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Computed tomography-based radiomics diagnostic approach for differential diagnosis between early-and late-stage pancreatic ductal adenocarcinoma

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World j.urnal of Gastrointestinal Oncology 2024年第4期16卷 1256-1267页

作者： Shuai Ren Li-Chao Qian Ying-Ying Cao marcus j.Daniels Li-Na Song Ying Tian Zhong-Qiu Wang Department of Radiology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND One of the primary reasons for the dismal survival rates in pancreatic ductal adenocarcinoma(PDAC)is that most patients are usually diagnosed at late *** is an urgent unmet clinical need to identify and develop diagnostic methods that could precisely detect PDAC at its earliest *** A total of 71 patients with pathologically proved PDAC based on surgical resection who underwent contrast-enhanced computed tomography(CT)within 30 d prior to surgery were included in the *** staging was performed in accordance with the 8th edition of the American j.int Committee on Cancer staging *** features were extracted from the region of interest(ROI)for each patient using Analysis Kit *** most important and predictive radiomics features were selected using Mann-Whitney U test,univar-iate logistic regression analysis,and minimum redundancy maximum relevance(MRMR)*** forest(RF)method was used to construct the radiomics model,and 10-times leave group out cross-validation(LGOCV)method was used to validate the robustness and reproducibility of the *** A total of 792 radiomics features(396 from late arterial phase and 396 from portal venous phase)were extracted from the ROI for each patient using Analysis Kit *** most important and predictive features were selected using Mann-Whitney U test,univariate logistic regression analysis,and MRMR *** method was used to construct the radiomics model with the nine most predictive radiomics features,which showed a high discriminative ability with 97.7%accuracy,97.6%sensitivity,97.8%specificity,98.4%positive predictive value,and 96.8%negative predictive *** radiomics model was proved to be robust and reproducible using 10-times LGOCV method with an average area under the curve of 0.75 by the average performance of the 10 newly built *** The radiomics model based on CT could serve as a promising non-invasive method in differential diag

关键词： Pancreatic ductal adenocarcinoma Radiomics Computed tomography American j.int Committee on Cancer staging

The effect of Laves phases and nano-precipitates on the electrochemical corrosion resistance of Mg-Al-Ca alloys under alkaline conditions

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j.urnal of Magnesium and Alloys 2024年第6期12卷 2447-2461页

作者： Markus Felten Veronika Chaineux Siyuan Zhang Ali Tehranchi Tilmann Hickel Christina Scheu j.shua Spille Marta Lipińska-Chwałek j.achim Mayer Benj.min Berkels marcus Hans Imke Greving Silj. Flenner Sandra Sefa Daniela Zander Chair of Corrosion and Corrosion Protection RWTH Aachen UniversityAachen 52072 Germany Max-Planck-Institut für Eisenforschung GmbH Düsseldorf 40237 Germany Central Facility for Electron Microscopy RWTH Aachen UniversityAachen 52074 Germany Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons Forschungszentrum Jülich GmbHJülich 52428Germany Mathematical Image and Signal Processing Aachen Institute for Advanced Study in Computational Engineering ScienceRWTH Aachen UniversityAachen 52062 Germany Materials Chemistry RWTH Aachen UniversityAachen 52074 Germany Institute of Materials Physics Helmholtz-Zentrum HereonGeesthacht 21502 Germany

The electrochemical corrosion mechanisms of Mg alloys were extensively studied in previous investigations of different chemical com-positions,modified surface states and various electrolyte ***,recent research focused on the active state of Mg dissolution,leading to unresolved effects of secondary phases adj.cent to a stableα-solid solution passive *** present study investigates the fundamental electrochemical corrosion mechanisms of three different Laves phases with varying phase morphologies and phase fractions in the passive state of Mg-Al-Ca *** microstructure was characterized by(transmission-)electron microscopy and synchrotron-based transmission X-ray *** electrochemical corrosion resistance was determined with a standard three-electrode setup and advanced in-situ flow cell measurements.A new electrochemical activity sequence(C15>C36>α-Mg>C14)was obtained,as a result of a stable passive layer formation on theα-solid ***,nm-scale Mg-rich precipitates were identified within the Laves phases,which tend to inhibit the corrosion kinetics.

