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Phosphoprotein Phosphatase 1 Isoforms Alpha and Gamma Respond Differently to Prodigiosin Treatment and Present Alternative Kinase Targets in Melanoma Cells

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Journal of Biophysical Chemistry 2014年第2期5卷 67-77页

作者： Margarida Fardilha Joao Figueiredo margarita espona-fiedler Juliana Felgueiras Luis Korrodi-Gregorio Sara L.C.Esteves Sandra Rebelo Odete A.B.da Cruz Silva Edgar da Cruz e Silva Ricardo Perez-Tomas Laboratory of Signal Transduction Centre for Cell BiologyBiology Department and Health Sciences DepartmentUniversity of AveiroAveiroPortugal Department of Pathology and Experimental Therapeutics Cancer Cell Biology Research GroupUniversity of BarcelonaBarcelonaSpain Laboratory of Neuroscience Centre for Cell BiologyBiology Department and Health Sciences DepartmentUniversity of AveiroAveiroPortugal

Reversible protein phosphorylation is a central regulatory mechanism of cell function. Deregulation of the balanced actions of protein kinases and phosphatases has been frequently associated with several pathological conditions, including cancer. Many studies have already addressed the role of protein kinases misregulation in cancer. However, much less is known about protein phosphatases influence. Phosphoprotein Phosphatase 1 (PPP1) is one of the major serine/threonine protein phosphatases who has three catalytic isoforms: PPP1CA, PPP1CB, and PPP1CC. Its function is achieved by binding to regulatory subunits, known as PPP1-interacting proteins (PIPs), which may prefer a catalytic isoform. Also, some inhibitors/enhancers may exhibit isoform specificity. Here we show that, prodigiosin (PG), a molecule with anticancer properties, promotes the formation of PPP1CA-AKT complex and not of PPP1CC-MAPK complex. Both, AKT and MAPK, are well-known PIPs from two pathways that crosstalk and regulate melanoma cells survival. In addition, the analysis performed using surface plasmon resonance (SPR) technology indicates that PPP1 interacts with obatoclax (OBX), a drug that belongs to the same family of PG. Overall, these results suggest that PG might, at least in part, act through PPP1C/PIPs. Also, this study is pioneer in demonstrating PPP1 isoform-specific modulation by small molecules.

关键词： Phosphoprotein Phosphatase 1 Catalytic Subunit Surface Plasmon Resonance Mitogen-Activated Protein Kinase V-Akt Murine Thymoma Viral Oncogene Glycogen Synthase Kinase 3

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Snapshot Survey of the Presence of Perfluoroalkyl Substances in Products, Articles, and the Environment in Ecuador

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Engineering 2024年第6期37卷 49-61页

作者： Heidelore fiedler Luis Vega-Bustillos Jenny Arias-Pastrano Lander Vinicio Pérez-Aldás Jose Castro-Díaz MTM Research Centre School of Science and TechnologyÖrebro UniversityÖrebro 70182Sweden Undersecretariat of Environmental Quality Ministry of EnvironmentWater and Ecological Transition of EcuadorQuito 170525Ecuador Department of Environmental Chemistry The Technical University of AmbatoHuachi CampusAmbato 180207Ecuador Alternativavision Ambiental Cia.Ltda. Mexico 03100Mexico

The Stockholm Convention on Persistent Organic Pollutants(POPs)is a legally binding instrument for 186 Parties(status:April 2023).Accordingly,among other responsibilities,countries are obliged to report the production,import,or export of the POPs listed in Annexes A,B,or C;provide information to registers;maintain inventories;and monitor the presence of POPs in the *** the broader context of international chemicals and waste management,producer responsibilities,harmonized reporting,and compliance with national and international regulations,Ecuador has addressed the newly listed group of perfluorinated alkyl substances(PFAS)in its national implementation plan and sent selected products from its national market for PFAS *** products analyzed came from the initially listed fields of specific exemptions and acceptable purposes,including:fire-fighting foams;photographic aids;greasers/degreasers;various kinds of paper/packaging;textiles;and leather,coatings,cleaners,metal plating,and *** results showed that the three PFAS presently listed in the Stockholm Convention could be quantified in only a few samples;additional PFAS,not yet listed in the Convention also had low detection *** the number of samples was limited,the samples covered a large spectrum of sample matrices,making it possible to conclude that—once these products become waste and are regulated under the Basel Convention—they would not constitute a disposal ***,verification of the presence of PFAS in products on the market is expected to pose an analytical challenge for both,developed and developing countries.

