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Neoadjuvant radiotherapy for rectal cancer management

World Journal of Gastroenterology 2019年第33期25卷 4850-4869页

作者： Gerard Feeney Rishabh Sehgal margaret sheehan Aisling Hogan Mark Regan Myles Joyce Michael Kerin Department of General/Colorectal Surgery Galway University HospitalGalway H91 YR71Ireland Department of Histopathology Galway University HospitalGalway H91 YR71Ireland

Thirty per cent of all colorectal tumours develop in the *** location of the rectum within the bony pelvis and its proximity to vital structures presents significant therapeutic challenges when considering neoadjuvant options and surgical *** patients with early rectal cancer can be adequately managed by surgery ***,a significant proportion of patients with rectal cancer present with locally advanced disease and will potentially benefit from down staging prior to *** therapy involves a variety of options including radiotherapy,chemotherapy used alone or in *** radiotherapy in rectal cancer has been shown to be effective in reducing tumour burden in advance of curative *** gold standard surgical rectal cancer management aims to achieve surgical removal of the tumour and all draining lymph nodes,within an intact mesorectal package,in order to minimise local *** is critically important that all rectal cancer cases are discussed at a multidisciplinary meeting represented by all relevant ***-operative staging including CT thorax,abdomen,pelvis to assess for distal disease and magnetic resonance imaging to assess local involvement is *** radiology and MDT discussion are integral in identifying patients who require neoadjuvant *** Neoadjuvant radiotherapy is potentially beneficial it may also result in morbidity and thus should be reserved for those patients who are at a high risk of local failure,which includes patients with nodal involvement,extramural venous invasion and threatened circumferential *** aim of this review is to discuss the role of neoadjuvant radiotherapy in the management of rectal cancer.

关键词： Rectal cancer Neoadjuvant therapy Low anterior resection syndrome Stoma Transanal endoscopic microsurgery Trans-anal total mesorectal excision Robotic surgery Watch and wait

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解码火星的天文学家欧仁·米歇尔·安东尼亚第

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中国国家天文 2024年第2期18卷 28-35页

作者：比尔·希恩刘晗(译) 不详北京外国语大学北京师范大学对外经济贸易大学英语学院

这位希腊裔法国天文学家称得上是历史上最杰出的行星目视观测者。世间所有行星天文学家里,欧仁·米歇尔·安东尼亚第(Eugene Michel Antoniadi)是最有名的其中一位。他所绘出的火星图不仅准确细致,艺术性也极强,因而闻名于世。

关键词：目视观测天文学家火星行星米歇尔艺术性

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Nonlinear Bend Stiffener Analysis Using A Simple Formulation and Finite Element Method

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China Ocean Engineering 2011年第4期25卷 577-590页

作者： TONG Dong Jin LOW Ying Min sheehan John M Marlrrme Research Centre Nanyang Technological University Singapore 639798 Singapore School of Civil ＆ Environmental Engineering Nanyang Technological University Singapore 639798 Singapore Acergy Singapore Pte Ltd Singapore 119963 Singapore

Flexible marine risers are commonly used in deepwater floating systems. Bend stiffeners are designed to protect flexible risel against excessive bending at the connection with the hull. The structure is usually analyzed as a cantilever beam subjected to an inclined point load. As deflections are large and the bend stiffener material exhibits nonlinear stress-strain characteristics, geometric and material nonlinearities are important considerations. A new approach has been developed to solve this nonlinear problem. Its main advantage is its simplicity; in fact the present method can be easily implemented on a spreadsheet. Finite element analysis using ABAQUS is performed to validate the method. Solid elements are used for the bend stiffener and flexible pipe. To simulate the near inextensibility of flexible risers, a simple and original idea of using truss elements is proposed. Through a set of validation studies the present method is found to be in a good agreement with the finite element analysis. Further, parametric studies are performed by using both methods to identify the key parameters and phenomena that are most critical in design. The most important finding is that the common practice of neglecting the internal steel sleeve in the bend stiffener analysis is non-conservative and therefore needs to be reassessed.

关键词： bend stiffener cantilever beam nonlinear finite element analysis

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The calculus of violence

The calculus of violence

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作者： Aaron sheehan-Dean.

