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Phylogenetic and ecological reevaluation of the order Onygenales

Fungal Diversity 2022年第4期115卷 1-72页

作者： Hazal Kandemir Karolina Dukik marcus de melo teixeira J.Benjamin Stielow Fatima Zohra delma Abdullah M.S.Al‑Hatmi Sarah A.Ahmed Macit Ilkit G.Sybren de Hoog Center of Expertise in Mycology Radboud University Medical Center/Canisius Wilhelmina HospitalNijmegenThe Netherlands Division of Medical Mycology Faculty of MedicineUniversity ofÇukurovaAdanaTurkey Westerdijk Fungal Biodiversity Institute UtrechtThe Netherlands Faculdade de Medicina Universidade de BrasíliaBrasíliaBrazil Pathogen and Microbiome Institute Northern Arizona UniversityFlagstaffUSA Thermo Fisher Scientific LandsmeerThe Netherlands Natural&Medical Sciences Research Center University of NizwaNizwaOman Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of Education of Guizhou&Key Laboratory of Medical Microbiology and ParasitologySchool of Basic Medical SciencesGuizhou Medical UniversityGuiyangChina

The order Onygenales is classified in the class Eurotiomycetes of the subphylum *** in this order have classically been isolated from soil and dung,and two lineages contain causative agents of superficial,cutaneous and systemic infections in *** ecology and habitat choices of the species are driven mainly by the keratin and cellulose degradation *** present study aimed to investigate whether the ecological trends of the members of Onygenales can be interpreted in an evolutionary sense,linking phylogenetic parameters with habitat preferences,to achieve polyphasic definitions of the main taxonomic *** processes were estimated by multiple gene genealogies and divergence time *** described families,namely,Arthrodermataceae,Ajellomycetaceae,Ascosphaeraceae,Eremascaceae,Gymnoascaceae,Onygenaceae and Spiromastigoidaceae,were accepted in Onygenales,and two new families,Malbrancheaceae and Neogymnomycetaceae,were introduced.A number of species could not be assigned to any of the defined *** study provides a revised overview of the main lines of taxonomy of Onygenales,supported by multilocus analyses of ITS,LSU,TUB,TEF1,TEF3,RPB1,RPB2,and ribosomal protein 60S L10(L1)(RP60S)sequences,combined with available data on ecology,physiology,morphology,and genomics.

关键词： Ancestral reconstruction Evolution Onygenales Taxonomy

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delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of Cardiovascular Diseases 2024年第6期14卷 392-400页

作者： Clarice teixeira Silva Araújo Arnon Salviato Mameri Thúlio Carrera Guarçoni Venturini marcus Tadeu Aguilar Constantino Matos Igor Morais Araujo Lopes Luiz Gustavo Ribeiro de Carvalho Murad Cleberson Duartes Ovani Guilherme Vassalo Morais Fernanda Venturini de Castro Danielle Lopes Rocha Lucas Crespo de Barros Rodolfo Costa Sylvestre Luiz Fernando Machado Barbosa Roberto Ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa Casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de Cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from december 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous Coronary Intervention Coronary Reperfusion Pandemic COVID-19

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Scoping review on vector-borne diseases in urban areas:transmission dynamics,vectorial capacity and co-infection

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Infectious Diseases of Poverty 2018年第1期7卷 916-939页

作者： marcus Eder Fanny Cortes Noemia teixeira de Siqueira Filha Giovanny Vinicius Araujo de Franca Stephanie degroote Cynthia Braga Valery Ridde Celina Maria Turchi Martelli Public Health England Sierra Leone Country Office FreetownSierra Leone Aggeu Magalhaes Institute(IAM)/Oswaldo Cruz Foundation(Fiocruz) Avenida Professor Moraes Regos/n.Cidade Universitaria.CEP 50RecifePernambuco 740-465Brazil Universidade de Pernambuco(UPE) RecifePernambucoBrazil Liverpool School Of Tropical Medicine(LSTM) LondonUK Secretariat of Health Surveillance Ministry of HealthBrasiliaBrazil University of Montreal School of Public Health(ESPUM) MontrealQuebecCanada IRD(French Institute For Research on Sustainable development) CEPED(IRD-UniversiteParis Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance

Background:Transmission dynamics,vectorial capacity,and co-infections have substantial impacts on vector-borne diseases(VBDs)affecting urban and suburban *** key factors can provide insight into priority research areas and offer suggestions for potential *** body:Through a scoping review,we identify knowledge gaps on transmission dynamics,vectorial capacity,and co-infections regarding VBDs in urban ***-reviewed and grey literature published between 2000 and 2016 was *** screened abstracts and full texts to select *** an extraction grid,we retrieved general data,results,lessons learned and recommendations,future research avenues,and practice *** classified studies by VBD and country/continent and identified relevant knowledge *** 773 articles selected for full-text screening,50 were included in the review:23 based on research in the Americas,15 in Asia,10 in Africa,and one each in Europe and *** largest body of evidence concerning VBD epidemiology in urban areas concerned dengue and *** arboviruses covered included chikungunya and West Nile virus,other parasitic diseases such as leishmaniasis and trypanosomiasis,and bacterial rickettsiosis and *** articles retrieved in our review combined transmission dynamics and vectorial capacity;only two combined transmission dynamics and *** review identified significant knowledge gaps on the role of asymptomatic individuals,the effects of co-infection and other host factors,and the impacts of climatic,environmental,and socioeconomic factors on VBD transmission in urban *** included the trade-off from narrowing the search strategy(missing out on classical modelling studies),a lack of studies on co-infections,most studies being only descriptive,and few offering concrete public health *** research is needed on transmission risk in homes and workplaces,given increasingly dynamic and mobil