关键词： Laves phase STEM Magnesium Corrosion Passive layer

Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

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World j.urnal of Radiology 2024年第6期16卷 211-220页

作者： Shuai Ren Li-Chao Qian Xiao-j.ng Lv Ying-Ying Cao marcus j.Daniels Zhong-Qiu Wang Li-Na Song Ying Tian Department of Radiology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND Solid pseudopapillary neoplasms of the pancreas(SPN)share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes(PDAC with cystic changes),which may result in unnecessary *** To investigate the value of computed tomography(CT)in differentiation of SPN from PDAC with cystic *** This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes,confirmed through pathological *** and qualitative analysis was performed,including assessment of age,sex,tumor size,shape,margin,density,enhancement pattern,CT values of tumors,CT contrast enhancement ratios,“floating cloud sign,”calcification,main pancreatic duct dilatation,pancreatic atrophy,and peripancreatic invasion or distal *** logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes,and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their *** When compared to PDAC with cystic changes,SPN had a lower age(32 years vs 64 years,P0.05).The area under the receiver operating characteristic curve of the combination was 0.833(95%confidence interval:0.708-0.957)with 78.6%sensitivity,81.3%specificity,and 80.4%accuracy in differentiation of SPN from PDAC with cystic *** A larger tumor size,“floating cloud sign,”and peri

关键词： Solid pseudopapillary neoplasm Pancreas Pancreatic ductal adenocarcinoma Computed tomography Differential diagnosis

Outcomes of a non-randomised audit of single pigtail suture stents in urolithiasis management of Asian patients in Singapore

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Asian j.urnal of Urology 2024年第2期11卷 324-330页

作者： Ee j.an Lim Zhen Wei Choo Reshma Mangat Pradeep Durai Sarvaj.t Biligere Yiquan Tan Loh Hin Yeung marcus Nicole Andrea Seet Li Ting Chin Tiong Heng Stefania Ferreti Vineet Gauhar Urology Department Singapore General HospitalSingapore Urology Department Tan Tock Seng HospitalSingapore Urology Department Ng Teng Fong HospitalSingapore Urology Department Azienda Ospedaliera-Uiversitaria(Hospital and University of Parma)ParmaItaly

Obj.ctive:Double-j.Dj.ureteric stents are commonly placed perioperatively for semirigid or flexible ureteroscopic renal *** is believed that lesser stent material within the bladder mitigates stent-related *** study aimed to evaluate the j.Fil ureteral stent,a single pigtail suture stent compared with conventional Dj.stent in relation to stent symptoms in an Asian population undergoing ureterorenal ***:Based on internal audit committee recommendation approval,the records of 50 patients retrieved,available data of 41 patients who were prospectively enrolled into two groups(Group 1[j.Fil stent group],n=21 and Group 2[Dj.stent group],n=20)between August 2020 to j.nuary 2021,were *** compared were nature of procedure,stone location and size,ease of deployment or removal,and complications.A modified universal stent symptom questionnaire was used to assess morbidity of stent symptoms within 48 h of insertion and at ***:Both groups had similar median age,distribution in male to female ratio,and stone *** overall median universal stent symptom questionnaire score at insertion was similar for bladder pain,flank or loin pain,and quality of life between Group 1 and 2;however,at removal Group 1 fared significantly better than Group 2,especially for flank or loin pain and pain at *** groups had similar ease in insertion with no hospital ***:Our audit favoured the single pigtail suture stent in Asian ureters in mitigating stent-related *** showed a good safety profile with easy deployment and *** promises a new standard in stenting.

关键词： Stent Ureteroscopy Pigtail suture stent Asianpatient Flexible ureteroscopic renal surgery

自适应辅助通气的潮气量决定因素：一项多中心观察研究

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麻醉与镇痛 2010年第1期6卷 92-98页

作者： Dave A. Dongelmans Denise P. Veelo Alexander Bindels j.n M. Binnekade Kees Koppenol Matty Koopmans j.ke C. Korevaar Michael A. Kuiper marcus j. schultz 杨婷(译) 姚尚龙(校) Department of Intensive Care Medidne University of Amsterdam Amsterdam The Netherlands Department of Anesthesiology Academic Medical Center University of Amsterdam Amsterdam The Netherlands Department of Intensive Care Medicine Catharina Hospital Eindhoven Eindhoven The Netherlands Department of Intensive Care Medi- cine Medical Centre Leeuwarden Leeuwarden The Netherlands Department of Clinical Epidemiology and Biostatistics Academic Medical Center University of Amsterdam Amsterdam The Netherlands HERMES Critical Care Group Amsterdam The Netherlands Laboratory for Experimental Intensive Care and Anesthesiology( L. E. I. C. A) Academic Medical Center University of Amsterdam Amsterdam The Netherlands 不详

