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Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Metal and organo-catalysed asymmetric hydroaminomethylation of styrenes

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催化学报 2015年第1期36卷 106-112页

作者： Barbara Villa-marcos Jianliang Xiao Department of Chemistry University of Liverpool

A new protocol that enables asymmetric hydroaminomethylation of styrenes to afford chiral amines has been developed. Catalysed by an Rh-phosphine species and a chiral phosphoric acid, styrenes are converted into β-chiral amines with good enantioselectivities under syngas in the presence of an amine and Hantzsch ester. The reaction involves two key steps, hydroformylation and reductive amination, with the former catalysed by the Rh species whilst the latter by the phosphoric acid.

关键词：苯乙烯不对称有机催化金属对映选择性加氢甲酰化手性胺酸催化

Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan marcos Caram Costa Marina Maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar Luis Guilherme de Oliveira Silva Marcel Silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

Filtering cylindrical–conical hydrocyclone

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Particuology 2019年第6期17卷 54-62页

作者： Fernanda FSalvador marcos ASBarrozo Luiz GMVieira Federal University of Espírito Santo Center of Agricultural Sciences and EngineeringDepartment of Rural EngineeringZIP Code:29500-000AlegreESBrazil Federal University of Uberlândia Chemical Engineering SchoolBlock 1 KCampus Santa MônicaZIP Code:38400-902UberlândiaMGBrazil

Hydrocyclones have versatile applications in various industrial *** functionn on the principle of centrifugal separation to remove a dispersed phase(particles or drops)from a continuous phase(fluid).In unconventional filtering hydrocyclones,the separation efficiency and energy costs have been improved by combining filtration with centrifugal *** work investigated experimentally the effect of incorporating a cylinder and a porous cone in a conventional *** also evaluated the effects of the main geometric dimensions of the separator on the hydrocyclone performance.A differential-evolution algorithm was applied to optimize the hydrocyclone performance,which was represented as the maximum total efficiency and minimum Euler *** experimental results validated the optimization results and showed that hydrocyclones with optimized geometries exhibited higher total efficiencies(89.59%)and lower Euler numbers(582)than hydrocyclones with other experimental configurations.

关键词： Solid–liquid separation Hydrocyclone Filtration Differential evolution

Isolation and characterization of nine microsatellite loci from Aphelinus mali （Hymenoptera： Aphelinidae）, a parasitoid of Eriosoma lanigerum （Hemiptera： Aphididae）

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Insect Science 2010年第6期17卷 549-552页

作者： Bias Lavandero marcos Dominguez Instituto de Biologia Vegetal y Biotecnologia Universidad de Talca Casilla 747 Talca Chile

Nine novel microsatellite markers are presented for Aphelinus mali, a parasitoid of the woolly apple aphid Eriosoma lanigerum. Loci were characterized for 28 individuals from a single orchard in central Chile. Seven loci were polymorphic within A. mali （3-6 alleles per locus; observed heterozygosity ranging from 0.04 to 0.57） and are therefore useful for population genetic studies within this species.

关键词： Aphelinus mali Chalcidoidea Chile microsatellite population genetics

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Imprinting in plants

Chinese Science Bulletin 2009年第14期54卷 2383-2389页

作者： GUTIERREZ-marcos Jose Warwick HRI University of WarwickWellesbourneCV35 9EF UK

Genomic imprinting leads to the differential expression of parental alleles after fertilization. Imprinting appears to have evolved independently in mammals and flowering plants to regulate the development of nutrient-transfer placental tissues. In addition, the regulation of imprinting in both mammals and flowering plants involves changes in DNA methylation and histone methylation, thus suggesting that the epigenetic signals that regulate imprinting have been co-opted in these distantly related species.

关键词：开花植物 DNA甲基化基因组印记哺乳类动物差异表达基因胎盘组织养分转移信号调节

Intestinal microbiota and its interaction to intestinal health in nursery pigs

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Animal Nutrition 2022年第1期8卷 169-184页

作者： marcos Elias Duarte Sung Woo Kim Department of Animal Science North Carolina State UniversityRaleighNC27695United States

The intestinal microbiota has gained increased attention from researchers within the swine industry due to its role in promoting intestinal maturation,immune system modulation,and consequently the enhancement of the health and growth performance of the *** review aimed to provide updated scientific information on the interaction among intestinal microbiota,dietary components,and intestinal health of *** small intestine is a key site to evaluate the interaction of the microbiota,diet,and host because it is the main site for digestion and absorption of nutrients and plays an important role within the immune *** diet and its associated components such as feed additives are the main factors affecting the microbial composition and is central in stimulating a beneficial population of *** microbiotaehost interaction modulates the immune system,and,concurrently,the immune system helps to modulate the microbiota *** direct interaction between the microbiota and the host is an indication that the mucosa-associated microbiota can be more effective in evaluating its effect on health *** was demonstrated that the mucosa-associated microbiota should be evaluated when analyzing the interaction among diets,microbiota,and *** addition,supplementation of feed additives aimed to promote the intestinal health of pigs should consider their roles in the modulation of mucosa-associated microbiota as biomarkers to predict the response of growth performance to dietary interventions.

