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Green-light fundus autofluorescence in diabetic macular edema

International Journal of Ophthalmology(English edition) 2013年第1期6卷 75-80页

作者： Lukas Reznicek Simeon Dabov Christos Haritoglou Anselm Kampik marcus kernt Aljoscha S Neubauer Department of Ophthalmology Ludwig Maximilians University

AIM:To evaluate the role of central green-light fundus autofluorescence (FAF) in diabetic macular edema(DME). METHODS:A consecutive series of 92 study eyes with diabetic retinopathy were included. Out of those, 51 diabetic eyes had DME and were compared to 41 diabetic eyes without DME. In all subjects, green-light FAF images were obtained, quantified and classified into various FAF patterns. Cross-sectional optical coherence tomography (OCT) scans were obtained for evaluation of Inner/Outer segment (IS/OS) layer integrity, measurements of central RPE-IS/OS layer thickness as well as classification of DME into various subtypes. ·RESULTS:Meancentralgreen-lightFAFintensityofeyes with DME (1.289 ±0.140)log did not significantly differ from diabetic patients without DME (1.317 ±0.137)log. Most classifiable FAF patterns were seen in patients with cystoid DME. Mean central retinal thickness (CRT) of all study eyes with DME was (501.9±112.4)μm compared to (328.2±27.0)μm in diabetic patients without DME. Patients with DME had significantly more disrupted photoreceptor IS/OS layers than diabetic patients without DME (28/51 vs 5/41, P <0.001). Mean RPE-IS/OS thickness of patients with DME (60.7±14.1)μm was significantly (P<0.001) lower than in diabetic eyes without DME (73.5 ±9.4)μm. Correlation analysis revealed non-significant correlations of green-light FAF intensity and OCT parameters in all subtypes of DME. ·CONCLUSION:Our results indicate a poor correlation of central green-light FAF intensity with CRT, IS/OS layer integrity or RPE-IS/OS layer thickness in diabetic patients with or without DME and its various subtypes. Thus, central green-light FAF is not suitable for detection of retinal thickening in DME.

关键词： diabetic macular edema fundus autofluorescence optical coherence tomography

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Correlation of leaking microaneurysms with retinal thickening in diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2011年第3期4卷 269-271页

作者： Lukas Reznicek marcus kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer Department of Ophthalmology Ludwig-Maximilians University

AIM: To investigate the contribution of fluorescein angiographic leaking microaneurysms (leak-MA) versus non-leaking microaneurysms (non-leak-MA) to retinal thickening in diabetic ***: A consecutive series of 38 eyes from 24 patients with diabetic retinopathy was ***-MA and non-leak-MA in each eye were selected in pairs at corresponding topographic *** was defined by late phase fluorescein angiograms compared to early *** thickness was measured with Heidelberg Spectralis OCT topographically aligned on early phase angiograms at the MA site and within a 1 mm ***: In all eyes,significant retinal thickening at the site of leaking compared to non-leaking microaneurysms was observed (356±69μm vs 318±56μm,P <0.001),showing a mean increase in thickness in the areas of leak-MA vs non-leak-MA of 38±39μm (95% confidence interval 2551μm,P<0.001).All 1mm area measurements also showed significant (P<0.001) thickening of the leak-MA with average thickness of leak-MA vs non-leak-MA as 351±67μmvs 319±59μm;minimum thickness 311±62μm vs 284±60μm;maximum thickness 389±78μm vs 352±66μm;and retina volume 26.4±6.0mmvs 23.6±3.7mm3,***: Leaking of microaneurysms on fluorescein angiography appears to cause focal thickening of retina,which can be measured with high-resolution ***,targeting leaking microaneursyms in diabetic retinopathy has the potential to reduce retinal thickening.

关键词： diabetic retinopathy microaneurysm retinal thickness OCT

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Role of wide-field autofluorescence imaging and scanning laser ophthalmoscopy in differentiation of choroidal pigmented lesions

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International Journal of Ophthalmology(English edition) 2014年第4期7卷 697-703页

作者： Lukas Reznicek Carmen Stumpf Florian Seidensticker Anselm Kampik Aljoscha S Neubauer marcus kernt Department of Ophthalmology Ludwig Maximilians University Muenchen

·AIM:Toevaluatethe diagnostic properties of wide-field fundus autofluorescence(FAF) scanning laser ophthalmoscope(SLO) imaging for differentiating choroidal pigmented lesions.·METHODS: A consecutive series of 139 patients were included, 101 had established choroidal melanoma with13 untreated lesions and 98 treated with ***-eight had choroidal nevi. All patients underwent a full ophthalmological examination, undilated wide-field imaging, FAF and standardized US examination. FAF images and imaging characteristics from SLO were correlated with the structural findings in the two patient groups.·RESULTS: Mean FAF intensity of melanomas was significantly lower than the FAF of choroidal nevi. Only 1out of 38 included eyes with nevi touched the optic disc compared to 31 out of 101 eyes with melanomas. In 18 out of 101 melanomas subretinal fluid was seen at the pigmented lesion compared to none seen in eyes with confirmed choroidal nevi. In 'green laser separation', a trend towards more mixed FAF appearance of melanomas compared to nevi was observed. The mean maximal and minimal transverse and longitudinal diameters of melanomas were significantly higher than those of nevi.·CONCLUSION: Wide-field SLO and FAF imaging may be an appropriate non-invasive diagnostic screening tool to differentiate benign from malign pigmented choroidal lesions.

