检索结果-南通市图书馆

Mangiferin,a natural xanthone,accelerates gastrointestinal transit in mice involving cholinergic mechanism

World Journal of Gastroenterology 2012年第25期18卷 3207-3214页

作者： Talita Cavalcante Morais Synara Cavalcante Lopes Karine Maria Martins Bezerra Carvalho Bruno rodrigues Arruda Francisco Thiago Correia de Souza Maria Teresa Salles Trevisan Vietla Satyanarayana Rao Flávia Almeida santos Department of Physiology and Pharmacology Brazilian SemiArid Institute of BiomedicineFaculty of MedicineFederal University of CearáFortaleza 60430-270Brazil Post-Graduate Programme in Medical Sciences Faculty of MedicineFederal University of CearáFortaleza 60430-140Brazil Department of Organic and Inorganic Chemistry Federal University of CearáFortaleza 60451-970Brazil

AIM： To investigate the effects of mangiferin on gas- trointestinal transit （GIT） in normal and constipated mice, together with the possible ***： Intragastrically-administered charcoal mealwas used to measure GIT in overnight starved Swiss mice. In the first experiments, mangiferin （3 mg/kg, 10 mg/kg, 30 mg/kg, and 100 mg/kg, po） or tegaserod （1 mg/kg, ip） were administered 30 min before the char- coal meal to study their effects on normal transit. In the second series, mangiferin （30 mg/kg） was tested on delayed GIT induced by several different pharma- cological agonists （morphine, clonidine, capsaicin） or antagonists （ondansetron, verapamil, and atropine） whereas in the third series, mangiferin （30 mg/kg, 100 mg/kg and 300 mg/kg） or tegaserod （1 mg/kg） were tested on 6 h fecal pellets outputted by freely fed mice. The ratio of wet to dry weight was calculated and used as a marker of fecal water content. RESULTS： Mangiferin administered orally significantly （P 〈 0.05） accelerated GIT at 30 mg/kg and 100 mg/kg （89% and 93%, respectively）, similarly to 5-hydroxytrypta- mine4 （5-H%） agonist tegaserod （81%） when compared to vehicle-treated control （63%）. Co-administered man- giferin （30 mg/kg） totally reversed the inhibitory effect of opioid agonist morphine, 5-HT3-receptor antagonist ondansetron and transient receptor potential vanilloid-1 receptor agonist capsaicin on GIT, but only to a partial extent with the GIT-delay induced by ~2-adrenoceptor agonist clonidine, and calcium antagonist verapamil. However, co-administered atropine completely blocked the stimulant effect of mangiferin on GIT, suggesting the involvement of muscarinic acetylcholine receptor activation. Although mangiferin significantly enhanced the 6 h fecal output at higher doses （245.5±10.43 mg vs 161.9±10.82 mg and 227.1±20.11 mg vs 161.9±10.82 mg of vehicle-treated control, at 30 and 100 mg/ kg, P 〈 0.05, respectively）, the effect of tegaserod was more potent （297.4±7.42 mg vs 161.9±1

关键词： Mangiferin Glucosylxanthone Gastrointes-tinal transit Prokinetic action Cholinergic mechanism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

3D Printed Scaffolds as a New Perspective for Bone Tissue Regeneration: Literature Review

引用

Materials Sciences and Applications 2016年第8期7卷 430-452页

作者： Raquel Couto de Azevedo Gonçalves Mota Emerson Oliveira da Silva Felipe Fortes de Lima Lívia rodrigues de Menezes Antonio Carlos santos Thiele Instituto de Macromoléculas Professora Eloisa Mano Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Universidade Federal do Rio de Janeiro Pólo Xerém Estr. de Xerém 27-Xerém Duque de Caxias-RJ Rio de Janeiro Brazil

Due to the high incidence of bone fractures in the population, it became necessary to produce scaffolds that are able to assist in tissue regeneration. It is necessary to find an appropriate balance between the mechanical and biological properties, in order to mimic the natural tissue, these properties are directly related to the architecture and their degree of porosity, as well as the size of their pores and their interconnectivity. In this perspective, the 3D printing stands out, where the structure is obtained layer by layer, according to a predetermined computational model which provides a greater control of architecture and scaffold geometry and overcomes, in this way, the limitations of traditional techniques of scaffolds manufacturing. In this way, the objective of this seminar is to present the state of the art of the polymer scaffolds produced by 3D printing and applied to bone tissue regeneration, highlighting the advantages and limitations of this process.

