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Serum Levels of Reproductive Hormones and Their Relationship with Age in Men with Benign Prostatic Hyperplasia in Benin City, Edo State

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Health 2020年第9期12卷 1121-1131页

作者： Babatunde Ishola Gabriel Adejumo Omolei Lilian Williams Efosa Bolaji Odigie Ifeoma Gloria Unachukwu Oladimeji Nasiru Abdulrahman Uchechukwu Dimkpa Simon Uzor oyarazi margaret adebowale Ojo Moses Oke Department of Medical Laboratory Science University of Benin Benin City Nigeria Department of Medical Laboratory Science College of Health Technology Offa Nigeria Department of Human Physiology Nnamdi Azikwe University Nnewi Campus Nnewi Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Virology/Immunology Federal School of Medical Laboratory Science Jos Nigeria Department of Medical Laboratory Science College of Health Technology Akure Nigeria

Background: Benign Prostatic Hyperplasia (BPH) is a common condition which occurs as men get older. Aim: We aimed at investigating the reproductive hormone profile of men with BPH and the relationship of these hormones with age. Methods: Twenty-nine men of age > 40 years were screened for prostate symptoms. The prostate examination included digital rectal examination and measurement of serum prostate-specific antigen levels. Demographic and clinical characteristics of subjects were obtained using a structured questionnaire. The serum levels of Testosterone (Te), Luteinizing hormone (LH), Follicle stimulating hormone (FSH) and Prolactin (PRL) were measured using ELISA method. Results: Our study indicated that age and levels of prostate specific antigen (PSA), LH and FSH were significantly (p Conclusion: This study suggests that the rise in serum levels of the hypothalamic-pituitary-testicular axis hormones in BPH patients as demonstrated by the present findings may be age-related since testicular dysfunction in aging men is associated with the decrease in androgen production which may stimulate an increased production of gonadotropins by negative feedback.

关键词： Hormones Age Men Prostate Hyperplasia

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Reproductive Hormone Profiles and Their Relationships with Sexual Function in Patients with Prostate Cancer after Rapid Prostatectomy in Benin City

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Advances in Sexual Medicine 2020年第4期10卷 119-130页

作者： Babatunde Ishola Gabriel Adejumo Omolei Lilian Williams Efosa Bolaji Odigie Ifeoma Gloria Unachukwu Oladimeji Nasiru Abdulrahman Uchechukwu Dimkpa Simon Uzor oyarazi margaret adebowale Ojo Moses Oke Department of Medical Laboratory Science University of Benin Benin Nigeria Department of Medical Laboratory Science College of Health Technology Ilorin Nigeria Department of Human Physiology Nnamdi Azikwe University Nnewi Campus Awka Nigeria Department of Applied Science Faculty of Health and Applied Sciences University of West of England Bristol UK Department of Virology/Immunology Federal School of Medical Laboratory Science Jos Nigeria Department of Medical Laboratory Science College of Health Technology Akure Nigeria

There are limited studies examining the relationship between serum reproductive hormone levels and sexual functions among prostate cancer (PCa) patients after rapid prostatectomy (RP). Aim: The present study aimed at evaluating the correlation between post-operative serum levels of some male reproductive hormones of PCa patients and their sexual functions in the months following RP. A total of 20 male patients with clinically localized PCa who had undergone RP within the last 12 months prior to commencement of the study, were invited to participate. The postoperative serum levels of their luteinizing hormone (LH), follicle stimulating hormone (FSH) and total testosterone (Te) were measured. They also completed a structured health and lifestyle questionnaire to obtain information on their demographic characteristics and detailed medical history. Our data indicated normal mean levels of post-operative Te (4.34 ± 4.38 ng/ml) in the patients following RP, while the mean levels of FSH (39.24 ± 34.12 miu/ml) and LH (21.67 ± 25.73 miu/ml) were on the increase and far above normal ranges for healthy men. Data indicated a significant positive correlation between Te and frequency of sexual intercourse (r = 508;p < 0.05), libido (r = 0.429;p <

关键词： Reproductive Hormone Sexual Function Prostate Cancer Rapid Prostatectomy

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The Level of CD4<sup>+</sup>T Cell Count among Reproductive Age Women Coinfected with Human Immune Virus, Hepatitis Surface Antigen and Herpes Simplex Virus in Kogi State, Nigeria

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Health 2018年第10期10卷 1449-1458页

作者： Babatunde Ishola Gabriel Adejumo Francis Enifo Oronsaye Uteno Itanyi Drisu margaret oyarazi adebowale Ojo Moses Oke Uchechukwu Dimkpa Kingsley Ifeanyichukwu Omosor Oladimeji Nasiru Abdulrahman Esmond Nwanbunneze Ukatu Emmanuel Alaba Michael Medical Laboratory Science Department University of Benin Benin City Nigeria Department of Medical Services Federal Polytechnic Idah Nigeria Medical Laboratory Science Department Federal School of Medical Laboratory Sciences and Health Technology Jos Nigeria Medical Laboratory Science Department School of Health Sciences and Technology Akure Nigeria Physiology Department Nnewi Campus Nnamdi Azikiwe University Awka Nigeria Shalom Diagnostic Medical Laboratory Warri Nigeria Medical Laboratory Science Department College of Health Technology Offa Nigeria Gulin Pharmaceuticals Nigeria Limited Sango Ottaa Nigeria Medical Laboratory Science Department College of Health Sciences and Technology Idah Nigeria

