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development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.laMonte Andrea Z.laCroix Eleanor M.Simonsick Steven P.Hooker Humberto Parada jr. John Bellettiere Arun Kumar Herbert Wertheim School of Public Health and Human longevity Science University of California San DiegoLa JollaCA 92093USA department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(Ml),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several Ml VO_(2max)prediction ***:The Baltimore longitudinal Study of Aging(BlSA)participants with valid VO2_(max)tests were included(n=1080).least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BlSA,(b)by sex,(c)using all BlSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±Sd)and the measured VO_(2max)was 21.6±5.9 ml/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 ml/kg/min,3.6 ml/kg/min,3.4 ml/kg/min,3.6 ml/kg/min,and 3.5 ml/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** Ml can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology Mortality

Extreme drought triggers parallel shifts in wood anatomical and physiological traits in upper treeline of the Mediterranean Andes

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Ecological Processes 2024年第1期13卷 132-143页

作者： luiz Santini jr. dylan Craven daigard Ricardo Ortega Rodriguez Manolo Trindade Quintilhan Stephanie Gibson-Carpintero Cristina Aravena Torres fidel A.Roig Ariel A.Mu?oz Alejandro Venegas-Gonzalez Hémera Centro de Observación de la Tierra Universidad Mayor GEMA Center for Genomics Ecology and Environment Universidad Mayor data Observatory foundation ANID Technology Center depart-ment of forest Sciences ESALQ-University of Sao Paulo department of Plant Biology Institute of Biology University of Campinas Instituto de Geografía Universidad Nacional Autónoma de México (UNAM) Argentine Institute of Nivology Glaciology and Environmental Sciences(IANIGLA CONICET ) Institute of Geography Pontificia Universidad Católica de Valparaíso Instituto de Ciencias Agroalimentarias Animales y Ambientales (ICA3) Universidad de O'Higgins

Background Treeline ecotones of Mediterranean ecoregions have been affected by the increasing intensity and severity of droughts. Even though the effect of droughts on forest dynamics has been widely documented, knowledge is relatively scarce of how extreme climate episodes affect the hydraulic structure and, therefore, the phys-iology of woody plants. The Mediterranean Andes have experienced an uninterrupted period of drought since 2010, including an extremely dry year in 2019 with approximately 80% rainfall deficit. Here, we investigated shifts in wood anatomical and physiological traits of Kageneckia angustifolia, an endemic treeline species, in response to this drought *** We evaluated the xylem plasticity of three K. angustifolia populations across their natural distribution(31–35° Sl) based on anatomical(vessel structure and distribution) and physiological(intrinsic water-use efficiency) variables in the tree rings. We focused on the period 2000–2020 that corresponds to before the megadrought(2000–2007),(ii) megadrought(2008–2018) and(iii) hyperdrought(2019–2020). The variables were annualized and analyzed by linear mixed-effects *** Our results provide insights to the anatomical and physiological mechanisms underlying the resilience of treeline forests to persistent droughts in central Chile. We found that the extreme drought in 2019–2020 triggered shifts in vessel size and frequency that increased hydraulic safety. These significant shifts in vessel traits occurred in parallel with a decrease in pit aperture area and an increase in water-use efficiency, further increasing the resilience of K. angustifolia to extreme drought *** Our results revealed coordinated shifts in vessel size and frequency and water-use efficiency in response to the megadrought, thereby reducing vulnerability to hydraulic failure. The apparent resilience of K. angustifolia to extreme droughts suggests that this adaptation to drought stress may incre

关键词： dendro-anatomy Kageneckia angustifolia Xylem vulnerability drought Climate change

Report for Type 2 Bayes-fuzzy Estimation in No-data Problem

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Applied Mathematics 2024年第1期15卷 46-50页

作者： Houju Hori jr. Kazuhisa Takemura Yukio Matsumoto Nara Cmmunity Tsubakikishi Shrine Nara Japan department of Psychology Waseda University Tokyo Japan The Institute of Mathematical Statistics Tachikawa Japan