关键词： Scaffolds 3D Printing Tissue Engineering Bone Tissue

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni

引用

World Journal of Gastroenterology 2008年第38期14卷 5842-5850页

作者： Sheilla Andrade Oliveira Bruno Solano Freitas Souza Carla Adriana Guimares-Ferreira Elton Sá Barreto Siane Campos Souza Luiz Antonio rodrigues Freitas Ricardo Ribeiro-dos-santos Milena Botelho Pereira Soares Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Centro de Pesquisas Aggeu Magalhes Fundao Oswaldo Cruz Recife Av Moraes Rego s/n Cidade Universitária Recife 50670-420 PE Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas Salvador 40295-001 BA Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Hospital So Rafael Av So Rafael 2152 So Marcos Salvador 41256-900 BA Brazil

AIM： To investigate the potential of bone marrow mononuclear cells （BM-MCs） in the regeneration of hepatic lesions induced by Schistosoma mansoni （***） chronic infection. METHODS： Female mice chronically infected with *** were treated with BM-MCs obtained from male green fluorescent protein （GFP） transgenic mice by intravenous or intralobular injections. Control mice received injections of saline in similar conditions, Enzyme-linked immunosorbent assay （ELISA） assay for transforming growth factor-beta （TGF-β）, polymerase chain reaction （PCR） for GFP DNA, immunofluorescence and morphometric studies were performed. RESULTS： Transplanted GFP^＋ cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by Fluorescence in situ hybridization （FISH） analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-β, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of ***-infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with ***, was found in livers of infected mice after cellular therapy. CONCLUSION： In conclusion, transplanted BMCs migrate to and reduce the damage of chronic fibrotic liver lesions caused by ***.

关键词： Schistosoma mansoni Liver injury Fibrosis Bone marrow cells Transplantation Albumin Oval cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unsupervised Methods to Classify Real Data from Offshore Wells

引用

American Journal of Operations Research 2021年第5期11卷 227-241页

作者： Antônio Orestes De Salvo Castro Mayara De Jesus Rocha santos Fabiana rodrigues Leta Cláudio Benevenuto C. Lima Gilson Brito Alves Lima Rio de Janeiro State University (UERJ) Rio de Janeiro Brazil Department of Engineering of Fluminense Federal University (UFF) Niterói Brazil Petróleo Brasileiro S.A Rio de Janeiro Brazil

In the petroleum industry, sensor data and information are valuable. It can detect, predict and help to understand processes during oil production. Offshore wells require more attention. Once workovers, maintenance, and intervention are more costly than onshore wells. Coupling data-driven methods for well-monitoring applications, two unsupervised classification methods, one statistical and one machine learning-based, are proposed to detect anomalies in well data. The novelty is presented by applying a Control Chart using a 3 standard deviations window for the Permanent Downhole Gauge Pressure sensor (P-PDG), and a Fuzzy C-means algorithm to classify data from pressure and temperature sensors in an offshore field. The main goal in structuring a classified data set is using it to train machine learning models to monitor and manage petroleum production. Modeling applications for early fault detection systems in offshore production, based on real-time data from production sensors, require classified data sets. Then, labeling two target classes: “normal” and “fault” is a key step to be implemented in order to train the machine learning models. Therefore, this paper applies two methodologies to classify a real-time data set to create a training data set divided into “normal” and “fault” classes. Thus, it is possible to visualize the abnormal events pointed out by the methodologies and compare how sensible is each method. In addition, it is proposed a random forest application to test the per

关键词： Unsupervised Classification Fuzzy C-Means Control Chart

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Climatic Projections of Lightning in Southeastern Brazil Using CMIP5 Models in RCP’s Scenarios 4.5 and 8.5

