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对有特殊需要的学生的教育:全纳性教育体系的一个方面

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中国特殊教育 1997年第3期 1-6页

作者： margaretc.Wang 郭伯良 TEMPLE大学人类发展和教育研究中心中央教育科学研究所 100088

建立长期的互享国际信息与合作对特殊教育事业的发展是极为有意义的。一体化教育的实施给学校的教学活动、学生的认识与学习过程带来积极影响。文章在揭示28种影响变量之后，提出全纳性教育体系的概要，以构建有特殊教育需要的儿童随班... 详细信息

建立长期的互享国际信息与合作对特殊教育事业的发展是极为有意义的。一体化教育的实施给学校的教学活动、学生的认识与学习过程带来积极影响。文章在揭示28种影响变量之后，提出全纳性教育体系的概要，以构建有特殊教育需要的儿童随班就读的服务体系。

关键词：互享国际信息教学策略全纳性教育体系

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Carotid Endothelial VCAM-1 Is an Early Marker of Carotid Atherosclerosis and Predicts Coronary Artery Disease in Swine

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Journal of Biomedical Science and Engineering 2015年第11期8卷 767-779页

作者： Isabelle Masseau Douglas K. bowles Department of Biomedical Sciences University of Missouri Columbia MO USA Département des Sciences Cliniques Faculté de Médecine Vétérinaire Université de Montréal Québec Canada Dalton Cardiovascular Research Center University of Missouri Columbia MO USA

Objective: The aim was to determine if endothelial VCAM-1 (eVCAM-1) expression in the common carotid artery (CCA) would correlate with predictive markers of atherosclerotic disease, would precede reduction of markers of endothelial cell function and would predict coronary artery disease (CAD). Methods and results: Carotid arterial segments (bifurcation, proximal and distal CCA) were harvested from 14 and 24 month-old male castrated familial hypercholesterolemic (FH) swine, a model of spontaneous atherosclerosis. Quantification of local expression of eVCAM-1, intimal macrophage accumulation, oxidative stress, intima-media (I/M) ratio, intima-media thickness (IMT), endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (p-eNOS) in selected regions of the carotids revealed a relationship between local inflammation and atherosclerotic plaque progression. Importantly, inflammation was not uniform throughout the CCA. Endothelial VCAM-1 expression was the greatest at the bifurcation and increased with age. Finally, eVCAM-1 best estimated the severity of CAD compared to blood levels of glucose, hypercholesterolemia, carotid IMT, and p-eNOS. Conclusion: Our data suggested that eVCAM-1 was closely associated with atherosclerotic plaque progression and preceded impairment of EDD. Thus, this study supported the use of carotid VCAM-1 targeting agents to estimate the severity of CAD.

关键词： VCAM-1 Endothelial Cells Carotid Artery Atherosclerosis

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Trends in the management of anorectal melanoma:A multiinstitutional retrospective study and review of the world literature

2017年

作者： (美)Michael bowles

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World Journal of Gastroenterology 2021年第3期27卷 267-280页

作者： Josh Bleicher Jessica N Cohan Lyen C Huang William Peche T Bartley Pickron Courtney L Scaife Tawnya L bowles John R Hyngstrom Elliot A Asare Department of Surgery Huntsman Cancer Institute at the University of UtahSalt Lake CityUT 84114United States Department of Surgery George E Wahlen Department of Veterans Affairs Medical CenterSalt Lake CityUT 84114United States Department of Surgery Intermountain Medical CenterMurrayUT 84107United States