It is well known that the system (1 + 1) can be unequal to 2, because this system has both observation error and system error. furthermore, we must provide our mustered service within our cool head and warm heart, where two states of nature are existing upon us. Any system is regarded as the two-dimensional variable error model. On the other hand, we consider that the fuzziness is existing in this system. Though we can usually obtain the fuzzy number from the possibility theory, it is not fuzzy but possibility, because the possibility function is as same as the likelihood function, and we can obtain the possibility measure by the maximal likelihood method (i.e. max product method proposed by dr. Hideo Tanaka). Therefore, fuzzy is regarded as the only one case according to Vague, which has both some state of nature in this world and another state of nature in the other world. Here, we can consider that Type 1 Vague Event in other world can be obtained by mapping and translating from Type 1 fuzzy Event in this world. We named this estimation as Type 1 Bayes-fuzzy Estimation. When the Vague Events were abnormal (ex. under War), we need to consider that another world could exist around other world. In this case, we call it Type 2 Bayes-fuzzy Estimation. Where Hori et al. constructed the stochastic different equation upon Type 1 Vague Events, along with the general following probabilistic introduction method from the single regression model, multi-regression model, AR model, Markov (decision) process, to the stochastic different equation. furthermore, we showed that the system theory approach is Possibility Markov Process, and that the making decision approach is Sequential Bayes Estimation, too. After all, Type 1 Bays-fuzzy estimation is the special case in Bayes estimation, because the pareto solutions can exist in two stochastic different equations upon Type 2 Vague Events, after we ignore one equation each other (note that this is Type 1 case), we can obtain both its

关键词： Bayes-fuzzy Estimation Possibility Markov Process Possibility Reserved Judgement

from the dust:extracellular vesicles as regulators of development and neuroregeneration

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Neural Regeneration Research 2024年第5期19卷 933-934页

作者： leon G.Coleman jr The University of North Carolina at Chapel Hill School of MedicineDepartment of PharmacologyBowles Center for Alcohol StudiesChapel HillNCUSA

first impressions can have a lasting *** science,this can be especially problematic,because our lack of understanding often causes us to mislabel and thus ignore important biological *** this vein,extracellular vesicles(EVs)were once considered to be“cellular dust”.Similar to the previous concept of“junk dNA”to describe protein non-coding regions,EVs are far more than just cellular *** fact,EVs are emerging as key mediators of intracellular communication across nearly all biological *** includes peripheral immune responses(e.g.,arthropathies and sepsis),intra-organ communication(Seim et al.,2023),and a host of other physiological and pathological states(figure 1A and B).

关键词： figure extracellular

Impact on Soil Organic C and Total Soil N from Cool- and Warm-Season legumes Used in a Green Manure-forage Cropping System

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Agricultural Sciences 2024年第3期15卷 333-357页

作者： Clark B. Neely francis M. Rouquette jr. Cristine l.S. Morgan frank M. Hons William l. Rooney Gerald R. Smith department of Soil and Crop Science Washington State University Pullman WA USA Texas A&M Agrilife Research Overton TX USA Chief Scientific Officer Soil Health Institute Morrisville NC USA department of Soil and Crop Science Texas A&M University College Station TX USA

Annual forage legumes are important components of livestock production systems in East Texas and the southeastern US. forage legumes contribute nitrogen (N) to cropping systems through biological N fixation, and their seasonal biomass production can be managed to complement forage grasses. Our research objectives were to evaluate both warm- and cool-season annual forage legumes as green manure for biomass, N content, ability to enhance soil organic carbon (SOC) and soil N, and impact on post season forage grass crops. Nine warm-season forage legumes (WSl) were spring planted and incorporated as green manure in the fall. forage rye (Secale cereale l.) was planted following the incorporation of WSl treatments. Eight cool-season forage legumes (CSl) were fall planted in previously fallow plots and incorporated as green manure in late spring. Sorghum-sudangrass (Sorghum bicolor x Sorghum bicolor var. sudanense) was planted over all treatments in early summer after forage rye harvest and incorporation of CSl treatments. Sorghum-sudangrass was harvested in June, August and September, and treatments were evaluated for dry matter and N concentration. Soil cores were taken from each plot, split into depths of 0 to 15, 15 to 30 and 30 to 60 cm, and soil C and N were measured using combustion analysis. Nylon mesh bags containing plant samples were buried at 15 cm and used to evaluate decomposition rate of above ground legume biomass, including change in C and N concentrations. Mungbean (Vigna radiata l. [Wilczek]) had the highest shoot biomass yield (6.24 t dM ha-1) and contributed the most total N (167 kg∙ha-1) and total C (3043 kg∙ha-1) of the WSl tested. decomposition rate of WSl biomass was rapid in the first 10 weeks and very slow afterward. Winter pea (Pisum sativum l. spp. sativum), arrow leaf clover (Trifolium vesiculosum Savi.), and crimson clover (Trifolium incarnatum l.) were the most productive CSl in this trial. Austrian winter pea

关键词： Annual legumes Soil N Soil Organic C Green Manure deer Browse forage Cropping Systems

Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson Scott f.d.Edelson John G.Quiles Cyrus V.Edelson Eric M.Montminy Christian l.Horn John P.Magulick don C.Rockey department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger jr.Hospital of Cook County ChicagoIllinoisUSA digestive disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between february 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of Child-Pugh,Model for End-Stage liver disease-Sodium,and fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(CSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** Child-Pugh score did not correlate well with the presence of CSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

Water Scarcity in Conakry, Guinea: Challenges and Proposed Strategies for a Way forward

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Journal of Water Resource and Protection 2024年第4期16卷 264-280页

作者： Bernard lassimo diawara Gerald d. S. Quoie jr.Zhuo li Justin Junior loua College of Environmental Science and Engineering Tongji University Shanghai China UNEP-Tongji Institute of Environment for Sustainable development Tongji University Shanghai China State Key laboratory of Pollution Control and Resources Reuse Tongji University Shanghai China Business School Sichuan University Chengdu China

The capital of Guinea, Conakry, faces a notable difficulty due to a water shortage, which is worsened by the rapid increase in population and urban development. The Guinean Water Company (SEG) faces challenges in supplying water to the entire city due to its limited area of approximately 420 km2 and a population of 2 million. Moreover, the population growth rate is anticipated to increase dramatically, exacerbating the difficulty of fulfilling future water requirements. As a result, this study employs data from the Knoema website and the Institute of National Statistics of Guinea (INS) to examine the water production and distribution process by the SEG. The study examines the challenges related to water scarcity in Conakry and suggests strategies to assist the city in managing the present circumstances and planning for the future. The primary objective is to get a long-lasting water supply and uphold water quality to advance public health.

关键词： Water Scarcity Conakry Population Growth SdGs SEG

legume Green Manure and Intercropping for High Biomass Sorghum Production

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Agricultural Sciences 2024年第6期15卷 605-621页

作者： Clark B. Neely francis M. Rouquette jr. Cristine l. S. Morgan frank M. Hons William l. Rooney Gerald R. Smith department of Soil and Crop Science Washington State University Pullman WA USA Texas A&M Agrilife Research Overton TX USA Soil Health Institute Morrisville NC USA department of Soil and Crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertilizers, legumes were commonly used as green manure crops for their ability to fix atmospheric nitrogen (N). A three-year study at Overton, TX examined legume integration into high-biomass sorghum (Sorghum bicolor l.) production systems on a lilbert loamy fine sand recently cultivated after a fertilized bermudagrass [Cynodon dactylon (l.) Pers.] pasture. In this split-split plot design, ‘dixie’ crimson clover (Trifolium incarnatum l.) and ‘Iron and Clay’ cowpea (Vigna unguiculata l.) were integrated into a high-biomass sorghum production system to evaluate impacts on N concentration, C concentration, and yield of high-biomass sorghum and their impacts on soil total N and soil organic carbon (SOC). Main plots were split into crimson clover green manure (ClGM) and winter fallow (fAll) followed by three sub-plots split into warm-season crop rotations: cowpea green manure (CPGM), cowpea-sorghum intercrop (CPSR), and sorghum monocrop (SORG). Three N fertilizer treatments (0, 45, 90 kg N∙ha−1) were randomized and applied as sub-sub plots. The ClGM increased (P sorghum biomass yield (16.5 t dM∙ha−1) 28% in year three but had no effect in the first two years. The CPSR treatment reduced sorghum yield up to 62% compared to SORG;whereas CPGM increased sorghum yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum biomass yield. decrease in SOC and soil N over time indicated mineralization of organic N and may explain why no N fertilizer response was observed in sorghum biomass yield. Cowpea showed strong potential as a green manure crop but proved to be too competitive for successful intercropping in high-biomass sorghum production systems.

关键词： High-Biomass Sorghum legumes Green Manure Intercrop Cowpea Crimson Clover Soil Organic Carbon Soil Nitrogen

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行善不为人知的亿万富豪

空中英语教室（高级版．彭蒙惠英语） 2024年第6期 12-13,41页

作者： Bill Murphy,jr. 不详

时间是2009年,一群亿万富豪秘密聚集在纽约市家餐厅,其中包括:沃伦·巴菲特、比尔:盖茨、奥普拉·温弗瑞、迈克尔·布隆伯格、查克·菲尼。“且慢,”我猜很多人读到这里会说,“我知道前面那四位,但查克·菲尼是谁?”就算你不知道他是谁。

关键词：亿万富豪查克纽约市