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Effects of sulforaphane on brain mitochondria: mechanistic view and future directions

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第4期21卷 263-279页

作者： Fernanda Rafaela JARDIM Fhelipe Jolner Souza de ALMEIDA Matheus Dargesso LUCKACHAKI marcos roberto de oliveira Forensic Institute Forensic Toxicology DivisionPostmortem Toxicology SectorCEP 90160-093Porto AlegreRSBrazil Postgraduate Program in Health Sciences(PPGCS) Federal University of Mato Grosso(UFMT)CEP 78060-900CuiabaMTBrazil department of Chemistry Federal University of Mato Grosso(UFMT)CEP 78060-900CuiabaMTBrazil Postgraduate Program in Chemistry(PPGQ) Federal University of Mato Grosso(UFMT)CEP 78060-900CuiabaMTBrazil department of Biochemistry Prof.“Tuiskon Dick” Federal University of Rio Grande do Sul(UFRGS)CEP 90035-000Porto AlegreRSBrazil

The organosulfur compound sulforaphane(SFN;C6H11NOS2) is a potent cytoprotective agent promoting antioxidant, anti-inflammatory, antiglycative, and antimicrobial effects in in vitro and in vivo experimental models. Mitochondria are the major site of adenosine triphosphate(ATP) production due to the work of the oxidative phosphorylation(OXPHOS) system. They are also the main site of reactive oxygen species(ROS) production in nucleated human cells. Mitochondrial impairment is central in several human diseases, including neurodegeneration and metabolic disorders. In this paper, we describe and discuss the effects and mechanisms of action by which SFN modulates mitochondrial function and dynamics in mammalian cells. Mitochondria-related pro-apoptotic effects promoted by SFN in tumor cells are also discussed. SFN may be considered a cytoprotective agent, at least in part, because of the effects this organosulfur agent induces in mitochondria. Nonetheless, there are certain points that should be addressed in further experiments, indicated here as future directions, which may help researchers in this field of research.

关键词： Sulforaphane Brain Mitochondria Antioxidant Nuclear factor erythroid 2-related factor 2(Nrf2)

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Behavior of wood basic density according to environmental variables

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Journal of Forestry Research 2022年第2期33卷 497-505页

作者： Gabriel marcos Vieira oliveira JoséMárcio de Mello Carlos Rogério de Mello Joséroberto Soares Scolforo Eder Pereira Miguel Thiago Campos Monteiro Brazil Institute of Agricultural and Forestry defense of Espírito Santo(IDAF) Av.Lourival Lugon Moulinnº300CentroJerônimo MonteiroES CEP:29.550-000Brazil department of Forestry Sciences Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Engineering department Universidade Federal de Lavras-UFLACaixa Postal 3037LavrasMG CEP:37.200-000Brazil Forestry Engineering department Faculdade de TecnologiaUniversity of Brasilia-UnBCampus Universitário Darcy RibeiroCaixa Postal 4357Asa Norte-BrasíliaDF CEP:70910-900Brazil department of Forestry Engineering and Technology Universidade Federal do Paraná-UFPRAv.Pref.Lothário Meissner632Jardim BotânicoCuritibaPR CEP:80.210-170Brazil

The relationships between climate conditions and wood density in tropical forests are still poorly *** quantify spatial dependence of wood density in the state of Minas Gerais(MG,Brazil),map spatial distribution of density,and correlate density with climate variables,we extracted data from the Forest Inventory of Minas Gerais for 1988 trees scaled throughout the territory and measured wood density of discs removed from the *** variables were extracted from the database of the Ecological-Economic Zoning of Minas *** spatial analysis,tree densities were measured at 44 georeferenced sampling *** data were subjected to exploratory analysis,variography,cross-validation,model selection,and ordinary *** relationships between wood density and environmental variables were calculated using dispersion matrices,linear correlation,and *** density proved to be highly spatially dependent,reaching a correlation of 96%,and was highly continuous over a distance of 228 *** distribution of wood density followed a continuous gradient of 514-659 kg m^(−3),enabling corre-lation with environment *** was correlated with mean annual precipitation(−0.57),temperature(0.63),and evapotranspiration(0.83).Geostatistical methods proved useful in predicting wood density in native tropical forests with different climate *** results confirmed the sensitivity of wood density to climate change,which could affect future carbon stock in forests.

