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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Numerical assessment of the influence of former mining activities and plasticity of rock mass on deformations of terrain surface

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International Journal of Mining Science and Technology 2021年第2期31卷 209-214页

作者： PawełSikora marek wesołowski Department of Mining Faculty of MiningSafety Engineering and Industrial AutomationSilesian University of Technology44-100 GliwicePoland

This paper presents the results of numerical simulations carried out to confirm the influence of former mining activities on deformation of the mining *** assessment of deformation changes was carried out with the use of FLAC3 D program based on the finite difference *** calculations were carried out for the example of actual mining operations in seams 703/1-2 and 707/2 of‘‘Marcel"Coal *** into account the influence of the model’s plastic features and the so-called activation of a higher occurring seam in conducted simulations enabled obtaining a very good description of the measured *** on the results one may state that numerical model can be used to assess the influence of former mining activities and the direction of conducted exploitation on deformations of the mining *** factors are not recognized by geometric-integral theories commonly used for predicting the influence of mining operations on the *** results presented in this paper confirm that the applied method of simulating the phenomenon of reactivation of post-mining goafs is correct.

关键词： Rock mass Numerical modeling Post-mining Goafs Land surface deformations

Random failure mechanism method for assessment of working platform bearing capacity with a linear trend in undrained shear strength

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第6期13卷 1513-1530页

作者： Marcin Chwaa marek Kawa Department of Civil Engineering Wroclaw University of Science and TechnologyWybrzeze Wyspianskiego 27Wrocław50-370Poland

A bearing capacity evaluation for the surface strip foundation on a working platform modelled on a twolayered substrate is considered in the *** upper layer is assumed as man-made and wellcontrolled and thus *** lower layer modelling natural cohesive soil is subjected to spatial variability of undrained shear *** random failure mechanism method(RFMM)is used to evaluate the bearing *** approach employs a kinematic assessment of the critical load and incorporates the averaging of three-dimensional(3 D)random field along dissipation surfaces that result from the failure mechanism geometry.A novel version of the approach considering an additional linear trend of undrained shear strength in the spatially variable layer is *** high efficiency of the RFMM algorithm is *** influences of foundation length,trend slope in the spatially variable layer,fluctuation scales,and thickness of the homogenous sand layer on the resulting bearing capacity evaluations are ***,for selected cases,verification of the RFMM based assessment obtained using random finite difference method(RFDM)based on 3 D analysis is *** types of analyses are performed using RFDM based on associated and non-associated flow *** associated flow rule which corresponds to RFMM,the RFMM is conservative and efficient and thus it seems ***,if RFDM employs non-associated flow rule(much lower dilation angle for sand layer),the efficient RFMM is no longer *** this situation,a combined approach that improves the efficiency of the numerical method is suggested.

关键词： Two-layered soil Random bearing capacity Fluctuation scale Kinematical approach Upper bound Random finite difference method(RFDM) working platform

Dynamic analysis of an offshore pipe laying operation using the reel method

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Acta Mechanica Sinica 2011年第1期27卷 44-55页

作者： marek Szczotka University of Bielsko-Biaa Willowa 2 43-309 Bielsko-BiaaPoland and AXTech ASVerftsgt.10P.O.Box 2008 6042 MoldeNorway

A system designed for a rigid and flexible pipe laying purposes is presented in the *** and numerical models are developed by using the rigid finite element method（RFEM）.The RFEM is an efficient solution in the time *** and dynamic problems related to pipe installation are solved by taking the advantage of simple interpretation and implementation of the *** deformations of the pipe during spooling and when it is reeled out at sea are considered.A material model implemented is used to take into consideration nonlinear material *** particular,the full elasto-plastic material characteristics with hardening and Bauschinger effect are *** analyses are performed and the results attached in this work demonstrates how the sea conditions influence the machinery and pipeline,assuming a passive reel drive system. The influence of several other operational parameters on dynamic loads is *** active system,implemented as a part of the mathematical model,improves the system *** results are presented as well.

关键词： Offshore pipeline installation · Reel vessel · Large elasto-plastic deformations

Demise of the Jablonna Reef(Zechstein Limestone)and the onset of gypsum deposition(wuchiapingian,west Poland):carbonate-to-evaporite transition in a saline giant

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Journal of Palaeogeography 2020年第3期9卷 363-377页

作者： Tadeusz marek Peryt marek Jasionowski Pawet Raczyiiski Krzysztof Chtdek Polish Geological Institute-National Research Institute Rakowiecka 400-975 WarszawaPoland lnstitute of Geological Sciences University of WrodawPI.Maksa Borna 950-205 WroclawPoland Polish Oil and Gas Company Naftowa 365-705 Zielona G6raPoland.

