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Journal of Civil Engineering and Architecture 2024年第4期18卷 186-198页

作者： Bianca Bispo dos Reis Jorge Daniel de Melo Moura marcos vinício de camargo Everaldo Pletz Graduate Program in Architecture and Urbanism Londrina State UniversityJardim Portal de Versalhes 1Londrina 86057-970PRBrazil department of Civil Engineering Federal Technological University of Paraná(UTFPR)Apucarana 86812-460PRBrazil Retired professor department of Structural Engineering Londrina State UniversityLondrina 86057-970PRBrazil

This article presents a study on the structural behavior of transversely prestressed laminated timber slabs,focusing on an innovative approach:vertically misaligned *** misalignment,achieved by sliding vertically the wooden lamellae rather than aligning them,enhances the slab’s cross-section moment of inertia,thereby improving load-bearing capacity and *** involved two groups of structural size specimens:one with vertically aligned lamellae(control group)and the other with misaligned lamellae(study group).Results showed the study group exhibited 42%superior stiffness and 10%less load capacity compared to the *** typically occurred individually in the lamellae,particularly in those with defects or lower modulus of elasticity,concentrated in the middle third of the slabs’free span where tensile stresses *** a higher number of failed lamellae,the study group demonstrated promising *** of prestressing bar indicated no damage at all in the thread,suggesting potential for reducing bar *** findings offer crucial insights into applying these slabs in timber construction as well as to any kind of construction.

关键词： Transversal prestressed slabs wooden construction plantation wood flexural testing design methodology

Treatment of patients with multiple brain metastases by isolated radiosurgery:Toxicity and survival

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World Journal of Clinical Oncology 2023年第10期14卷 400-408页

作者： Andrévinícius de camargo marcos Duarte de Mattos Murilo Kenji Kawasaki Danilo Nascimento Salviano Gomes Allisson Bruno Barcelos Borges vinicius de Lima Vazquez Raphael L C Araujo department of Radiotherapy Barretos Cancer HospitalSão PauloBarretos 14784-400Brazil department of Radiation Therapy Hospital DF Star Rede D´OrBrasília 70390-140Brazil department of Surgery Barretos Cancer HospitalSão PauloBarretos 14784-400Brazil department of Surgery Universidade Federal de São PauloSão Paulo 04024-002Brazil IEP Barretos Cancer HospitalSão PauloBarretos 14784-400Brazil

BACKGROUND Radiosurgery for multiple brain metastases has been more reported recently without using whole-brain ***,the sparsity of the data still claims more information about toxicity and survival and their association with both dosimetric and geometric aspects of this *** To assess the toxicity and survival outcome of radiosurgery in patients with multiple(four or more lesions)brain *** In a single institution,data were collected retrospectively from patients who underwent radiosurgery to treat brain metastases from diverse primary *** with 4-21 brain metastases were treated with a single fraction with a dose of 18 Gy or 20 *** clinical variables collected were relevant to toxicity,survival,treatment response,planning,and dosimetric *** Spearman’s rank correlation coefficients,Mann-Whitney test,Kruskal-Wallis test,and Log-RESULTS From August 2017 to February 2020,55 patients were *** was the most common complaint(38.2%).The median overall survival(OS)for patients with karnofsky performance status(KPS)>70 was 8.9 mo,and this was 3.6 mo for those with KPS≤70(P=0.047).Patients with treated lesions had a median progression-free survival of 7.6 *** were no differences in OS(19.7 vs 9.5 mo)or progression-free survival(10.6 vs 6.3 mo)based on prior *** was no correlation found between reported toxicities and planning,dosimetric,and geometric variables,implying that no additional significant toxicity risks appear to be added to the treatment of multiple(four or more)*** No associations were found between the evaluated toxicities and the planning dosimetric parameters,and no differences in survival rates were detected based on previous treatment status.

关键词： Radiosurgery Brain metastases Radiotherapy Survival Toxicity Cancer

Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability

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World Journal of Gastroenterology 2010年第3期16卷 312-319页

作者： Adriana camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini Blood Transfusion Center Botucatu Medical SchoolUNESP-Sao Paulo State University department of Pathology-Federal University of Ceara Ludwig Institute of Cancer Research department of Pathology Medical SchoolUNESP-Sao Paulo State University department of Gastroenterology Surgery Medical SchoolUNESP-Sao Paulo State University

AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric ***: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact ***: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and ***: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression.