BACKGROUND Anorectal melanoma(ARM)is a rare disease with a poor *** on optimal treatment is limited and surgical management varies *** hypothesized that the frequency of abdominoperineal resection used as primary treatment of ARM has decreased over the past several *** To update our understanding of outcomes for patients with ARM and analyze management trends around the *** This is a multi-institutional,retrospective study of patients treated for ARM at 7 *** included both large,academic,tertiary care centers and smaller,general community *** prospectively maintained institutional tumor registries,we identified 24 patients diagnosed with ARM between January 2000 and May *** analyzed factors prognostic for recurrence and *** then used Cox regression to measure overall survival(OS)and melanoma-specific *** also performed a literature review to assess trends in surgical management and *** Of the 24 patients diagnosed with ARM,12(50.0%)had local,8(33.3%)regional,and 4(16.7%)distant disease at *** time to recurrence was 10.4 mo[interquartile range(IQR)7.5-17.2]with only 2 patients(9.3%)not developing recurrence following surgical *** OS was 18.8 mo(IQR 13.5-33.9).One patient is still alive without recurrence at 21.4 mo from diagnosis;no other patient survived 5 *** surgical management with abdominoperineal resection(APR)vs wide excision(WE)did not lead to differences in OS[hazard ratio=1.4(95%CI:0.3-6.8)].Review of the literature revealed geographic differences in surgical management of ARM,with increased use of WE in the United States and Europe over time and more frequent use of APR in Asia and *** was no significant improvement in survival over *** There is wide variation in the management of ARM and survival outcomes remain poor regardless of *** management should aim to minimize morbidity.

关键词： Melanoma Anorectal melanoma Literature review Melanoma surgery Surgical oncology Colorectal surgery

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3-5岁汉语儿童叙事能力发展的实验研究

中国特殊教育 2017年第11期 92-96页

作者：刘玉娟 Lori E.Skibbe Ryan P.bowles 中国教育科学研究院北京100088 Michigan State University East Lansing48824

叙事能力指有组织地表述事物或事件的语言能力,在儿童社会性、情感和认知发展过程中具有重要作用。本研究采用叙事评估工具(Narrative Assessment Protocol)测查了3-5岁汉语儿童叙事能力的发展,研究发现:(1)叙事评估工具能够反应汉语儿... 详细信息

叙事能力指有组织地表述事物或事件的语言能力,在儿童社会性、情感和认知发展过程中具有重要作用。本研究采用叙事评估工具(Narrative Assessment Protocol)测查了3-5岁汉语儿童叙事能力的发展,研究发现:(1)叙事评估工具能够反应汉语儿童叙事能力的发展趋势;(2)3-5岁幼儿在叙事能力评估的各个维度表现出了随年龄增长而发展变化的趋势,5岁组在各维度上都显著优于其他两个年龄组;(3)该样本中的儿童在故事讲述中,不会主动给出题目和结尾,较少使用比喻、拟声等修辞手法。

关键词：汉语儿童叙事能力评估发展

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用电子探针分析结果确定岩石中单颗粒晶质铀矿的年龄

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地质地球化学 1992年第3期20卷 132-134,F003,F004页

作者： J.F.W.bowles 马丽君刘晓东江西省抚州市华东地质学院

用电子探针测得的单个晶质铀矿(UO_2)颗粒中U、Th与Pb的含量可用来计算该晶质铀矿颗粒的形成年龄。该年龄称为化学年龄。用本法计算了一系列具很宽年龄范围的天然样品的年龄。与同位素测定结果相比较,用本法算得的年龄是可靠的。以前人... 详细信息

用电子探针测得的单个晶质铀矿(UO_2)颗粒中U、Th与Pb的含量可用来计算该晶质铀矿颗粒的形成年龄。该年龄称为化学年龄。用本法计算了一系列具很宽年龄范围的天然样品的年龄。与同位素测定结果相比较,用本法算得的年龄是可靠的。以前人们提出的计算化学年龄的近似公式并不十分可靠,尤其是当Th含量高和样品年龄较老时更是如此。介绍了用迭代法计算化学年龄的方法,该法应用精确的计算公式,且晶质铀矿年龄的计算结果与同位素测定值相比较也是可靠的。对于矿物和矿物结构记载了多次地质事件信息的样品,本方法特别有用。对两个记载了双重年龄信息的样品实例进行了讨论,旨在说明这些年龄值与主岩形成过程中各种地质事件的关系。一个实例是冲积层重矿物样品,由于所含的晶质铀矿年龄值明显不同,说明它们来自两个不同的蚀源区。另一个实例说明同一岩石样品中可区分出两种铀矿化相,一个相与沉积成岩过程有关,第二个相记载了晚期构造运动时铀的再活化。

关键词：铀矿床年龄岩石电子探针晶质

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