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Association of polymorphisms of cytosine arabinoside- metabolizing enzyme gene with therapeutic efficacy for acute myeloid leukemia

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Chinese Medical Journal 2012年第12期125卷 2137-2143页

作者： XU Pei-pei CHEN Bao-an FENG Ji-feng CHENG Lu XIA Guo-hua LI Yu-feng QIAN Jun DING Jia-hua LU Zu-hong WANG Xue-mei XU Ke margaret schultz Department of Hematology Zhongda Hospital and Faculty ofOncology Medical School Southeast University Nanjing Jiangsu210009 China Department of Oncology Jiangsu Province Cancer InstituteNanjing Jiangsu 210009 China State Key Laboratory for Bioelectronics Southeast UniversityNanjing Jiangsu 210096 China Department of Hematology Huaian First People＇s HospitalHuaian Jiangsu 223300 China Department of Hematology Zhenjiang First People＇s HospitalZhenjiang Jiangsu 212002 China Sloan Kettering Cancer Center New York 10065 USA Weill Comell Medical College New York 10065 USA

Background The cytosine arabinoside （Ara-C）-based chemotherapy is the major remedial measure for acute myeloid leukemia （AML）. Deoxycytidine kinase （DCK） and cytidine deaminase （CDA） are the key enzymes in the metabolism of Ara-C. Many single nucleotide polymorphisms （SNPs） and haplotypes of DCK and CDA, which contribute to susceptibility to Ara-C, have been identified in Africans and Europeans. However, there has been no report about the relation among three SNPs in DCK （rs115543896, rs72552079, and rs111454937） and two SNPs in CDA （rs2072671 and rs60369023）, and their clinical response to Ara-C for a Chinese population. In this study, we aimed to investigate whether these five SNPs are associated with the therapeutic outcomes of Ara-C-based chemotherapy regimens in patients with AML. Methods A total of 151 Chinese patients with AML were enrolled in our study. SNPs genotyping were performed using the MassARRAY system by means of the matrix-assisted laser desorption ionization-time of flight mass spectrometry （MALDI-TOF-MS） method. Results The results illustrated that DCKrs111454937 AA genotype was more frequent in patients with higher platelet count, and A allele frequency was significantly higher in the group 〈40 years, lower white blood cell （WBC） count patients group and the group with platelet counts 〉60xl0e/L. Meanwhile, both DCKrs72552079 TC （OR=1.225, 95% C1=1.225-9.851, P=0.0192） and CDArs60369023 GA （OR=9.851,95% C1=1.31-77.93, ,~=-0.0263） significantly improved Ara-C-based chemotherapy response. While DCKrs11554389 AA （OR=0.147, 95% CI=0.027-0.801, P=0.0267） was associated with the decrease of Ara-C-based chemotherapy response. Conclusion It is evident that the DCK and CDA polymorphisms might be the important markers for the AML patients＇ therapy outcomes in a Chinese population.

关键词： deoxycytidine kinase cytidine deaminase single nucleotide polymorphisms acute myeloid leukemia

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Prevalence and knowledge of hepatitis C in a middle-aged population,Dunedin,New Zealand

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World Journal of Gastroenterology 2015年第35期21卷 10224-10233页

作者： Jane Vermunt margaret Fraser Peter Herbison Anna Wiles Martin Schlup Michael schultz Department of Medicine Dunedin School of MedicineUniversity of Otago Gastro-enterology Unit Dunedin HospitalSouthern District Health Board Department of Preventive and Social Medicine University of Otago