关键词： Emerging or newly listed POPs Stockholm Convention Products and articles PFAS analysis Developing countries

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ITPK1 is an InsP_(6)/ADP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer Danye Qiu Debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi Dorothea fiedler Henning J.Jessen Gabriel Schaaf Ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2D,3C,4C,and 7D and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

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Escape to the high canopy thermal deficiency causes niche expansion in a forest-floor ant

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Insect Science 2017年第4期24卷 699-707页

作者： Bernhard Seifert Patrick fiedler Roland Schultz Senckenberg Museum of Natural History Gorlitz 02826 Gorlitz Germany Faculty of Environmental Sciences Technical University Dresden 01069 Dresden Germany

The small formicoxenine ant Temnothorax saxonicus was known from about 40 localities in Central Europe nesting in anorganie substrates on floor of xerothermous forests whereas investigations of 198 tree canopies in 19 forest sites of the same region provided no indication for arboreal nesting or foraging. We present the first evidence for canopy-nesting populations of T. saxonicus on old Quercus trees in 3 sites having maximum calibrated topsoil temperatures of 17.9 ± 0.3 ℃ which were significantly （P 〈 0.007） lower than 22.8 ± 2.0 ℃ measured in 5 sites with ground-nesting populations. The thermal deficit on forest floor inhibits brood development in ground nests and caused a moving to canopy were maximum calibrated temperatures of the, now wooden, substrates are at least 26.1 ℃for the whole canopy and 30.8 ℃ in more sun-exposed spots. T. saxonieus competed here successfully with the obligatory canopy ants T. affinis and T. cortiealis. The distributional data of this rope-climbing study support former results that highest nest densities of small arboreal ants occur in temperate climate over the entire canopy mantle of single trees situated in open land or in park-like environments but occur in the top of the canopy in tree stands with high degree of canopy closure.

关键词： canopy temperature foraging distance microhabitat selection soil temper-ature soil temperature calibration Temnothorax

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DNA barcoding-based species delimitation increases species count of Eois （Geometridae） moths in a well-studied tropical mountain forest by up to 50%

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Insect Science 2011年第3期18卷 349-362页

作者： Patrick Strutzenberger Gunnar Brehm Konrad fiedler Department of Animal Biodiversity University of Vienna Rennweg 14 1030 Wien Austria Institut for Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum Friedrich Schiller Universitat Erbertstrasse 1 07743 Jena Germany

The genus Eois comprises an important part of megadiverse assemblages of geometrid moths in mountain rainforests of southern Ecuador. In this study we report：（i） on the construction of a DNA barcode library of Eois for identification purposes; and （ii） the exploration of species diversity through species delimitation by pair-wise distance thresholds. COl barcode sequences were generated from 408 individuals （at least 105 species） collected on a narrow geographic scale （-40 km2） in the Reserva Bioldgica San Francisco. Analyses of barcode sequence divergence showed that species delimitations based solely on external morphology result in broad overlap of intra- and interspecific distances. Species delimitation at a 2% pair-wise distance threshold reveals a clear barcoding gap. Fifty-two previously unrecognized species were identified, 31 of which could only be distinguished by an integrative taxonomy approach. Twelve additional putative species could only be recognized by threshold-based delimitation. Most splits resulted in two or three newly perceived cryptic taxa. The present study increased the number of Eois species recorded from that small area of Andean mountain forest from 102 to 154 （morphology- plus integrative taxonomy-based） or even 166 （sequence-based）, leaving the species accumulation curve still far from reaching an asymptote. Notably, in no case did two or more previously distinguished morphospecies have to be lumped. This barcode inventory can be used to match larvae to known adult samples without rearing, and will therefore be of vital help to extend the currently limited knowledge about food plant relationships and host specialization.

关键词： cryptic species Ecuador integrative taxonomy Larentiinae larvae

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Metadata Analysis of Persistent Organic Pollutants in National Pools of Human Milk in Support of the Stockholm Convention Implementation

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环境与健康(英文) 2023年第1期1卷 41-52页

作者： Heidelore fiedler University School of Science and TechnologyMTM Research Centre70218 ÖrebroSweden

A set of human milk samples,consisting of pools from up to 50 mothers that delivered their first baby was assessed for the persistent organic pollutants(POPs)listed in the Stockholm *** must be noted that only samples that qualified for the criteria,as established in the global monitoring plan of the Stockholm Convention,following an initial protocol from the World Health Organization,were *** data do not allow for an assessment of POP concentrations in breast milk with lactation period nor,in most cases and when not indicated otherwise,a comparison within the same *** assessment does not rank the POPs as to the risk for *** the measurements provide a basis for countries to compare among POPs or with other countries.A regional preference for certain POPs could not be identified;thus,taking into account global food supply chains and local production elsewhere does not allow us to prioritize a country for a certain *** the highest concentrations were always found for the sum of DDT,these samples were not prominent in multivariate statistical *** best indicator for the scale of POPs in breast milk was the sampling year:the earlier a national pool was created,the higher and the wider spread were the concentrations:see the example of dioxin-like POPs and indicator *** some POPs,the income of a country seems to indicate scale and POP *** population density was not found to be a suitable predictor or *** all POPs seemed to level off and some POPs were only measured after the entry-into-force of the Stockholm Convention in 2004,we do not have a strong indicator to determine POP concentrations in the 1980s or before.

