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天然气工业 1999年第1期19卷 76-79页

作者：梁明熙中国海洋石油南海西部公司

南海西部石油公司在其管辖的莺歌海、琼东南盆地中深层勘探中遇到高温高压储层，在中外专家的协助下于１９９４年７月在水深１１５ｍ的崖２１—１构造上钻成深度４６８８ｍ的探井，经测试地层压力为１０５．１５ＭＰａ，地层温度２０６... 详细信息

南海西部石油公司在其管辖的莺歌海、琼东南盆地中深层勘探中遇到高温高压储层，在中外专家的协助下于１９９４年７月在水深１１５ｍ的崖２１—１构造上钻成深度４６８８ｍ的探井，经测试地层压力为１０５．１５ＭＰａ，地层温度２０６℃，获得齐全准确的各项数据。在半潜式钻井平台上进行高温高压井测试是世界石油界探讨和努力解决的难题。防止意外井喷事故是测试的先决条件。对地面设备、井下工具和工艺方法的选取一切应以安全为前提，只有这样才能取全各项资料数据，确保顺利压井以及起出管柱。通过对一些测试成功井的技术总结，提出了对海上高温高压井测试技术的认识和看法，提出了目前存在的问题和今后有待于改进的方向。

关键词：高温地层钻井平台中途测试高压井海上油气田

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现代汉语与越南语存在句语用比较研究

海外华文教育 2013年第2期 165-178页

作者： Hoàng t■ nguyên 胡志明市人文与社会科学大学中国语文系越南胡志明市70000

存在句是存现句最典型的一种。对于这种特殊的句子,至今已有不少学者深入研究并在此方面获得了相当大的成果。本文力图将现代汉语与越南语"存在句"(C■U t■N t■I)的语用进行比较分析。

关键词：现代汉语存在句越南语CAU tON tAI 语用比较

阿芬太尼和艾司洛尔对气管插管时循环和儿茶酚胺反应的影响

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中华麻醉学杂志 1999年第3期19卷 146-148页

作者：龚志毅 J.C.Yang K.F.ng t.S.Siu 罗爱伦中国医学科学院香港大学麻醉系

目的　比较阿芬太尼和艾司洛尔对气管插管时循环及儿茶酚胺反应的影响。方法　 35例病人随机分为 3组 ,A组为对照组 ,B组为艾司洛尔组 ,C组为阿芬太尼组。插管前 B、C组分别给予2 mg/ kg艾司洛尔、30μg/ kg阿芬太尼。静注硫喷妥钠和维... 详细信息

目的　比较阿芬太尼和艾司洛尔对气管插管时循环及儿茶酚胺反应的影响。方法　 35例病人随机分为 3组 ,A组为对照组 ,B组为艾司洛尔组 ,C组为阿芬太尼组。插管前 B、C组分别给予2 mg/ kg艾司洛尔、30μg/ kg阿芬太尼。静注硫喷妥钠和维库溴铵诱导插管。结果　插管后 3分 ,阿芬太尼组收缩压显著降低 (P<0 .0 1) ,B、C两组的心率低于对照组 (P<0 .0 5 )。 A、B两组的血浆去甲肾上腺素浓度 (NE)增加 ,均高于其基础值 (P<0 .0 1) ,但阿芬太尼组 NE水平无明显改变 ,肾上腺素水平较基础值降低 (P<0 .0 1)。结论　艾司洛尔 2 mg/ kg可在一定程度上缓解插管时的循环反应。阿芬太尼 30μg/ kg能完全抑制插管时的循环及儿茶酚胺反应。

关键词：气管内插管术阿芬太尼艾司洛尔血液动力学

Fourier transform technique in variational treatment of two-electron parabolic quantum dot

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Chinese Physics B 2009年第8期18卷 3508-3516页

作者： S.Sakiroglu A.Yιldιz .Dogan K.Akgngr H.Epik Y.Ergn H.Sarι .Skmen Physics Department Dokuz Eyll University Physics Department Anadolu University Physics Department Cumhuriyet University

In this work, we propose an efficient method of reducing the computational effort of variational calculation with a Hylleraas-like trial wavefunction. the method consists of introducing integral transforms for the terms as r12^κ exp （-λτ12） which provide the calculation of the expectation value of energy and the relevant matrix elements to be done analytically over single-electron coordinates instead of Hylleraas coordinates. We have used this method to calculate the ground state energy of a two-electron system in a spherical dot and a disk-like quantum dot separately. Under parabolic confinement potential and within effective mass approximation size and shape effects of quantum dots on the ground state energy of two electrons have been investigated. the calculation shows that our results even with a small number of basis states are in good agreement with previous theoretical results.