AIM:To determine the prevalence of infection with hepatitis C virus(HCV) in those most at risk of advanced liver disease and to identify gaps in knowledge of ***: Questionnaires were mailed to randomly selected residents aged 40-59 to assess the extent of their general knowledge about HCV. The questionnaire assessed demographics, the extent of general knowledge about viral hepatitis, potential risks for infection and the prevalence of risk factors associated with increased progression of liver fibrosis. Anonymised residual laboratory blood samples from 40-59 years old people from Dunedin taken in hospital or in the community, were tested for HCV antibodies and alanine transaminase(ALT), aspartate transaminase(AST), gamma-glutamyl transpeptidase(GGT). Linear regression was performed to examine whether the demographics sex, age, socio-economic status, qualification level and occupation sector(categorical variables) were predictors of level of general knowledge about hepatitis. For the demographics that werefound to be significant predictors of score outcome, multiple regression analysis was used to determine independent effects. χ2 tests were used to compare our selected sample and our responder population demographics, to the demographics of the entire 40-59 years old population in Dunedin using the 2006 NZ census data. Exact confidence intervals for the proportion positive for HCV and HBV were calculated using the binomial ***: The response rate to the mailed questionnaire was 431/1400(30.8%). On average 59.4% questions were answered correctly. Predictors for higher scores, indicating greater knowledge about symptoms and transmission included sex(female, P < 0.01), higher level of qualification(P < 0.000) and occupation sector(P < 0.000). Sharing intravenous drug utensils was a known risk factor for disease transmission(94.4%), but the sharing of common household items such as a toothbrush was not. 93% of the population were unaware that HCV

关键词： Hepatitis C Prevalence Knowledge Treatment Transmi

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Proteogenomics for pediatric brain cancer

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BIOCELL 2021年第6期45卷 1459-1463页

作者： margaret SIMONIAN University of Californian Los Angeles David Geffen School of MedicineLos Angeles90095USA

Pediatric central nervous system tumors are the most common tumors in children,it constitute 15%–20%of all malignancies in children and are the leading cause of cancer related deaths in *** is an emerging field of biological research that utilizes a combination of proteomics,genomics,and transcriptomics to aid in the discovery and identification of biomarkers for diagnosis and therapeutic *** proteogenomics analysis of pediatric tumors identified underlying biological processes and potential treatments as well as the functional effects of somatic mutations and copy number variation driving tumorigenesis.

关键词： Proteogenomics Brain cancer Targeted therapy

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A Shared Neural Node for Multiple Innate Behaviors in Drosophila

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Neuroscience Bulletin 2018年第6期34卷 1103-1104页

作者： margaret S.Ho School of Life Science and Technology ShanghaiTech University

The nervous system orchestrates diverse behaviors such as reproduction, sleep, feeding, and aggression, and selects a single behavior for execution at any given time. This requires neural mechanisms for behavioral selection sensitive to both internal physiological states and external environmental conditions. For example, hungry animals

关键词： In A Shared Neural Node for Multiple Innate Behaviors in Drosophila

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Evidence of a Light-Sensing Role for Folate in Arabidopsis Cryptochrome Blue-Light Receptors

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Molecular Plant 2008年第1期1卷 68-74页

作者： Nathalie Hoang Jean-Pierre Bouly margaret Ahmad Universite Paris Vl Casier 156 4 Place Jussieu 75005 Paris France Penn State University 25 Yearsley Mill Road Media PA 19063 USA

Arabidopsis cryptochromes cry1 and cry2 are blue-light signalling molecules with significant structural similarity to photolyases-a class of blue-light-sensing DNA repair enzymes. Like photolyases, purified plant cryptochromes have been shown to bind both flavin and pterin chromophores. The flavin functions as a light sensor and undergoes reduction in response to blue light that initiates the signalling cascade. However, the role of the pterin in plant cryptochromes has until now been unknown. Here, we show that the action spectrum for light-dependent degradation of cry2 has a significant peak of activity at 380 nm, consistent with absorption by a pterin cofactor. We further show that cry1 protein expressed in living insect ceils responds with greater sensitivity to 380 nm light than to 450 nm, consistent with a light-harvesting antenna pigment that transfers excitation energy to the oxidized flavin of cry1. The pterin biosynthesis inhibitor DHAP selectively reduces cryptochrome responsivity at 380 nm but not 450 nm blue light in these cell cultures, indicating that the antenna pigment is a folate cofactor similar to that of photolyases.

