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Journal of Science in Sport and Exercise 2023年第1期5卷 16-24页

作者： marcus lee Jericho Wee Nick Dobbin Quintin Roman Gabriel Choong Sport Science National Youth Sports InstituteSingaporeSingapore Department of Health Professions Manchester Metropolitan UniversityManchesterUK Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Performance Pathway National Youth Sports InstituteSingaporeSingapore

Purpose This study examined the effects of tournament load on neuromuscular function,perceived wellness and coach rat-ings of performance across two 6-day netball *** Thirty-nine female youth netballers(age=14.6±0.5 years,stature=165.9±4.7 cm,body mass=56.5±7.2 kg)were categorised as HIGH(10-11 matches,n=20)or LOW(6 matches,n=19)tournament *** load,jump height,perceived wellness and coach ratings of performance were monitored *** HIGH tournament load resulted in greater reductions in jump height on match-day 4(-8.3%,±5.6%)when compared to *** tournament load resulted in greater reductions in perceived soreness(-0.9,±1.1 AU)and overall wellness(-2.6,±2.3 AU)on match-day 3,and a greater reduction in perceived sleep(-0.9,±1.1 AU)on match-day *** tournament load was negatively associated with sleep quality and coach ratings of performance(effect size correlation=-0.34 to-0.47)when compared to *** Our results indicate that a higher tournament load resulted in greater increases in neuromuscular fatigue,reduced perceived wellness,and lower ratings of *** should consider pre-tournament preparation and monitoring strategies to minimise the physiological disturbances during an intensified tournament.

关键词： Netball Monitoring Post-match fatigue Youth tournament Tournament structure

Hemorrhagic pancreatitis from fenofibrate and metformin toxicity:a case report

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World Journal of Emergency Medicine 2023年第6期14卷 495-498页

作者： marcus Aik Beng lee Mingwei Ng Paul Yugendra Yiju Yao R Ponampalam Boon Kiat Kenneth Tan Department of Emergency Medicine Singapore General HospitalSingapore 169608Singapore Analytical Toxicology Laboratory Health Sciences AuthoritySingapore 169078Singapore

Fibrates have been used for over forty-odd years to manage dyslipidemia and are generally considered safe and well-tolerated.^([1])However,little is known about the toxicity offibrates in overdose,[2]and most of the knowledge about fibrate toxicity comes from extrapolated observations of adverse effects encountered at therapeutic doses instead.

关键词： doses pancreatitis

TensorFlow solver for quantum Page Rank in large-scale networks

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Science Bulletin 2021年第2期66卷 120-126,M0003页

作者： Hao Tang Ruoxi Shi Tian-Shen He Yan-Yan Zhu Tian-Yu Wang marcus lee Xian-Min Jin Center for Integrated Quantum Information Technologies(IQIT) School of Physics and Astronomy and State Key Laboratory of Advanced Optical Communication Systems and NetworksShanghai Jiao Tong UniversityShanghai 200240China CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China Department of Physics Cambridge UniversityCambridge CB30HEUK

Google Page Rank is a prevalent algorithm for ranking the significance of nodes or websites in a network,and a recent quantum counterpart for Page Rank algorithm has been raised to suggest a higher accuracy of ranking comparing to Google Page *** quantum Page Rank algorithm is essentially based on quantum stochastic walks and can be expressed using Lindblad master equation,which,however,needs to solve the Kronecker products of an O(N^(4))dimension and requires severely large memory and time when the number of nodes N in a network increases above ***,we present an efficient solver for quantum Page Rank by using the Runge-Kutta method to reduce the matrix dimension to O(N^(2))and employing Tensor Flow to conduct GPU parallel *** demonstrate its performance in solving quantum stochastic walks on Erdos-Rényi graphs using an RTX 2060 *** test on the graph of 6000 nodes requires a memory of 5.5 GB and time of 223 s,and that on the graph of 1000 nodes requires 226 MB and 3.6 *** with QSWalk,a currently prevalent Mathematica solver,our solver for the same graph of 1000 nodes reduces the required memory and time to only 0.2%and 0.05%.We apply the solver to quantum Page Rank for the USA major airline network with up to 922 nodes,and to quantum stochastic walk on a glued tree of 2186 *** efficient solver for large-scale quantum Page Rank and quantum stochastic walks would greatly facilitate studies of quantum information in real-life applications.