关键词： two-electron quantum dot parabolic confinement variational method Hylleraas coor- dinates

StI571对恶性多发性神经胶质母细胞瘤(GBM)的体外抑瘤作用

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中国肿瘤临床 2004年第15期31卷 856-859页

作者：任欢李殿俊 Rainov ng 哈尔滨医科大学免疫学教研室哈尔滨市150086 英国利物浦大学神经医学系

目的:研究酪氨酸激酶抑制剂(StI571)对恶性胶质瘤细胞的肿瘤生物学调节作用。方法:用免疫组化法探查血小板源生长因子(PDGF)及其受体在t98G,U87MG,LNZ308,RG四种胶质瘤细胞的表达;Mtt法用于检查StI571/tMZ单独或联合应用对胶质瘤细胞的... 详细信息

目的:研究酪氨酸激酶抑制剂(StI571)对恶性胶质瘤细胞的肿瘤生物学调节作用。方法:用免疫组化法探查血小板源生长因子(PDGF)及其受体在t98G,U87MG,LNZ308,RG四种胶质瘤细胞的表达;Mtt法用于检查StI571/tMZ单独或联合应用对胶质瘤细胞的增殖抑制作用,StI571诱导的细胞凋亡途径由流式细胞仪检测,免疫印迹杂交法用来探查StI571抵抗细胞的蛋白激酶网络变化。结果:所用胶质瘤细胞均不同程度的表达PDGF及受体。StI571与tMZ相互协同作用于胶质瘤细胞株t98G;10滋mol/LStI571可部分抑制所测胶质瘤细胞增殖、可完全抑制其形成集落;高于10滋mol/L浓度的StI571可快速诱导胶质瘤细胞凋亡或坏死;胶质瘤细胞株t98G与StI571长期共培养后,瘤细胞蛋白激酶网络有较大改变。结论:研究表明,PDGF受体酪氨酸激酶抑制剂StI571有较强的抑制恶性胶质瘤细胞(GBM)增殖的作用并可能与其他化疗药物协同抗肿瘤。

关键词： St1571 酪氨酸激酶抑制剂恶性胶质母细胞瘤(GBM)

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越—中贸易的历史、现状与未来发展战略研究

越—中贸易的历史、现状与未来发展战略研究

作者：冯氏越英（Ph(?)ng th(?) Vi(?)t Anh）湖南大学

学位级别：硕士

越中两国是有着友好关系的邻邦,两国人民的传统友谊代代相传。由两国前辈领导人精心培育的“同志加兄弟”友好关系在新世纪得以传承并进一步发展。在“睦邻友好、全面合作、长期稳定、面向未来”十六字方针的基础上,越中两国领导提出了... 详细信息

