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A self-reported long-term follow-up of patients operated with either shortening techniques or a TachoSil grafting procedure

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Asian Journal of Andrology 2011年第2期13卷 326-331页

作者： marcus Horstmann Matthias Kwo bastian Amend Joerg Hennenlotter Arnulf Stenzl Department of Urology Eberhard Karls University Tuebingen Hoppe-Seyler-Str. 3 72076 Tuebingen Germany

The aim of this article is to analyse the long-term results of different surgical techniques for correction of penile deviations in Peyronie＇s disease. Patients who underwent surgery for a penile deviation in Peyronie＇s disease between 1997 and 2007 were included into this study. Cases were retrospectively analysed by chart review. The current situation was evaluated by a 16-item standardized questionnaire addressing penile straightness, sensation, length, sexual function and satisfaction. Ninety patients were contacted with a return rate of 75 （83%） evaluabie questionnaires. Thirty-two patients were operated by shortening techniques （STs） with either Schroeder-Essed （n= 16） or Nesbit （n= 16）. Forty-three were operated by a plaque in-lexcision and defect covering by TachoSil method （TM）. both groups were similar regarding age （ST 56 years, TM 57 years）, comorbidities, mean preoperative erection hardness score （EHS; 3.1 ST, 3.4 TM） and time of follow-up （total mean, 63 months）. Preoperatively ST patients had significantly less plaques （P〈0.05） and a lower deviation angle in comparison to TM patients （ST 56° versus TM 74°; P〈 0.001）. Still TM patients reported slightly better straightening results, but a significantly lower mean EHS （ST 3.3 versus TM 2.6; P〈0.001） during the follow-up. Satisfaction rates were similar in both groups. In conclusion, both techniques revealed to be safe and sustainable successful in penile straightening with better functional outcome of patients operated by STs.

关键词： Nesbit, penile deviation penile reconstruction Peyronie's disease Schroeder-Essed TachoSil grafting

Differences in Judo Attack Systems between Weight Categories

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Journal of Science in Sport and Exercise 2023年第3期5卷 263-273页

作者： Daniel brandão Kashiwagura Javier Courel-Ibáñez Felipe brandão Kashiwagura marcus Fábio Agostinho Emerson Franchini Martial Arts and Combat Sports research Group School of Physical Education and SportSport DepartmentUniversity of São PauloAv.Prof.Mello Morais65Cidade UniversitáriaSão PauloSP 05508-030Brazil Faculty of Sport Sciences University of MurciaMurciaSpain brazilian Judo Confederation Rio de JaneiroBrazil

Purpose In judo,athletes compete based on weight categories,which are required to adapt the training process accordingly,but not enough research is present to understand their *** present study aimed to verify the differences in judo attack systems performed between the seven male weight categories in world-class *** A cohort of 5847 attack systems from 1106 international judo matches was *** Chi-square auto-matic interaction detector was used to identify the association between the variables tori approach(attacker),uke approach(defender),tori’s grip,stance and direction of *** The main results showed that:(1)the grip is the main predictor of attack systems;(2)laterality exerts a strong influence on attack systems;(3)the≤81 kg and>100 kg categories were differentiated by the use of unconventional grips;(4)the≤60 kg used more kenka-yotsu(opposite sides)right stance with the Only right Hand grip;(5)the≤81 kg category used more the ai-yotsu(same side)left stance with the Only Left Hand *** The results reported from this study can help coaches and athletes in choosing the best technical-tactical actions when developing combat strategies.

关键词： Martial arts Decision tree Analysis Athletes Judoka Fight dynamics

relevance of long QT syndrome in clinical neurology

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World Journal of Neurology 2013年第3期3卷 25-28页

作者： marcus M Unger Klaus Fassbender Department of Neurology Saarland University 66421 Homburg Germany

Long QT syndrome(LQTS) is a cardiac conduction disorder that predisposes patients at potentially fatal cardiac events. Inherited conditions and acquired factors contribute to LQTS. A number of frequently prescribed CNS-active drugs prolong the QT interval. The clinical neurologist may encounter LQTS when initiating a pharmacotherapy or when increasing the dosage of drugs. The clinical neurologist may also encounter LQTS during the diagnostic work-up of patients with unexplained loss of consciousness, because LQTS may present as convulsive syncope. Some studies report an association of LQTS and stroke. Awareness of LQTS may help to recognize and prevent potentially fatal cardiac events associated with LQTS. This concise article highlights the clinically most relevant aspects of LQTS in the field of neurology.