关键词： Gastric cancer Methylation Microsatellite instability Helicobacter pylori Epstein Barr virus

Paraconsistent Algorithm Extractor of Contradiction Effects―ParaExtr_(ctr)

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Journal of Software Engineering and Applications 2011年第10期4卷 579-584页

作者： Joao Inácio Da Silva Filho Germano Lambert-Torres Luiz Fernando Pompeo Ferrara Maurício Conceicao Mário marcos Rosa dos Santos Alexandre Shozo Onuki Joséde Melo camargo Alexandre Rocco Santa Cecilia University Santos CityBrazil Itajuba Federal University ItajubaBrazil Eletropaulo Metropolitano Eletricidade de Sao Paulo S.A. Sao Paulo CityBrazil

Nowadays networks of analyses based in non-classic logics are used with success in the treatment of uncertainties. The characteristic of accepting the contradiction in his structure is the main cause of the methodologies based in Paraconsistent Logic is ideals for applications in systems of analyses and decision making. In this work we presented an algorithm based in Paraconsistent logic capable to extract in a gradual way the effects of the contradiction in originated signals of information of uncertain knowledge database. The Algorithm Paraconsistent Extractor of Contradiction effects - Paraextrctrctr is formed with base in fundamental concepts of the Paraconsistent Annotated Logic with annotation of two values (PAL2v) it can be applied in filters of networks of analyses of signal information where uncertain and contradictory signals can be present. The process of extraction of the effect of the contradiction is always begun by the largest inconsistency degree among two signals that belong to the group that is in analysis. In the end of the analysis it is found a consensus value. In this work we presented numeric example and one example of application of the Paraextrctrctr in Load Profile Forecast used in support to decision of the operation in an Electric Power System, but his application potentiality is demonstrated in several fields of the Artificial Intelligence.

关键词： Algorithm Non-Classic Logic Paraconsistent Annotated Logic

Influence of the sintering temperature on ferroelectric properties of potassium-sodium niobate piezoelectric ceramics

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Journal of Advanced Dielectrics 2021年第3期11卷 8-15页

作者： J.A.Cortés J.camargo M.F.Rachia F.Rubio-marcos L.Ramajo M.Castro M.A.Ramírez Sao Paulo State University—UNESP Faculty of Engineering of Guaratingueta.Av.Dr.Ariberto Pereira da Cunha 333 Portal das Colinas 12516-410GuaratinguetaSPBrazil Research Institute for Materials Science and Technology INTEMA Av.Colon 10850B7608FDQ Mar del PlataArgentina Electroceramics department Instituto de Cerámica y Vidrio CSICKelsen 528049MadridSpain Escuela Politécnica Superior.Universidad Antonio de Nebrija Pirineos 55 28040MadridSpain

The effect of sintering condition on structure,microstructure,and ferroelectric properties of(K_(0.44)Na_(0.52)Li_(0.04))(Nb_(0.86)Ta_(0.10)Sb_(0.04))-O_(3)(KNL-NTS)has been *** powders have been synthesized by the solid-state reaction method and sintered at different temperatures(1115℃,1125℃,and 1140℃).Then,samples were characterized by thermogravimetric analysis,X-ray diffraction,scanning electron microscopy,and impedance *** XRD results,the perovskite structure and small peaks corresponding to a secondary phase were *** processed at the highest temperatures showed higher densities and good piezoelectric properties(d_(33),K_(p),and K_(t)),particularly specimens sintered at 1125℃ presented the highest piezoelectric performance.

关键词： KNL-NTS lead-free ferroelectric properties

Pulmonary In Situ Adenocarcinoma with Mosaic Paving Pattern

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Open Journal of Medical Imaging 2018年第1期8卷 10-15页

作者： Caio Augusto dos Santos Zachini Stefanie Gallotti Borges Carneiro Francisco Barbosa de Araujo Neto Tulio Henrique Martinez Felipe camargo de Carvalho marcos Duarte Guimaraes Leandro Tristao Abi-Ramia de Moraes department of Radiology at Hospital Heliopolis Sao PauloBrazil