关键词： Human breast milk national income population density trend analysis regional assessment Stockholm Convention on POPs

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EXPERIMENTAL INVESTIGATION ON ORDERED AND CHAOTIC PHENOMENA OF VORTEX SHEDDING IN THE WAKE FLOW BEHIND A TWO-DIMENSIONAL CIRCULAR CYLINDER

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Science China Mathematics 1992年第1期35卷 81-90页

作者：魏中磊吴忠 H.E.fiedler Department of Mechnics Peking University Beijing 100871 PRC Hermann-Fottinger Institut Technische Universitat Berlin 1000 Berlin 12

In this paper, some preliminary experiments of ordered and chaotic vortex sheddingsbehind a 2--D circular cylinder at Reynolds numbers ranging from R_e=50 to 400 are presented.A transition in vortex shedding from the laminar to chaotic state occurs at Re=184.6-193.5,but it is seemingly not through the quasi--periodicity routes. There is a couple of dis-continuities in slope on the curve of the relationship between the vortex shedding frequencyand Reynolds number. The discontinuity at Re = 70 might correspond to the change of themode of the oblique vortex shedding. The second one at Re = 193.5 is responsible for thetransition from the ordered to the chaotic state.

关键词： ordered and chaotic phenomena vortex shedding wake.

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城市电动自行车设计,当极简主义遇见使用质量

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工业设计 2024年第1期 23-23页

作者： Alexander Forst Dennis fiedler 不详

这款城市电动自行车从轻巧与创新的车架结构、流畅的造型语言、惊人的高度集成,到出色的设计和制造质量,在各个层面上都达到了非常高的质量标准。盘式制动器、灯和遥控器的电缆巧妙地藏在车体内,将操作刹车的杠杆支架集成在车把中,将照... 详细信息

这款城市电动自行车从轻巧与创新的车架结构、流畅的造型语言、惊人的高度集成,到出色的设计和制造质量,在各个层面上都达到了非常高的质量标准。盘式制动器、灯和遥控器的电缆巧妙地藏在车体内,将操作刹车的杠杆支架集成在车把中,将照明系统完全集成在车架中。此外,重量轻、紧凑的电机还与下管无缝融合,使整辆车充满动感、极致简约。

关键词：电动自行车极简主义盘式制动器照明系统车架结构无缝融合质量标准遥控器

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Ordered and chaotic phenomena of vortex shedding in an excited wake flow behind a 2-D oscillating circular cylinder

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Science China Mathematics 1995年第4期38卷 447-461页

作者：魏中磊张子强 H.E.fiedler Department of Mechanics Peking University Beijing 100871 China H-F Institute TU D-10623 Berlin Germany

The behavior of synchronization in an open flow dynamical system, especially in an excited wake flow behind a 2-D oscillating circular cylinder with Reynolds number Re ranging from 45 to 200 is presented. The experiment reveals that only under certain conditions can the competition between frequencies of oscillating cylinder and the vortex shedding in the wake flow result in 'window of chaos' with the mixed RTN and Feigenbaum scenario in the range of Re<185.

关键词： synchronization chaotic behavior wake vortex shedding oscillation.

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吸湿对单向亚麻纤维复合材料力学性能的影响

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复合材料学报 2022年第2期39卷 608-616页

作者：贾云龙 fiedler Bodo 常州工学院航空与机械工程学院/飞行学院常州213032 汉堡工业大学聚合物与复合材料研究所汉堡D21073

为探明亚麻纤维增强树脂复合材料(FFRPs)在长期潮湿环境中的力学性能变化规律,基于真空辅助树脂模塑传递成型(VARTM)手段制备了的干燥状态的单向FFRPs(纤维体积分数为40vol%)。试验研究了FFRPs在30°C、80%相对湿度(RH)环境中放置5天、3... 详细信息

为探明亚麻纤维增强树脂复合材料(FFRPs)在长期潮湿环境中的力学性能变化规律,基于真空辅助树脂模塑传递成型(VARTM)手段制备了的干燥状态的单向FFRPs(纤维体积分数为40vol%)。试验研究了FFRPs在30°C、80%相对湿度(RH)环境中放置5天、35天、86天后拉伸力学性能变化。结果表明,FFRPs在湿热环境中吸水量近似符合一维情况下的Fickian第二定律,饱和吸水量为5.3%左右。FFRPs在垂直于纤维方向上的拉伸强度和模量随吸湿度增加递减,断口微观分析表明吸湿降低了纤维基体界面结合性能。然而,FFRPs在纤维方向上的拉伸强度并未因吸湿降低,反而在吸湿过程呈现出先减小后增加的趋势,此变化规律文献中尚未报道:相比干燥状态,放置5天后拉伸强度下降5.7%;放置35天后拉伸强度增加18.7%;放置86天时样品已处在饱和吸湿状态,拉伸强度略微减小,但仍比干燥状态增加13.7%。FFRPs在纤维取向上拉伸强度变化可解释为多因素共同作用的结果。

关键词：植物纤维复合材料亚麻纤维吸湿拉伸力学性能耐久性

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