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The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期13卷 561-584页

作者： Karen López Miguel Daniel Ricardo Martínez Ávila Lliset Álvarez Pérez Gisselle Martínez Rabasa Alejandro Linchenat Lambert Roberto Esperón Noa Lisandra Heredia Manzano margarita de quesada amigó Rafael I. Reyes Velázquez Danay Corrales Otero Ramon Ropero Toirac Idelmis Curbelo Heredia Mircea Betancourt Cabeza Tania A. Agrelo Ramos Rosa María Muñoz Reyes Juan Jesús Lence Anta Rosalía Fuentes Sosa Karelia Silvera Candó Kirenia Silva Rodríguez Zaida Lastre Sosa Mayte Robaina García Eduardo Sanz David Marquez department of Medical Oncology INOR La Habana Cuba department of Gynaeco-Oncology INOR La Habana Cuba department of Anatomical Pathology INOR La Habana Cuba department of Imaging INOR La Habana Cuba Clinical Research Section INOR La Habana Cuba department of Onco-Psychology INOR La Habana Cuba Clinical Laboratory department INOR La Habana Cuba Clinical Trials Pharmacy department INOR La Habana Cuba department of Biostatistics CENCEC La Habana Cuba Scientific department CATALYSIS Madrid Spain

Background: 70% of ovarian cancer cases are diagnosed at an advanced stage (III or IV) of the disease and, in turn, with a high prevalence of peritoneal carcinosis and ascites, which leads to progressive malnutrition in patients, with the consequent deterioration of their general condition. There is a very important relationship between nutritional status, quality of life, survival, and the ability to tolerate multidisciplinary treatment of peritoneal carcinosis. Methods: A phase II, open-label, single-center, non-randomised clinical trial was conducted that included 36 patients with advanced disease who were administered the nutritional supplement Ocoxin, 30 ml twice a day, beginning one week before chemotherapy (CT) based on carboplatin/paclitaxel, of which they receive three cycles with neoadjuvant intent. Ocoxin treatment was continued during chemotherapy and for three weeks after completion of the last cycle, as well as during any periods for which this treatment was discontinued due to toxicity. The effect of Ocoxin on the quality of life was assessed through the QLQ C30 and QLQ OV28 questionnaires from the start of treatment until the end of the follow-up period. In addition, the Karnofsky Index and nutritional parameters were assessed. Results: There were no significant differences between adverse events versus baseline values, except in leukocytes, lymphocytes, neutrophils, ALT, and AST. There was no deterioration of the QoL scales, except for those related to the effects of chemotherapy and alopecia. Conclusions: Ocoxin as an adjuvant to chemotherapy appears to improve better tolerance to chemotherapy, showed a good safety profile, and improved quality of life. For further information on Ocoxin neoadjuvant therapy benefits, a phase III clinical trial will be needed.

关键词： Chemotherapy Radiotherapy Ovarian Cancer Oncology Quality of Life Ad-juvant Therapy Supportive Care

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Tree diametric-species diversity is affected by human impact in old Scots pine dominated forest in boreal Fennoscandia

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Forest Ecosystems 2020年第1期7卷 92-103页

作者： Gonzalo de quesada Timo Kuuluvainen department of Forest Ecology University of HelsinkiP.O.Box 24FIN-00014 HelsinkiFinland

Background:Forest structural and compositional variability is of fundamental importance for forest ecosystem functioning and species *** purpose of this research was to examine how human impact has affected the compositional-structural diversity of mature pine-dominated boreal forest in boreal *** this a new approach was used,based on the classification of tree sizes by the diameter at breast height(dbh)and tree species,resulting in a new variable,the diametric-species,the variation of which describes the compositional-structural diversity of the *** variable was used to compare the structural-compositional diversity among three forest classes with different degree of human influence,using rarefaction as the main tool of analysis,complemented by analyses based on common diversity ***:The results showed that the near-natural forest was the most diverse and the managed forest the least *** the other hand,the diversity of near-natural and selectively logged forests were similar,suggesting that selectively logged forests are equal to the natural forest in their compositional-structural *** analysis solely on tree species showed no significant differences among the forest classes of different human *** Shannon diversity index showed no significant difference between the forest classes for the diametric-species and tree species classifications only,but the Simpson index signaled a slight difference between the selectively logged and managed forest classes for the diametric-species ***,the Sorensen index detected a difference among forest classes in the diametric-species ***:Forest utilization had an adverse impact on forest compositional-structural diversity of mature Scots pine *** analysis also shows that the novel approach based on diametric-species classification could be a useful tool for forest diversity analysis and comparison,especially in speci

