francis Adu-Ababio James Appiah Amoateng peter Donkor Kwame Nkrumah University of Science and Technology Dental School Kumasi Ghana Kumasi South Hospital Kumasi Ghana Komfo Anokye Teaching Hospital Oral Health Directorate Kumasi Ghana University of Ghana School of Medicine and Dentistry Accra Ghana

Background: The idea of establishing a Dental school at the Kwame Nkrumah University of Science and Technology (KNUST) was borne out of a need. There was a shortfall in the supply of dental surgeons, especially in the northern half of the country. Aim/Objective: To seek for feedback from KNUST Dental school graduates over the past six about their overall assessment of the BDS courses taught during their clinical training and challenges faced in the course of their training. Methodology: A cross-sectional retrospective study of all KNUST Dental school graduates from 2012 to 2017. A structured goggle form questionnaire was developed. The Google form link was emailed to the representatives who in turn forwarded the link to their year mates. The questionnaire was filled online and submitted as requested. Results: This represented 63.0% of the entire graduates from KNUST Dental School. The male to female ratio was 1.3:1.0. The age range of our graduate was from 24 yrs (3.8%) to 32 years (1.9%). The average age was 26.3 years. 48.10% of respondents said their training was very good. The major challenges were inadequate clinical space (25.2%) and lack of materials and dental chairs for students’ clinic (27.3%). Conclusion: On the whole, the quality of the training was rated as very good even though some of the courses taught during the clinical training were rated as poor. Inadequate dental chairs, laboratory and clinic materials, supervision of student’s clinic were some of the major challenges expressed by the graduates.

关键词： Dentistry Perspective Graduates Challenges Students

The assessment of atrial function by velocity-encoded magnetic resonance imaging

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World Journal of Cardiovascular Diseases 2013年第2期3卷 18-24页

作者： Charles C. Vu John F. Heitner Igor Klem peter J. Cawley Anna Lisa C. Crowley Manesh R. Patel Jonathan W. Weinsaft Michele A. Parker Michael Elliott Robert M. Judd Raymond J. Kim joseph C. Greenfield Jr. Division of Cardiology New York Methodist Hospital Brooklyn USA Division of Cardiology New York Presbyterian Hospital Weill Cornell Medical Center New York USA Division of Cardiology University of Washington School of Medicine Seattle USA Duke Cardiovascular Magnetic Resonance Center Duke University Medical Center Durham USA Stony Brook School of Medicine Stony Brook USA

Introduction: The purpose of this study was to assess velocity-encoded cardiac magnetic resonance imaging (Ve-CMR) in a population of patients referred for cardiac magnetic resonance imaging (CMR), to determine the variability of atrial function, and to identify clinical parameters associated with left atrial function. Methods: This is a prospective study evaluating patients who were referred to our CMR center for a clinical CMR. Left atrial function was obtained via Ve-CMR thru-plane images across the mitral valve after acquiring 2 perpendicular in-plane images as “scouts”. The atrial function and mitral inflow were quantified by computer analysis (Argus, Siemens). Atrial function was defined as atrial contraction (A-wave) volume divided by total inflow volume. Left atrial volumes were calculated via computer analysis. Mitral regurgitation and left ventricular ejection fractions were assessed visually. Results: Thirty-nine patients, with mean age 56 +/- 10 years, were enrolled. The mean left atrial function was 22.9% +/-14.5%;the range in left atrial function was 0% - 57%. There was a significant positive correlation between atrial function and increased left ventricular ejection fraction (r = 0.44, P < 0.01). There was a significant negative correlation between atrial function and severity of mitral regurgitation (r = -0.60, P < 0.01), as well as left atrial volume (r = -0.36, P = 0.02). Conclusion: Our results indicate a wide variability in left atrial function and a significant association between left atrial function and left ventricular ejection fraction, left atrial volume and mitral regurgitation.

关键词： Atrial Function Velocity-Encoded Cardiovascular Magnetic Resonance

Sediment Yield Dynamics during the 1950s Multi-Year Droughts from Two Ungauged Basins in the Edwards Plateau, Texas

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Journal of Water Resource and Protection（水资源与保护） 2015年第16期 1345-1362页

作者： joseph K. Sang peter M. Allen John A. Dunbar Jeffrey G. Arnold joseph D. White

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专家对VSAT未来的展望

成都信息工程学院学报 1993年第2期15卷 115-123页

作者： Leonard S.Golding joseph Rinde Andrew J.Viterbi peter P.Nuspl Richard W.Jestin Pierre Bartholome joseph N.Pelton K.M.Sundara Murthy Barry G.Evans 王春芳