关键词： Quantum stochastic walk Quantum PageRank Lindblad master equation TensorFlow GPU parallel computing Runge-Kutta method

Esophageal obstruction due to enteral feed bezoar:A case report and literature review

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World Journal of Gastrointestinal Endoscopy 2010年第10期2卷 352-356页

作者： Esther-lee marcus Ron Arnon Arkadiy Sheynkman Yehezkel G Caine Joseph Lysy Chronic Ventilation Unit Herzog HospitalPOB 3900Jerusalem 91035Israel Department of Gastroenterology Hadassah-Hebrew University Medical CenterPO Box 12000Jerusalem 91120Israel

This paper describes a rare complication of enteral feeding,esophageal obstruction due to feeding formula bezoar,and reviews the published cases. An attempt to re-insert the nasogastric tube in a chronically ventilated 80-year-old female fed via a nasogastric tube with Jevity failed. An esophagogastroduodenoscopy revealed an 18 cm-long concretion of the feeding formula,fi-lling most of the esophageal lumen,which was removed endo scopically. Forty-two cases of feeding formula esophageal bezoars have been reported in the literature. The formation of feeding formula bezoars is triggered by acidic gastroesophageal reflux. The acidic pH in the esophagus causes clotting of the casein in the formula. Predisposing factors for bezoar formation are:mechanical ventilation,supine position,neurological diseases,diabetes mellitus,hypothyroidism,obesity and history of partial gastrectomy. Diagnosis and removal of the bezoar is done endoscopically. Feeding in a semi-recumbent position,administration of prokinetic agents and proton pump inhibitors may prevent this complication.

关键词： Casein Enteral feeding Esophageal bezoar Nasogastric tube

Cell Wall Biology： Perspectives from Cell Wall Imaging

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Molecular Plant 2011年第2期4卷 212-219页

作者： Kieran J.D. lee Susan E. marcus J. Paul Knox Centre for Plant Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK

Polysaccharide-rich plant cell walls are important biomaterials that underpin plant growth, are major repositories for photosynthetically accumulated carbon, and, in addition, impact greatly on the human use of plants. Land plant cell walls contain in the region of a dozen major polysaccharide structures that are mostly encompassed by cellulose, hemicelluloses, and pectic polysaccharides. During the evolution of land plants, polysaccharide diversification appears to have largely involved structural elaboration and diversification within these polysaccharide groups. Cell wall chemistry is well advanced and a current phase of cell wall science is aimed at placing the complex polysaccharide chemistry in cellular contexts and developing a detailed understanding of cell wall biology. Imaging cell wall glycomes is a challenging area but recent developments in the establishment of cell wall molecular probe panels and their use in high throughput procedures are leading to rapid advances in the molecular understanding of the spatial heterogeneity of individual cell walls and also cell wall differences at taxonomic levels. The challenge now is to integrate this knowledge of cell wall heterogeneity with an understanding of the molecular and physiological mechanisms that underpin cell wall properties and functions.

关键词： Cell structure cell walls fluorescence imaging development cell wall imaging polysaccharides

Evaluation of Unified Model Microphysics in High-resolution NWP Simulations Using Polarimetric Radar Observations

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Advances in Atmospheric Sciences 2018年第7期35卷 771-784页

作者： marcus JOHNSON Youngsun JUNG Daniel DAWSON Timothy SUPINIE Ming XUE Jongsook PARK Yong-Hee lee Center for Analysis and Prediction of Storms (CAPS) University of Oklahoma Norman OK 73072 USA School of Meteorology University of Oklahoma Norman OK 73072 USA Purdue University West Lafayette IN 47907 USA Korea Meteorological Administration Seoul 07062 Korea

The UK Met Office Unified Model（UM） is employed by many weather forecasting agencies around the globe. This model is designed to run across spatial and time scales and known to produce skillful predictions for large-scale weather systems. However, the model has only recently begun running operationally at horizontal grid spacings of ～1.5 km [e.g.,at the UK Met Office and the Korea Meteorological Administration（KMA）]. As its microphysics scheme was originally designed and tuned for large-scale precipitation systems, we investigate the performance of UM microphysics to determine potential inherent biases or weaknesses. Two rainfall cases from the KMA forecasting system are considered in this study： a Changma（quasi-stationary） front, and Typhoon Sanba（2012）. The UM output is compared to polarimetric radar observations in terms of simulated polarimetric radar variables. Results show that the UM generally underpredicts median reflectivity in stratiform rain, producing high reflectivity cores and precipitation gaps between them. This is partially due to the diagnostic rain intercept parameter formulation used in the one-moment microphysics scheme. Model drop size is generally both underand overpredicted compared to observations. UM frozen hydrometeors favor generic ice（crystals and snow） rather than graupel, which is reasonable for Changma and typhoon cases. The model performed best with the typhoon case in terms of simulated precipitation coverage.