关键词： Diametric-species Boreal forest diversity Rarefaction analysis Human intervention Compositional-structural diversity

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Moult intensity constraints along the complete moult sequence of the House Sparrow(Passer domesticus)

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Avian Research 2023年第3期14卷 394-404页

作者： Santi Guallar Javier quesada departament de Vertebrats Museu de Ciencies Naturals de BarcelonaBarcelona08003CataloniaSpain

Sequence and intensity are two essential components of bird *** the moult sequences of remex tracts are highly homogenous across passerines,other tracts apparently show a high ***,order of moult activation among tracts are insufficiently ***,dynamics of moult intensity as moult progresses remains poorly ***,we provide detailed quantitative description of moult sequence and intensity in the House Sparrow(Passer domesticus).To understand their role,we tested two hypotheses on the:1) protection function of moult sequence,and 2) aerodynamic and physiological constraints on moult *** scored percentage growth of 313 captured sparrows using the mass of the feathers of each tract(also length for remiges)to monitor moult intensity throughout the complete moult progress,which is defined as the fraction of new and growing feathers in a moulting bird relative to the total *** sequence was highly variable both within wing coverts and among feather tracts,with moult sequence differing among all birds to some *** only found support for the protection function between greater coverts and both tertials and ***-moult intensity conformed to theoretical predictions,therefore lending support to the aerodynamic-constraint ***,remex-moult speed plateaued during the central stages of moult ***,overall plumage-moult speed did not fit predictions of the physiological-constraint hypothesis,showing that the remex moult is only constrained by *** results indicate that aerodynamic loss is not simply the inevitable effect of moult,but that moult is finely regulated to reduce aerodynamic *** propose that the moult of the House Sparrow is controlled through sequence and intensity adjustments in order to:1) avoid body and wing growth peaks;2) fulfil the protection function between some key feather tracts;3) reduce detrimental effects on flight ability;4) keep remex seque

关键词： Functional constraints Local polynomial regression Passerine moult Physiological constraints Raggedness

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Multiphysics Simulation of a Novel Concept of MEMS-based Solid Propellant Thruster for Space Propulsion

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Journal of Thermal Science 2011年第6期20卷 527-533页

作者： José A.Moríigo José Hermida-quesada dept.of Space Programmes National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain Propulsion EngineerPh.D. dept.of Aerodynamics and Propulsion National Institute for Aerospace Technology Ctra.Ajalvir km.4Torrejón de Ardoz 28850 MadridSpain

This work analyzes a novel MEMS-based architecture of submillimeter size thruster for the propulsion of small spacecrafts,addressing its preliminary characterization of *** architecture of microthruster comprises a setup of miniaturized channels surrounding the solid-propellant reservoir filled up with a high-energetic *** channels guide the hot gases from the combustion region towards the nozzle entrance located at the opposite side of the *** simulations of the transient response of the combustion gases and wafer heating in thruster firings have been conducted with FLUENT under a multiphysics modelling that fully couples the gas and solid parts *** approach includes the gas-wafer and gas-polymer thermal exchange,burnback of the polymer with a simplified non-reacting gas pyrolysis model at its front,and a slip-model inside the nozzle portion to incorporate the effect of gas-surface and rarefaction onto the gas ***,accurate characterization of thruster operation requires the inclusion of the receding front of the polymer and heat transfer in the moving gas-solid *** study stresses the improvement attained in thermal management by the inclusion of lateral micro-channels in the *** particular,the temperature maps reveal the significant dependence of the thermal loss on the instantaneous surface of the reservoir wall exposed to the heat flux of hot ***,the simulations stress the benefit of implementing such a pattern of micro-channels connecting the exit of the combustion reservoir with the *** results prove that hot gases flowing along the micro-channels exert a sealing action upon the heat flux at the reservoir wall and partly mitigate the overall thermal loss at the inner-wall vicinity during the *** analysis shows that propellant decomposition rate is accelerated due to surface preheating and it suggests that a delay of the flame extinction into the reservoir

关键词： micronozzles spacecraft micropropulsion solid propellant thrusters

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Analysis of Viscous Heating in a Micro-Rocket Flow and Performance

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Journal of Thermal Science 2008年第2期17卷 116-124页

作者： José A.Moríigo José Hermida quesada dept.of Space Programmes National Institute for Aerospace Technology dept.of Aerodynamics and Propulsion National Institute for Aerospace Technology

