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2007年

作者： marcus GONCALVES.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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晚期肿瘤病人的疼痛治疗(英文)

中国临床药理学杂志 1989年第1期 1-4页

作者： marcus M.reidenberg Cornell University Medical College U.S.A

由于麻醉性镇痛药治疗不当,致使对转移性肿瘤病人的疼痛不能控制,此现象在世界范围内较普遍。对此,世界卫生组织制订出一套逐级治疗方案。该方案采用口服常规给药,并逐步增加麻醉性药物治疗的强度。对疼痛的初始治疗,使用阿斯匹林及其... 详细信息

由于麻醉性镇痛药治疗不当,致使对转移性肿瘤病人的疼痛不能控制,此现象在世界范围内较普遍。对此,世界卫生组织制订出一套逐级治疗方案。该方案采用口服常规给药,并逐步增加麻醉性药物治疗的强度。对疼痛的初始治疗,使用阿斯匹林及其他非甾体类抗炎免疫镇痛药。如不能控制,则加用一种弱的阿片类药物,如可待因。如仍不能控制,此时应给强阿片类药物,如吗啡。另外,采用常规给药,而不是视病人需要给予治疗(疼痛复发或加剧)。使麻醉性药物治疗剂量个体化,代谢迅速的病人给予高剂量后,能获得较好的镇痛效果。

关键词：病人疼痛麻醉性

Field controllable electronic properties of MnPSe_(3)/WS_(2) heterojunction for photocatalysis

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Journal of Central South University 2021年第12期28卷 3728-3736页

作者： FANG Li-mei ZENG Ying EKHOLM marcus HU Chun-feng FENG Qing-guo Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Department of Physics Chemistry and Biology(IFM)Linkopings UniversitySE-58183 LinkopingSweden

Transition metal dichalcogenides are interesting candidates as photocatalysts for hydrogen evolution *** MnPSe_(3)/WS_(2) heterostructure is hence studied here with first principles calculations by exploring its electronic properties under the application of an electric *** is discovered that the band gap will decrease from the WS_(2) monolayer to the MnPSe_(3)/WS_(2) heterostructure with Perdew-burke-Ernzerhof functional,while increase slightly when electron correlation is *** conduction band minimum of the heterostructure is determined by the MnPSe3 layer,while the valence band maximum is contributed by the WS_(2)*** band edges and band gap suggest that the heterostructure will have good photocatalytic properties for water ***,comparing to monolayer WS_(2),the light absorption in both the ultraviolet and visible regions will be *** an electric field is present,a linear relation is observed between the electric field and the band gap within specific range,which can thus modulate the photocatalytic performance of this heterostructure.

关键词： MnPSe_(3) WS_(2) heterostructure electric field photocatalysis first principles

Survival outcomes and predictors of mortality,re-bleeding and complications for acute severe variceal bleeding requiring balloon tamponade

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World Journal of Hepatology 2022年第8期14卷 1584-1597页

作者： Charlotte Y Keung Aparna Morgan Suong T Le marcus robertson Paul Urquhart Michael P Swan Department of Gastroenterology Monash HealthMelbourne 3168VictoriaAustralia Department of Gastroenterology Eastern HealthMelbourne 3128VictoriaAustralia Department of Medicine Monash UniversityMelbourne 3168VictoriaAustralia Monash Digital Therapeutics and Innovation Laboratory Monash UniversityMelbourne 3168VictoriaAustralia

bACKGrOUND Acute severe variceal bleeding(AVb)refractory to medical and endoscopic therapy is infrequent but associated with high *** cohort studies from 1970-1980s no longer represent the current population as balloon tamponade is no longer first-line therapy for variceal bleeding;treatments including vasoactive therapies,intravenous antibiotics,endoscopic variceal band ligation are routinely used,and there is improved access to definitive treatments including transjugular intrahepatic portosystemic ***,only a few studies from the current era exist to describe the practice of balloon tamponade,its outcomes,and predictors with a requirement for further updated *** To describe current management of AVb requiring balloon tamponade and identify the outcomes and predictors of mortality,re-bleeding and *** A retrospective multi-centre cohort study of 80 adult patients across two large tertiary health networks from 2008 to 2019 in Australia who underwent balloon tamponade using a Sengstaken-blakemore tube(SbT)were included for *** were identified using coding for balloon *** primary outcome of this study was all-cause mortality at 6 wk after the index *** outcomes included re-bleeding during hospitalisation and complications of balloon *** of these outcomes were determined using univariate and multivariate binomial *** The all-cause mortality rates during admission and at 6-,26-and 52 wk were 48.8%,51.2%and 53.8%,*** haemostasis was achieved in 91.3%and re-bleeding during hospitalisation occurred in 34.2%.Independent predictors of 6 wk mortality on multivariate analysis included the Model for Endstage Liver disease(MELD)score(Or 1.21,95%CI 1.06-1.41,P=0.006),advanced hepatocellular carcinoma(Or 11.51,95%CI 1.61-82.20,P=0.015)and re-bleeding(Or 13.06,95%CI 3.06-55.71,Pre were no relevant predictors of re-bleeding but a larg