关键词： Intestinal health Mucosa-associated microbiota Nursery pig

Long-term forest management after wildfire(Catalonia,NE Iberian Peninsula)

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Journal of Forestry Research 2020年第1期31卷 269-278页

作者： marcos Francos Xavier Ubeda Paulo Pereira GRAM(Grup de Recerca Ambiental Mediterrania) Department of GeographyUniversity of BarcelonaMontalegre608001 BarcelonaSpain Environmental Management Centre Mykolas Romeris UniversityVilniusLithuania

Studies of post-fire soil status in Mediterranean ecosystems are common;however,few have examined the effects of long-term forest management after a wildfire on physicochemical soil ***,we analyzed differences in soil properties attributable to long-term postfire management and assessed the sustainability of these management practices in relation to the soil *** study area is located in Odena in the northeast region of the Iberian Peninsula consisted of the control forest(burned more than 30 years ago),low density forest(LD;burned in a wildfire in 1986 and managed in 2005)and high density forest(HD;burned in a wildfire in 1986 and no managed).For soils from each plot,we measured soil water repellency,aggregate stability,total nitrogen(TN),soil organic matter(SOM),inorganic carbon(IC),pH,electrical conductivity,extractable calcium,magnesium,sodium,potassium(K),phosphorus,aluminum(Al),manganese(Mn),iron(Fe),zinc,copper,boron,chrome,silicon and sulfur and calculated the ratios of C/N,Ca+Mg/(Na+K)^1/2,Ca/Al and Ca/*** differences were found in TN,IC,SOM,pH,K,Al,Mn,Fe and C/N ratio(p<0.05).All soil properties were found to have largely recovered their pre-fire *** were affected by the post-fire management practices implemented 20 years after the fire,as reflected in their respective physicochemical properties,so that soil properties at the control and LD sites are more similar today than those at the control and HD ***,sustainable forest management can overcome soil degradation in areas affected by wildfire in the medium-and long-term by improving soil properties.

关键词： Soil chemical properties Aggregate stability Post-fire management Wildfire risk Vegetal density

Effect of pre-and post-wildfire management practices on plant recovery after a wildfire in Northeast Iberian Peninsula

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Journal of Forestry Research 2020年第5期31卷 1647-1661页

作者： marcos Francos Paulo Pereira Xavier Ubeda GRAM(Grup de Recerca Ambiental Mediterrania) Department of GeographyUniversity of BarcelonaMontalegre608001 BarcelonaSpain Environmental Management Centre Mykolas Romeris UniversityVilniusLithuania

Fire and pre-or post-fire management practices shape the distribution and richness of plant ***,the effects of pre-and post-fire management on vegetation recovery were studied at different times,up to 18 months after a *** months after a 2015 wildfire,18 study plots were established(three 4-m^2 plots for each treatment),vegetation regrowth was monitored and vegetal species richness(S),evenness(IT),density(D),diversity(H0)and maximum diversity(HMax)after 2,10 and 18 *** treatments were(1)control,unaffected by 2015 wildfire;(2)no treatment(NT),burned in 2015 wildfire and not managed;(3)managed in 2005 and burned in 2015(M05B);(4)managed in 2015,2 months before wildfire(M15B);(5)cut and manual removal after the 2015 wildfire(CR);(6)cut and no trunk removal randomly deposited on topsoil after the 2015 wildfire(CL).All the treatments were carried out in a Pinus halepensis Miller *** 10 and 18 months after the wildfire,vegetation recovery was greater in NT,CR and CL plots than in M05B and M15B the *** 18 months after the wildfire,Brachypodium retusum(Pers.)*** Rosmarinus officinalis *** still dominant,especially in M15B,corroborating the belief that pre-fire treatment reduced ecosystem resilience and vegetal recovery compared to the NT and post-fire managed *** was significantly lower 10 months after wildfire in control plots,and IT was significantly higher in that inventory than previously in *** months after the wildfire,H0 was significantly lower in *** months post-wildfire,HMax was significantly lower in the control *** months after the wildfire,HMax,was significantly higher in CR,CL and M05B than in the control and M15B ***,pre-fire management was detrimental to post-fire vegetation recovery,while manual post-fire management proved beneficial.

关键词： Forest management Vegetation recovery Diversity Richness Evenness