引言在本研究中，我们在心胸外科手术后患者中观察了自适应辅助通气（adaptive support ventilation，ASV）。我们明确了在这种微处理器控制机械通气模式下的潮气量（tidal volumes，VT）和潮气量的影响因素。方法这是一项在荷兰的三家... 详细信息

引言在本研究中，我们在心胸外科手术后患者中观察了自适应辅助通气（adaptive support ventilation，ASV）。我们明确了在这种微处理器控制机械通气模式下的潮气量（tidal volumes，VT）和潮气量的影响因素。方法这是一项在荷兰的三家加强监护病房进行的为期5个多月的前瞻性、多中心观察研究。机械通气的数据在患者来到加强监护病房后的稳定状态下收集。结果数据来自心胸外科术后的连续346例患者：其中262例患者采用自适应辅助通气模式，84例患者采用压力控制机械通气模式。在ASV模式下，每实际公斤体重（ABW）的VT（mean±SD）为7．1±1．6ml，每理想公斤体重（IBW）的、VT为8.3±1.5ml。而在恰当设定体重（SBW）（如，理想体重IBW）的患者，VT为8．1±1．4ml／kg。在压力控制机械通气模式下，VT为7．3±1．4ml／kgIBW（P〈0．001vsASV）。多变量logistic回归分析表明ASV模式的VT仅依赖于两个参数：呼吸频率和设定体重的正确性。结论ASV模式的VT依赖于两个参数：呼吸频率和设定体重的正确性。第一个因素并没有重要的临床意义，因为呼吸频率是由微处理器自动选择的。第二个因素在临床上非常重要，因为这是受操作者影响的唯一因素。我们的数据表明了在ASV模式下设定正确体重的重要性。在ASV模式下，绝大多数患者的VT〉8ml／kg IBW。未来还需要进行随机临床试验来将ASV和其他通气模式进行比较。

关键词：辅助通气潮气量自适应多中心 logistic回归分析机械通气模式微处理器控制理想体重

Collective Computation,Information Flow,and the Emergence of Hunter-Gatherer Small-Worlds

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j.urnal of Social Computing 2022年第1期3卷 18-37页

作者： marcus j.Hamilton the Department of Anthropology University of Texas at San AntonioSan AntonioTX 78249USA.

Two key features of human sociality are anatomically complex brains with neuron-dense cerebral cortices,and the propensity to form complex social networks with *** brains and complex social networks facilitate flows of fitness-enhancing energy and information at multiple scales of social ***,we consider how these flows interact to shape the emergence of macroscopic regularities in hunter-gatherer macroecology relative to other mammals and non-human *** computation is the processing of information by complex adaptive systems to generate inferences in order to solve adaptive *** hunter-gatherer societies the adaptive problem is to resolve uncertainty in generative models used to predict complex environments in order to maximize inclusive *** macroecological solution is to link complex brains in social networks to form collective brains that perform collective *** developing theory and analyzing data,the author shows hunter-gatherers bands of~16 people,or~4 co-residing families,form the largest collective brains of any social ***,because individuals,families,and bands interact at multiple time scales,these fission-fusion dynamics lead to the emergence of the macroscopic regularities in hunter-gatherer macroecology we observe in cross-cultural *** results show how computation is distributed across spatially-extended social networks forming decentralized knowledge systems characteristic of hunter-gatherer *** flow of information at scales far beyond daily interactions leads to the emergence of small-worlds where highly clustered local interactions are embedded within much larger,but sparsely connected multilevel metapopulations.

关键词： complex adaptive systems hierarchically modular networks collective brains macroecology allometry mammals primates

Organizing and Disorganizing Resonances of Microtubules, Stem Cells, and Proteins Calculated by a Quantum Equation of Coherence

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j.urnal of Modern Physics 2022年第12期13卷 1530-1580页

作者： Hans j. H. Geesink marcus Schmieke DSM-Research Geleen Netherlands Institute of Existential Consciousness Research (ECR) Berlin Germany Dev Sanskriti University Haridwar India

