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Stigma Receptivity Is Controlled by Functionally Redundant MAPK Pathway Components in Arabidopsis

Molecular Plant 2020年第11期13卷 1582-1593页

作者： Muhammad Jamshed Subramanian Sankaranarayanan Kumar Abhinandan marcus A.Samuel University of Calgary BI 392Department of Biological Sciences2500 University Dr.NWCalgaryAB T2N 1N4Canada Senior Scientist Frontier Agri-Science Inc98 Ontario StreetPort HopeON L1A2V2Canada Department of Botany and Plant Pathology Purdue UniversityWest LafayetteIN 47907USA

In angiosperms,the process of pollination relies on species-specific interaction and signaling between the male(pollen)and female(pistil)counterparts where the interplay between several pollen and stigma proteins decides the fate of the *** Brassicaceae,the dry stigmatic papillary cells control pollen germination by releasing resources only to compatible pollen thereby allowing pollen to hydrate and *** the identification of a number of stigmatic proteins that facilitate pollination responses,the signaling mechanisms that regulate functions of these proteins have remained ***,we show that,in Arabidopsis,an extremely functionally redundant mitogen-activated protein kinase(MAPK)cascade is required for maintaining stigma receptivity to accept compatible *** genetic analyses demonstrate that in stigmas,five MAPK kinases(MKKs),MKK1/2/3/7/9 are required to transmit upstream signals to two MPKs,MPK3/4,to mediate compatible *** functions of these five MKKs in the quintuple mutant(mkk1/2/3RNAi/mkk7/9)phenocopied pollination defects observed in the m pk4RNAi/m pk3 double *** further show that this MAPK nexus converges on Exo70A1,a previously identified stigma receptivity factor essential for *** that pollination is the crucial initial step during plant reproduction,understanding the mechanisms that govern successful pollination could lead to development of strategies to improve crop yield.

关键词： reproduction pollination stigma receptivity compatibility MAPK redundancy Exo70A1 exocytosis phosphorylation

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Antioxidant Activity and Phytochemical Screening in Acacia rigidula Benth. Leaves

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Advances in Bioscience and Biotechnology（生命科学与技术进展） 2024年第1期

作者： Aneth Ochoa-Negrete Rene Rangel marcus Antonius Ynalvez Ruby A. Ynalvez

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AIMS65: A promising upper gastrointestinal bleeding risk score but further validation required

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World Journal of Gastroenterology 2014年第39期20卷 14515-14516页

作者： Ray Boyapati Avik Majumdar marcus Robertson Department of Gastroenterology and Liver Transplant Austin Hospital Heidelberg VIC 3084 Australia

A novel upper gastrointestinal bleeding risk stratification score(AIMS65) has recently been developed and validated. It has advantages over existing risk scores including being easy to remember and lack of subjectivity in calculation. We comment on a recent study that has cast doubt on the applicability of AIMS65 in the peptic ulcer disease population. Although promising, further studies are required to evaluate the validity of AIMS65 in various populations.

关键词： Gastrointestinal haemorrhage AIMS65 Endoscopy Prognosis Hemostasis Gastrointestinal bleeding

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Super-resolution of PROBA-V images using convolutional neural networks

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Astrodynamics 2019年第4期3卷 387-402页

作者： marcus Martens DarioIzzo Andrej Krzic Daniel Cox European SpaceAgency Noordwijk2001AZthe Netherleneds

European Space Aqency(ESA)’s PROBA-V Earth observation(EO)satellite enables us to monitor our planet at a large scale to study the interaction between vegetation and climate,and provides guidance for important decisions on our common global ***,the interval at which high-resolution images are recorded spans over several days,in contrast to the availability of lower-resolution images which is often *** collect an extensive dataset of both high-and low-resolution images taken by PROBA-V instruments during monthly periods to investigate Multi Image Super-resolution,a technique to merge several low-resolution images into one image of higher *** propose a convolutional neural network(CNN)that is able to cope with changes in illumination,cloud coverage,and landscape features which are introduced by the fact that the different images are taken over successive satellite passages at the same *** a bicubic upscaling of low resolution images taken under optimal conditions,we find the Peak Signal to Noise Ratio of the reconstructed image of the network to be higher for a large majority of different *** shows that applied machine learning has the potential to enhance large amounts of previously collected EO data during multiple satellite passes.

关键词： deep learning convolutional neural network (CNN) super-resolution imaging remote sensing Earth observation(EO)

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THE HOSPITAL FORMULARY:A TYPE OF ESSENTIAL DRUG PROGRAM

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中国临床药理学杂志 1993年第1期 8-9页

作者： marcus M.Reidenberg Cornell University Medical College New York

Hospital pharmacies in the United States stock a limited number of drugs. The drugs that arestocked are selected to be able to treat all of the problems occuring in hospitalized patients. This requiresan extensive list of drugs, but far fewer than are available on the American market. Let us examinethe hospital formulary system and think of it as an example of an essential drugs program.