关键词： Cardiac conduction disorder Adverse drug effects Antipsychotics Antidepressants Torsades de pointes Syncope Seizure disorder Stroke

Inhibition of 11 β-hydroxysteroid dehydrogenase in gulinea pig kidney by three bioflavonoids and their interactions with gossypol

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Inhibition of 11 β-hydroxysteroid dehydrogenase in gulinea ...

作者： marcus M reidenberg Department of pharmacology and medicineCornell University Medical College

Objective To study the effects of some bioflavonoids on the gossypol-induced *** The 11β-hydroxysteroid dehydrogenase (11β-OHSD)protein was prepared from guinea pig kidney .The activity of 11β-OHSD with NAD as the coenzyme was measured by *** drug interaction was analysed by isobolographic *** The 11β-OHSD can be inhibited by some *** IC50(95% confidence limits) values were:quercetin 164(79341)μmol/L,morin 913(385173)μmol/L,and naringenin 2193(1114315)μmol/*** the 11β-OHSD was treated with quercetin,tangeretin,morin,naringenin plus gossypol,the combination index (CI)values were 0.92,0.85,0.98,and 1.01 *** The interaction of some bioflavonoids with gossypol might be one of the factors for gossypol induced hypokalemia.

关键词： Drug interactions Flavones Gossypol Hydroxysteroid dehydrogenases Hypokalemia

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Expression profiles of gastric cancer molecular subtypes in remnant tumors

作者： (美)Alfred marcus

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 265-278页

作者： marcus Fernando Kodama Pertille ramos Marina Alessandra Pereira Leonardo Cardili Evandro Sobroza de Mello Ulysses ribeiro Jr bruno Zilberstein Ivan Cecconello Department of Gastroenterology Instituto do CancerHospital das ClinicasHCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01249000São PauloBrazil Department of Pathology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01249000São PauloBrazil

bACKGrOUND remnant gastric cancer(rGC)is a carcinoma arising in the stomach remnant after previous gastric *** is frequently reported as a tumor with a poor prognosis and distinct biological features from primary gastric cancer(PGC).However,as it is less frequent,its profile regarding the current molecular classifications of gastric cancer has not been *** To evaluate a cohort of rGC according to molecular subtypes of GC using a panel of immunohistochemistry and in situ hybridization to determine whether the expression profile is different between PGC and *** Consecutive rGC patients who underwent gastrectomy between 2009 and 2019 were assessed using seven GC panels:Epstein-barr virus in situ hybridization,immunohistochemistry for mismatch repair proteins(MutL homolog 1,MutS homolog 2,MutS homolog 6,and PMS1 homolog 2),p53 protein,and E-cadherin *** characteristics and survival of these patients were compared to 284 PGC *** A total of 40 rGC patients were enrolled in this *** to PGC,older age(Pr body mass index(P=0.010),and lower hemoglobin level(Pre associated with rGC *** difference was observed regarding Lauren’s type and pathologic Tumor Node Metastasis stage between the *** the profiles evaluated,EbV-positive tumors were higher in rGC compared to PGC(P=0.039).The frequency of microsatellite instability,aberrant p53 immunostaining,and loss of E-cadherin expression were similar between rGC and *** rates of simultaneous alterations in two or more profiles were observed in rGC compared to PGC(Prding to the molecular classification,the subtypes were defined as EbV in nine(22.5%)cases,microsatellite instability in nine(22.5%)cases,genomically stable in one(2.5%)case,and chromosomal instability in 21(52.5%)*** was no significant difference in survival between molecular subtypes in rGC *** rGC w

关键词： Stomach neoplasms Gastric remnant Gastric remnant cancer Adenocarcinoma Immunohistochemistry

Angle-tunable intersubband photoabsorption and enhanced photobleaching in twisted bilayer graphene

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Nano research 2021年第8期14卷 2797-2804页

作者： Eva A.A.Pogna Xianchong Miao Driele von Dreifus Thonimar V.Alencar marcus V.O.Moutinho Pedro Venezuela Cristian Manzoni Minbiao Ji Giulio Cerullo Ana Maria de Paula Istituto di Nanoscienze CNr-NANO Laboratory NESTPiazza San Silvestro 12Pisa 56127Italy State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Departamento de Fisica Institute de Ciencias ExatasUniversidade Federal de Minas GeraisBelo Horizonte-MG 31270-901Brazil Departamento de Fisica Institute de Ciencias Exatas e BiologicasUniversidade Federal de Ouro PretoOuro Preto-MG 35400-000Brazil Ndcleo Multidisciplinar de Pesquisas em Computagao-NUMPEX-COMP Campus Duque de CaxiasUniversidade Federal do Rio de JaneiroDuque de Caxias-RJ25265-970Brazil Institute de Fisica Universidade Federal FluminenseUFFNiteroi-RJ24210-346Brazil IFN-CNr Dipartimento di FisicaPolitecnico di MilanoPiazza L.da Vinci 32Milano 20133Italy