引用

American Journal of Climate Change 2017年第3期6卷 539-553页

作者： Ana Paula Paes dos santos Osmar Pinto Júnior Sérgio Rodrigo Quadros dos santos Francisco José Lopes de Lima Everaldo Barreiros de Souza André Arruda rodrigues de Morais Eldo E. ávila Analía Pedernera National Institute for Space Research (INPE) S&atilde o José dos Campos Brazil Vale Institute of Technology (ITV) Belém Brazil National University of Cordoba (UNC) Córdoba Argentina

Given the high and increasing lightning incidence over the Southeast of Brazil and the various impacts that this phenomenon generates to society, there is a growing need in predicting its occurrence, in order to minimize its consequences. In this context, this work presents the development of a methodology for the projection of lightning in the State of S?o Paulo (Southeastern Brazil), using the HadGEM2-ES and CSIRO-Mk3.6 models in two IPCC climate change scenarios: RCP4.5 and RCP8.5. Since lightning is not an output variable of climate models, tests were carried out to evaluate the relationship between the observed data of oceanic and atmospheric fields, which are known as outputs of the models, and the lightning from the RINDAT and BrasilDAT detection networks. As result, a correlation of 0.84 was obtained. In the projections, it was verified that, while during a large portion of the current climate we observed events of lightning below the average, the future climate reveals the preponderance of anomalously above average events, both in the scenario of intermediate-low emissions (RCP4.5) and in the scenario of high emissions (RCP8.5), suggesting a change in the pattern of the lightning incidence in the State of S?o Paulo.

关键词： Lightning Climatic Projections Southeastern Brazil

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fertilization with Nitrogen, Phosphorus and Potassium in Upland Rice Cultivars in the Southern Region of Rondônia, Brazil

引用

American Journal of Plant Sciences 2015年第14期6卷 2263-2271页

作者： Edimar rodrigues Soares Robertt Fernandes Laércio da Silva Londero Leandro Galon Fabiana Ferreira Pires Marcelo de Andrade Barbosa Diego Lopes dos santos Samara Cristina Sampaio Correa Everton Augusto Sampaio Correa Remy Carvalho dos santos Department of Soil Science S&atilde o Paulo State University (UNESP) Jaboticabal Brazil Department of Agronomy Federal Institute of Education Science and Technology of Rond&ocirc nia (IFRO) Colorado do Oeste Brazil Department of Agronomy College Amazon (FAMA) Vilhena Brazil Department Herbology Federal University of the Border South (UFFS) Erechim Brazil Federal University Mato Grosso (UFMT) Cuiaba Brazil

The upland rice productivity in the state of Rond?nia is still low, in view of the potential of culture. The use of cultivars adapted to different regions and more responsive to fertilizer employed is an essential practice which can change that. The aim of this study was to evaluate the agronomic characteristics and productivity of two upland rice cultivars with nitrogen, phosphorus and potassium (N-P-K) doses in two municipalities in the southern state of Rondonia region. The experimental design was a randomized block design with four replications in a factorial 2 × 2 × 5, with the first factor composed of two cultivars (hybrid Ecco and conventional farming AN Cambará), the second factor, the environment of the two municipalities, Cerejeiras and Vilhena and the third factor of five doses of N-P-K (0-0-0, 30-40-30, 60-60-60, 90-90-90 and 120-100-120 kg·ha-1). The characteristics evaluated were: tillering, number of integers and sterile grains per panicle, weight of 1000 grains, grain yield (kg·ha-1) and whole grain yield. There was no triple interaction between the three factors for any of the traits. The hybrid Ecco has higher tillering ability than AN Cambara and presents fewer sterile grains per panicle, heavier 1000 grains and hence greater productivity. For both cultivars, the highest yields are obtained with a dose of 120-100-120 kg·ha-1 N-P-K. For the Ecco, the productivity is achieved with this dose and the dose of 90-90-90 kg·ha-1 is statistically similar. There is no difference in productivity between the municipalities when the dose of N-P-K is less than 60-60-60 kg·ha-1. The highest yield of whole grains in function of N-P-K fertilization is obtained in Cerejeiras.