关键词： Unified Model microphysics polarimetric radar radar simulator numerical weather prediction

Vessel density and En-face segmentation of optical coherence tomography angiography to analyse corneal vascularisation in an animal model

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Eye and Vision 2019年第1期6卷 6-16页

作者： Kavya Devarajan Wen Di lee Hon Shing Ong Nyein C.Lwin Jacqueline Chua Leopold Schmetterer Jodhbir S.Mehta marcus Ang Singapore Eye Research Institute SingaporeSingapore Singapore National Eye Center SingaporeSingapore Eye-ACP Duke-NUS Graduate Medical SchoolSingaporeSingapore Department of Clinical Pharmacology Medical University of ViennaViennaAustria Center for Medical Physics and Biomedical Engineering Medical University of ViennaViennaAustria Nanyang Technological University SingaporeSingapore

Background:Optical coherence tomography angiography(OCTA)is a novel non-invasive angiography technology that has recently been extensively studied for its utility in anterior segment *** this study,we compared a split-spectrum amplitude decorrelation angiography(SSADA)OCTA and an optical micro-angiography(OMAG SD)OCTA system to current angiographic technique,indocyanine green angiography(ICGA),to assess corneal vascularisation in an animal ***:We imaged 16 rabbits,(one eye per animal)with corneal vascularisation using SSADA OCTA(AngioVue;Optovue Inc.,USA),OMAG OCTA(Angioscan;RS-3000 Nidek ***.,Japan)and ICGA in the same region of interest of the cornea at successive *** then analysed all scanned images for vessel density measurements and used paired t-tests and Bland-Altman plots to examine for significant *** en-face segmentation images from each of the OCTA scans were also extracted and were matched at every 50μm segmentation to be compared for vessel density at the respective ***:Bland-Altman plots revealed a good agreement between all three imaging techniques(P>0.05)for all vessel density measurements computed,and the ranges of 95%limit of agreement were acceptable from a clinical *** significant difference was reported,with ICGA(μ=16.52±8.94%)being more comparable to the OMAG OCTA(μ=16.23±9.51%;p=0.50)than the SSADA OCTA(μ=17.09±7.34%;p=0.33)***,a good correlation value(r>0.9)was obtained when comparing the vessel density measurements of the en-face segmentations between the OCTA ***:Comparable vessel density quantification between the two OCTA systems,and with ICGA was *** analysis of the vasculature at different depths showed varied performance in the two OCTA systems relative to each *** implications of the study may help to aid in the development of better OCTA algorithms for the anterior segment and its use in clinical translational research.

关键词： OCTA Corneal vascularisation Optical micro angiography Split-spectrum amplitude decorrelation angiography Vessel density Anterior segment En-face OCTA

Can we omit systematic biopsies in patients undergoing MRI fusion-targeted prostate biopsies?

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Asian Journal of Andrology 2023年第1期25卷 43-49页

作者： Jeffrey J Leow Soon Hock Koh marcus WL Chow Wayren Loke Rolando Salada Seok Kwan Hong Yuyi Yeow Chau Hung lee Cher Heng Tan Teck Wei Tan Department of Urology Tan Tock Seng HospitalSingapore 308433Singapore lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore Department of Diagnostic Radiology Tan Tock Seng HospitalSingapore 308433Singapore