越中两国是有着友好关系的邻邦,两国人民的传统友谊代代相传。由两国前辈领导人精心培育的“同志加兄弟”友好关系在新世纪得以传承并进一步发展。在“睦邻友好、全面合作、长期稳定、面向未来”十六字方针的基础上,越中两国领导提出了“好邻居、好朋友、好同志、好伙伴”的四好精神,发展越中全面战略合作伙伴关系。越南和中国在区域和国际问题方面有许多共同的关注和共同利益。进一步发展两国的传统友好与合作关系符合两国人民的基本愿望和长期利益,有利于本地区的和平、稳定与繁荣。越南和中国都是社会主义国家,国情相近,并都正在努力建设社会主义定向市场经济体系。近几年来,两国领导互访频繁,加强沟通,政治和战略合作不断得到促进。经济、贸易、科学技术和文化社会等领域的双边合作也不断发展,双方在平等互利原则上签署了一系列合作文件。进一步加强越中经贸合作,全面促进和深化两国经贸合作关系符合双方的基本利益,是越中两国共同发展的共同需求。为了促进越中经贸全面发展,越南政府和中国政府于2006年11月签署了《关于扩大和深化双边经济贸易合作的协定》和《关于开展两廊一圈合作的谅解备忘录》。2008年,两国领导人已决定将越中关系升为全面战略合作伙伴关系。在这基础上,双方共同研究和建设《越南社会主义共和国政府和中华人民共和国政府2012年至2016年经贸合作五年发展规划》20多年来,越中经贸关系呈现良好发展趋势,双边经济、贸易合作关系不断向多领域、多方面和多样化趋势发展。同时,越中两国在多个领域都具备各自的优势,又具有互补性,经贸合作潜力巨大。两国政府都重视维护本国经济的快速、稳定增长,促进双方贸易合作迅速、健康和稳定发展随着两国经济的不单发展,双方关系日益加强,双边经济、贸易合作展望将从深度和广度发展。“两廊一圈”的合作,《越中2012年至2016年经贸合作五年发展规划》的签署与实施是为了给越中经贸关系发展指明方向,促进越中两国经贸合作快速、可持续稳定和有序发展,扩大合作领域,提高合作质量和水平,改善贸易平衡,实施优势互补,互利共赢,促进两国经济社会健康、可持续发展。

关键词：越中贸易发展战略 “两廊一圈”

Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

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Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-Smith Chee H.ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia the Institute for Mental and Physical Health and Clinical translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia the Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective the placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCts)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** this is a secondary analysis of a nutraceutical depression RCt which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(tPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** this is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

Pakl mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression

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Journal of Molecular Cell Biology 2017年第5期9卷 384-394页

作者： Kejing Zeng Lili tian Adam Sirek Weijuan Shao Ling Liu Yu-ting Chiang Jonathan Chernoff Dominic S. ng Jianping Weng tianru Jin Department of Endocrinology and Metabolism the Third Affiliated Hospital of Sun Yat-Sen University and Guangdong Provincial Key Laboratory of Diabetology Guangzhou 510630 china toronto General Research Institutes University Health Network Toronto M56 1L7 Canada Department of Physiology Faculty of Medicine University of Toronto Toronto MSS 1A8 Canada Cancer Biology Program Fox Chase Cancer Center PhiLadelphia PA 19111-2497 USA Keenan Research Centre Li Ka Shing Knowledge Institute Department of Medicine St. Michael's Hospital Toronto MSB lW8 Canada

Insulin can stimulate hepatic expression of carbohydrate-responsive element-binding protein （ChREBP）. As recent studies revealed potential metabolic beneficial effects of ChREBP, we asked whether its expression can also be regulated by the dietary polyphenoi curcumin. We also aimed to determine mechanisms underlying ChREBP stimulation by insulin and curcumin. the effect of insulin on ChREBP expression was assessed in mouse hepatocytes, while the effect of curcumin was assessed in mouse hepatocytes and with curcumin garage in mice. Chemical inhibitors for insulin signaling molecules were utilized to identify involved signaling molecules, and the involvement of p21-activated protein kinase 1 （Pakl） was determined with its chemical inhibitor and Pokl-/- hepatocytes. We found that both insulin and curcumin-stimulated ChREBP expression in Akt-independent but MEK/ERK-dependent manner, involving the inactivation of the transcriptional repressor Oct-1. Aged Pokl-/- mice showed reduced body fat volume. Pakl inhibition or its genetic deletion attenuated the stimulatory effect of insulin or curcumin on ChREBP expression. Our study hence suggests the existence of a novel signaling cascade Pakl/MEK/ERK/Oct-1 for both insulin and curcumin in exerting their glucose-lowering effect via promoting hepatic ChREBP production, supports the recognition of beneficial functions of ChREBP, and brings us a new overview on dietary polyphenols.

关键词： Akt ChREBP curcumin dietary polypheno[ intervention insulin Oct-l Pakl

Power and Bandwidth Allocation in Cooperative Dirty Paper Coding

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Power and Bandwidth Allocation in Cooperative Dirty Paper Co...