关键词： Oryza sativa L. Productivity Hybridization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Response to Commentary by Dr. Matthew J. Clarkson on

引用

Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio Silva Neto Cláudio Avelino rodrigues santos Paolo Lucas rodrigues-Silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos santos Rosangela Vieira Andrade Jonato Prestes Thiago dos santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Agrobacterium tumefaciens-mediated transformation of Eucalyptus urophylla clone BRS07-01

引用

Journal of Forestry Research 2020年第2期31卷 507-519页

作者： Gisela Manuela de Franca Bettencourt Carlos Ricardo Soccol Thais Salete Giovanella Luziane Franciscon Daiane Rigoni Kestring Isabel rodrigues Gerhardt Juliana Degenhardt-Goldbach Department of Bioprocess Engineering and Biotechnology Federal University of ParanaAvenida Cel.Francisco Heraclito dos Santos210CuritibaParanaBrazil Department of Agronomy Federal University of ParanaRua dos Funcionarios1540CuritibaParanaBrazil Embrapa Forestry Estrada da RibeiraKm 111ColomboParanaBrazil Embrapa Agricultural Informatics Av.Andre Tosello209CampinasSao PauloBrazil

Genetic transformation is becoming routine for engineering specific traits in important clones of recalcitrant species such as Eucalyptus;however,the efficiency is still low for most species,so many researchers still use seeds instead of clones as initial *** work aimed to develop a genetic transformation protocol,based on a highly efficient in vitro organogenesis protocol,for an Eucalyptus urophylla clone selected in our breeding *** growth regulators were evaluated for indirect organogenesis and *** a two-step protocol,the combination of callus induction media supplemented with 0.5 μM thidiazuron+0.5 μM naphthaleneacetic acid(NAA)and shoot induction media supplemented with 5.0 μM benzylaminopurine+1.0 lM NAA allowed up to 85.6%shoot formation with more shoots per explants when compared with other *** plants expressing the uidA gene were obtained using Agrobacterium tumefaciens and selected for kanamycin resistance.A RAPD analysis was used to check for somaclonal *** tests using 11 RAPD primers,we did not observe somaclonal variation in the in vitro stages evaluated.

关键词： Eucalyptus Genetic transformation In vitro regeneration Plant growth regulators Somaclonal variation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Congenital Granular Cell Lesion:A Case Report

引用

Case Reports in Clinical Medicine 2014年第10期3卷 566-569页

作者： Dionline Borges Paulo Bruna rodrigues Barbosa Jerúsia Oliveira Ibiapina Ana Maria Goncalves Rebelo Teresinha Castello Branco Carvalho Lina Gomes dos santos Department of Specialty Medicine Health Sciences CenterFederal University of PiauíTeresinaBrazil Department of Pathology Sao Marcos HospitalTeresinaBrazil

The congenital granular cell lesion is a rare disease that affects newborns. We present a case of a patient with nodular lesions that were located on the anterior part of the maxillary alveolar. The surgical resection... 详细信息

关键词： Congenital Epulis Congenital Granular Cell Lesion Surgery

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanical Circulatory Support in Patients with Sepsis： A Case Series

引用

Journal of Pharmacy and Pharmacology 2018年第5期6卷 541-546页

作者： Helmgton Jose Brito de Souza Henrique Louzan Machado Thiago do Amaral Cavalcante Leonardo Jadyr santos rodrigues Alves Diogo Assis Souza Rafael Ramos Amaral Felipe Bruno santos da Cunha Marcus Vinicius Nasimento dos santos Glauco Kalil da Silva Pina Isaac Azevedo Silva Ricardo Borros Corso The Department of Medicine University Center of Brasilia Brasilia 70790-075 Brazil

MCS （mechanical circulatory support） has shown great efficacy in treatment of respiratory mid cardiovascular diseases when conventional therapy is insufficient. The use of ECMO （extracolporeal membrane oxygenation） for the treatment of cardiogenic shock secondary to sepsis is still controversial. Studies have shown that ECMO should be considered as a valuable therapeutic option in cases of refractory cardiovascular dysfunction in severe septic patients, although more studies ale needed to consolidate its efficacy. We report the case of two patients, without previous history of cardiopathy, subjected to temporary MCS, with use of ECMO for the treatment of refractory cardiogenic shock secondary to sepsis.

关键词： ECMO MCS sepsis cardiogenic shock.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：