Van der Waals heterostructures obtained by artificially stacking two-dimensional crystals represent the frontier of material engineering,demonstrating properties superior to those of the starting *** control of the interlayer twist angle has opened new possibilities for tailoring the optoelectronic properties of these *** bilayer graphene with a strong interlayer coupling is a prototype of twisted heterostructure inheriting the intriguing electronic properties of *** the effects of the twist angle on its out-of-equilibrium optical properties is crucial for devising optoelectronic *** this aim,we here combine excitation-resolved hot photoluminescence with femtosecond transient absorption *** hot charge carrier distribution induced by photo-excitation results in peaked absorption bleaching and photo-induced absorption bands,both with pronounced twist angle *** simulations of the electronic band structure and of the joint density of states enable to assign these bands to the blocking of interband transitions at the van Hove singularities and to photo-activated intersubband *** tens of picoseconds relaxation dynamics of the observed bands is attributed to the angle-dependence of electron and phonon heat capacities of twisted bilayer graphene.

关键词： twisted bilayer graphene transient absorption microscopy hot-photoluminescence van der Waals heterostructures optoelectronic properties van Hove singularities

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思维压抑量表:中文版的结构、信度及效度

中国临床心理学杂志 2012年第2期20卷 143-147页

作者： marcus A.rodriguez 贾珂钱铭怡北京大学心理学系北京100871 复旦大学上海200433

目的:在大学生群体中对思维压抑量表(White bear Suppression Inventory,WbSI)进行修订并考察其信效度。方法:采用方便取样方法,对样本一的125名大学生施测WbSI及贝克抑郁问卷,以检验该量表的效度,并随机选取其中33名学生,在初测4周后... 详细信息

目的:在大学生群体中对思维压抑量表(White bear Suppression Inventory,WbSI)进行修订并考察其信效度。方法:采用方便取样方法,对样本一的125名大学生施测WbSI及贝克抑郁问卷,以检验该量表的效度,并随机选取其中33名学生,在初测4周后进行了重测;对样本二的383名大学生施测WbSI、宾州忧虑问卷、事件影响量表-修订版及想法行为混淆量表。对样本三的334名大学生施测WbSI、帕多瓦量表、特质焦虑问卷及多元个人传统性量表-宿命迷信分量表。结果:对样本一的探索性因素分析获得WbSI的3个因素(闯入性思维、思维压抑和转移注意),3个因素可解释总变异的52.4%;对样本二和样本三的验证性因素分析显示,三因素模型拟合最好(χ2/df=3.45,CFI=0.91,TLI=0.89,rMSEA=0.07,SrMr=0.06)。WbSI总分的内部一致性系数为0.87,重测信度为0.59;3个因素的内部一致性系数分别为0.83、0.66和0.70。女性WbSI得分均显著高于男性。效标效度分析表明WbSI与抑郁(r=0.29)、特质焦虑(r=0.42)、创伤后应激障碍症状(r=0.42)、强迫症状(r=0.30)及广泛性焦虑症状(r=0.44)呈显著正相关。本研究还探索了迷信在OCD症状的发展维持中的作用,结果支持迷信导致了思维压抑从而导致了OCD症状(χ2/df=5.04,CFI=0.88,TLI=0.82,rMSEA=0.11,SrMr=0.08)。结论:思维压抑量表的中文修订版具有良好的信效度。

关键词：思维压抑效度焦虑障碍强迫症

Grape Seed Extract and the Fetal Ductus Arteriosus: A Potential Danger of a Common Herbal Supplement

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International Journal of Clinical Medicine 2016年第10期7卷 685-689页

作者： brian benjamin marcus Schamberger Eric Ebenroth Department of Pediatrics Section of Pediatric Cardiology 705 Riley Hospital Drive Indiana University School of Medicine Indianapolis IN USA

A female at 28 weeks gestation was referred to pediatric cardiology for a fetal arrhythmia. The echocardiogram revealed premature constriction of the fetal ductus arteriosus. Her work up was unremarkable except for her use of an herbal supplement, grape seed extract, which is advertised as a potent anti-inflammatory medication, and has biochemical properties similar to other medications that have been shown to cause premature ductal constriction. The use of herbal remedies increases each year. Although the public is inundated with radio, television, and internet advertisements for these products, little unbiased information regarding the possible dangers of toxicity or adverse reactions exists. As physicians, we need to be aware of these products, and counsel our patients accordingly.

关键词： Grape Seed Extract Prenatal Medications Ductus Arteriosus Cardiology Herbal remedies