Micro-rockets for propulsion of small spacecrafts exhibit significant differences with regard to their macroscale counterparts,mainly caused by the role of the viscous dissipation and heat transfer processes in the micron-sized *** goal of this work is to simulate the transient operation of a micro-rocket to investigate the effects of viscous heating on the flow and performance for four configurations of the expanding gas and wafer *** modelling follows a multiphysics approach that solves the fluid and solid regions fully coupled.A contin- uum-based description that incorporates the effects of gas rarefaction through the micro-nozzle,viscous dissipa- tion and heat transfer at the solid-gas interface is ***-equilibrium is addressed with the implementa- tion of a 2nd-order slip-model for the velocity and temperature at the *** results stress that solid-fluid cou- pling exerts a strong influence on the flowfield and performance as well as the effect of the wafer during the first instants of the transient in micro-rockets made of low and high thermal conductivity materials.

关键词： Micronozzles propulsion MEMS slip flow viscous heating

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Short-term microbial responses to soluble inorganic P input in a tropical lowland rain forest in Amazonia

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Pedosphere 2021年第6期31卷 964-972页

作者： Yuri W.L.de SOUSA Erika BUSCARDO Carlos A.N.quesada Henrique E.M.NASCIMENTO Laszlo NAGY National Research Institute for Amazonia Manaus 69067-375(Brazil) department of Forestry University of BrasiliaBrasilia 70910-900(Brazil) Centre for Functional Ecology University of CoimbraCoimbra 3000-456(Portugal) department of Animal Biology University of CampinasCampinas 13083-862(Brazil)

In non-flooded lowland rain forests with low soil phosphorus(P)in parts of Amazonia,P cycling largely occurs via leaf litter recycling by arbuscular mycorrhizal(AM)fungal *** high input of P into these ecosystems occurs during drought years with increased *** the length and frequency of drought events are projected to increase in the region,a single-dose nutrient addition experiment was carried out to test how this would impact P *** application rate of 4 kg P ha^(-1) was used,which corresponds to twice the amount of litter-derived P in an average *** was hypothesized that i)the added mineral P would be immobilized by soil microorganisms,leading to measurable increase in soil microbial biomass carbon(C)and P and ii)AM colonization rate would be reduced by the pulse in mineral P available for plant *** results did not support either of our *** addition of P did not have an effect on AM root colonization,nor was P immobilized by soil microbiota during the experimental *** lack of a difference between the control and treatment at our study site could be attributed to the relatively low one-off dose of P applied that did not change either the colonization rate of roots by AM fungi or the amount of soil available labile *** obtain a mechanistic understanding of the availability,capture,and use of P by plant-symbiont associations in tropical rain forest ecosystems,further integrated studies of the soil-plant system combining long-term nutrient manipulations,modeling,and experimental approaches are required.

关键词： Amazon basin arbuscular mycorrhizal fungi nutrient addition phosphorus cycling soil microbial biomass

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Use of absorbable meshes in laparoscopic paraesophageal hernia repair

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World Journal of Gastrointestinal Surgery 2019年第10期11卷 388-394页

作者： Bernabé M quesada Adelina E Coturel department of Surgery Cosme Argerich Hospital

Paraesophageal hernia(PEH)repair is one of the most challenging upper gastrointestinal *** high rate of recurrence is due mostly to the low quality of the crura and size of the hiatal *** an attempt to diminish the recurrence rates,some clinical investigators have begun performing meshreinforced cruroplasty with nonabsorbable meshes like polypropylene or *** main problem with these materials is the occurrence,in some patients,of serious mesh-related morbidities,such as erosions into the stomach and the esophagus,some of which necessitate subsequent esophagectomy or *** meshes can be synthetic or biological and were introduced in recent years for PEH repair with the intent of diminishing the recurrence rates observed after primary repair alone but,theoretically,without the risks of morbidities presented by the nonabsorbable *** current role of absorbable meshes in PEH repair is still under debate,since there are few data regarding their long-term efficacy,particularly in terms of recurrence rates,morbidity,need for revision,and quality of *** this opinion review,we analyze all the presently available evidence of reinforced cruroplasty for PEH repair using nonabsorbable meshes(synthetic or biological),focusing particularly on recurrence rates,mesh-related morbidity,and long-term quality of life.

