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Punica granatum Leaf Lipophilic Fraction Favours Mortality by Attenuating Inflammation in Mice with Polymicrobial Sepsis

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 355-367页

作者： Nagila Caroline Fialho Sousa Isabella Fernandes da Silva Figueiredo Mizael Calacio de Araujo Elaine Pereira de Andrade Thais Costa Alves Bruna Letícia Rosa da Silva Domingos Magno Santos Pereira Saulo JoseFigueiredo Mendes Joao Francisco Silva Rodrigues Jaqueline Pessoa Pontes Simone Aparecida Teixeira AndreAlvares Marques Vale marcus Vinicius Dias-Souza Lidio Goncalves Lima-Neto Vera Lucia dos Santos Ana Paula Azevedo-Santos Marcelo Nicolas Muscara Valerio Monteiro-Neto Andrea de Souza Monteiro Luis Claudio Nascimento da Silva Elizabeth Soares Fernandes Programa de Pos-graduacao Universidade CEUMARua JosueMontellon°1RenascencaSao LuisMA 65075-120Brazil Departamento de Farmacologia Universidade de Sao PauloAv.Prof.Lineu Prestesn°1524Sala 326ButantanSao PauloSP 05508-900Brazil Programa de Pos-graduacao em Ciências em Saude Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuisMA 65080-805Brazil Departamento de Microbiologia Universidade Federal de Minas GeraisAv.Antonio Carlosn°6627PampulhaBelo HorizonteMG 31270-901Brazil Departamento de Patologia Universidade Federal do MaranhaoAvenida dos Portuguesesn°1966BacangaSao LuísMA 65080-805Brazil

Punica granatum *** known antimicrobial and anti-inflammatory *** of different parts of this plant have been commonly used in the folk medicine to prevent and treat infections;and studies have supported the use of *** extracts for this ***,little is known of the effects of ***-derived fractions in severe infectious diseases such as ***,we investigated the actions of the hexane fraction(HF),rich in lipophilic compounds,obtained from the leaves of this plant,in a murine model of polymicrobial *** pre-treatment with HF increased mortality in septic *** same animals presented with lower levels of interleukin-6,nitric oxide and hydrogen peroxide in their peritoneal lavage samples than vehicle *** also increased polymorphonuclear cell accumulation in to the peritoneum of mice with ***-derived nitric oxide upon lipopolysaccharide stimuli was markedly reduced by incubation with ***,triterpenes,phytosterols,vitamin E and ascorbyl palmitate were detected in the *** results indicate that *** leaf lipophilic fractions may worsen sepsis *** effect may be associated with its bioactive compounds which act synergistically or not,increasing sepsis mortality in vivo.

关键词： P.granatum infection inflammation

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卵细胞内单精子注射受孕后出生儿童的眼部检查

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 21-21页

作者： Wikstrand M.H. Strmland k. Flodin S. 邢咏新 Department of Ophthalmology Sahlgrenska University Hospital/Mlndal 431 80 Mlndal Sweden Dr.

Purpose: To investigate visual function and ocular morphology in children born after intracytoplasmic sperm injection (ICSI)-and compare them with visual function and ocular morphology in matched children born after spontaneous conception. Methods: A total of 137 children born after ICSI and 159 control children were examined at the age of 5 years in a blinded study. The two groups were matched for age, gender and maternal age. The children underwent a detailed ophthalmological investigation by an ophthalmologist and an orthoptist. Results: A total of 90.4% of the ICSI children had a visual acuity (VA) in the better eye of ≥ 0.8, compared with 93.7% of the controls (NS). No significant differences were found between ICSI children and controls with regard to hyperopia, myopia, astigmatism, heterotropia, stereoscopic vision and convergence. One child with Goldenhar syndrome and one with marcus Gunn syndrome were observed in the ICSI group. One child in the ICSI group was treated for retinopathy of prematurity. Conclusion: In this limited study group, no significant differences in visual function and/or ocular morphology were found between children born after ICSI and matched control children at the age of 5 years.