Magnetic resonance imaging(MRI)-targeted prostate biopsy is the recommended investigation in men with suspicious lesion(s)on *** role of concurrent systematic in addition to targeted biopsies is currently *** our prospectively maintained database,we identified men with at least one Prostate Imaging-Reporting and Data System(PI-RADS)≥3 lesion who underwent targeted and/or systematic biopsies from May 2016 to May *** significant prostate cancer(csPCa)was defined as any Gleason grade group≥2 *** 545 patients who underwent MRI fusion-targeted biopsy,222(40.7%)were biopsy naïve,247(45.3%)had previous prostate biopsy(s),and 76(13.9%)had known prostate cancer undergoing active *** cancer was more commonly found in biopsy-naïve men(63.5%)and those on active surveillance(68.4%)compared to those who had previous biopsies(35.2%;both P<0.001).Systematic biopsies provided an incremental 10.4%detection of csPCa among biopsy-naïve patients,versus an incremental 2.4%among those who had prior negative *** regression found age(odds ratio[OR]=1.03,P=0.03),prostate-specific antigen(PSA)density≥0.15 ng ml^(−2)(OR=3.24,P<0.001),prostate health index(PHI)≥35(OR=2.43,P=0.006),higher PI-RADS score(vs PI-RADS 3;OR=4.59 for PI-RADS 4,and OR=9.91 for PI-RADS 5;both P<0.001)and target lesion volume-to-prostate volume ratio≥0.10(OR=5.26,P=0.013)were significantly associated with csPCa detection on targeted *** conclusion,for men undergoing MRI fusion-targeted prostate biopsies,systematic biopsies should not be omitted given its incremental value to targeted biopsies *** factors such as PSA density≥0.15 ng ml^(−2),PHI≥35,higher PI-RADS score,and target lesion volume-to-prostate volume ratio≥0.10 can help identify men at higher risk of csPCa.

关键词： prostate biopsy prostate cancer prostate health index prostate-specific antigen software fusion Uronav

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新型钢丝网复合墙板的研制

新型建筑材料 2007年第1期34卷 26-28页

作者：邓军 marcus M.K.lee 华南理工大学交通学院广东广州510641 英国南安普敦大学土木工程与环境学院

结合特殊的水泥基材料,研制了一种新型的预制钢丝网复合墙板。由于这种水泥基材料的非碳化性,它和钢丝网浇筑成的薄板最小厚度仅需6 mm,并具有良好的防水、防冻和防火性能。由薄板、加劲肋和泡沫保温层构成的复合墙板,具有极好的保温隔... 详细信息

结合特殊的水泥基材料,研制了一种新型的预制钢丝网复合墙板。由于这种水泥基材料的非碳化性,它和钢丝网浇筑成的薄板最小厚度仅需6 mm,并具有良好的防水、防冻和防火性能。由薄板、加劲肋和泡沫保温层构成的复合墙板,具有极好的保温隔热性能和力学性能,适用于建筑物的外墙。

关键词：新型墙板钢丝网复合墙板水泥基材料

The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2039-2055页

作者： Kan Xing Wu Thinesshwary Yogarajah marcus Wing Choy Loe Parveen Kaur Regina Ching Hua lee Chee Keng Mok Yi Hao Wong Patchara Phuektes Li Sze Yeo Vincent T.K.Chow Yong Wah Tan Justin Jang Hann Chu Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University Health SystemNational University of SingaporeSingapore 117597Singapore Department of Pathobiology Faculty of Veterinary MedicineKhonkaen UniversityKhonkaen 40002Thailand Infectious Disease Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A∗STAR)Singapore 138648Singapore lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore NUSMed Biosafety Level 3 Core Facility Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117599Singapore

Positive-sense RNA viruses modify intracellular calcium stores,endoplasmic reticulum and Golgi apparatus(Golgi)to generate membranous replication organelles known as viral *** factories provide a conducive and substantial enclave for essential virus replication via concentrating necessary cellular factors and viral proteins in ***,we identified the vital role of a broadspectrum antiviral,peruvoside in limiting the formation of viral ***,we revealed the pleiotropic cellular effect of Src and PLC kinase signaling via cyclin-dependent kinase 1 signaling leads to Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1(GBF1)phosphorylation and Golgi vesiculation by peruvoside *** ramification of GBF1 phosphorylation fosters GBF1 deprivation consequentially activating downstream antiviral signaling by dampening viral factories *** investigation showed signaling of ERK1/2 pathway via cyclin-dependent kinase 1 activation leading to GBF1 phosphorylation at Threonine 1337(T1337).We also showed 100%of protection in peruvoside-treated mouse model with a significant reduction in viral titre and without measurable cytotoxicity in *** findings highlight the importance of dissecting the broad-spectrum antiviral therapeutics mechanism and pave the way for consideration of peruvoside,host-directed antivirals for positive-sense RNA virus-mediated disease,in the interim where no vaccine is available.

关键词： Positive-sense RNA viruses Peruvoside Antiviral CDKI signaling Viral factories Calcium efflux Broad-spectrum Golgi apparatus