关键词： balloon tamponade Acute variceal bleeding Sengstaken-blakemore tube Mortality Complications Haemostasis

Tumor–stromal cross-talk modulating the therapeutic response in pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 461-472页

作者： Christopher C.M.Neumann Ellen von Horschelmann Anja reutzel-Selke Elisabeth Seidel Igor Maximilian Sauer Johann Pratschke marcus bahra rosa bianca Schmuck Department of Surgery Campus Charité Mitte Campus Virchow-KlinikumExperimental SurgeryCharité-Universitatsmedizin BerlinBerlinGermany berlin Institute of Health Department of SurgeryCampus CharitéMitte and Campus Virchow-KlinikumAugustenburger Platz 113353 BerlinGermany

background: Pancreatic ductal adenocarcinoma(PDAC) is a highly malignant solid tumor with a dismal prognosis. The stroma component makes up to 90% of the tumor mass and is thought to be one of the main reasons for the tumor’s high chemoresistance. Cancer associated fibroblasts(CAFs) have previously been identified to be the key stromal players. This is the first time we provide detailed in vitro experiments investigating tumor–stromal interactions when exposed to three well-known chemotherapeutic agents. Methods: Monocultures, indirect and direct co-cultures of two PDAC cell lines(AsPC and Panc-1) and six primary patients derived CAFs were treated with gemcitabine, nab-paclitaxel and the γ-secretaseinhibitor(GSI) DAPT. The cell viability of each component was measured with XTT. Finally, IL-6 concentrations of the supernatants were analyzed. results: On the contrary to PDAC cell lines, CAF monocultures hardly responded to any treatment which suggested that stroma(CAFs) itself is more resistant to standard chemo-treatments than the epithelial cancer cells. Moreover, only a weak chemotherapeutic response was observed in direct co-cultures of cancer cells with CAFs. A change in the morphology of direct co-cultures was accompanied with the chemoresistance. CAFs were observed to build cage-like structures around agglomerates of tumor cells. High levels of IL-6 were also associated with a reduced response to therapy. Indirect co-cultures make the tumor–stromal interaction more complex. Conclusions: CAFs are highly chemoresistant. Direct cell–cell contact and high levels of IL-6 correlate with a high chemoresistance.

关键词： Pancreatic cancer Tumor microenvironment Cancer associated fibroblasts Cancer–stroma co-culture Atroma targeted therapy

The global regulation of c-di-GMP and cAMP in bacteria

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mLife 2024年第1期3卷 42-56页

作者： Cong Liu rui Shi marcus S.Jensen Jingrong Zhu Jiawen Liu Xiaobo Liu Di Sun Weijie Liu Jiangsu Key Laboratory of Phylogenomics&Comparative Genomics School of Life SciencesJiangsu Normal UniversityXuzhouChina Key Laboratory of Metabolic Engineering and biosynthesis Technology Ministry of Industry and Information TechnologyNanjing University of Science and TechnologyNanjingChina

Nucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in *** best-studied examples are cyclic AMP(cAMP)and bis-(3'-5')-cyclic dimeric guanosine monophosphate(c-di-GMP),which both act as global *** regulatory frameworks of c-di-GMP and cAMP in bacteria show several parallels but also significant *** this review,we llustrate the global regulatory models of the two nucleotide second messengers,compare the different regulatory frameworks between c-di-GMP and cAMP,and discuss the mechanisms and physiological significance of cross-regulation between c-di-GMP and cAMP.c-di-GMP responds to numerous signals de-pendent on a great number of metabolic enzymes,and it regulates various signal transduction pathways through its huge number of effectors with varying *** contrast,due to the limited quantity,the cAMP metabolic enzymes and its major effector are regulated at different levels by diverse *** performs its global regulatory function primarily by controlling the transcription of a large number of genes via cAMP receptor protein(CrP)in most *** review can help us understand how bacteria use the two typical nucleotide second messengers to effectively coordinate and integrate various physiological processes,providing theoretical guidelines for future research.

关键词： bacteria cAMP c-di-GMP cross-regulation CrP

building a Machine Learning-based Ambulance Dispatch Triage Model for Emergency Medical Services

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Health Data Science 2023年第1期3卷 17-25页

作者： Han Wang Qin Xiang Ng Shalini Arulanandam Colin Tan marcus E.H.Ong Mengling Feng Saw Swee Hock School of Public Health National University Health SystemNational University of SingaporeSingapore. Singapore Civil Defence Force Singapore. Health Services research Centre Singapore Health ServicesSingapore. Health Services and Systems research Duke-NUS Medical SchoolNational University of SingaporeSingapore. Department of Emergency Medicine Singapore General HospitalSingapore. Institute of Data Science National University of SingaporeSingapore.