关键词： Biomass Climate variables Geostatistics Hardwood Forest inventory Minas Gerais

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Selection signatures in Canchim beef cattle

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Journal of Animal Science and Biotechnology 2017年第1期8卷 15-23页

作者： Ismael Urbinati Nedenia Bonvino Stafuzza marcos Túlio oliveira Tatiane Cristina Seleguim Chud roberto Hiroshi Higa Luciana Correia de Almeida Regitano Maurício Mello de Alencar marcos Eli Buzanskas Danísio Prado Munari departamento de Ciencias Exatas Univ Estadual PaulistaFaculdade de Ciencias Agrairias e VeterinairiasjaboticabalSao Paulo 14884-900Brazil departamento de Tecnologia UNESP-Univ Estadual PaulistaFaculdade de Ciencias Agrarias e VeterinariasJaboticabalSao Paulo 14884-900Brazil Embrapa Agricultural Informatics CampinasSao Paulo 13083-886Brazil Embrapa Southeast Livestock Sao CarlosSao Paulo 13560-970Brazil

Background： Recent technological advances in genomics have allowed the genotyping of cattle through single nucleotide polymorphism（SNP） panels. High-density SNP panels possess greater genome coverage and are useful for the identification of conserved regions of the genome due to selection, known as selection signatures（SS）. The SS are detectable by different methods, such as the extended haplotype homozygosity（EHH）; and the integrated haplotype score（i HS）, which is derived from the EHH. The aim of this study was to identify SS regions in Canchim cattle（composite breed）, genotyped with high-density SNP ***： A total of 687,655 SNP markers and 396 samples remained for SS analysis after the genotype quality control. The i HS statistic for each marker was transformed into pi HS for better interpretation of the *** BTA5 and BTA14 showed pi HS 〉 5, with 39 and nine statistically significant SNPs（P 〈 0.00001）,respectively. For the candidate selection regions, i HS values were computed across the genome and averaged within non-overlapping windows of 500 Kb. We have identified genes that play an important role in metabolism,melanin biosynthesis（pigmentation）, and embryonic and bone ***： The observation of SS indicates that the selection processes performed in Canchim, as well as in the founder breeds（i.e. Charolais）, are maintaining specific genomic regions, particularly on BTA5 and BTA14. These selection signatures regions could be associated with Canchim characterization.

关键词： Composite breed Extended haplotype homozygosity Genomics Single nucleotide polymorphism

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Selection of Bacillus thuringiensis strains in citrus and their pathogenicity to Diaphorina citri (Hemiptera: Liviidae) nymphs

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Insect Science 2020年第3期27卷 519-530页

作者： Silvia de oliveira Dorta Juliana Balbinotte Rose Monnerat Joao roberto Spotti Lopes Tatiane da Cunha Odimar Zanuzo Zanardi Marcelo Pedreira de Miranda marcos Antonio Machado Juliana de Freitas-Astua Programs de Pos-Graduagao em Microbiologia Agricola Escola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Laboratorio de Biotecnologia Centro de Citricultura Sylvio MoreiraInstituto Agronomico de CampinasCordeiropolisSPBrazil Laboratorio de Insetos Vetores de Fitopatdgenos Departamento de Entomologia e AcarologiaEscola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Embrapa Recursos Geneticos e Biotecnologia BrasiliaDFBrazil Fundo de defesa da Citricultura(Fundecitrus) AraraquaraSPBrazil Embrapa Mandioca e Fruticultura Cruz das AlmasBABrazil Laboratdrio de Bioquimica Fitopatoldgica Instituto BioldgicoSao PauloSPBrazil

Bacillus thuringiensis(Bt)toxins are effective in controlling insect pests either through the spraying of products or when expressed in transgenic *** discovery of endophytic Bt strains opened new perspectives for studies aimed at the control of sap‐sucking insects,such as the Asian citrus psyllid Diaphorina citri Kuwayama(Hemiptera:Liviidae),a vector of“Candidatus Liberibacter spp.,”associated with citrus huanglongbing(HLB).In this study,translocation of endophytic Bt strains in citrus seedlings inoculated with Bt suspension delivered by soil‐drench,and their systemic pathogenicity to *** nymphs were *** pathogenicity of three wild‐type Bt strains against *** third‐instar nymphs was *** the 10 recombinant strains tested(each of them harboring a single cry or cyt gene),3 can be highlighted,causing 42%–77%and 66%–90%nymphal mortality at 2 and 5 d after inoculation,*** isolation of Bt cells from young citrus shoots and dead nymphs,and PCR performed with specific primers,confirmed the involvement of the Bt strains in the psyllid *** is the first report showing the translocation of Bt strains from citrus seedling roots to shoots and their potential to control *** nymphs that fed on these soil‐drench inoculated *** Bt strains that caused the highest mortality rates have the potential to be used as bioinsecticides to control *** and the identified genes can be used for the production of transgenic Bt citrus.