关键词： ARABIDOPSIS thaliana CRYPTOCHROMES PLANT growth SEEDLINGS BLUE light

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The Authority of Age： Institutions for Childhood Development in China, 1895-1910

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Frontiers of History in China 2012年第1期7卷 32-60页

作者： margaret Tillman Department of History University of California at Berkeley Berkeley CA 94720-2550 USA

The structure of aged-based education and the science of childhood development were introduced to China in the last decades of the Qing dynasty. Drawing on period textbooks, journal articles, and school documents for women and children, this study argues that the theory of childhood development helped shape socialized play and citizenship training in new schools. These new institutions followed scientific insights about childhood development in terms of both physical and emotional growth. Educators hoped to found schools that would inculcate respect for political authority within the classroom, and administrators took unprecedented steps in documenting and regulating children. Schools not only became places for disseminating learning, but also centers for gathering information about children and their families, as well as about childhood itself. The production of knowledge and the institutionalization of schools for preschool children helped usher in new trends that denaturalized childrearing outside of the family domain.

关键词： late-Qing educational reforms early childhood education age-based developmental learning caregivers (baomu)

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The Construction of Gender in Modern Chinese Law： Discrepant Gender Meanings in the Republican Civil Code

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Frontiers of History in China 2012年第2期7卷 282-309页

作者： margaret Kuo Department of History California State University Long Beach CA 90840-1601 USA Center for the Pacific Rim University of San Francisco San Francisco CA 94117 USA

This article examines the intersection of law, gender, and modernity during the transitional Republican era （1912-49）. It approaches the topic through a critical reading of the Republican Civil Code of 1929-30, and related commentary on the code by Chinese legal experts. By analyzing the gender assumptions embodied in several newly emergent categories of legal regulation, including legal personhood, minimum marriage age, consent, domicile, surnames, marital property, and child custody, the article＇s line of questioning reveals how gender meanings helped to shape modem concepts like universality, equality, and freedom. The findings illustrate the ways in which Republican civil law broke with late imperial legal and gender norms tied to Confucian patrilineal ideology and in addition established new legal and gender meanings that helped to consolidate Chinese politics on a republican basis and to reconfigure modem gender difference on a conjugal basis.

关键词： gender formation law modernity Republican Civil Code legal personhood marriage age individual consent twentieth-century China

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A Griesbachian(Early Triassic) Mollusc Fauna from the Sidazhai Section, Southwest China, with Paleoecological Insights on the Proliferation of Genus Claraia(Bivalvia)

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Journal of Earth Science 2018年第4期29卷 794-805页

作者： Yunfei Huang Jinnan Tong margaret L Fraiser School of Geosciences Yangtze University State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Department of Geosciences University of Wisconsin-Milwaukee

After the end-Permian mass extinction, genus Claraia （Bivalvia） was the most abundant and most noticeable fossil during the survival and recovery stage. However, the reasons for the proliferation of Claraia are still debated. This paper describes a new Griesbachian （Early Triassic） mollusc fauna from deep-water settings in South China in the aftermath of end-Permian mass extinction. This fauna yielded five bivalve species in two genera （Claraia griesbachi, C. wangi, C. stachei, C. radialis, and Promyalina putiatinensis） and two ammonoid species （Ophiceras sp. and Ussuridiscus sp.） and could be assigned to the Claraia wangi-C, griesbachi assemblage zone, indicating a Middle-Late Griesbachian Age. The bivalves were dominated by Claraia griesbachi and were featured by articulated Claraia fossils. As Claraia was epibyssate, it was an excellent autochthonous fauna. While the shallow and deep marine water became dysoxic to anoxic globally, as indicated by recent studies of the early Early Triassic, we suggest the genus Claraia could tolerate dysoxic and/or anoxic conditions and its proliferation could be attributed to its physiological features which were adapted to the stressed environment. The wide distribution of Claraia was probably related to its planktonic larval stage. Where the larva of Claraia could have been transported by ocean flow and increased its potential for long-distance dispersal. In addition, Claraia was a significant disaster and opportunistic taxon during the Early Triassic based on observations in South China.