关键词：单精子注射眼部检查视功能眼科检查自然妊娠眼科医生立体视 arcus 矫正师无显著性差异

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广西文化艺术中心

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建筑实践 2020年第2期3卷 62-69页

作者：曼哈德·冯·格康尼古劳斯·格茨德克·海勒克里斯多夫·贝勒汉娜·蒂尔斯杰西卡·拉斯特米凯尔·斯腾贝格吴子恒徐欣凌冯彩麦克·耶格王莉雯·克诺尔霍格·施穆克亚历山大·施尼伯马库斯·坦岑德克·赛费特冯·格康玛格及合伙人建筑师事务所

广西文化艺术中心为南宁提供了一个崭新的举办音乐文化活动的公共设施,将为歌剧、古典交响音乐会、音乐剧、联欢会等提供演出场所。歌剧厅、音乐厅和多功能厅作为三个独立的体量被置于一个浅色天然石材基座上,基座内为辅助性功能空间。... 详细信息

广西文化艺术中心为南宁提供了一个崭新的举办音乐文化活动的公共设施,将为歌剧、古典交响音乐会、音乐剧、联欢会等提供演出场所。歌剧厅、音乐厅和多功能厅作为三个独立的体量被置于一个浅色天然石材基座上,基座内为辅助性功能空间。歌剧院位于西南端,内部设有1,600个坐席,约600m^2的舞台面向人工湖打开。

关键词：音乐剧文化艺术中心音乐厅混响时间 Section

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宝马世界

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城市环境设计 2020年第4期126卷 134-149页

作者：沃尔夫·狄·普瑞克斯 Paul kath Tom Wiscombe Waltraut Hoheneder Mona Marbach Hans Aescht Beatrix Basting Guy Bebiè Chris Beccone Johannes Behrens Marcelo Bernardi Pawel Bodzak Verena Boyer Antja Bulthaup Claudia Buhmann Timo Carl Jan Chaldil Ing Tse Chen Tadeusz Chimiak Andrea Christmann Patrick Erhardt Stephan Exsternbrink Wolfgang Fiel Benedikt Frass Helmut Fr?tscher Volker Gessendorfer Andrea Graser Lukas Haller Markus Henning Armin Hess Jens Hoff Tamas Horvath Robert Huebser Astrid Jagersberger Marin Jurycz Gregor kassl Areta keller Markus klausecker Tobias klein Martin konrad Quirin krumbholz Caroline kufferath Marion Lattenmayer Stefan Laub Wolfgang Leitgeb Andreas Mieling karin Miesenberger Dennis Milam Elke Müller Henrike Münker Claudia Nehammer Martin Oberascher Alexander Ott Stefan Pfefferle Florian Pfeifer Markus Pillhofer Ekkehard Rehfeld Goswin Rothenthal Wolfgang Ruthensteiner Jasmin Sauerbier Florian Schafschetzy kristina Schinegger karolin Schmidbaur Patrick Schneider katharina Schneider Hubert Schoba Angus Schoenberger Andrea Sch?ning Anja Sorger Gernot Stangl Mark Steinmetz Sigrid Steinwender Martina Tippelskirch Dionicio Valdez Pascal Vauclair Akvile Rimantaite Andreas Weissenbach Heribert Wolfmayer Irina Zahler 2007 Ari Marcopoulos Gerald Zugmann Hélène Binet Duccio Malagamba marcus Buck Christian Richters Richard Walch

项目大事记/CHRONOLOGY竞赛（一等奖）/Competition（1st Prize）:2001规划设计起始时间/Start of Planning:11/2001施工起始时间/Start of Construction:08/2003投入使用/Opening:20/10/2007-21/10/2007项目参数/PROJECT DATA用地面积/Site Area:约25 000m2/Approx. 25 000m2建筑毛面积/Gross Floor Area:约73 000m2（除坡道）=100%/Approx.73 000m2（excluding ramps）=100%地上建筑毛面积/Gross Floor Area above ground:约28 500m2=40%/Approx.28 500m2=40%地下建筑毛面积/Gross Floor Area underground:约44 500m2=60%/Approx.44 500m2=60%

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay k Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh khatri Michael kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,pke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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