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IoT-Solar Energy Powered Smart Farm Irrigation System

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Journal of Electronic Science and Technology 2019年第4期17卷 332-347页

作者： A.R.Al-Ali Ahmad Al Nabulsi Shayok Mukhopadhyay Mohammad Shihab Awal sheehan Fernandes Ailabouni Khalil the Department of Computer Science and Engineering American University of SharjahSharjah 26666 the Department of Electrical Engineering American University of SharjahSharjah 26666 Al Arif Contracting Dubai 6170 SAFEgroup Automation Melbourne 2321 Honeywell UAE Masdar City 45595

As the Internet of things(IoT)technology is evolving,distributed solar energy resources can be operated,monitored,and controlled *** design of an IoT based solar energy system for smart irrigation is essential for regions around the world,which face water scarcity and power ***,such a system is designed in this *** proposed system utilizes a single board system-on-a-chip controller(the controller hereafter),which has built-in WiFi connectivity,and connections to a solar cell to provide the required operating *** controller reads the field soil moisture,humidity,and temperature sensors,and outputs appropriate actuation command signals to operate irrigation *** controller also monitors the underground water level,which is essential to prevent the pump motors from burning due to the level in the water *** proposed system has three modes of operations,*** local control mode,mobile monitoring-control mode,and fuzzy logic-based control *** the purpose of the proposed system validation,a prototype was designed,built,and tested.

关键词： Fuzzy logic Internet of things(IoT) renewable energy smart irrigation.

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Testing of a Full-Scale Composite Floor Plate

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Engineering 2019年第2期5卷 223-233页

作者： Dennis Lam Xianghe Dai Therese sheehan School of Engineering University of Bradford Bradford BD7 IDP United Kingdom

A full-scale composite floor plate was tested to investigate the flexural behavior and in-plane effects of the floor slab in a grillage of composite beams that reduces the tendency for longitudinal splitting of the concrete slab along the line of the primary beams. This is important in cases where the steel decking is discontinuous when it is orientated parallel to the beams. In this case, it is important to demonstrate that the amount of transverse reinforcement required to transfer local forces from the shear connectors can be reduced relative to the requirements of Eurocode 4. The mechanism under study involved in-plane compression forces being developed in the slab due to the restraining action of the floor plate, which was held in position by the peripheral composite beams;while the secondary beams acted as transverse ties to resist the forces in the floor plate that would otherwise lead to splitting of the slab along the line of the primary beams. The tendency for cracking along the center line of the primary beam and at the peripheral beams was closely monitored. This is the first large floor plate test that has been carried out under laboratory conditions since the Cardington tests in the early 1990s, although those tests were not carried out to failure. This floor plate test was designed so that the longitudinal force transferred by the primary beams was relatively high (i.e., it was designed for full shear connection), but the transverse reinforcement was taken as the minimum of 0.2% of the concrete area. The test confirmed that the primary beams reached their plastic bending resistance despite the discontinuous decking and transverse reinforcement at the minimum percentage given in Eurocode 4. Based on this test, a reduction factor due to shear connectors at edge beams without U-bars is proposed.

关键词： Floor plate test Composite beams Edge beams Eurocode 4 In-plane effect Column removal Robustness

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Chemical and physical variations of cannabis smoke from a variety of cannabis samples in New Zealand

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Forensic Sciences Research 2019年第2期4卷 168-178页

作者： Thomas J.sheehan Hilary J.Hamnett Richard Beasley Paul S.Fitzmaurice Toxicology Institute of Environmental Science and Research(ESR)PoriruaNew Zealand Medical Research Institute of New Zealand WellingtonNew Zealand Toxicology Unit Imperial College LondonLondonUK. Gribbles Veterinary Palmerston NorthNew Zealand

Studies have compared the chemical properties of tobacco smoke to those of cannabis smoke,with the objective of identifying the chemical attributes responsible for the mutagenicity and carcinogenicity of cannabis *** studies have included small sample sizes and produced conflicting *** aim of this study was to assess the major chemical and physical variations of cannabis smoke across a range of cannabis samples of different potencies and origins,sourced from the illegal market in New *** cannabis samples were studied ranging from 1.0%to 13.4%delta-9-tetrahydrocannabinol(D9THC)content.A smoking machine was used to smoke“joints”(cannabis cigarettes)and the chemical/physical properties of the smoke *** chemical constituents of the smoke extracts were analysed by gas chromatography/mass spectrometry.A range of different chemical constituents(in addition to D9THC)were identified and their concentrations *** were identified as the major variable in cannabis smoke,showing a 40-fold range in total terpenoid *** of the total particulate matter showed that significantly different levels of particulate matter were produced between the different cannabis samples,ranging from 14.6 to 66.3 mg/g of cannabis *** D9THC delivery efficiency during smoking was also investigated and produced consistent results showing a mean and median of 12.6%and 10.8%,respectively,of the theoretically available D9THC(ranging from 7.2%to 28.0%).