Background: There are pockets of evidence to show the existence of co-infections of viral particles in humans. Aim: The study aimed at evaluating the CD4+ T cell count among women of reproductive age co-infected with human immune virus, hepatitis surface antigen and herpes simplex virusin Kogi state, Nigeria. Methodology: 342 females of reproductive age within the ages of 15 - 49 years participated in this study. They were recruited from various local government areas of three Senatorial districts of Kogi state. Blood samples were collected from participants and analyzed for HSV1/HSV2, HIV, HBsAg and CD4 using different scientific methods and procedures. Results: There was no significant differences in mean CD4+ T cell counts between subjects who tested positive and those who tested negative for only HSV1 (p = 0.61), HSV2 (p = 0.95), HIV (p = 0.48) and co-infection for HSV1, HSV2, HIV (0.68). In contrast, mean CD4+ T cell count was significantly higher in those who tested positive compared with those who tested negative for HBsAg alone (p = 0.03) and those co-infected with HSV1, HSV2, HBsAg (p = 0.01). Analysis of variance (ANOVA) indicated no significant differences in CD4+ T cell counts among the different classes of infections. Conclusion: This study shows no decline in the count of CD4+ T cell on the co-infections of HSV1, HSV2 and HIV, but higher significant difference in those co-infected with HSV1, HSV2 and HBsAg was recorded among the women of child bearing age in Kogi state.

关键词： HSV1/HSV2 CD4 HIV HBsAg Coinfections Women Kogi State Nigeria

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Seroprevalence, Type-Specific of Herpes Simplex Virus and Associated Risk Factors among Women of Child Bearing Age in Kogi State, Nigeria

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Health 2018年第7期10卷 1006-1017页

作者： Uteno Itanyi Drisu Francis Enifo Oronsaye Babatunde Ishola Gabriel Adejumo Gregory Ashimedua Uchuno Alaba Michael Emmanuel Uchechukwu Dimkpa Kingsley Ifeanyichukwu Omosor margaret oyarazi adebowale Oladimeji Nasiru Abdulrahman Esmond Nwanbunwanne Ukatu Department of Medical Services Federal Polytechnic Idah Nigeria Medical Laboratory Science Department University of Benin Benin City Nigeria External Quality Assurance Department Medical Laboratory Science Council of Nigeria Abuja Nigeria Medical Laboratory Science Department College of Health Sciences and Technology Idah Nigeria Physiology Department Nnewi Campus Nnamdi Azikiwe University Awka Nigeria Shalom Diagnostic Medical Laboratory Warri Nigeria Medical Laboratory Science Department Federal School of Medical Laboratory Sciences and Health Technology Jos Nigeria Medical Laboratory Science Department College of Health Technology Offa Nigeria Gulin Pharmaceauticals Nigeria Limited Sango-Ota Nigeria

Background: Viruses of the Herpes viridae family infect 90% of the Earth’s population. Humans are the hosts of at least nine unique herpes viruses. Aim: This study is aimed at evaluating the seroprevalence of type specific herpes simplex virus infection and the associated risk factors in a cross-section of asymptomatic healthy women of childbearing age in Kogi state, Nigeria. Methodology: A total of 330 females of child bearing age (15 - 49 years) participated in this study. They were recruited from various local government areas of three Senatorial districts of Kogi state. Blood samples were collected from participants and analyzed for HSV-1 and HSV-2 antibodies (IgG) quantitatively with ELISA kit. Results: The overall prevalence of HSV was 76.7%. Data further show that majority (96.4%) of the population studied had HSV-1, while 77% had HSV-2 infections. Results also showed that the young adults indicated prevalence of 95.7% for HSV-1 and 74.7% for HSV-2, while in the middle aged, the prevalence were 98.6% for HSV-1, and 84.9% for HSV-2. 99.2% of the married women were positive for HSV-1, while 86.9% were positive for HSV-2. 94.5% of the unmarried women were positive for HSV-1, while 70.5% were positive for HSV-2. The risk of HVS-1 or VS-2 infections was not associated with age, age of first sexual exposure and number sex partners before marriage. Married women were at greater risk for HSV-1 (p = 0.03) and HSV-2 (p ≤ 0.001) infections compared to the unmarried women. Conclusion: The prevalence of the HSV-1 and HSV-2 infections was high among asymptomatic healthy women of childbearing age in Kogi state, Nigeria. Efforts should be made to increase the awareness of HSV infection among the child bearing populace.

关键词： HSV-1/HSV-2 Antibody Infection Women Kogi State Nigeria

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