关键词： bivalves Claraia disaster species paleoecology Early Triassic.

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Antenatal care positive responses to pregnant women in preventing and controlling malaria in pregnancy:the sub-Saharan African perspective

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World Journal of Pediatrics 2022年第7期18卷 453-462页

作者： margaret Tete Telay Doe Ousman Bajinka Amadou Barrow Department of Oecupational and Environmental Health Xiangya School of Public Health.Central South University.ChangshaPeople's Republic of China Department of Microbiology.Central South University ChangshaHunan ProvincesChina China-Africa Research Centre of Infectious Diseases School of Basic Medical SciencesCentral South UniversityChangsha 410078HunanChina Heidelberg Institute of Global HealthUniversity Hospital and Medical FacultyHeidelberg University.HeidelbergGermany School of Medicine and Allied Health Sciences University of The GambiaBanjulThe Gambia

Background The response to antenatal care(ANC)for maternal and offspring outcomes,especially in pregnant women has been thoroughly ***,despite the number of interventional studies on the treatment of sulfadoxine-pyrimethamine combination(IPTp-SP)uptake,the point in point cases of the positive responses of ANC in improving health conditions of pregnant women are not found in the *** sources This review collected ANC responses to the positive health outcomes for pregnant women with malaria,the challenges faced regarding IPTp-SP uptake during ANC visits and the role of ANC in preventing and controlling malaria in sub-Saharan *** elucidated ANC and uptake of optimal intermitent preventive IPTp-SP and further described ANC as a tool for heterogeneity for malaria *** ANC is seen as a microscope to malaria in pregnacy,maternal iron deficiency and anemia checkpoints,ANC and malaria treatment strategies,and ANC and the use of insecticide treated nets(ITN).The review further discussed ANC attendance influencing factors,limitations to ANC implications and the prospects in ANC visits on preventing malaria in *** A declining trend of malaria transmission in Africa has been observed in recent ***,the burden of malaria in pregnancy remains a health *** rate of SP resistance,low uptake of IPTp-SP,low LLINs distribution,late gestational ANC visits and low turnaround for optimal ANC visits for first time mothers’aggrevated the malaria-endemic settings among pregnant women in sub-Saharan Africa.

关键词： Malaria-Pregnant women ANC visits Pregnancy outcome IPTp-SP uptake

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A Solution to the C-Value Paradox and the Function of Junk DNA： The Genome Balance Hypothesis

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Molecular Plant 2015年第6期8卷 899-910页

作者： Michael Freeling Jie Xu margaret Woodhouse Damon Lisch Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA Maize Research Institute Sichuan Agricultural University Wenjiang Sichuan 611130 China Department of Botany and Plant Pathology Purdue University West Lafayette IN 47907 USA

The Genome Balance Hypothesis originated from a recent study that provided a mechanism for the phenom- enon of genome dominance in ancient polyploids： unique 24nt RNA coverage near genes is greater in genes on the recessive subgenome irrespective of differences in gene expression. 24nt RNAs target transposons. Transposon position effects are now hypothesized to balance the expression of networked genes and pro- vide spring-like tension between pericentromeric heterochromatin and microtubules. The balance （coordi- nation） of gene expression and centromere movement is under selection. Our hypothesis states that this balance can be maintained by many or few transposons about equally well. We explain known balanced dis- tributions of junk DNA within genomes and between subgenomes in allopolyploids （and our hypothesis passes ＂the onion test＂ for any so-called solution to the C-value paradox）, importantly, when the allotetra- ploid maize chromosomes delete redundant genes, their nearby transposons are also lost; this result is ex- plained if transposons near genes function. The Genome Balance Hypothesis is hypothetical because the position effect mechanisms implicated are not proved to apply to all junk DNA, and the continuous nature of the centromeric and gene position effects have not yet been studied as a single phenomenon.

关键词： junk DNA transposons C-value paradox gene regulation balance

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