关键词： Arboviruses Disease vectors Coinfection Urban population Epidemiology Review

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Epidemiological Study of Pediatric Surgery at Regional Hospital of Sorocaba between 2008 and 2012 by a Single Surgeon

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Surgical Science 2017年第8期8卷 375-383页

作者： Raíssa teixeira Rosalino Natália Iwakura Martelli Neil F. Novo Willy marcus Franç a Medical Science and Health Faculty Pontifical Catholic University of S&atilde o Paulo (PUC-SP) S&atilde o Paulo Brazil department of Medicine Service of Statistical Studies of Pontifical Catholic University of S&atilde o Paulo (PUC-SP) S&atilde o Paulo Brazil Medical Science and Health Faculty Pontifical Catholic University of S&atilde o Paulo (PUC-SP) S&atilde o Paulo Brazil

Introduction: volume increase of Pediatric Surgery (PedSur) due to factors not yet fully clarified contrast with the scarcity of pediatric surgeons in Brazil and globally. Geographic distribution, surgical care costs, and graduation period might contribute to this dearth. In Brazil, vacancy occupation rate in PedSur is below 43% (162 vacancies/year). Aim: analyze the volume of procedures performed on 0 - 12 year-old patients in PedSur by a single Specialist at Hospital Regional (HR);compare with the literature and propose the outset of a PedSur Medical Residence program. Material & Method: 1912 attendances were fulfilled on 986 children who were submitted to surgical procedures between 2008 and 2012 at HR by a single specialist. Results: Surgical procedures were performed on 1137 children, an average of 227/year or 197 children per year. Surgery was carried out in 667 (68%) boys and 319 (32%) girls. Hernias, appendectomies and circumcisions were the most frequent external surgeries. 437 (44%) patients were discharged on the same day and, 549 (56%) were hospitalized. In the Pediatric ICU and in the Neonatal ICU 181 procedures were performed (18%). Conclusion: It was possible to make evident the distribution of surgeries on children, the degree of complexity and a sufficient number of subjects for training in this Specialty. The obtained data allow the development of a study with regards to the inception of a Medical Residence in PedSur at HR for training and retaining the professional in the region.

关键词： Patient Care Pediatric Surgery Epidemiology Resident Education

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Gastric Gist as Cause of High Digestive Hemorrhage

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Journal of Biosciences and Medicines 2019年第1期7卷 42-47页

作者： Vinicius Moreira Paladino Thiago Sande Miguel Vinicius Sande Miguel Marcia Machado Galvao Pereira Fernando Antonio Galvao Pereira Carolina Galvao teixeira Caroline Guida Babinski Nayrton Kalys Cruz dos Anjos Caio marcus de Andrade Lopes Daniel Almeida da Costa The Medical School at the Center of Higher Education of Valenca ValencaBrazil Unigranrio Medical School Rio de JaneiroBrazil Faculty of Medical Sciences and Health of Juiz de Fora Juiz de ForaBrazil

Introduction: Gastrointestinal stromal tumor (GIST) occurrence is uncommon and usually manifested by nonspecific signs and symptoms, which hinders its reasoning as a diagnostic hypothesis. The objective is to report a case of female GIST with curative treatment through video-laparoscopy with partial gastrectomy. Case report: A 61-year-old female patient attended the Luiz Gioseffi Jannuzzi School Hospital (HELGJ) emergency room, with a sudden onset of upper gastrointestinal bleeding with hemodynamic instability. After stabilization, she was admitted for diagnostic investigation, showing sub-epithelial lesion of antrum in upper digestive endoscopy (Ude) and solid-cystic mass in the gastric antrum to computed tomography (CT). The conduct was the video laparoscopy surgical approach with partial gastrectomy. The histopathological and immunohistochemical aspects of the surgical specimen showed a gastrointestinal stromal tumor (GIST) in a gastric antrum of low grade of malignancy, positive e-Kit and mycotic index (50 cga) Discussion: Compared to the scarce reports in literature, the case described presented typical epidemiology, but the clinical picture was not the most incident. Conclusions: Given the rarity of this pathology cases, it is essential to report these in order to elucidate the specificities and also to discuss diagnostic and therapeutic methods.

关键词： Gastrointestinal Stromal Tumor Gastrointestinal Hemorrhage Immunohistochemistry

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Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial Sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho Sousa Isabella Fernandes da Silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da Silva Domingos Magno Santos Pereira Saulo JoseFigueiredo Mendes Joao Francisco Silva Rodrigues Jaqueline Pessoa Pontes Simone Aparecida teixeira AndreAlvares Marques Vale marcus Vinicius Dias-Souza Lidio Goncalves Lima-Neto Vera Lucia dos Santos Ana Paula Azevedo-Santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de Souza Monteiro Luis Claudio Nascimento da Silva Elizabeth Soares Fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em Saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation

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