CONTEXT: Adenocarcinoma already comprises half the cases of lung cancer. Its insidious clinical evolution contributes to the fact that, in absolute numbers, lung tumor is the cancer with the highest mortality in the world. When still in situ, the adenocarcinoma is even quieter, making its typical presentation on the computerized tomography of an irregular semisolid nodule smaller than 3.0 cm. It is often diagnosed in a finding of examination in an asymptomatic patient. The prevalence of in situ adenocarcinoma (ISA) is less than 5% of pulmonary malignancies and its radiological presentation with a diffuse mosaic paving pattern is even more unusual, mimicking other conditions more frequent to this finding. CASE REPORT: We describe the case of a 44-year-old male patient with a history of chronic smoking admitted to the emergency room at a referral hospital in S?o Paulo on 12/16/2016 with a complaint of progressive dyspnea associated with dry cough for 3 months, intermittent fever and weight loss of 8 kg in 2 months. A chest X-ray and computed tomography showed discrete focal points of peribroncovascular consolidation, predominantly central, areas with frosted glass attenuation associated with smooth thickening of the interlobular septa, sometimes interspersed with areas of preserved parenchyma, giving an aspect of “crazing paving” with diffuse distribution by the pulmonary parenchyma. The patient underwent a biopsy with the anatomicopathological diagnosis of primary Adenocarcinoma in situ of the lung. CONCLUSION: We emphasize that the “crazing paving” of adenocarcinoma in situ pulmonary should be considered and known by the radiologist, because although isolated it is a rare condition, its early distrust in cases of atypical evolution of the most common injuries can avoid a diagnosis in phases more advanced and higher mortality.

关键词： Adenocarcinoma In Situ Lung Adenocarcinoma Lung Cancer Mosaic Attenuation Tomography

In Vivo Preliminary Study on Bone Neoformation Behavior of Three Types of Calcium Phosphate Bioceramics

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Journal of Biosciences and Medicines 2014年第2期2卷 36-42页

作者： Nelson H. A. camargo Enori Gemelli Aury N. de Moraes Bruna D. da Costa Nilson Oleskovicz Ademar L. Dallabrida Doughlas Regalin marcos Paulo Antunes de Lima department Mechanical Engineering Santa Catarina State University Joinville Brazil department of Veterinary Medicine Santa Catarina State University Lagres Brazil

Calcium phosphate microporous bioceramics and biphasic compositions of hydroxyapatite and β-calcium phosphate, in the form of microporous granular biomaterials, are research topics and present themselves as potential orthopedic and biomedical applications in rebuilding and repairing maxillofacial bones and tooth structure. This is associated with the characteristics of microstructure, biocompatibility, bioactivity and bone conductivity properties which these materials offer when applied in vivo or in a simulation environment. This study aimed to assess the behavior of bone neoformation of three types of calcium phosphate biomaterials in in vivo tests with sheep within 60 and 90 days, with the help of a scanning electron microscope. The biomaterials used were provided by the Group of Biomaterials at the Santa Catarina State University. The in vivo tests were carried out by generating, on sheep, tibial bone defects, three of which were filled with biomaterial (one different biomaterial for each bone defect generated), whilst the fourth received a bone fragment obtained during the generation of the defect in question, to serve as a control group. The scanning electron microscopy (SEM) technique was used for carrying out the preliminary characterization studies so as to observe new bone formation and osseointegration. The X-ray diffractometry (XRD) served as a support for the characterization of crystalline phases. The results obtained are encouraging and show that the biomaterials presented good performance in the process of bone formation, biomaterial osseointegration by a new tissue and bone mineralization.

关键词： Bioceramics Microstructure Bone Neoformation Characterization

Influence of Water Content on the Quality of Pigeonpea Seeds

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American Journal of Plant Sciences 2017年第10期8卷 2397-2406页

作者： Cristiane Fernandes Lisboa Rodrigo Starnek Lopes de Araújo Itamar Rosa Teixeira José Hortêncio Mota Alessandro Guerra Da Silva marcos Eduardo Viana de Araújo deyner Damas Aguiar Silva Edgar Estevam Franca Isneider Luiz Silva Fernando Ribeiro Teles de camargo department of Agricultural Engineering Sate University of Goiás Anápolís Brazil department of Agricultural University of Rio Verde Rio Verde Brazil department of Agricultural Federal University of Goiás Jataí Brazil