background:In charge of dispatching the ambulances,Emergency Medical Services(EMS)call center specialists often have difficulty deciding the acuity of a case given the information they can gather within a limited *** there are protocols to guide their decision-making,observed performance can still lack sensitivity and *** learning models have been known to capture complex relationships that are subtle,and well-trained data models can yield accurate predictions in a split of a ***:In this study,we proposed a proof-of-concept approach to construct a machine learning model to better predict the acuity of emergency *** used more than 360,000 structured emergency call center records of cases received by the national emergency call center in Singapore from 2018 to *** were created using call records,and multiple machine learning models were ***:A random Forest model achieved the best performance,reducing the over-triage rate by an absolute margin of 15%compared to the call center specialists while maintaining a similar level of under-triage ***:The model has the potential to be deployed as a decision support tool for dispatchers alongside current protocols to optimize ambulance dispatch triage and the utilization of emergency ambulance resources.

关键词： Services absolute proof

The role of the PI3K/AKT/mTOr pathway in brain tumor metastasis

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 80-89页

作者： Silvia Crespo marcus Kind Alexandre Arcaro Division of Pediatric Hematology/Oncology Bern University HospitalCH-3008 BernSwitzerland

The PI3K/AKT/mTOr(PAM)pathway is involved in a variety of cellular functions and often contributes to oncogenesis and cancer *** has been recognized that this pathway is frequently activated in the most common central nervous system cancers of adults and children,malignant gliomas and medulloblastomas(Mb).In these tumors,the PAM network controls key functions necessary for cell invasion and metastasis,such as cell *** review summarizes the current knowledge about the role of PAM signaling in cell invasion and metastasis in gliomas and *** approaches to inhibit cell invasion and metastasis by targeting the PAM pathway will also be discussed.

关键词： PI3K/AKT/mTOr pathway glioblastoma medulloblastoma metastasis

Clostridium difficile causing acute renal failure: Case presentation and review

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World Journal of Gastroenterology 2005年第8期11卷 1245-1247页

作者： Jasmin Arrich Gottfried H.Sodeck Gürkan Seng(o|¨)lge Christoforos Konnaris marcus Müllner Anton N.Laggner Hans Domanovits Department of Emergency Medicine Department of Medicine Ⅲ Department of Internal Medicine Ⅳ

AIM: Clostridium difficile infection is primarily a nosocomial infection but asymptomatic carriers of Clostridium difficile can be found in up to 5% of the general population. Ampicillin, cephalosporins and clindamycin are the antibiotics that are most frequently associated with Clostridium difficile-associated diarrhea or colitis. Little is known about acute renal failure as a consequence of Clostridium difficile-associated diarrhea. METHODS: In this case report, we describe the course of Clostridium difficile-associated diarrhea in an 82-year-old patient developing acute renal failure. Stopping the offending agent and symptomatic therapy brought a rapid improvement of diarrhea and acute renal failure, full recovery was gained 18 d after admission. In a systematic review we looked for links between the two conditions. rESULTS: The link between Clostridium difficile-assoaated diarrhea and acute renal failure in our patient was most likely volume depletion. However, in experimental studies a direct influence of Clostridium difficile toxins on renal duct cells could be shown. CONCLUSION: rapid diagnosis, nonspecific supportive treatment and specific antibiotic treatment, especially in the elderly, may lower excess mortality Clostridium difficile-associated diarrhea and renal failure being possible complications.

关键词： Acute renal failure Clostridium difficile, Diarrhea

Highly insulating thermoplastic blends comprising a styrenic copolymer for direct‐current power cable insulation

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High Voltage 2022年第2期7卷 251-259页

作者： Yingwei Ouyang Amir Masoud Pourrahimi IdaÖstergren marcus Mellqvist JakobÅnevall Azadeh Soroudi Anja Lund Xiangdong Xu Thomas Gkourmpis Per‐Ola Hagstrand Christian Müller Department of Chemistry and Chemical Engineering Chalmers University of TechnologyGöteborgSweden Department of Electrical Engineering Chalmers University of TechnologyGöteborgSweden Innovation&Technology Borealis ABStenungsundSweden

The impact of the composition of blends comprising low‐density polyethylene(LDPE),isotactic polypropylene(PP)and a styrenic copolymer additive on the thermomechanical properties as well as the direct‐current(DC)electrical and thermal conductivity is *** presence of 5 weight percent(wt%)of the styrenic copolymer strongly reduces the amount of PP that is needed to enhance the storage modulus above the melting temperature of LDPE from 40 to 24 wt%.At the same time,the copolymer improves the consistency of the thermomechanical properties of the resulting ternary *** both the DC electrical and thermal conductivity strongly decrease with PP content,the addition of the styrenic copolymer appears to have little influence on either ***,PP in combination with small amounts of a styrenic copolymer not only allows to reinforce LDPE at elevated temperatures but also functions as an electrical conductivity‐reducing additive,which makes such thermoplastic ternary formulations possible candidates for the insulation of high‐voltage power cables.

关键词： property. blends copolymer