关键词： Paraesophageal hernia Laparoscopy Mesh Absorbable Biological

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Landform Instability and Land-use Dynamics in Tropical High Mountains, Central Mexico

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Journal of Mountain Science 2012年第3期9卷 414-430页

作者： GARCíA-ROMERO Arturo ACEVES-quesada José Fernando ARREDONDO-LEóN Carlos departamento de Geografía Física Instituto de Geografía Universidad Nacional Autónoma de México. Circuito exterior s/n Ciudad Universitaria 04510 Mexico Distrito Federal Mexico Unidad Académica de Estudios Regionales de la Coordinación de Humanidades Universidad Nacional Autónoma de México

This investigation is an analysis of the influence of landform instability on the distribution of land-use dynamics in a hydrographical basin, located in the Mexican Volcanic Belt mountain range (central Mexico), currently affected by substantial changes in land use and deforestation. A landform map was produced, in addition to seven attribute maps - altimetry, drainage density, slope, relief energy, potential erosion, geology and tectonics - which were considered as factors for determining landform instability through Multi-criteria Evaluation Analysis. Likewise, the direction and rhythm of land-use dynamics were analyzed in four dates - between 1976 and 2000 - and cross tabulations were made between them, in order to analyze the trends and processes of land-use dynamics. Afterwards, the databases obtained were cross tabulated with the landform variables to derive areas, percentages and correlation indices. In the study area, high-instability landforms are associated with most ancient volcanic and sedimentary landforms, where high altitude, drainage density, slope and potential to develop gravitational and fluvial processes are the major factors favouring a land-use pattern, dominated by the conservation of extensive forest land, abandonment of human land use and regeneration of disturbed areas. In contrast, low-instability landforms correspond to alluvial plains and lava hills covered by pyroclasts, where low potential erosion to develop fluvial processes, added to water and soil availability and accessibility, have favoured a land-use pattern dominated by the expansion of agroforestry plantations and human settlements, showing a marked trend towards either intensification or permanence of the current land use and with little abandonment and regeneration.

关键词： Landform instability Multi-criteriaEvaluation Analysis Land-use change and processes Tuxpan River Basin

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Corrigendum to“Moult intensity constraints along the complete moult sequence of the House Sparrow(Passer domesticus)”[Avian Res.14(2023)100125]

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Avian Research 2023年第4期14卷 716-717页

作者： Santi Guallar Javier quesada departament de Vertebrats Museu de Ciències Naturals de BarcelonaBarcelona08003CataloniaSpain

In the original version of this article,we published a figure showing a gap in the confidence intervals for body and tail due to data paucity for mid stages of moult ***,we amended this problem adding data from the 2023 moulting season,during which we obtained 139 moult records from 98 *** final sample size used for plotting these results are shown in the caption *** amendment corroborates the conclusion already stated:body moult does not seem to be under physiological constraints,although primary moult appears to be tightly controlled to reduce aerodynamic losses.

关键词： constraints stated conclusion

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Influence of olive oil and its components on mesenchymal stem cell biology

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World Journal of Stem Cells 2019年第12期11卷 1045-1064页

作者： Antonio Casado-Díaz Gabriel Dorado Jose Manuel quesada-Gómez CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES) Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain departement Bioquímica y Biología Molecular Campus Rabanales C6-1-E17Campus de Excelencia Internacional Agroalimentario(ceiA3)Universidad de CórdobaCIBERFESCórdoba 14071Spain Unidad de Gestión Clínica de Endocrinología y Nutrición CIBER de Fragilidad y Envejecimiento Saludable(CIBERFES)Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC)Hospital Universitario Reina SofíaCórdoba 14004Spain

Extra virgin olive oil is characterized by its high content of unsaturated fatty acid residues in triglycerides,mainly oleic acid,and the presence of bioactive and antioxidant *** consumption is associated with lower risk of suffering chronic diseases and unwanted processes linked to aging,due to the antioxidant capacity and capability of its components to modulate cellular signaling *** of olive oil can alter the physiology of mesenchymal stem cells(MSCs).This may explain part of the healthy effects of olive oil consumption,such as prevention of unwanted aging *** date,there are no specific studies on the action of olive oil on MSCs,but effects of many components of such food on cell viability and differentiation have been *** objective of this article is to review existing literature on how different compounds of extra virgin olive oil,including residues of fatty acids,vitamins,squalene,triterpenes,pigments and phenols,affect MSC maintenance and differentiation,in order to provide a better understanding of the healthy effects of this ***,most studies have shown a positive effect of these compounds on *** collective findings support the hypothesis that at least part of the beneficial effects of extra virgin olive oil consumption on health may be mediated by its effects on MSCs.

关键词： Olive oil Mesenchymal stem cells Cellular differentiation Aging Cellular niche Mediterranean diet

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