Microbial deposits commonly occur at the transition between carbonate and sulphate facies,and they also abound in the uppermost part of the middle wuchiapingian Zechstein Limestone in west *** deposits occur as isolated reefs of the basinal zone and in the condensed sequences in most parts of the study *** deposits of the latter category reflect evaporative drawdown,and the abrupt boundary between the carbonate and sulphate deposits in the basin suggests the nature of evaporites that start to precipitate as soon as they reach the saturation level.A few-metre-thick unit of mostly brecciated microbial deposits at the top,reefal portion of the Zechstein Limestone records extreme palaeoenvironmental events that occurred at the transition from carbonate to sulphate *** events are related first to subaerial exposure of the reef,which lasted several 10~5 years and then to the Lower Anhydrite transgression.

关键词： Carbonate-sulphate transition Late Permian Reefs Microbial deposits Salt giants Central Europe

Strongly Lensed Transient Sources:A Review

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Chinese Physics Letters 2022年第11期39卷 72-91页

作者： Kai Liao marek Biesiada Zong-Hong Zhu School of Physics and Technology Wuhan UniversityWuhan 430072China National Centre for Nuclear Research Pasteura 702-093 WarsawPoland Department of Astronomy Beijing Normal UniversityBeijing 100875China

The past decades have witnessed a lot of progress in gravitational lensing with two main targets:stars and galaxies(with active galactic nuclei).The success is partially attributed to the continuous luminescence of these sources making the detection and monitoring relatively *** the running of ongoing and upcoming large facilities/surveys in various electromagnetic and gravitational-wave bands,the era of time-domain surveys would guarantee constant detection of strongly lensed explosive transient events,for example,supernovae in all types,gamma ray bursts with afterglows in all bands,fast radio bursts,and even gravitational *** transients have many advantages over the traditional targets in studying the Universe,and magnification effect helps to understand the transients themselves at high *** this review article,on base of the recent achievements in literature,we summarize the methods of searching for different kinds of lensed transient signals,the latest results on detection and their applications in fundamental physics,astrophysics,and *** the same time,we give supplementary comments as well as prospects of this emerging research direction that may help readers who are interested in entering this field.

关键词： gravitational galaxies stars

Numerical solution of Volterra integral equations with singularities

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Frontiers of Mathematics in China 2013年第2期8卷 239-259页

作者： marek KOLK Arvet PEDAS Institute of Mathematics University of Tartu J. Liivi 2 Tartu 50409 Estonia

The numerical solution of linear Volterra integral equations of the second kind is discussed. The kernel of the integral equation may have weak diagonal and boundary singularities. Using suitable smoothing techniques and polynomial splines on mildly graded or of the proposed algorithms is studied given. uniform grids, the convergence behavior and a collection of numerical results is give.

关键词： Boundary singularity collocation method smoothing transformation Volterra integral equation weakly singular kernel

Vitali Type Convergence Theorems for Banach Space Valued Integrals

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Acta Mathematica Sinica,English Series 2013年第11期29卷 2027-2036页

作者： marek BALCERZAK Kazimierz MUSIAL Institute of Mathematics Lodz University of Technologyul.Wolczańska 21593-005 LodzPoland Institute of Mathematics University of WroclawPl.Grunwaldzki 2/450-384 WroclawPoland

Let （Ω,∑,μ） be a complete probability space and let X be a Banach space. we introduce the notion of scalar equi-convergence in measure which being applied to sequences of Pettis integrable functions generates a new convergence theorem. we Mso obtain a Vituli type Z-convergence theorem for Pettis integrals where Z is an ideal on N. Keywords Convergence theorems for integrals, Pettis integral, scalar equi-convergence in measure, Z-convergence

关键词： Convergence theorems for integrals Pettis integral scalar equi-convergence in measure I-convergence 28A20 28B05 40A10 40A30 46G10

Characterization of multiphase gas–solid flow and accuracy of turbulence models for lower stage cyclones used in suspension preheaters

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1618-1629页

作者： marek wasilewski Stanislaw Anweiler Maciej Masiukiewicz Faculty of Production Engineering and Logistics Opole University of Technology76 Proszkowska St.45-758 OpolePoland Faculty of Mechanical Engineering Opole University of Technology76 Proszkowska St.45-758 OpolePoland

This study involved the analysis and characterization of the multiphase flow phenomenon inside the lower stage cyclone separator used in the clinker burning *** analysis was performed using both CFD and experimental research *** few studies are devoted to such types of cyclone separators,which in addition to their basic functions are also responsible for the technological *** to the atypical working conditions of these cyclone separators,they are characterized with a complex geometry,which significantly differs from that of the traditional ***,the evaluation of the accuracy and level of reliability of the two models of turbulence closure—k-e RNG and RSM(RANS),and the *** results obtained led to the conclusion that for the lower stage cyclone separators,the LES model proved to be the most accurate(both in the case of forecasting the separation efficiency and pressure drop).The performance parameter(in particular the separation efficiency)values obtained for the RSM model were also characterized by high *** k-e RNG model was characterized by significantly larger deviations.

关键词： Cyclone separators Separation Multiphase flow CFD Pressure drop Clinker burning