关键词： THE HOSPITAL FORMULARY

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CONTINUING MEDICAL EDUCATION,AN IMPORTANT PART OF A COMPREHENSIVE ESSENTIAL DRUGS PROGRAM

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中国临床药理学杂志 1993年第1期 10-12页

作者： marcus M.Reidenberg Cornell University Medical College New York

An essential drugs program starts with the preparation of a list of essential drugs based on theprinciples set out in the WHO Committee report. The next step in implementing an essential drugsprogram is to arrange for every drug on the essential drugs list to be available to everyone in the populationto be covered by the program. Preparing an essential drugs list and making the drugs available

关键词： CONTINUING MEDICAL EDUCATION,AN IMPORTANT PART OF A COMPREHENSIVE ESSENTIAL DRUGS PROGRAM very

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Immuno-oncology in triple-negative breast cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 133-144页

作者： Anne-Sophie Heimes marcus Schmidt Department of Obstetrics and Gynecology University Medical Center MainzMainz 55131Germany

The immune system plays an important role in breast ***-negative breast cancer(TNBC)has a higher mutational load compared to other *** addition,higher levels of tumor-associated antigens suggests that immunotherapies are a promising treatment option especially for *** review discusses both the complexity of the immune system and the cancer immune-cell *** fact,a higher level of tumor-infiltrating lymphocytes is associated with an improved prognosis as well as a better response to chemotherapy in *** target structures within the cancer immune-cell cycle are the so-called“immune checkpoints”.Immune checkpoint inhibitors(ICPi)block the interaction of certain cell surface proteins that serve as“brakes”of immune *** studies have shown ICPi improved survival in early as well as advanced ***,this has the price of increasing,mainly,immune-mediated *** strengthen tumor-specific T cell-mediated immunity by“releasing the brake”of the immune *** combination with chemotherapy,ICPi are already approved for *** a further step,individualized vaccination strategies against tumor-associated neoantigens represent another promising approach.A liposome-formulated intravenous RNA vaccine encoding different tumor-associated antigens is currently being studied in TNBC and leads to neoantigen-specific immune *** novel strategies will improve the prognosis of patients with triple-negative breast cancer.

关键词： Tumor infiltrating lymphocytes cancer-immunity-cycle immune checkpoint inhibitors vaccination,tumor-associated antigens neoantigens

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Assessment of the spatial extent of permafrost in the Upper Indus Basin(UIB)

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Journal of Mountain Science 2023年第6期20卷 1508-1525页

作者： Wasim HASSAN G.JEELANI A.P.DIMRI marcus NüSSER Department of Earth Sciences University of KashmirSrinagar 190006India School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067India Department of Geography South Asia Institute(SAI)Heidelberg UniversityHeidelberg 69115Germany Heidelberg Centre for the Environment(HCE) Heidelberg UniversityHeidelberg 69120Germany

Climate change differentially influences the frozen ground,a major dynamic component of the cryosphere,on a local and regional *** the warming climate with pronounced effects reported at higher altitudes,the characterization of the frozen ground is very important in the Upper Indus Basin(UIB),an important and critical region with respect to climate and hydro-glaciological *** this study,the efficiency and reliability of the surface frost number model are assessed in delineating the spatial extent of different classes of frozen ground in the *** daily MODIS land surface temperature(LST)with ground surface temperature(GST)and surface geomorphological expressions as ground validation datasets are used jointly in efficiently determining the extent of different classes of frozen ground(continuous and discontinuous permafrost and seasonal frost).The LST and GST resonate with each other in the annual cycle of temperature variation,however,with mean annual LST exhibiting an offset(cold bias)of 5 to 7℃relative to mean *** study shows that the highest permafrost extent is observed in areas where the lowest thinning rates of glacier ice are reported and vice *** surface frost number model categorizes an area of 38%±3%and 15%±3%in the UIB as permafrost and seasonal frost,*** on the altitude model,the lower limit of alpine permafrost is approximated at a mean altitude of 4919±590 m *** the *** present study acts as preliminary work in the data sparse and inaccessible regions of the UIB in characterizing the frozen and unfrozen ground and may act as a promising input data source in glaciohydro-meteorological models for the Himalaya and *** addition,the study also underlines the consideration of this derelict cryospheric climatic variable in defining and accounting for the sustainable development of socio-economic systems through its intricate ramification on agricultural activity,landscape stability and infrastruc

关键词： Upper Indus Basin Land surface temperature Ground surface temperature Surface frost number Permafrost Seasonal frost

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Leveraging Robust Artificial Intelligence for Mechatronic Product Development —A Literature Review

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International Journal of Intelligence Science（智能科学国际期刊） 2024年第1期

作者： Alexander Nüßgen RenéDegen marcus Irmer Fabian Richter Cecilia Boström Margot Ruschitzka

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Early Hearing Detection and Intervention in the United States: Achievements and Challenges in the 21^(st) Century

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China CDC weekly 2020年第21期2卷 378-382页

作者： Xidong Deng marcus Gaffney Scott D.Grosse National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and PreventionAtlantaGAUnited States

INTRODUCTION Congenital hearing loss affects approximately two infants per 1,000 live births in the United States(USA),making it one of the nation’s most common developmental disabilities(1).When left undetected,permanent congenital hearing loss can negatively impact children through delays in their speech,language,social,and emotional development(2).Children who are identified as deaf or hard of hearing(D/HH)should begin receiving intervention services as early as possible to help mitigate the potential adverse effects(3).

关键词： Achievements Challenges emotional

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