关键词： imaging autofluorescence scanning laser ophthalmoscopy choroidal lesion melanoma

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Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2016年第6期9卷 858-862页

作者： Kaveh Abri Aghdam Lukas Reznicek Mostafa Soltan Sanjari Carsten Framme Anna Bajor Annemarie Klingenstein marcus kernt Florian Seidensticker Department of Ophthalmology University Eye HospitalMedical School of Hannover Carl-Neuberg-Straβe 1Hannover 30625 Germany Department of Ophthalmology Ludwig Maximilians University Mathildenstr. 8 Munich 80336 Germany Eye Research Center Rassoul Akram Hospital lranUniversity of Medical Sciences Sattarkhan-Niayesh StreetTehran 14456-13131 Iran

AIM： To evaluate the association between the size of peripheral retinal non-perfusion and the number of intravitreal ranibizumab injections in patients with treatment-naive branch retinal vein occlusion （BRVO） and macular edema. METHODS： A total of 53 patients with treatment-naive BRVO and macular edema were included. Each patient underwent a full ophthalmologic examination including optical coherence tomography （OCT） imaging and ultra wide-field fluorescein angiography （UWFA）. Monthly intravitreal ranibizumab injections were applied according to the recommendations of the German Ophthalmological Society. Two independent, masked graders quantified the areas of peripheral retinal non-perfusion. RESULTS： Intravitreal injections improved bestcorrected visual acuity （BCVA） significantly from 22.23± 16.33 Early Treatment of Diabetic Retinopathy Study （ETDRS） letters to 36.23 ±15.19 letters （P〈0.001）, and mean central subfield thickness significantly reduced from 387±115 pm to 321±115 μm （P=0.01）. Mean number of intravitreal ranibizumab injections was 3.61±1.56. The size of retinal non-perfusion correlated significantly with the number of intravitreal ranibizumab injections （R= 0.724, P〈0.001）. CONCLUSION： Peripheral retinal non-perfusion in patients with BRVO associates significantly with intravitreal ranibizumab injections in patients with BRVO and macular edema.

关键词： angiography branch retinal vein occlusion non-perfusion retina wide-field

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视网膜耳蜗脑微血管病并突发周边视野缺损及听力损失:Susac综合征1例(英文)

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国际眼科杂志 2010年第2期10卷 222-224页

作者： marcus kernt Aljoscha S Neubauer Stephan Thurau Mi-chael W Ulbig 路德维希马克西米利安大学眼科

目的:报告1例25岁女性患Susac综合征(SS),突发周边视野缺损及听力丧失。方法:报告1例25岁女性患者突发周边视野缺损及听力丧失,并记录视网膜超广角血管造影检查结果之间的相互关系以及所展现的视野缺损。结果:患者显现出SS特有的临床三... 详细信息

目的:报告1例25岁女性患Susac综合征(SS),突发周边视野缺损及听力丧失。方法:报告1例25岁女性患者突发周边视野缺损及听力丧失,并记录视网膜超广角血管造影检查结果之间的相互关系以及所展现的视野缺损。结果:患者显现出SS特有的临床三联征。我们可以看出视网膜超广角血管造影检查结果和视野缺损之间的一些相互关系。结论:经证明超广角血管造影术是一个在临床治疗中检测和追踪SS周围病变的有价值的工具。

关键词： Susac综合征广角血管造影术欧宝全景照相系统眼底成像视网膜微血管病

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糖尿病视网膜病变中微动脉瘤荧光素渗出与视网膜增厚的关系(英文)

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国际眼科杂志 2011年第7期11卷 1137-1139页

作者： Lukas Reznicek marcus kernt Christos Haritoglou Michael Ulbig Anselm Kampik Aljoscha S Neubauer Ludwig-Maximilians大学眼科

目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光... 详细信息

目的:观察糖尿病视网膜病变患者血管荧光素造影微动脉瘤处渗出与视网膜增厚的关系。方法:选取糖尿病视网膜病变患者24例38眼,首次及末次血管荧光素造影检查确定是否存在微动脉瘤荧光素渗出。根据毛细血管闭塞区的位置选取微动脉瘤荧光素渗出与未渗出各1眼配对进行对比。在微动脉瘤和直径为1mm区域使用光学相干断层成像术(OCT)测量视网膜厚度。结果:微动脉瘤荧光素渗出眼视网膜厚度明显高于未渗出眼(356±69μmvs318±56μm,P<0.001),渗出眼平均增长厚度高于未渗出眼(95%的可信区间为25～51μm,P<0.001).在直径为1mm区域,渗出眼视网膜厚度和平均增长厚度均明显高于未渗出眼(351±67μmvs319±59μm;最小值311±62μmvs284±60μm;最大值389±78μmvs352±66μm)。结论:血管荧光素造影显示微动脉瘤荧光素渗出可以增加视网膜厚度,并运用高分辨率OCT测量。因此,对糖尿病视网膜病变患者早期诊断微动脉瘤荧光素是否渗出可以抑制视网膜增厚。

关键词：糖尿病视网膜病变微动脉瘤视网膜厚度 OCT

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