关键词： Asian citrus psyllid Citrus sinensis Cry toxins endophytic Bt huanglongbing young shoots

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A message classifier based on multinomial Naive Bayes for online social contexts

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Journal of Management Analytics 2018年第3期5卷 213-229页

作者： Thársis Salathiel de Souza Viana marcos de oliveira Ticiana Linhares Coelho da Silva Mário Sérgio Rodrigues Falc ao and Enyo JoséTavares Gonçalves Universidade Federal do CearáQuixadáBrazil

Children and teenagers today are increasingly connected to the *** use by minors of social networks applications,and games that are connected to the internet offer the possibility of communication,can make them exposed to various *** of the most troubling threats is sexual *** the objective of this project is to create a model for classifying messages,as normal or dangerous,according to the risk they present to the *** addition to integrating the developed model with a project that analyzes the behavior of minors in a social network(Facebook),and calculates the risk of the minor be a victim of sexual ***,we use the model in the classification of messages obtained from a server of the game Minecraft,quite popular among children.

关键词： messages exchange classification social media children and teenagers protection minecraft clustering messages

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Linking sedimentary provenance,climate and tectonics in the Neoproterozoic SeridóBelt,Borborema Province(NE Brazil)

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Geoscience Frontiers 2023年第6期14卷 414-431页

作者： Carlos V.A.Ribeiro marcos C.C.Sales Armando L.S.de oliveira Ricardo Sallet Programa de Pós-graduação em Geologia Instituto de GeociênciasUniversidade de Brasília(UnB)CEP 70910-900 BrasíliaDFBrazil Programa de Pós-Graduação em Geociências Universidade Federal de PernambucoDepartamento de GeologiaCentro de Tecnologia e GeociênciasAv.da ArquiteturaCEP 50740-530 RecifePEBrazil departamento de Geologia Universidade Federal do Rio Grande do NorteCEP 59078-970 NatalRNBrazil

The SeridóBelt,at the extreme northeast of Brazil,is one of the several Neoproterozoic mobile belts related to the Brasiliano/Pan-African Orogeny in Western *** lithostratigraphy of the SeridóBelt comprises basal quartzites and metaconglomerates(Equador Formation)overlain by hornblende-bearing paragneisses,calc-silicate rocks and marbles(Jucurutu Formation)and biotiteschists(SeridóFormation).We investigated the sedimentary provenance of these rocks based on an integration of compiled whole-rock geochemistry,Sm-Nd isotopes,U-Pb detrital zircon ages and a new set of whole-rock trace elements *** Formation quartzites have major and trace elements patterns that resemble cratonic sandstones,with a typical felsic provenance consistent with the isotopic composition of plutonic Archean to Paleoproterozoic basement *** proxies suggest that these rocks were deposited in fresh waters under anoxic conditions and moderate to intense weathering conditions(CIA=58–79).A shift in provenance led to an increase in intermediate-mafic sources during the deposition of the Jucurutu and Seridó*** elements from rock types in these units are nearly identical,yet they differ on the contents of some high field-strength elements(e.g.,Sc,V and Ni),which are higher in the SeridóFormation than average *** proxies show similar depositional environments,with brackish to marine conditions for the Jucurutu and Seridóformations under anoxic to euxinic *** conditions are consistently lower in the Jucurutu Formation(CIA=58–66)in comparison with the SeridóFormation(CIA=60–88).Compiled U-Pb data suggest maximum depositional ages of 633±11 Ma and 633±6 Ma for Jucurutu and Seridóformations,respectively,suggesting deposition following the ca.645–635 Ma Marinoan *** compared the geochemistry of the SeridóFormation schists with currently exposed basement rocks and showed a strong affinity with Neoproterozoic arc-related

关键词： Whole-rock geochemistry Marinoan Glaciation U-Pb detrital zircon Brasiliano Orogeny

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Proximal Methods with Bregman Distances to Solve VIP on Hadamard Manifolds with Null Sectional Curvature

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Journal of the Operations Research Society of China 2021年第3期9卷 499-523页

作者： Erik Alex Papa Quiroz Paulo roberto oliveira Universidad Nacional Mayor de San marcos Universidad Privada del NorteLimaPeru PESC-COPPE Federal University of Rio de JaneiroRio de Janeiro CEP 21941-972Brazil

We present an extension of the proximal point method with Bregman distances to solve variational inequality problems(VIP)on Hadamard manifolds with null sectional *** some natural assumptions,as for example,the existence of solutions of the VIP and the monotonicity of the multivalued vector field,we prove that the sequence of the iterates given by the method converges to a solution of the ***,this convergence is linear or superlinear with respect to the Bregman distance.