自从VSAT(天线口径非常小的地球站)建立和发展以来,使很多领域不断取得进步。这些领域包括使用超大规模集成技术的技术合成,射频单元集成和批量生产技术、天线的改进和批量生产技术、对新用户和网络协议的支持、用户控制管理选择、高功... 详细信息

自从VSAT(天线口径非常小的地球站)建立和发展以来,使很多领域不断取得进步。这些领域包括使用超大规模集成技术的技术合成,射频单元集成和批量生产技术、天线的改进和批量生产技术、对新用户和网络协议的支持、用户控制管理选择、高功率低损耗放大器、网络监控新技术、发展新应用领域等。在过去的五年中。

关键词： VSAT 地球站射频单元天线口径话音业务网络监控网络协议批量生产网络层协议公共信道

“战争!到处是战争!”:戈培尔日记中的中日战争

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抗日战争研究 2019年第4期 93-102,M0004页

作者：何铭生姜涛(译) 丹麦哥本哈根大学跨文化与地区研究系中国社会科学院近代史研究所

纳粹德国宣传部部长约瑟夫·戈培尔的完整日记直至近年才为历史学家所利用。以往有关中日战争前后德国政治的重要论著,都未能利用这份极具潜在价值的史料。本文尝试初步探讨戈培尔日记新材料的问世将在何种程度上修正过去有关德国卷入... 详细信息

纳粹德国宣传部部长约瑟夫·戈培尔的完整日记直至近年才为历史学家所利用。以往有关中日战争前后德国政治的重要论著,都未能利用这份极具潜在价值的史料。本文尝试初步探讨戈培尔日记新材料的问世将在何种程度上修正过去有关德国卷入远东危机的观点。文章尤其关注1937年希特勒在决策中所扮演的角色,并具体例举相关证据,证明这位德国独裁者转向亲日立场,实际早于过往的推测。此外,戈培尔日记表明,希特勒东亚观所受到的纳粹意识形态的影响也可能超出以往的估计。

关键词：纳粹党德国戈培尔希特勒

脑动静脉畸形血管造影评估和血管内治疗的报道标准

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国际脑血管病杂志 2013年第1期21卷 1-7页

作者： Mahesh V Jayaraman Philip M Meyers Colin P Derdeyn Justin F Fraser Joshua A Hirsch M Shazam Hussain Kristine A Blackham Clifford J Eskey Mary E Jensen Christopher J Moran Charles joseph Prestigiacoma peter A Rasmussen Cameron G McDoumll 冀雅彬(译) 姬仲(译) From the Departments of Diagnostic Imaging and Neurosury Alp ert Medical School Brown University Providence Rhode Island USA Department of Radiology and Neurological Surgery Columbia University New York New York USA Neuroradiology Department Washington University in St Louis St Louis Missouri USA Department of Neurological Surgery University of Kentucky Louisville Kentucky USA Departt of Interventional and Diagnostic Neuromdiology Massachusetts General Hospital Boston Massachusetts USA Cerebrovascular Center Cleveland Clinic Cleveland Ohio USA University Hospitals Department of Radiology Case Westem Reserve University Cleveland Ohio USA Department of Radiology Neurology and Neurosur Dartrnouth-Hitchcock Medical Center Lebanon New Hampshire USA Department of Radiology and Neurological Surgery University of irginia Charlottesville V-trginia USA Department of Neurological Surgery New Jersey Medical School University of Medicine and Dentistry of New Jersey Newark New Jersey USA Neurosurgery Department Cleveland Clinic Cleveland Ohio USA Neurosurgery Department Barrow Neurological Institute Phoenix Arizona USA 南方医科大学南方医院神经内科广州510515

本指南根据一个致力于中枢神经系统动静脉畸形（arteriovenousmalformation，AVM）患者评估和治疗的多学科专家组共识制定。该报道标准为临床试验设计以及那些希望报道脑AVM血管内治疗的临床研究人员提供了一个样板。不同治疗方案的直... 详细信息

本指南根据一个致力于中枢神经系统动静脉畸形（arteriovenousmalformation，AVM）患者评估和治疗的多学科专家组共识制定。该报道标准为临床试验设计以及那些希望报道脑AVM血管内治疗的临床研究人员提供了一个样板。不同治疗方案的直接比较对于医疗诊治的标准化、良好治疗转归的最大化以及新方法和新技术的评估至关重要。

关键词：脑动静脉畸形血管内治疗标准化血管造影临床研究人员中枢神经系统脑AVM 试验设计