Conformational states of microtubules and proteins have typical spatial-spectral arrangements of atoms, called spatial coherence, that are characteristic for building, homeostasis, decay, and apoptosis. Microtubules show a principle of a self-organizing-synergetic structure called a Fröhlich-Bose-Einstein state. The spatial coherence of this state can be described by a toroidal quantum equation of coherence. In this space, microtubules and proteins have typical discrete frequency patterns. These frequencies comply with two proposed quantum wave equations of respective coherence (regulation) and decoherence (deregulation), that describe quantum entangled and disentangled states. The proposed equation of coherence shows the following typical scale invariant distribution of energy: En = ħωref 2q3m. The proposed model supports quantum entanglement and is in line with the earlier published models of Fröhlich, Davydov, and Chern. A meta-analysis shows a semi-harmonic scale-invariant pattern for microtubules, stem cells, proteins, and EEG- and MEG-patterns. A fit has been found for about 50 different organizing frequencies and 5 disorganizing frequencies of measured microtubule frequencies that fit with the calculated values of the proposed quantum equations, which are positioned in a nested toroidal geometry. All measured and analysed frequencies of microtubules comply with the same energy distribution found for Bose-Einstein condensates. The overall results show a presence of an informational quantum code, a direct relation with the eigenfrequencies of microtubules, stem cells, DNA, and proteins, that supplies information to realize biological order in life cells and substantiates a collective Fröhlich-Bose-Einstein type of behaviour and further support the models of Tuszynski, Hameroff, Bandyopadhyay, Del Giudice and Vitiello, Katona, Pettini, and Pokorny.

关键词： Quantum Coherence Coherence and Decoherence Electromagnetic Frequencies Quantum Biology Quantum Wave Equation Fröhlich Microtubules Proteins Healthy and Unhealthy Frequency Patterns

On Local Nonreflecting Boundary Conditions for Time Dependent Wave Propagation

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Chinese Annals of Mathematics,Series B 2009年第5期30卷 589-606页

作者： marcus j. GROTE Imbo SIM Department of Mathematics University of Basel

The simulation of wave phenomena in unbounded domains generally requires an artificial boundary to truncate the unbounded exterior and limit the computation to a finite *** the artificial boundary a boundary condition is then needed,which allows the propagating waves to exit the computational domain without spurious *** 1977,Engquist and Maj.a proposed the first hierarchy of absorbing boundary conditions,which allows a systematic reduction of spurious reflection without moving the artificial boundary farther away from the *** pioneering work,which initiated an entire research area,is reviewed here from a modern *** developments such as high-order local conditions and their extension to multiple scattering are also ***,the accuracy of high-order local conditions is demonstrated through numerical experiments.

关键词：吸收边界条件波的传播时间依赖人工边界多重散射高阶精度虚假反射反射系统

Cell Wall Microstructure Analysis Implicates Hemicellulose Polysaccharides in Cell Adhesion in Tomato Fruit Pericarp Parenchyma

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Molecular Plant 2009年第5期2卷 910-921页

作者： j.se j. Ordaz-Ortiz Susan E. marcus j. Paul Knox Centre for Plant Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT United Kingdom

Methods developed to isolate intact cells from both unripe and ripe tomato fruit pericarp parenchyma have allowed the cell biological analysis of polysaccharide epitopes at the surface of separated cells. The LM7 pectic homogalacturonan epitope is a marker of the j.nctions of adhesion planes and intercellular spaces in parenchyma systems. The LM7 epitope persistently marked the former edge of adhesion planes at the surface of cells separated from unripe and ripened tomato fruit and also from fruits with the Cnr mutation. The LM 11 xylan epitope was associated, in sections, with cell walls lining intercellular space but the epitope was not detected at the surface of isolated cells, being lost during cell isolation. The LM15 xyloglucan epitope was present at the surface of cells isolated from unripe fruit in a pattern reflecting the former edge of cell adhesion planes/intercellular space but with gaps and apparent breaks. An equivalent pattern of LM15 epitope occurrence was revealed at the surface of cells isolated by pectate lyase action but was not present in cells isolated from ripe fruit or from Cnr fruit. In contrast to wild-type cells, the LM5 galactan and LM21 mannan epitopes occurred predominantly in positions reflecting intercellular space in Cnr, suggesting a concerted alteration in cell wall microstructure in response to this mutation. Galactanase and mannanase, along with pectic homogalacturonan-degrading enzymes, were capable of releasing cells from unripe fruit parenchyma. These observations indicate that hemicellulose polymers are present in architectural contexts reflecting cell adhesion and that several cell wall polysaccharide classes are likely to contribute to cell adhesion/cell separation in tomato fruit pericarp parenchyma.

关键词： Cell walls fruit development tomato cell adhesion cell separation polysaccharide.