关键词： Proximal point methods Hadamard manifolds Bregman distances Variational inequality problems Monotone vector field

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eIF3 subunit M regulates blood meal digestion in Rhodnius prolixus affecting ecdysis, reproduction, and survival

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Insect Science 2023年第5期30卷 1282-1292页

作者： Pilar Ameijeiras Natalia Capriotti Sheila Ons Pedro L.oliveira marcos Sterkel Laboratorio de Neurobiología de Insectos(LNI) Centro Regional de Estudios GenómicosFacultad de Ciencias ExactasUniversidad Nacional de La PlataCENEXACONICETLa PlataBuenos AiresArgentina Instituto de Bioquímica Médica Leopoldo de Meis Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular(INCT-EM) Rio de JaneiroBrazil

In triatomines,blood-feeding triggers many physiological processes including post embryonic development and *** feeding habits,such as hematophagy,can shape gene functions to meet the challenges of each type of *** gut of blood-sucking insects faces particular challenges after feeding due to the quantity and the quality of the food ingested.A comparison of transcriptomic and proteomic data indicates that post transcriptional regulation of gene expression is crucial in the triatomine *** was proposed that eukaryotic translation initiation factor 3 subunit m(eIF3m)and eIF3e define 2 different eIF3 complexes with a distinct affinity for the different mRNAs,thus selecting the set of mRNAs to be translated and constituting a post transcriptional mode of regulation of gene *** the eIF3m is mainly expressed in the gut,we evaluated its relevance in Rhodnius prolixus physiology through RNA interference-mediated gene *** knockdown of eIF3m reduced the digestion rate,affecting the processes triggered by a blood *** silencing inhibited molting and caused premature death in nymphs while impaired ovary development,oviposition and increased resistance to starvation in adult *** survival of males after feeding(resistance to starvation)was not affected by eIF3m *** information regarding the eIF3m function in insects is scarce and the phenotypes observed in *** upon eIF3m silencing are different and more severe than those previously described in Drosophila melanogaster,indicating a pleiotropic role of this gene in triatomines.

关键词： egg hatching hematophagous vectors lifespan oviposition post embryonic development starvation resistance

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Diversity of filamentous fungi in leaf litter and aerial litter in semideciduous forest,Bahia,Brazil

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Journal of Forestry Research 2015年第2期26卷 479-485页

作者： marcos Fabio oliveira Marques Edemir Barbosa dos Santos Luis Fernando Pascholati Gusmaao Laborato rio de Biologia Molecular de Fungos Universidade do Estado da BahiaCampus VIIBr 407Km 127Rod.Lomanto JuoniorSenhor do BonfimBA 44230-000Brazil Laboratorio de Micologia (LAMIC) Universidade Estadual de Feira de SantanaCaixa Postal 252Feira de SantanaBA 44036-900Brazil

The fungi have wide distribution in ecosystems and can be found colonizing various substrates,where they act as efficient decomposers,participating in cycling of *** present study aimed to assess the diversity,richness and composition of filamentous fungi in leaf litter and aerial litter in a semi-deciduous forest in the Chapada Diamantina,Bahia,*** of leaf litter and aerial litter were collected monthly from October/2009 to September/2010 in eight installments in the studied *** samples were washed,placed in moist chambers and incubated.47 taxa were identified,37 in leaf litter and 35 in aerial litter,with 25 species common to both.A similarity of 69 % according to Sorensen *** similarity was considered low when the sample points were compared to the same *** fungi showed sporadic intervals.

关键词： Plant debris Species richness Tropical microfungi

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Environmental geochemistry:Introduction

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Geoscience Frontiers 2022年第1期13卷 374-375页

作者： Luis F.O.Silva marcos L.S.oliveira department of Civil and Environmental.Universidad de la Costa CUCCalle 58#55-66BarranquillaAtlánticoColombia departamento de Ingeniería Civil y Arquitectura Universidad de LimaAvenida Javier Prado Este 4600Santiago de Surco 1503Peru

Assessing the physical,geographic,chemical,and geological aspects are important to understand environmental impacts as well as health concerns in view of building a more sustainable planet with circular economies that would last for the foreseeable *** the recent years,the significance of incorporating ecosystem,anthropogenic activities,and climate has fortified from being an academic concern(e.g.,WEF,2011)into a broadly societal concern as the forecasted realities of environmental deterioration and global climate change come to pass.

关键词： geochemistry climate planet

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