关键词： Forensic science forensic toxicology cannabis smoke delta-9-tetrahydrocannabinol terpenoids gas chromatography/mass spectrometry total particulate matter

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The effects of a daily, 6-week exergaming curriculum on balance in fourth grade children

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Journal of Sport and Health Science 2013年第3期2卷 131-137页

作者： Dwayne P.sheehan Larry Katz Department of Physical Education and Recreation Studies Mount Royal University Faculty of Kinesiology University of Calgary

Balance is an essential component of movement and is critical in the ability to participate in physical activity. Developing an exergaming curriculum for schools has the potential to improve balance or postural stability in children. In this study, a purposely-built exergaming center in an elementary school was used to test fourth grade students with a specially designed exergaming curriculum oriented toward improving postural stability. The program was implemented over a 6-week period, 34 min per day, 4-5 days per week. Two control groups were used：（1） a physical education （PE） class geared toward agility, balance, and coordination （ABC） improvement, and （2） a typical PE curriculum class. Exergaming students improved their postural stability significantly over a 6-week period compared to those in the typical PE class. Improvements in postural stability were also evident in the ABC class. Postural stability in the girls was better than the boys in all pre- and post-intervention tests. This study demonstrates that exergaming is a practical resource in the PE class to improve postural stability.

关键词： Balance Children Elementary school Exergaming Fundamental movement skills

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Colonic perforation in Behet's syndrome

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World Journal of Gastroenterology 2008年第42期14卷 6578-6580页

作者： Catherine M Dowling Arnold DK Hill Carmel Malone John J sheehan Shona Tormey Kieran Sheahan Enda McDermott Niall J O’Higgins Department of Surgery St. Vincents University Hospital Elm Park Dublin 4 Ireland Department of Radiology St. Vincent's University Hospital Elm Park Dublin 4 Ireland Department of Pathology St. Vincent's University Hospital Elm Park Dublin 4 Ireland

A 17-year-old gentleman was admitted to our hospital for headache, the differential diagnosis of which included Behcet＇s syndrome （BS）. He developed an acute abdomen and was found to have air under the diaphragm on erect chest X-ray. Subsequent laparotomy revealed multiple perforations throughout the colon. This report describes an unusual complication of Behcets syndrome occurring at the time of presentation and a review of the current literature of reported cases.

关键词： Colonic perforation Behcet's syndrome

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Comparison of Geographically Weighted Regression of Benthic Substrate Modeling Accuracy on Large and Small Wadeable Streams

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Journal of Geographic Information System 2021年第2期13卷 194-209页

作者： Ken R. sheehan Stuart A. Welsh KnoWhere LLC 969 Ocean Blvd #3 Hampton NH USA U.S. Geological Survey West Virginia Cooperative Fish and Wildlife Research Unit West Virginia University Morgantown West Virginia USA

Aquatic habitat assessments encompass large and small wadeable streams which vary from many meters wide to ephemeral. Differences in stream sizes within or across watersheds, however, may lead to incompatibility of data at varying spatial scales. Specifically, issues caused by moving between scales on large and small streams are not typically addressed by many forms of statistical analysis, making the comparison of large (>30 m wetted width) and small stream (2 values of large and small stream streams. Results also provided a much needed method for comparison of large and small wadeable streams. Our results have merit for aquatic resource managers, because they demonstrate ability to spatially model and compare substrate on large and small streams. Using depth to guide substrate modeling by geographically weighted regression has a variety of applications which may help manage, monitor stream health, and interpret substrate change over time.

关键词： Stream Habitat Modeling Geographically Weighted Regression Spatial Scale Habitat Interpolation Geographic Information System

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