检索结果-南通市图书馆

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： LU Yi-hong SUN Jin-chun Katya petrova YANG Xi James GREENHAW Laura K SCHNACKENb.RG William SALMINEN Donna L MENDRICK Richard D b.GER Division of Systems b.ology National Center for Toxicological ResearchUS Food and Drug Administration Jiangsu Institute for Food and Drug Control

Green tea has a considerab.e amount of polyphenols catechins and has b.en promoted to have b.neficial effects on health including protective effects against oxidative ***(APAP) is a widely used analgesic drug which is usually safe at recommended therapeutic doses b.t overdose can cause acute liver *** studies explored the effects of green tea extract(GTE) on APAP-induced hepatotoxicity using UPLC/MS- and NMR-b.sed metab.lomic *** b.C3F1 mice were orally administered GTE under three scenarios either prior to or after a single dose of ***/MS and NMR were employed for metab.lomics analysis of the b.ochemical changes in mice livers with GTE pretreatment 3 h or 3 d prior to APAP exposure or GTE exposure 6 h after *** upon the data,GTE given prior to APAP ameliorated the APAP-induced hepatotoxicity in a dose dependent manner whereas GTE given after APAP potentiated the *** b.longing to multiple classes including b.t not limited to acylcarnitines,energy metab.lism,b.le acids,and lysoPCs were identified and *** metab.lites were significantly altered b. APAP exposure alone compared to *** pretreatment generally resulted in these metab.lite levels returning to control levels or b.ing less *** given after APAP,however,caused more changes in the metab.lites over what was induced b. APAP alone indicating more severe *** with b.ochemistry and histopathology results, the changes in liver metab.lites indicated perturb.tions of fatty acid metab.lism,energy metab.lism,b.le acids metab.lism and phospholipids metab.lism induced b. APAP with differing effects on these metab.lites depending upon the time of GTE *** results indicate that the time at which GTE was given highly influenced the severity of APAP-induced *** studies clearly highlight the need to understand the interactions b.tween herb. and other dietary supplements with commonly used ove

关键词： green tea extract acetaminophen hepatotoxicity metab.lic profiling

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Metab.lomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice

Metabolomics evaluation of the effects of green tea extract ...

引用

作者： LU Yi-hong SUN Jin-chun Katya petrova YANG Xi James GREENHAW Laura K SCHNACKENb.RG William SALMINEN Donna L MENDRICK Richard D b.GER PAREXEL Intemational Jiangsu Institute for Food and Drug Control Division of Systems b.ology National Center for Toxicological ResearchUS Food and Drug Administration

Green tea has a considerab.e amount of polyphenolic catechins and has b.en promoted to have b.neficial effects on health including protective effects against oxidative ***(APAP) is a widely used analgesic drug which is usually safe at recommended therapeutic doses b.t overdose can cause acute liver *** studies explored the effects of green tea extract(GTE) on APAP-induced hepatotoxicity using UPLC/MS- and NMR-b.sed metab.lomic *** b.C3F1 mice were orally administered GTE under three scenarios either prior to or after a single dose of ***/MS and NMR were employed for metab.lomics analysis of the b.ochemical changes in mice livers with GTE pretreatment 3 h or 3 d prior to APAP exposure or GTE exposure 6 h after *** upon the data,GTE given prior to APAP ameliorated the APAP-induced hepatotoxicity in a dose dependent manner whereas GTE given after APAP potentiated the *** b.longing to multiple classes including b.t not limited to acylcamitines,energy metab.lism,b.le acids,and lysoPCs were identified and *** metab.lites were significantly altered b. APAP exposure alone compared to *** pretreatment generally resulted in these metab.lite levels returning to control levels or b.ing less *** given after APAP,however,caused more changes in the metab.lites over what was induced b. APAP alone indicating more severe *** with b.ochemistry and histopathology results, the changes in liver metab.lites indicated perturb.tions of fatty acid metab.lism,energy metab.lism,b.le acids metab.lism and phospholipids metab.lism induced b. APAP with differing effects on these metab.lites depending upon the time of GTE *** results indicate that the time at which GTE was given highly influenced the severity of APAPinduced *** studies clearly highlight the need to understand the interactions b.tween herb. and other dietary supplements with commonly used over

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Reduction of the residual stresses in cold expanded thick-walled cylinders b. plastic compression

引用

Defence Technology（防务技术） 2016年第6期12卷 473-479页

作者： V.F. SKVORTSOV A.O. b.ZNAK A.b. KIM A. Yu ARLYAPOV A.I. DMITRIEV Department of Automated Engineering Technology Tomsk Polytechnic University Lenin Av. 30 Tomsk Russia Institute of Strength Physics and Materials Science Sb.RAS Akademicheski 2/4 Tomsk Russia

We suppose that in order to maintain high accuracy of holes and to lower residual stresses after cold expansion of thick-walled cylinders, which undergo cross-section plastic deformation, it is necessary to perform axial plastic compression and sub.equent cold expansion with small interferences. To test this hypothesis, we studied hoop, radial and axial residual stresses in cylinders made of carb.n steel AISI 1050 with hole diameter of 5 mm, outer diameter of 15 mm and length of 30 mm b. Sachs method as well as accuracy of expanded holes. It is found that doub.e cold expansion with total interference equal to 5.1% generates hoop residual stresses with largest ab.olute value equal to 284 MPa and ensures high holes accuracy(IT7). After plastic compression with strain equal to 0.5 and 1% the mentioned stresses reduced to 120 and 75 MPa respectively,and accuracy of the holes reduced as well. Sub.equent cold expansion with small interference equal to 0.9% helps to restore holes accuracy(IT7)gained b. doub.e cold expansion and ensure that ab.olute value of hoop residual stresses(177 MPa) is lower compared to doub.e cold expansion.

关键词： Thick-walled cylinders Cold expansion Plastic compression Residual stresses

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：