The species Cajanus cajan L. where pigeonpea is from presents a harvest potential in tropical regions for it is used as human and animal feed, besides being used as green fertilizer. However, the harvest area of this Fabaceae is still insignificant, due to especially the lack of quality seeds. In this context, it is possible to affirm that drying and store are portrayed as important steps for obtaining superior quality seeds. The aim of this study is to evaluate the physiologic quality of dwarf pigeonpea seeds, with different water content during storage. A factorial scheme 3 × 6 was adopted in the delimitation completely randomized, with four replications. Treatments were constituted by the combination of lots of seeds containing three different water contents (11%, 14% and 16%), submitted to a 10-month storage period, with evaluations every two months (0, 2, 4, 6, 8 and 10). Seeds were stocked in a bag type kraft under normal lab conditions, that is, no control. Physiologic quality of the seeds was evaluated through the following tests: Germination Pattern Test—GPT, first count of germination, accelerated aging and electric conductivity. It can be concluded that pigeonpea with hard seeds containing water content at 11% existing superior physiologic quality throughout the 10-month storage, under no controlled condition, certainly promoted by the less intense breathing from the reserves cumulated in the seed lot. Pigeonpea seeds storage with water content superior to 14% promotes a sharp decrease of physiologic quality, due to an increase in metabolic activity.

关键词： Cajanus cajan L. Physiologic deterioration Seed Quality Viability and Vigour

Phytochemical Screening, Extraction of Essential Oils and Antioxidant Activity of Five Species of Unconventional Vegetables

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American Journal of Plant Sciences 2015年第16期6卷 2632-2639页

作者： marcos Schleiden Sousa Carvalho Maria das Gracas Cardoso Luciane Vilela Resende marcos de Souza Gomes Luiz Roberto Marques Albuquerque Anni Cristini Silvestri Gomes Thaís Aparecida Sales Karen Caroline camargo David Lee Nelson Gabriele Mikami Costa Mariana Araújo Espósito Luis Felipe Lima e Silva department of Agriculture Federal University of Lavras Lavras Brazil department of Chemistry Federal University of Lavras Lavras Brazil Federal University of Vales de Jequitinhonha e Mucuri Unaí Brazil Federal University of Vales de Jequitinhonha e Mucuri Diamantina Brazil

Unconventional vegetables, in general, are plants that have been largely consumed by the population at some point and, because of changes in eating behavior, now present reduced economic and social expression and have lost ground to other vegetables. The objectives of this study were to perform phytochemical screening of the ethanol extracts of Rumex acetosa L., Tropaeolum majus L., Solanum muricatum, Stachys byzantina K. Koch and Solanum betaceum Cav. and evaluate their antioxidant potentials via the methods involving scavaging of the DPPH free radical and the ABTS radical, phosphomolybdenum and reducing power. In phytochemical screening, five species of unconventional vegetables tested positive for tannins;for sesquiterpene, lactones and other lactones. These tests were positive for Tropaeolum majus L. and Rumex acetosa L., Solanum betaceum Cav. and Solanum muricatum tested negative for steroids. Only Solanum betaceum Cav. gave positive tests for flavonoids. Among the five plant species studied, Stachys byzantina K. Koch presented the greatest antioxidant potential in all the methods evaluated.

关键词： Rumex acetosa L. Tropaeolum majus L. Stachys byzantina K.Koch Reducing Power

Analysis of PTEN Methylation Pattern by Pyrosequencing in Renal Cell Carcinoma

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Journal of Cancer Therapy 2020年第12期11卷 793-802页

作者： Eurico Cleto Ribeiro de Campos marcos Gonçalves Adriano Júnior Marcus Rivabem Winheski Renan Martins Ademar Lopes department of Oncology Surgery of Prevent Senior Sao Paulo Group Sao Paulo Brasil Oncology Surgical department of Evangélico Mackenzie University Hospital Curitiba Paraná Ponta Grossa State University Paraná Brasil Hospital A. C. camargo Sao Paulo Brazil

Objectives: We aimed to determine the frequency of PTEN (phosphatase with tensin homology deleted in chromosome 10) hypermethylation in renal cell carcinoma (RCC) and its impact on overall (OS) and disease-free survival (DFS). The association between PTEN hypermethylation and clinic and pathologic factors was also analyzed. Materials and Methods: The authors analyzed 137 patients who had undergone a radical or partial nephrectomy between 1997 and 2011. The methylation pattern was quantified individually at multiple CpG islands that are located on the exon 1 of PTEN gene by pyrosequencing. Results: Mean follow-up was 32.3 months. PTEN hypermethylation was detected with a low frequency (3.6%). There were no deaths or disease recurrence among patients with PTEN hypermethylation. Determining the association between PTEN hypermethylation and clinical and pathological factors was not possible due to the low frequency observed. Conclusion: The results show that the methylation of promoter CpG sites in PTEN is relatively infrequent in renal carcinogenesis and has no prognostic impact on survival.

关键词： Methylation PTEN Pyrosequencing Renal Cell Carcinoma